Treatment of the idiopathic nephrotic syndrome: Regimens and outcomes in children and adults

Journal of the American Society of Nephrology

Volumn 8, Issue 5, 1997, Pages 824-832

  Tune, Bruce M ^a   Mendoza, Stanley A ^b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; AZATHIOPRINE; CHLORAMBUCIL; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; METHYLPREDNISOLONE; PREDNISONE;

ADULT; CHILD; GLOMERULOSCLEROSIS; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; NEPHROTIC SYNDROME; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REVIEW; TREATMENT OUTCOME;

EID: 0030775894     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/asn.v85824     Document Type: Review

References (50)

1. Nash MA, Edelmann CM Jr, Bernstein J, Barnett HL: Minimal change nephrotic syndrome, diffuse mesangial hypercellularity, and focal glomerular sclerosis. In: Pediatric Kidney Disease, edited by Edelmann CM Jr, Boston, Little, Brown, and Co., 1992, pp 1267-1290
2. Dorhout Mees EJ: Edema formation in the nephrotic syndrome. Contrib Nephrol 43: 64-75, 1984
3. Rich AR: A hitherto undescribed vulnerability of the juxtamedullary glomeruli in lipoid nephrosis. Bull Johns Hopkins Hosp 100: 173-186, 1957
4. Cornfeld D, Schwartz MW: Nephrosis: A long-term study of I children treated with corticosteroids. J Pediatr 68: 507-515, 1966
5. Churg J, Habib R, White RHR: Pathology of the nephrotic syndrome in children. Lancet 1: 1299-1302, 1970
6. White RHR, Glasgow EF, Mills RJ: Clinicopathological study of nephrotic syndrome in childhood. Lancet 1: 1353-1359, 1970
7. Coldbeck JH: Experience with alkylating agents in the treatment of children with the nephrotic syndrome. Med J Austr 2: 987, 1963
8. Abramowicz M, Barnett HL, Edelmann CM Jr, Greifer I, Kobayashi O, Arneil GC, Barron BA, Gordillo PG, Hallman N, Tiddens HA: Controlled trial of azathioprine in children with nephrotic syndrome. Lancet 1: 959-961, 1970
9. Habib R: Focal glomerular sclerosis. Kidney Int 4: 355-361, 1973
10. D'Agati V: The many masks of focal segmental glomerulosclerosis. Kidney Int 46: 1223-1241, 1994
11. Haas M, Spargo BH, Coventry S: Increasing incidence of focal-segmental glomerulosclerosis among adult nephropathies: A 20-year renal biopsy study. Am J Kidney Dis 26: 740-750, 1995
12. Sibley RK, Mahan J, Mauer M, Vernier RL: A clinicopathologic study of forty-eight infants with nephrotic syndrome. Kidney Int 27: 544-552, 1985
13. Tune BM, Lieberman E, Mendoza SA: Steroid-resistant nephrotic focal segmental glomerulosclerosis: A treatable disease. Pediatr Nephrol 10: 772-778, 1996
14. Brodehl J: The treatment of minimal change nephrotic syndrome: Lessons learned from multicentre co-operative studies. Eur J Pediatr 150: 380-387, 1991
15. Siegel NJ, Goldberg B, Krassner LS, Hayslett JP: Long-term follow-up of children with steroid-resistant nephrotic syndrome. J Pediatr 81: 251-258, 1972
16. Barratt TM, Soothill JF: Controlled trial of cyclophosphamide in steroid-sensitive relapsing nephrotic syndrome of childhood. Lancet 2: 479-482, 1970
17. Grupe WE, Makker SP, Ingelfinger JR: Chlorambucil treatment of frequently relapsing nephrotic syndrome. N Engl J Med 295: 746-749, 1976
18. Niaudet P, Habib R: Cyclosporine in the treatment of idiopathic nephrosis. J Am Soc Nephrol 5: 1049-1056, 1994
19. Gregory MJ, Smoyer WE, Sedman A, Kershaw DB, Valentini RP, Johnson K, Bunchman TE: Long-term cyclosporine therapy of pediatric nephrotic syndrome: A clinical and histologic analysis. J Am Soc Nephrol 7: 543-549, 1996
20. Nolasco F, Cameron JS, Heywood EF, Hicks J, Ogg C, Williams DG: Adult-onset minimal change nephrotic syndrome: A long-term follow-up. Kidney Int 29: 1215-1223, 1986
21. Pei Y, Cattran D, Delmore T, Katz A, Lang A, Rance P: Evidence suggesting under-treatment in adults with idiopathic focal segmental glomerulosclerosis: Regional glomerulonephritis registry study. Am J Med 82: 938-944, 1987
22. Meyrier A, Simon P: Treatment of corticoresistant idiopathic nephrotic syndrome in the adult: Minimal change disease and focal segmental glomerulosclerosis. Adv Nephrol 17: 127-150, 1988
