TRPC6 and FSGS: The latest TRP channelopathy

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1772, Issue 8, 2007, Pages 859-868

  Mukerji, Nirvan ^a   Damodaran, Tirupapuliyur V ^a   Winn, Michelle P ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

ACTN4; CD2AP; Familial focal segmental glomerulosclerosis; Familial nephropathy; Genetic; Hereditary; Kidney; Nephrin; Podocin; TRPC6

Indexed keywords

ACTININ; ALPHA ACTININ 4; ANGIOTENSIN II; CALCIUM; CD2 ASSOCIATED PROTEIN; MUTANT PROTEIN; NEPHRIN; PHOSPHOLIPASE C; PODOCIN; STRUCTURAL PROTEIN; TACROLIMUS; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL 6; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; APOPTOSIS; CALCIUM CELL LEVEL; CARBOXY TERMINAL SEQUENCE; CELL INTERACTION; CELL MEMBRANE; CHANNELOPATHY; CYTOPENIA; DIAPHRAGM DISEASE; DRUG INHIBITION; DYNAMICS; ENZYME ACTIVATION; EXPERIMENT; FOCAL GLOMERULOSCLEROSIS; GLOMERULOSCLEROSIS; HUMAN; IN VIVO STUDY; KIDNEY DISEASE; MAMMAL; MEMBRANE DEPOLARIZATION; MUTATION; NONHUMAN; PODOCYTE; PODOCYTOPENIA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; REVIEW; SEGMENTAL GLOMERULOSCLEROSIS; SPECIES;

ACTININ; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CHANNELOPATHIES; CYTOSKELETAL PROTEINS; GENETIC DISEASES, INBORN; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICROFILAMENT PROTEINS; MODELS, BIOLOGICAL; MUTATION; NEPHROTIC SYNDROME; PODOCYTES; TRPC CATION CHANNELS;

MAMMALIA;

EID: 34547438723     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2007.03.005     Document Type: Review

References (98)

1. Haas M., Spargo B.H., and Coventry S. Increasing incidence of focal-segmental glomerulosclerosis among adult nephropathies: a 20-year renal biopsy study. Am. J. Kidney Dis. 26 (1995) 740-750
2. Barisoni L., Kriz W., Mundel P., and D'Agati V. The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy. J. Am. Soc. Nephrol. 10 (1999) 51-61
3. Verani R.R., and Conley S.B. Sickle cell glomerulopathy with focal segmental glomerulosclerosis. Child Nephrol. Urol. 11 (1991) 206-208
4. Conlon P.J., Butterly D., Albers F., Rodby R., Gunnells J.C., and Howell D.N. Clinical and pathologic features of familial focal segmental glomerulosclerosis. Am. J. Kidney Dis. 26 (1995) 34-40
5. Winn M.P., Conlon P.J., Lynn K.L., Howell D.N., Gross D.A., Rogala A.R., Smith A.H., Graham F.L., Bembe M., Quarles L.D., Pericak-Vance M.A., and Vance J.M. Clinical and genetic heterogeneity in familial focal segmental glomerulosclerosis. International Collaborative Group for the Study of Familial Focal Segmental Glomerulosclerosis. Kidney Int. 55 (1999) 1241-1246
6. Kambham N., Markowitz G.S., Valeri A.M., Lin J., and D'Agati V.D. Obesity-related glomerulopathy: an emerging epidemic. Kidney Int. 59 (2001) 1498-1509
7. Barakat A.J., Arianas P., Glick A.D., and Butler M.G. Focal sclerosing glomerulonephritis in a child with Laurence-Moon-Biedl syndrome. Child Nephrol. Urol. 10 (1990) 109-111
8. Hara M., Ichida F., Higuchi A., Tanizawa T., and Okada T. Nephropathy associated with Charcot-Marie-Tooth disease. Int. J. Pediatr. Nephrol. 5 (1984) 99-102
9. Winn M.P., Conlon P.J., Lynn K.L., Farrington M.K., Creazzo T., Hawkins A.F., Daskalakis N., Kwan S.Y., Ebersviller S., Burchette J.L., Pericak-Vance M.A., Howell D.N., Vance J.M., and Rosenberg P.B. A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science 308 (2005) 1801-1804
10. Konrad M., Schlingmann K.P., and Gudermann T. Insights into the molecular nature of magnesium homeostasis. Am. J. Physiol., Renal Physiol. 286 (2004) F599-F605
