Downregulation of androgen, estrogen and progesterone receptor genes and protein is involved in aging-related erectile dysfunction

International Journal of Impotence Research

Volumn 15, Issue 6, 2003, Pages 391-396

  Shirai, M ^a   Yamanaka, M ^a   Shiina, H ^a   Igawa, M ^b   Fujime, M ^c   Lue, T F ^d   Dahiya, R ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b SHIMANE UNIVERSITY   (Japan)

^c JUNTENDO UNIVERSITY   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aging; Erectile dysfunction; Steroid hormone receptor genes

Indexed keywords

ANDROGEN RECEPTOR; COMPLEMENTARY DNA; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; PROGESTERONE RECEPTOR;

ADOLESCENT; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; ELECTROSTIMULATION; ERECTILE DYSFUNCTION; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGING; ANIMALS; DOWN-REGULATION; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GENE EXPRESSION; IMPOTENCE; MALE; PENIS; RATS; RATS, INBRED F344; RECEPTORS, ANDROGEN; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE;

EID: 0346503052     PISSN: 09559930     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijir.3901050     Document Type: Article

References (21)

1. Feldmann HA et al. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994; 151: 54-61.
2. Jonler M et al. The effect of age, ethnicity and geographical location on impotence and quality of life. Br J Urol 1995; 75: 651-655.
3. Penson DF et al. Androgen and pituitary control of penile nitric oxide synthase and erectile function in the rat. Biol Reprod 1996; 55: 567-574.
4. Guerra-Araiza C et al. Progesterone receptor isoforms expression in the prepuberal and adult male rat brain. Brain Res Bull 2001; 54: 13-17.
5. El-Sakka A et al. Effects of diabetes on nitric oxide synthase and growth factor genes and protein expression in an animal model. Int J Impot Res 1999; 11: 123-132.
6. Bakircioglu ME et al. Decreased trabecular smooth muscle and caveolin-1 expression in the penile tissue of aged rats. J Urol 2001; 166: 734-738.
7. Dahiya R et al. Differential gene expression of growth factors in young and old rat penile tissues is associated with erectile dysfunction. Int J Impot Res 1999; 11: 201-206.
8. Ferrini M et al. Aging-related expression of inducible nitric oxide synthase and markers of tissue damage in the rat penis. Biol Reprod 2001; 64: 974-982.
9. Garban H et al. Effect of aging on nitric oxide-mediated penile erection in rats. Am J Physiol 1995; 268: H467-H475.
10. Baskin LS et al. The effect of testosterone on androgen receptors and human penile growth. J Urol 1997; 158: 1113-1118.
11. Shabsigh R. The effect of testosterone on the cavernous tissue and erection. World J Urol 1997; 15: 21-26.
12. Traish AM et al. Effects of castration and androgen replacement on erectile function in a rabbit model. Endocrinology 1999; 140: 1861-1868.
13. Banerjee PP et al. Age-dependent and lobe-specific spontaneous hyperplasia in the brown Norway rat prostate. Biol Reprod 1998; 59: 1163-1170.
14. Aversa A et al. Androgen and penile erection: evidence for a direct relationship between free testosterone and cavernous vasodilation in men with erectile dysfunction. Clin Endocrinol 2000; 53: 517-522.
15. Kuiper GGJM et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 1997; 138: 867-870.
16. Zhou Y et al. Hepatic stellate cells contain the functional estrogen receptor beta but not the estrogen receptor alpha in male and female rats. Biochem Biophys Res Commun 2001; 286: 1059-1065.
17. Lindner V et al. Increased expression of estrogen receptor-beta mRNA in male blood vessels after vascular injury. Circ Res 1998; 83: 224-229.
18. Spyridopoulos I et al. Estrogen-receptor-mediated inhibition of human endothelial cell apoptosis. Estradiol as a survival factor. Circulation 1997; 95: 1505-1514.
19. Choi KC et al. Estradiol upregulates antiapoptotic Bcl-2 messenger ribonucleic acid and protein in tumorigenic ovarian surface epithelium cells. Endocrinology 2001; 142: 2351-2360.
20. Yamanaka M et al. Loss of anti-apoptotic genes in aging rat crura. J Urol 2002; 168: 2296-2300.
21. Labombarda F et al. Modulation of NADPH-diaphorase and glial fibrillary acidic protein by progesterone in astrocytes from normal and injured rat spinal cord. J Steroid Biochem Mol Biol 2000; 73: 159-169.