Rational discovery of novel nuclear hormone receptor antagonists

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 3, 2000, Pages 1008-1013

  Schapira, Matthieu ^a   Raaka, Bruce M ^a   Samuels, Herbert H ^a   Abagyan, Ruben ^a,b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [(5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 2 NAPHTHYL)CARBOXAMIDO]BENZOIC ACID; 4 [2 [5,6 DIHYDRO 5,5 DIMETHYL 8 (4 METHYLPHENYL) 2 NAPHTHYL]ETHYNYL]BENZOIC ACID; ACOLBIFENE; ALITRETINOIN; ANTIESTROGEN; BEXAROTENE; CELL NUCLEUS RECEPTOR; ESTROGEN RECEPTOR ALPHA; HORMONE RECEPTOR BLOCKING AGENT; HORMONE RECEPTOR STIMULATING AGENT; MIFEPRISTONE; RALOXIFENE; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; TAMOXIFEN;

ALGORITHM; ARTICLE; CELL NUCLEUS; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SCREENING; DRUG TARGETING; HORMONE RECEPTOR INTERACTION; LIGAND BINDING; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DOMAIN;

ALGORITHMS; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DATABASES, FACTUAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ESTROGEN RECEPTOR ALPHA; FALSE POSITIVE REACTIONS; HELA CELLS; HORMONE ANTAGONISTS; HORMONES; HUMANS; LIGANDS; MODELS, MOLECULAR; MONTE CARLO METHOD; PROTEIN CONFORMATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, ESTROGEN; RECEPTORS, RETINOIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0033965389     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.3.1008     Document Type: Article

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