11. Bach G. Mucolipidosis type IV. Mol. Genet. Metab. 73 (2001) 197-203
12. Wu G., and Somlo S. Molecular genetics and mechanism of autosomal dominant polycystic kidney disease. Mol. Genet. Metab. 69 (2000) 1-15
13. Ahvenainen E.K., Hallman N., and Hjelt L. nephrotic syndrome in newborn and young infants. Ann. Paediatr. Fenn. 2 (1956) 227-241
14. Kestila M., Mannikko M., Holmberg C., Gyapay G., Weissenbach J., Savolainen E.R., Peltonen L., and Tryggvason K. Congenital nephrotic syndrome of the Finnish type maps to the long arm of chromosome 19. Am. J. Hum. Genet. 54 (1994) 757-764
15. Kestila M., Lenkkeri U., Mannikko M., Lamerdin J., McCready P., Putaala H., Ruotsalainen V., Morita T., Nissinen M., Herva R., Kashtan C.E., Peltonen L., Holmberg C., Olsen A., and Tryggvason K. Positionally cloned gene for a novel glomerular proterin - nephrin is mutated in congenital nephrotic syndrome. Mol. Cell 1 (1998) 575-582
16. Lenkkeri U., Mannikko M., McCready P., Lamerdin J., Gribouval O., Niaudet P.M., Antignac C.K., Kashtan C.E., Homberg C., Olsen A., Kestila M., and Tryggvason K. Structure of the gene for congenital nephrotic syndrome of the Finnish type (NPHS1) and characterization of mutations. Am. J. Hum. Genet. 64 (1999) 51-61
17. Ruotsalainen V., Ljungberg P., Wartiovaara J., Lenkkeri U., Kestila M., Jalanko H., Holmberg C., and Tryggvason K. Nephrin is specifically located at the slit diaphragm of glomerular podocytes. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 7962-7967
18. Holzman L.B., St John P.L., Kovari I.A., Verma R., Holthofer H., and Abrahamson D.R. Nephrin localizes to the slit pore of the glomerular epithelial cell. Kidney Int. 56 (1999) 1481-1491
19. Holthofer H., Ahola H., Solin M.L., Wang S., Palmen T., Luimula P., Miettinen A., and Kerjaschki D. Nephrin localizes at the podocyte filtration slit area and is characteristically spliced in the human kidney. Am. J. Pathol. 155 (1999) 1681-1687
20. Tryggvason K., Ruotsalainen V., and Wartiovaara J. Discovery of the congenital nephrotic syndrome gene discloses the structure of the mysterious molecular sieve of the kidney. Int. J. Dev. Biol. 43 (1999) 445-451
21. Fuchshuber A., Jean G., Gribouval O., Gubler M.C., Broyer M., Beckmann J.S., Niaudet P., and Antignac C. Mapping a gene (SRN1) to chromosome 1q25-q31 in idiopathic nephrotic syndrome confirms a distinct entity of autosomal recessive nephrosis. Hum. Mol. Genet. 4 (1995) 2155-2158
22. Roselli S., Gribouval O., Boute N., Sich M., Benessy F., Attie T., Gubler M.C., and Antignac C. Podocin localizes in the kidney to the slit diaphragm area. Am. J. Pathol. 160 (2002) 131-139
23. Schwarz K., Simons M., Reiser J., Saleem M.A., Faul C., Kriz W., Shaw A.S., Holzman L.B., and Mundel P. Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin. J. Clin. Invest. 108 (2001) 1621-1629
24. Huber T.B., Simons M., Hartleben B., Sernetz L., Schmidts M., Gundlach E., Saleem M.A., Walz G., and Benzing T. Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains. Hum. Mol. Genet. 12 (2003) 3397-3405
25. Dustin M.L., Olszowy M.W., Holdorf A.D., Li J., Bromley S., Desai N., Widder P., Rosenberger F., van der Merwe P.A., Allen P.M., and Shaw A.S. A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. Cell 94 (1998) 667-677
26. Shih N.Y., Li J., Karpitskii V., Nguyen A., Dustin M.L., Kanagawa O., Miner J.H., and Shaw A.S. Congenital nephrotic syndrome in mice lacking CD2-associated protein. Science 286 (1999) 312-315
