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Bioorganic and Medicinal Chemistry

Volumn 10, Issue 5, 2002, Pages 1555-1566

Novel non-steroidal/non-anilide type androgen antagonists with an isoxazolone moiety

(6) Ishioka, Toshiyasu a Kubo, Asako b Koiso, Yukiko a Nagasawa, Kazuo a Itai, Akiko b Hashimoto, Yuichi a,c

a UNIVERSITY OF TOKYO (Japan)

b Inst of Medicinal Molecular Design (Japan)

c Tel: +81 3 5841 7847 ^* (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 N,N DIBUTYLAMINOPHENYLMETHYLENE) 3 METHYL 5(4H)ISOXAZOLONE; 4 (4 PYRROLIDINOPHENYLMETHYLENE) 3 (2 CHLOROPHENYL) 5(4H)ISOXAZOLONE; 4 (4 PYRROLIDINOPHENYLMETHYLENE) 3 (2 FLUOROPHENYL) 5(4H)ISOXAZOLONE; 4 (4 PYRROLIDINOPHENYLMETHYLENE) 3 (2 PYRIDYL) 5(4H)ISOXAZOLONE; 4 (4 PYRROLIDINOPHENYLMETHYLENE) 3 (3 NITROPHENYL) 5(4H)ISOXAZOLONE; 4 (4 PYRROLIDINOPHENYLMETHYLENE) 3 (4 CHLOROPHENYL) 5(4H)ISOXAZOLONE; 4 (4 PYRROLIDINOPHENYLMETHYLENE) 3 (4 FLUOROPHENYL) 5(4H)ISOXAZOLONE; 4 (4 PYRROLIDINOPHENYLMETHYLENE) 3 (4 NITROPHENYL) 5(4H)ISOXAZOLONE; 4 (4 PYRROLIDINOPHENYLMETHYLENE) 3 (4 PYRIDYL) 5(4H)ISOXAZOLONE; 4 (4 PYRROLIDINOPHENYLMETHYLENE) 3 PHENYLMETHYL 5(4H)ISOXAZOLONE; ANDROGEN RECEPTOR; ANTIANDROGEN; FLUTAMIDE; ISOXAZOLE DERIVATIVE; UNCLASSIFIED DRUG; TESTOSTERONE;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; CANCER INHIBITION; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PROSTATE CARCINOMA; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; CELL CULTURE; CELL DIVISION; DRUG DESIGN; DRUG EFFECT; IC 50; METABOLISM; PROTEIN BINDING; SYNTHESIS;

ANDROGEN ANTAGONISTS; CELL DIVISION; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; ISOXAZOLES; PROTEIN BINDING; RECEPTORS, ANDROGEN; STRUCTURE-ACTIVITY RELATIONSHIP; TESTOSTERONE; TUMOR CELLS, CULTURED;

EID: 0036186204 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/S0968-0896(01)00421-7 Document Type: Article

Times cited : (109)

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