A glucocorticoid-responsive mutant androgen receptor exhibits unique ligand specificity: Therapeutic implications for androgen-independent prostate cancer

Endocrinology

Volumn 143, Issue 5, 2002, Pages 1889-1900

  Krishnan, Aruna V ^a   Zhao, Xiao Yan ^a,d   Swami, Srilatha ^a   Brive, Lars ^b,e   Peehl, Donna M ^a   Ely, Kathryn R ^b   Feldman, David ^a,c  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BURNHAM INSTITUTE   (United States)

^c STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^d BAYER AG   (Germany)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; BICALUTAMIDE; CORTISONE; DEXAMETHASONE; FLUDROCORTISONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR ANTAGONIST; HYDROCORTISONE; MIFEPRISTONE; STEROID; TRIAMCINOLONE;

ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; BINDING AFFINITY; CASTRATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; GENE MUTATION; HORMONE ACTION; HORMONE DEPENDENCE; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; METASTASIS; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; TUMOR GROWTH;

EID: 0036225315     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.143.5.8778     Document Type: Article

References (40)

1. Mechanisms of androgen receptor activation and function
2. The biology of hormone refractory prostate cancer. Why does it develop?
3. Androgen receptor - An update of mechanisms of action in prostate cancer
4. Androgen receptor mutations in prostate cancer
5. Collocation of androgen receptor gene mutations in prostate cancer
6. The development of androgen-independent prostate cancer
7. Clinical Review 134. The endocrinology of prostate cancer
8. In vivo amplification of the androgen receptor gene and progression of human prostate cancer
9. Androgen receptor gene amplification: A possible molecular mechanism for androgen deprivation therapy failure in prostate cancer
10. Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone
11. Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers
12. Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer
13. Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence
14. Activation of two mutant androgen receptors from human prostatic carcinoma by adrenal androgens and metabolic derivatives of testosterone
15. Unusual specificity of the androgen receptor in the human prostate tumor cell line LNCaP: High affinity for progestagenic and estrogenic steroids
16. Ligand responsiveness in human prostate cancer: Structural analysis of mutant androgen receptors from LNCaP and CWR22 tumors
17. Disorders of the testis and male reproductive tract
18. Establishment of two human prostate cancer cell lines derived from a single bone metastasis
19. Two mutations identified in the androgen receptor of the new human prostate cancer cell line MDA PCa 2a
20. Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor
21. Prostate cancer schemes for androgen escape
22. 3 actions in LNCaP human prostate cancer cells are androgen-dependent
23. 3 and 9-cis retinoic acid in LNCaP human prostate cancer cells
24. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding
25. Activation of protein kinase-C inhibits vitamin D receptor gene expression
26. Atomic structure of progesterone complexed with its receptor
27. Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations
28. Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone
29. Back-bone dependent rotamer library for proteins. Application to side-chain prediction
30. Comparative protein modelling by satisfaction of spatial restraints
31. CHARMm: A program for macromolecular energy, minimization, and dynamics calculations
32. Cambridge crystallographic data center: Computer-based search, retrieval, analysis and display of information
33. Transcriptional activation of mouse mammary tumor virus-chloramphenicol acetyl transferase: A model to study the metabolism of cortisol
34. Mutant and wild-type androgen receptors exhibit cross-talk on androgen-, glucocorticoid-, and progesterone-mediated transcription
35. Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist
36. Androgen receptor gene mutations in human prostate cancer
37. Genetic alterations of androgen receptor gene in Japanese human prostate cancer
38. The adrenal cortex
39. A stable prostatic bioluminescent cell line to investigate androgen and antiandrogen effects
40. Glucocorticoids manifest androgenic activity in a cell line derived from a metastatic prostate cancer