27. Huber T.B., Kwoh C., Wu H., Asanuma K., Godel M., Hartleben B., Blumer K.J., Miner J.H., Mundel P., and Shaw A.S. Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin. J. Clin. Invest. 116 (2006) 1337-1345
28. Kirsch K.H., Georgescu M.M., Ishimaru S., and Hanafusa H. CMS: an adapter molecule involved in cytoskeletal rearrangements. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 6211-6216
29. Kim J.M., Wu H., Green G., Winkler C.A., Kopp J.B., Miner J.H., Unanue E.R., and Shaw A.S. CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility. Science 300 (2003) 1298-1300
30. Mathis B.J., Kim S.H., Calabrese M.H., Seidman J.G., Seidman C.E., and Pollack M.R. A locus for inherited focal segmental glomerulosclerosis maps to chromosome 19q13. Kidney Int. 53 (1998) 282-286
31. Kaplan J.M., Kim S.H., North K.N., Rennke H., Correia L.A., Tong H.Q., Mathis B.J., Rodriguez-Perez J.C., Allen P.G., Beggs A.H., and Pollak M.R. Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. Nat. Genet. 24 (2000) 251-256
32. Yao J., Le T.C., Kos C.H., Henderson J.M., Allen P.G., Denker B.M., and Pollak M.R. Alpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein. PLoS. Biol. 2 (2004) e167
33. Horwich A. Protein aggregation in disease: a role for folding intermediates forming specific multimeric interactions. J. Clin. Invest. 110 (2002) 1221-1232
34. Bucciantini M., Giannoni E., Chiti F., Baroni F., Formigli L., Zurdo J., Taddei N., Ramponi G., Dobson C.M., and Stefani M. Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature 416 (2002) 507-511
35. Reiser J., Polu K.R., Moller C.C., Kenlan P., Altintas M.M., Wei C., Faul C., Herbert S., Villegas I., Avila-Casado C., McGee M., Sugimoto H., Brown D., Kalluri R., Mundel P., Smith P.L., Clapham D.E., and Pollak M.R. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat. Genet. 37 (2005) 739-744
36. Clapham D.E., Runnels L.W., and Strubing C. The TRP ion channel family. Nat. Rev., Neurosci. 2 (2001) 387-396
37. McCleverty C.J., Koesema E., Patapoutian A., Lesley S.A., and Kreusch A. Crystal structure of the human TRPV2 channel ankyrin repeat domain. Protein Sci. 15 (2006) 2201-2206
38. Morenilla-Palao C., Planells-Cases R., Garcia-Sanz N., and Ferrer-Montiel A. Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity. J. Biol. Chem. 279 (2004) 25665-25672
39. Clapham D.E. TRP channels as cellular sensors. Nature 426 (2003) 517-524
40. Montell C., Birnbaumer L., Flockerzi V., Bindels R.J., Bruford E.A., Caterina M.J., Clapham D.E., Harteneck C., Heller S., Julius D., Kojima I., Mori Y., Penner R., Prawitt D., Scharenberg A.M., Schultz G., Shimizu N., and Zhu M.X. A unified nomenclature for the superfamily of TRP cation channels. Mol. Cell 9 (2002) 229-231
41. Beech D.J., Muraki K., and Flemming R. Non-selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP. J. Physiol. 559 (2004) 685-706
42. Zitt C., Zobel A., Obukhov A.G., Harteneck C., Kalkbrenner F., Luckhoff A., and Schultz G. Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion. Neuron. 16 (1996) 1189-1196
43. Lintschinger B., Balzer-Geldsetzer M., Baskaran T., Graier W.F., Romanin C., Zhu M.X., and Groschner K. Coassembly of Trp1 and Trp3 proteins generates diacylglycerol- and Ca2+-sensitive cation channels. J. Biol. Chem. 275 (2000) 27799-27805
44. Strubing C., Krapivinsky G., Krapivinsky L., and Clapham D.E. TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron. 29 (2001) 645-655
