A giant protease with a twist: The TPP II complex from Drosophila studied by electron microscopy

EMBO Journal

Volumn 21, Issue 22, 2002, Pages 5979-5984

  Rockel, Beate ^a   Peters, Jürgen ^b   Kühlmorgen, Brigitte ^b   Glaeser, Robert M ^a   Baumeister, Wolfgang ^b  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

Cryo electron microscopy; Three dimensional reconstruction; Tripeptidyl peptidase II

Indexed keywords

PROTEINASE; TRIPEPTIDYL PEPTIDASE II; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; DROSOPHILA; ELECTRON MICROSCOPY; IMAGE ANALYSIS; IMAGE PROCESSING; IMAGE RECONSTRUCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PURIFICATION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

ANIMALS; CRYOELECTRON MICROSCOPY; DROSOPHILA PROTEINS; EGG PROTEINS; IMAGE PROCESSING, COMPUTER-ASSISTED; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; PROTEIN CONFORMATION; SERINE ENDOPEPTIDASES;

DROSOPHILA MELANOGASTER; MAMMALIA; MELANOGASTER;

EID: 18744374439     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf601     Document Type: Article

References (27)

1. Baumeister, W., Walz, J., Zühl, F. and Seemüller, E. (1998) The proteasome: Paradigm of a self-compartmentalizing protease. Cell, 92, 367-380.
2. Coux, O., Tanaka, K. and Goldberg, A.L. (1996) Structure and functions of the 20S and 26S proteasomes. Annu. Rev. Biochem., 65, 801-847.
3. Geier, E., Pfeifer, G., Wilm, M., Lucchiari-Hartz, M., Baumeister, W., Eichmann, K. and Niedermann, G. (1999) A giant protease with potential to substitute for some functions of the proteasome. Science, 283, 978-981.
4. Glas, R., Bogyo, M., McMaster, J.S., Gaczynska, M. and Ploegh, H.L. (1998) A proteolytic system that compensates for loss of proteasome function. Nature, 392, 618-622.
5. Glickman, M.H. and Ciechanover, A. (2002) The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction. Physiol. Rev., 82, 373-428.
6. Harris, J.R. and Tomkinson, B. (1990) Electron-microscopic and biochemical-studies on the oligomeric states of human erythrocyte tripeptidyl peptidase 2. Micron Microsc. Acta, 21, 77-89.
7. Hegerl, R. (1996) The EM program package: A platform for image processing in biological electron microscopy. J. Struct. Biol., 116, 30-34.
8. Hegerl, R. and Altbauer, A. (1982) The 'EM' program system. Ultramicroscopy, 9, 109-116.
9. Hölzl, H. et al. (2000) The regulatory complex of Drosophila melanogaster 26S proteasomes: Subunit composition and localization of a deubiquitylafing enzyme. J. Cell Biol., 150, 119-129.
10. Ludtke, S.J., Baldwin, P.R. and Chiu, W. (1999) EMAN: Semiautomated software for high-resolution single-particle reconstructions. J. Struct. Biol., 128, 82-97.
11. Lupas, A, Flanagan, J.M., Tamura, T. and Baumeister, W. (1997) Self-compartmentalizing proteases. Trends Biochem. Sci., 22, 399-404.
12. Macpherson, E., Tomkinson, B., Bålöw, R.M., Hoglund, S. and Zetterqvist, O. (1987) Supramolecular structure of tripeptidyl peptidase II from human erythrocytes as studied by electron microscopy, and its correlation to enzyme activity. Biochem. J., 248, 259-263.
13. Renn, S.C., Tomkinson, B. and Taghert, P.H. (1998) Characterization and cloning of tripeptidyl peptidase II from the fruit fly, Drosophila melanogaster. J. Biol. Chem., 273, 19173-19182.
14. Rose, C. et al. (1996) Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature, 380, 403-409.
15. Saxton, W.O. and Baumeister, W. (1982) The correlation averaging of a regularly arranged bacterial cell envelope protein. J. Microsc., 127, 127-138.
16. Tamura, T., Tamura, N., Cejka, Z., Hegerl, R., Lottspeich, F. and Baumeister, W. (1996) Tricorn protease - The core of a modular proteolytic system. Science, 274, 1385-1389.
17. Tamura, N., Lottspeich, F., Baumeister, W. and Tamura, T. (1998) The role of tricom protease and its aminopeptidase-interacting factors in cellular protein degradation. Cell, 95, 637-648.
18. Tomkinson, B. (1998) Tripeptidyl-peptidase II. In Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (eds), Handbook of Proteolytic Enzymes. Academic Press, London, UK, pp. 338-340.
19. Tomkinson, B. (1999) Tripeptidyl peptidases: Enzymes that count. Trends Biochem. Sci., 24, 355-359.
20. Tomkinson, B. (2000) Association and dissociation of the tripeptidyl-peptidase II complex as a way of regulating the enzyme activity. Arch. Biochem. Biophys., 376, 275-280.
21. van Heel, M. and Frank, J. (1981) Use of multivariate statistics in analysing the images of biological macromolecules. Ultramicroscopy, 6, 187-194.
22. Voges, D., Zwickl, P. and Baumeister, W. (1999) The 26S proteasome: A molecular machine designed for controlled proteolysis. Annu. Rev. Biochem., 68, 1015-1068.
23. Voorhorst, W.G.B., Eggen, R.I.L., Geerling, A.C.M., Platteeuw, C., Siezen, R.J. and Devos, W.M. (1996) Isolation and characterization of the hyperthermostable serine protease, pyrolysin, and its gene from the hyperthermophilic archaeon Pyrococcus furiosus. J. Biol. Chem., 271, 20426-20431.
24. Walz, J., Tamura, T., Tamura, N., Grimm, R., Baumeister, W. and Koster, A.J. (1997) Tricorn protease exists as an icosahedral supermolecule in vivo. Mol. Cell, 1, 59-65.
25. Wang, E.W., Kessler, B.M., Borodovsky, A., Cravatt, B.F., Bogyo, M., Ploegh, H.L. and Glas, R. (2000) Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity. Proc. Natl Acad. Sci. USA, 97, 9990-9995.
26. Yao, T.T. and Cohen, R.E. (1999) Giant proteases: Beyond the proteasome. Curr. Biol., 9, R551-R553.
27. Zwickl, P., Seemüller, E., Kapelari, B. and Baumeister, W. (2001) The proteasome: A supramolecular assembly designed for controlled proteolysis. Adv. Protein Chem., 59, 187-222.