TRPC6 - A new podocyte gene involved in focal segmental glomerulosclerosis

Trends in Molecular Medicine

Volumn 11, Issue 12, 2005, Pages 527-530

  Kriz, Wilhelm ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CATION CHANNEL; ION CHANNEL;

AUTOSOMAL DOMINANT DISORDER; CAPILLARY PRESSURE; DISEASE COURSE; FOCAL GLOMERULOSCLEROSIS; GENE EXPRESSION; GENE MUTATION; GENETIC CODE; GENETIC DISORDER; GENETICS; PATHOGENESIS; PHYSIOLOGY; PODOCYTE; REVIEW;

EID: 28244495051     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2005.10.001     Document Type: Short Survey

References (33)

1. H. Pavenstadt Cell biology of the glomerular podocyte Physiol. Rev. 83 2003 253 307
2. W. Kriz, and M. Le Hir Pathways to nephron loss starting from glomerular diseases - insights from animal models Kidney Int. 67 2005 404 419
3. S. Barbaux Donor splice-site mutations in WT-1 are responsible for Frasier syndrome Nat. Genet. 17 1997 467 470
4. A. Hammes Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation Cell 106 2001 319 329
5. M. Winn A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis Science 308 2005 1801 1804
6. J. Reiser TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function Nat. Genet. 37 2005 739 744
7. C. Montell The TRP superfamily of cation channels Sci. STKE 2005 2005 re3
8. T. Gudermann A new TRP to kidney disease Nat. Genet. 37 2005 663 664
9. -/- mice Mol. Cell Biol. 25 2005 6980 6989
10. W. Kriz, and K. Endlich Hypertrophy of podocytes: a mechanism to cope with increased glomerular capillary pressures? Kidney Int. 67 2005 373 374
11. + channel: potential implications for the control of glomerular filtrations J. Am. Soc. Nephrol. 15 2004 2981 2987
12. N. Endlich Analysis of differential gene expression in stretched podocytes: osteopontin enhances adaptation of podocytes to mechanical stress FASEB J. 16 2002 1850 1852
13. M. Huang A stomatin-like protein necessary for mechanosensation in C. elegans Nature 378 1995 292 295
14. R. Durvasula Activation of a local tissue angiotensin system in podocytes by mechanical strain Kidney Int. 65 2004 30 39
15. S. Hoffmann Angiotensin II type 1 receptor overexpression in podoytes induces glomerulosclerosis in transgenic rats J. Am. Soc. Nephrol. 15 2004 1475 1487
16. J. Yao Alpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein PLoS Biol. 2 2004 e167
17. C. Pescucci Autosomal-dominant Alport syndrome: natural history of a disease due to COL4A3 or COL4A4 gene Kidney Int. 65 2004 1598 1603
18. J. Kreidberg WT-1 is required for early kidney development Cell 74 1993 679 691
19. R. Habib The nephropathy associated with male pseudohermaphroditism and Wilms' tumor (Drash syndrome): a distinctive glomerular lesion - report of 10 cases Clin. Nephrol. 24 1985 269 278
20. M. Zenker Human laminin β2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities Hum. Mol. Genet. 13 2004 2625 2632
21. P. Noakes The renal glomerulus of mice lacking s-laminin/laminin β2: nephrosis despite molecular compensation by laminin β1 Nat. Genet. 10 1995 400 406
22. M. Kestila Positionally cloned gene for a novel glomerular protein - nephrin - is mutated in congenital nephrotic syndrome Mol. Cell 1 1998 575 582
23. H. Putaala The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death Hum. Mol. Genet. 10 2001 1 8
24. N. Boute NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome Nat. Genet. 24 2000 349 354
25. S. Roselli Early glomerular filtration defect and severe renal disease in podocin-deficient mice Mol. Cell. Biol. 24 2004 550 560
26. J. Kaplan Mutations in ACTN4, encoding α-actinin-4, cause familial focal segmental glomerulosclerosis Nat. Genet. 24 2000 251 256
27. C. Kos Mice deficient in α-actinin-4 have severe glomerular disease J. Clin. Invest. 111 2003 1683 1690
28. C. Arrondel Expression of the nonmuscle myosin heavy chain IIA in the human kidney and screening for MYH9 mutations in Epstein and Fechtner syndromes J. Am. Soc. Nephrol. 13 2002 65 74
29. C. Kashtan Animal models of Alport syndrome Nephrol. Dial. Transplant. 17 2002 1359 1361
30. S. Dreyer Mutations in LMX1B cause abnormal skeletal patterning and renal dysplasia in nail patella syndrome Nat. Genet. 19 1998 47 50
31. C. Rohr The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes J. Clin. Invest. 109 2002 1073 1082
32. J. Miner Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation J. Clin. Invest. 109 2002 1065 1072
33. K. Endlich Update in podocyte biology Curr. Opin. Nephrol. Hypertens. 10 2001 331 340