45. Tsiokas L., Arnould T., Zhu C., Kim E., Walz G., and Sukhatme V.P. Specific association of the gene product of PKD2 with the TRPC1 channel. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 3934-3939
46. Tang Y., Tang J., Chen Z., Trost C., Flockerzi V., Li M., Ramesh V., and Zhu M.X. Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. J. Biol. Chem. 275 (2000) 37559-37564
47. van Huizen R., Miller K., Chen D.M., Li Y., Lai Z.C., Raab R.W., Stark W.S., Shortridge R.D., and Li M. Two distantly positioned PDZ domains mediate multivalent INAD-phospholipase C interactions essential for G protein-coupled signaling. EMBO J. 17 (1998) 2285-2297
48. Tsunoda S., Sierralta J., Sun Y., Bodner R., Suzuki E., Becker A., Socolich M., and Zuker C.S. A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade. Nature 388 (1997) 243-249
49. Chevesich J., Kreuz A.J., and Montell C. Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex. Neuron 18 (1997) 95-105
50. Craven S.E., and Bredt D.S. PDZ proteins organize synaptic signaling pathways. Cell 93 (1998) 495-498
51. Fanning A.S., and Anderson J.M. Protein-protein interactions: PDZ domain networks. Curr. Biol. 6 (1996) 1385-1388
52. Pawson T., and Scott J.D. Signaling through scaffold, anchoring, and adaptor proteins. Science 278 (1997) 2075-2080
53. Strubing C., Krapivinsky G., Krapivinsky L., and Clapham D.E. Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J. Biol. Chem. 278 (2003) 39014-39019
54. Vannier B., Peyton M., Boulay G., Brown D., Qin N., Jiang M., Zhu X., and Birnbaumer L. Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 2060-2064
55. Liman E.R., Corey D.P., and Dulac C. TRP2: a candidate transduction channel for mammalian pheromone sensory signaling. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 5791-5796
56. Hinkes B., Wiggins R.C., Gbadegesin R., Vlangos C.N., Seelow D., Nurnberg G., Garg P., Verma R., Chaib H., Hoskins B.E., Ashraf S., Becker C., Hennies H.C., Goyal M., Wharram B.L., Schachter A.D., Mudumana S., Drummond I., Kerjaschki D., Waldherr R., Dietrich A., Ozaltin F., Bakkaloglu A., Cleper R., Basel-Vanagaite L., Pohl M., Griebel M., Tsygin A.N., Soylu A., Muller D., Sorli C.S., Bunney T.D., Katan M., Liu J., Attanasio M., O'toole J.F., Hasselbacher K., Mucha B., Otto E.A., Airik R., Kispert A., Kelley G.G., Smrcka A.V., Gudermann T., Holzman L.B., Nurnberg P., and Hildebrandt F. Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Nat. Genet. 38 (2006) 1397-1405
57. Dietrich A., Mederos Y.S., Gollasch M., Gross V., Storch U., Dubrovska G., Obst M., Yildirim E., Salanova B., Kalwa H., Essin K., Pinkenburg O., Luft F.C., Gudermann T., and Birnbaumer L. Increased vascular smooth muscle contractility in TRPC6-/- mice. Mol. Cell. Biol. 25 (2005) 6980-6989
58. Barletta G.M., Kovari I.A., Verma R.K., Kerjaschki D., and Holzman L.B. Nephrin and Neph1 co-localize at the podocyte foot process intercellular junction and form cis hetero-oligomers. J. Biol. Chem. 278 (2003) 19266-19271
59. Sellin L., Huber T.B., Gerke P., Quack I., Pavenstadt H., and Walz G. NEPH1 defines a novel family of podocin interacting proteins. FASEB J. 17 (2003) 115-117
60. Gerke P., Huber T.B., Sellin L., Benzing T., and Walz G. Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1. J. Am. Soc. Nephrol. 14 (2003) 918-926
61. Khoshnoodi J., Sigmundsson K., Ofverstedt L.G., Skoglund U., Obrink B., Wartiovaara J., and Tryggvason K. Nephrin promotes cell-cell adhesion through homophilic interactions. Am. J. Pathol. 163 (2003) 2337-2346
