Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 29, 2007, Pages 11927-11932

  Bisson, W H ^a   Cheltsov, A V ^a   Bruey Sedano, N ^b   Lin, B ^b   Chen, J ^c   Goldberger, N ^c   May, L T ^d,e   Christopoulos, A ^e   Dalton, J T ^c   Sexton, P M ^e   Zhang, X K ^b   Abagyan, R ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b BURNHAM INSTITUTE   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e MONASH UNIVERSITY   (Australia)

Author keywords

Androgen receptor; Drug design; Prostate cancer

Indexed keywords

ACETOPHENAZINE; ANDROGEN RECEPTOR; ANDROSTANOLONE; ANTIANDROGEN; DOPAMINE RECEPTOR; FLUPHENAZINE; NEUROLEPTIC AGENT; PERICIAZINE; PHENOTHIAZINE DERIVATIVE; PROSTATE SPECIFIC ANTIGEN; SEROTONIN RECEPTOR;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL;

ANDROGEN ANTAGONISTS; BINDING, COMPETITIVE; CELL NUCLEUS; COMBINATORIAL CHEMISTRY TECHNIQUES; DOPAMINE; DRUG DESIGN; HELA CELLS; HUMANS; PHARMACEUTICAL PREPARATIONS; PHENOTHIAZINES; PROSTATE-SPECIFIC ANTIGEN; PROTEIN TRANSPORT; RECEPTORS, ANDROGEN; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, G-PROTEIN-COUPLED; SEROTONIN; TRANS-ACTIVATION (GENETICS);

EID: 34547522758     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0609752104     Document Type: Article

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