Hepatic Proprotein Convertases Modulate HDL Metabolism

Cell Metabolism

Volumn 6, Issue 2, 2007, Pages 129-136

  Jin, Weijun ^a   Wang, Xun ^a   Millar, John S ^a   Quertermous, Thomas ^b   Rothblat, George H ^c   Glick, Jane M ^a   Rader, Daniel J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

HUMDISEASE

Indexed keywords

ANGIOPOIETIN LIKE PROTEIN 3; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIVER ENZYME; PHOSPHOLIPID; PROPROTEIN CONVERTASE; SERINE PROTEINASE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CATABOLISM; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; FEMALE; HOMEOSTASIS; HYDROLYSIS; LIPOPROTEIN METABOLISM; MOUSE; NONHUMAN; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; BIOLOGICAL TRANSPORT; FEMALE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPASE; LIPIDS; LIPOPROTEINS, HDL; LIVER; MICE; MICE, INBRED C57BL; PROPROTEIN CONVERTASES;

EID: 34547571901     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2007.07.009     Document Type: Article

References (31)

1. Abifadel M., Varret M., Rabes J.P., Allard D., Ouguerram K., Devillers M., Cruaud C., Benjannet S., Wickham L., Erlich D., et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat. Genet. 34 (2003) 154-156
2. Acton S., Rigotti A., Landschulz K.T., Xu S., Hobbs H.H., and Krieger M. Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science 271 (1996) 518-520
3. Basak A. Inhibitors of proprotein convertases. J. Mol. Med. 83 (2005) 844-855
4. Benjannet S., Elagoz A., Wickham L., Mamarbachi M., Munzer J.S., Basak A., Lazure C., Cromlish J.A., Sisodia S., Checler F., et al. Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production. J. Biol. Chem. 276 (2001) 10879-10887
5. Benjannet S., Rhainds D., Essalmani R., Mayne J., Wickham L., Jin W., Asselin M.C., Hamelin J., Varret M., Allard D., et al. NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. J. Biol. Chem. 279 (2004) 48865-48875
6. Bojanovski D., Gregg R.E., Zech L.A., Meng M.S., Bishop C., Ronan R., and Brewer Jr. H.B. In vivo metabolism of proapolipoprotein A-I in Tangier disease. J. Clin. Invest. 80 (1987) 1742-1747
7. Christiansen-Weber T.A., Voland J.R., Wu Y., Ngo K., Roland B.L., Nguyen S., Peterson P.A., and Fung-Leung W.P. Functional loss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high-density lipoprotein cholesterol deficiency. Am. J. Pathol. 157 (2000) 1017-1029
8. Cohen J., Pertsemlidis A., Kotowski I.K., Graham R., Garcia C.K., and Hobbs H.H. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat. Genet. 37 (2005) 161-165
9. Goldstein J.L., Rawson R.B., and Brown M.S. Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis. Arch. Biochem. Biophys. 397 (2002) 139-148
10. Ishida T., Choi S., Kundu R.K., Hirata K., Rubin E.M., Cooper A.D., and Quertermous T. Endothelial lipase is a major determinant of HDL level. J. Clin. Invest. 111 (2003) 347-355
11. Jaye M., Lynch K.J., Krawiec J., Marchadier D., Maugeais C., Doan K., South V., Amin D., Perrone M., and Rader D.J. A novel endothelial-derived lipase that modulates HDL metabolism. Nat. Genet. 21 (1999) 424-428
12. Jin W., Millar J.S., Broedl U., Glick J.M., and Rader D.J. Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo. J. Clin. Invest. 111 (2003) 357-362
13. Jin W., Fuki I.V., Seidah N.G., Benjannet S., Glick J.M., and Rader D.J. Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase. J. Biol. Chem. 280 (2005) 36551-36559
14. Koishi R., Ando Y., Ono M., Shimamura M., Yasumo H., Fujiwara T., Horikoshi H., and Furukawa H. Angptl3 regulates lipid metabolism in mice. Nat. Genet. 30 (2002) 151-157
15. Ma K., Cilingiroglu M., Otvos J.D., Ballantyne C.M., Marian A.J., and Chan L. Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Proc. Natl. Acad. Sci. USA 100 (2003) 2748-2753
16. Maxwell K.N., and Breslow J.L. Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype. Proc. Natl. Acad. Sci. USA 101 (2004) 7100-7105
17. Nour N., Basak A., Chretien M., and Seidah N.G. Structure-function analysis of the prosegment of the proprotein convertase PC5A. J. Biol. Chem. 278 (2003) 2886-2895
18. Ono M., Shimizugawa T., Shimamura M., Yoshida K., Noji-Sakikawa C., Ando Y., Koishi R., and Furukawa H. Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo. J. Biol. Chem. 278 (2003) 41804-41809
19. Park S.W., Moon Y.A., and Horton J.D. Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver. J. Biol. Chem. 279 (2004) 50630-50638
20. Rader D.J. Molecular regulation of HDL metabolism and function: implications for novel therapies. J. Clin. Invest. 116 (2006) 3090-3100
21. Roebroek A.J., Taylor N.A., Louagie E., Pauli I., Smeijers L., Snellinx A., Lauwers A., Van de Ven W.J., Hartmann D., and Creemers J.W. Limited redundancy of the proprotein convertase furin in mouse liver. J. Biol. Chem. 279 (2004) 53442-53450
22. Scamuffa N., Calvo F., Chretien M., Seidah N.G., and Khatib A.M. Proprotein convertases: lessons from knockouts. FASEB J. 20 (2006) 1954-1963
23. Seidah N.G., and Chretien M. Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Res. 848 (1999) 45-62
24. Sewell D.A., Yuan C.X., and Robertson E. Proteomic signatures in laryngeal squamous cell carcinoma. ORL J. Otorhinolaryngol. Relat. Spec. 69 (2006) 77-84
25. Shimamura M., Matsuda M., Yasumo H., Okazaki M., Fujimoto K., Kono K., Shimizugawa T., Ando Y., Koishi R., Kohama T., et al. Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase. Arterioscler. Thromb. Vasc. Biol. 27 (2007) 366-372
26. Shimizugawa T., Ono M., Shimamura M., Yoshida K., Ando Y., Koishi R., Ueda K., Inaba T., Minekura H., Kohama T., and Furukawa H. ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase. J. Biol. Chem. 277 (2002) 33742-33748
27. Watanabe M., Hirano A., Stenglein S., Nelson J., Thomas G., and Wong T.C. Engineered serine protease inhibitor prevents furin-catalyzed activation of the fusion glycoprotein and production of infectious measles virus. J. Virol. 69 (1995) 3206-3210
28. Wong H., and Schotz M.C. The lipase gene family. J. Lipid Res. 43 (2002) 993-999
29. Yancey P.G., Asztalos B.F., Stettler N., Piccoli D., Williams D.L., Connelly M.A., and Rothblat G.H. SR-BI- and ABCA1-mediated cholesterol efflux to serum from patients with Alagille syndrome. J. Lipid Res. 45 (2004) 1724-1732
30. Zhang Y., Zanotti I., Reilly M.P., Glick J.M., Rothblat G.H., and Rader D.J. Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo. Circulation 108 (2003) 661-663
31. Zhong M., Munzer J.S., Basak A., Benjannet S., Mowla S.J., Decroly E., Chretien M., and Seidah N.G. The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity. J. Biol. Chem. 274 (1999) 33913-33920