62. Gerke P., Sellin L., Kretz O., Petraschka D., Zentgraf H., Benzing T., and Walz G. NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases. J. Am. Soc. Nephrol. 16 (2005) 1693-1702
63. Moller C.C., Wei C., Altintas M.M., Li J., Greka A., Ohse T., Pippin J.W., Rastaldi M.P., Wawersik S., Schiavi S., Henger A., Kretzler M., Shankland S.J., and Reiser J. Induction of TRPC6 channel in acquired forms of proteinuric kidney disease. J. Am. Soc. Nephrol. 18 (2007) 29-36
64. Li Y., Jia Y.C., Cui K., Li N., Zheng Z.Y., Wang Y.Z., and Yuan X.B. Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor. Nature 434 (2005) 894-898
65. Spassova M.A., Hewavitharana T., Xu W., Soboloff J., and Gill D.L. A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 16586-16591
66. Huber T.B., Schermer B., Muller R.U., Hohne M., Bartram M., Calixto A., Hagmann H., Reinhardt C., Koos F., Kunzelmann K., Shirokova E., Krautwurst D., Harteneck C., Simons M., Pavenstadt H., Kerjaschki D., Thiele C., Walz G., Chalfie M., and Benzing T. Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 17079-17086
67. Mundel P., and Shankland S.J. Podocyte biology and response to injury. J. Am. Soc. Nephrol. 13 (2002) 3005-3015
68. Kim Y.H., Goyal M., Kurnit D., Wharram B., Wiggins J., Holzman L., Kershaw D., and Wiggins R. Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat. Kidney Int. 60 (2001) 957-968
69. Pagtalunan M.E., Miller P.L., Jumping-Eagle S., Nelson R.G., Myers B.D., Rennke H.G., Coplon N.S., Sun L., and Meyer T.W. Podocyte loss and progressive glomerular injury in type II diabetes. J. Clin. Invest. 99 (1997) 342-348
70. Pavenstadt H., Kriz W., and Kretzler M. Cell biology of the glomerular podocyte. Physiol. Rev. 83 (2003) 253-307
71. Ding G., Reddy K., Kapasi A.A., Franki N., Gibbons N., Kasinath B.S., and Singhal P.C. Angiotensin II induces apoptosis in rat glomerular epithelial cells. Am. J. Physiol., Renal Physiol. 283 (2002) F173-F180
72. Hara M., Yanagihara T., and Kihara I. Urinary podocytes in primary focal segmental glomerulosclerosis. Nephron. 89 (2001) 342-347
73. Nakamura T., Ushiyama C., Osada S., Hara M., Shimada N., and Koide H. Pioglitazone reduces urinary podocyte excretion in type 2 diabetes patients with microalbuminuria. Metabolism 50 (2001) 1193-1196
74. Nakamura T., Ushiyama C., Suzuki S., Hara M., Shimada N., Sekizuka K., Ebihara I., and Koide H. Effects of angiotensin-converting enzyme inhibitor, angiotensin II receptor antagonist and calcium antagonist on urinary podocytes in patients with IgA nephropathy. Am. J. Nephrol. 20 (2000) 373-379
75. Cybulsky A.V., Carbonetto S., Huang Q., McTavish A.J., and Cyr M.D. Adhesion of rat glomerular epithelial cells to extracellular matrices: role of beta 1 integrins. Kidney Int. 42 (1992) 1099-1106
76. Regele H.M., Fillipovic E., Langer B., Poczewki H., Kraxberger I., Bittner R.E., and Kerjaschki D. Glomerular expression of dystroglycans is reduced in minimal change nephrosis but not in focal segmental glomerulosclerosis. J. Am. Soc. Nephrol. 11 (2000) 403-412
77. Shankland S.J., and Wolf G. Cell cycle regulatory proteins in renal disease: role in hypertrophy, proliferation, and apoptosis. Am. J. Physiol., Renal Physiol. 278 (2000) F515-F529
78. Sherr C.J., and Roberts J.M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13 (1999) 1501-1512
79. Shankland S.J. The podocyte's response to injury: role in proteinuria and glomerulosclerosis. Kidney Int. 69 (2006) 2131-2147
