A synthetic agonist at the orphanin FQ/nociceptin receptor ORL51: Anxiolytic profile in the rat

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 9, 2000, Pages 4938-4943

  Jenck, François ^a   Wichmann, Juergen ^a   Dautzenberg, Frank M ^a   Moreau, Jean Luc ^a   Ouagazzal, Abdel M ^a   Martin, James R ^a   Lundstrom, Kenneth ^a   Cesura, Andrea M ^a   Poli, Sonia M ^a   Roever, Stephan ^a   Koclzewski, Sabine ^a   Adam, Geo ^a   Kilpatrick, Gavin ^b  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b CeNes Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

8 (2,3,3A,4,5,6 HEXAHYDRO 1H PHENALEN 1 YL) 1 PHENYL 1,3,8 TRIAZASPIRO[4.5]DECAN 4 ONE; 8 (2,3,3A,4,5,6 HEXAHYDRO 1H PHENALENYL) 1 PHENYL 1,3,8 TRIAZASPIRO[4.5]DECAN 4 ONE; ALPRAZOLAM; ANXIOLYTIC AGENT; BENZODIAZEPINE DERIVATIVE; DIAZEPAM; G PROTEIN COUPLED RECEPTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); NOCICEPTIN RECEPTOR; OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ADAPTATION; AGONIST; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CONFLICT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; FEAR; INSTRUMENTAL CONDITIONING; MALE; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; STARTLE REFLEX; STRESS; TRANQUILIZING ACTIVITY;

ACOUSTIC STIMULATION; ALPRAZOLAM; ANIMALS; ANTI-ANXIETY AGENTS; COGNITION; CONFLICT (PSYCHOLOGY); DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSHOCK; EPILEPSY; FEAR; HUMANS; IMIDAZOLES; MALE; MAZE LEARNING; PAIN; PENTYLENETETRAZOLE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID; RECOMBINANT PROTEINS; SEIZURES; SELF STIMULATION; SPIRO COMPOUNDS; STARTLE REACTION;

ANIMALIA;

EID: 0034712756     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.090514397     Document Type: Article

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