80. Schulenberg B., Aggeler R., Beechem J.M., Capaldi R.A., and Patton W.F. Analysis of steady-state protein phosphorylation in mitochondria using a novel fluorescent phosphosensor dye. J. Biol. Chem. 278 (2003) 27251-27255
81. van Breemen C., Poburko D., and Okon E.B. TRP proteins: a new dimension in the treatment of occlusive vascular disease. Circ. Res. 98 (2006) 446-447
82. Li S., Westwick J., and Poll C. Transient receptor potential (TRP) channels as potential drug targets in respiratory disease. Cell Calcium 33 (2003) 551-558
83. Reiser J., von Gersdorff G., Simons M., Schwarz K., Faul C., Giardino L., Heider T., Loos M., and Mundel P. Novel concepts in understanding and management of glomerular proteinuria. Nephrol. Dial. Transplant. 17 (2002) 951-955
84. Mifsud S.A., Allen T.J., Bertram J.F., Hulthen U.L., Kelly D.J., Cooper M.E., Wilkinson-Berka J.L., and Gilbert R.E. Podocyte foot process broadening in experimental diabetic nephropathy: amelioration with renin-angiotensin blockade. Diabetologia 44 (2001) 878-882
85. Bonnet F., Cooper M.E., Kawachi H., Allen T.J., Boner G., and Cao Z. Irbesartan normalises the deficiency in glomerular nephrin expression in a model of diabetes and hypertension. Diabetologia 44 (2001) 874-877
86. Ponticelli C., and Passerini P. Other immunosuppressive agents for focal segmental glomerulosclerosis. Semin. Nephrol. 23 (2003) 242-248
87. Mendoza S.A., and Tune B.M. Treatment of childhood nephrotic syndrome. J. Am. Soc. Nephrol. 3 (1992) 889-894
88. Tune B.M., and Mendoza S.A. Treatment of the idiopathic nephrotic syndrome: regimens and outcomes in children and adults. J. Am. Soc. Nephrol. 8 (1997) 824-832
89. Pelaia G., Vatrella A., Cuda G., Maselli R., and Marsico S.A. Molecular mechanisms of corticosteroid actions in chronic inflammatory airway diseases. Life Sci. 72 (2003) 1549-1561
90. Xing C.Y., Saleem M.A., Coward R.J., Ni L., Witherden I.R., and Mathieson P.W. Direct effects of dexamethasone on human podocytes. Kidney Int. 70 (2006) 1038-1045
91. Segarra A., Vila J., Pou L., Majo J., Arbos A., Quiles T., and Piera L.L. Combined therapy of tacrolimus and corticosteroids in cyclosporin-resistant or -dependent idiopathic focal glomerulosclerosis: a preliminary uncontrolled study with prospective follow-up. Nephrol. Dial. Transplant. 17 (2002) 655-662
92. Marks A.R. Cellular functions of immunophilins. Physiol. Rev. 76 (1996) 631-649
93. Goel M., Garcia R., Estacion M., and Schilling W.P. Regulation of Drosophila TRPL channels by immunophilin FKBP59. J. Biol. Chem. 276 (2001) 38762-38773
94. Sinkins W.G., Goel M., Estacion M., and Schilling W.P. Association of immunophilins with mammalian TRPC channels. J. Biol. Chem. 279 (2004) 34521-34529
95. Kuwahara K., Wang Y., McAnally J., Richardson J.A., Bassel-Duby R., Hill J.A., and Olson E.N. TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling. J. Clin. Invest. 116 (2006) 3114-3126
96. Dietrich A., Gollasch V., Chubanov V., Mederos y Schnitzler M., Dubrovska G., Herz U., Renz H., Gudermann T., and Birnbaurmer L. Studies on TRPC6 deficient mice reveal its non-redundant role in the regulation of smooth muscle tone. Naunyn-Schmiedeberg's Arch. Pharmacol. 367 (2003) R63
97. Kerjaschki D. Caught flat-footed: podocyte damage and the molecular bases of focal glomerulosclerosis. J. Clin. Invest. 108 (2001) 1583-1587
98. Kriz W. TRPC6-A new podocyte gene involved in focal segmental glomerulosclerosis. Trends Mol. Med. 11 (2005) 527-530