23. Banfi G, Moriggi M, Sabadini E, Fellin G, D'Amico G, Ponticelli C: The impact of prolonged immunosuppression on the outcome of idiopathic focal-segmental glomerulosclerosis with nephrotic syndrome in adults: A collaborative retrospective study. Clin Nephrol 36: 53-59, 1991
24. Rydel JJ, Korbet SM, Borok RZ, Schwartz MM: Focal segmental glomerular sclerosis in adults: Presentation, course, and response to treatment. Am J Kidney Dis 25: 534-542, 1995
25. Meyrier A, Noël L-H, Auriche P, Callard P: Long-term renal tolerance of cyclosporin A treatment in adult idiopathic nephrotic syndrome. Kidney Int 45: 1446-1456, 1994
26. Tejani A, Stablein DH: Recurrence of focal segmental glomerulosclerosis posttransplantation: A special report of the North American Pediatric Renal Transplant Cooperative Study. J Am Soc Nephrol 2[Suppl 3]: 258-263, 1992.
27. Hayslett JP, Krassner LS, Bensch KG, Kashgarian M, Epstein FH: Progression of "lipoid nephrosis" to renal insufficiency. N Engl J Med 281: 181-187, 1969
28. Habib R, Gubler MC: Les lésions glomérulaires focales des syndromes néphrotiques idiopathiques de l'enfant. Nephron 8: 382-401, 1971
29. International Study of Kidney Disease in Childhood: Cyclophosphamide therapy in focal segmental glomerular sclerosis: A controlled clinical trial [Abstract]. Eur J Pediatr 140: 149, 1983.
30. Tarshish P, Tobin JM, Bernstein J, Edelman CM Jr: Cyclophosphamide does not benefit patients with focal segmental glomerulosclerosis: A report of the International Study of Kidney Disease in Childhood. Pediatr Nephrol 10: 590-593, 1996
31. Spitzer A, Gordillo-P G, Houston IB, Travis LB: Prospective, controlled trial of cyclophosphamide therapy in children with the nephrotic syndrome. Lancet 1: 423-427, 1974
32. Siegel NJ, Kashgarian M, Spargo BH, Hayslett JP: Minimal change and focal sclerotic lesions in lipoid nephrosis. Nephron 13: 125-137, 1974
33. Mongeau J-Y, Gorneille L, Robitaille P O'Regan S, Pelletier M: Primary nephrosis in childhood associated with focal glomerular sclerosis: Is long-term prognosis that severe? Kidney Int 20: 743-746, 1981
34. Geary DF, Farine M, Thorner P, Baumal R: Response to cyclophosphamide in steroid-resistant focal segmental glomerulosclerosclerosis: a reappraisal. Clin Nephrol 22: 109-113, 1984
35. Niaudet P, Broyer M, Habib R: Treatment of idiopathic nephrotic syndrome with cyclosporin A in children. Clin Nephrol 35: S31-S36, 1991.
36. Niaudet P: Treatment of childhood steroid-resistant idiopathic nephrosis with a combination of cyclosporine and prednisone. J Pediatr 125: 981-986, 1994
37. Melocoton TL, Kamil ES, Cohen AH, Fine RN: Long-term cyclosporine A treatment of steroid-resistant and steroid-dependent nephrotic syndrome. Am J Kidney Dis 18: 583-588, 1991
38. Tune BM, Kirpekar R, Sibley RK, Rezink VM, Griswold WR, Mendoza SA: Intravenous methylprednisolone and oral alkylating agent therapy of prednisone-resistant pediatric focal segmental glomerulosclerosis: A long-term follow-up. Clin Nephrol 43: 84-88, 1995
39. Miller JJ: Prolonged use of large intravenous steroid pulses in rheumatic diseases of children. Pediatrics 65: 989-994, 1980
40. Mendoza SA, Reznik VM, Griswold WR, Krensky AM, Yorgin PD, Tune BM: Treatment of steroid-resistant focal segmental glomerulosclerosis with pulse methylprednisolone and alkylating agents. Pediatr Nephrol 4: 303-307, 1990
41. Waldo FB, Benfield MR, Kohaut EC: Methylprednisolone treatment of patients with steroid-resistant nephrotic syndrome. Pediatr Nephrol 6: 503-505, 1992
42. Guillot AP, Kim MS: Pulse steroid therapy (pst) does not alter the course of focal segmental glomerulosclerosis (FSGS) [Abstract]. J Am Soc Nephrol 4: 276, 1993.
43. Ingulli E, Tejani A: Racial differences in the incidence and renal outcome of idiopathic focal segmentai glomerulosclerosis in children. Pediatr Nephrol 5: 393-397, 1991
44. Cameron JS, Turner DR, Ogg CS, Chantier C, Williams DG: The long-term prognosis of patients with focal segmental glomerulosclerosis. Clin Nephrol 10: 213-218, 1978
45. Korbet SM, Schwartz MM, Lewis EJ: Primary focal segmental glomerulosclerosis: Clinical course and response to therapy. Am J Kidney Dis 23: 773-783, 1994
46. Korbet SM, Genchi RM, Borok RZ, Schwartz MM: The racial prevalence of glomerular lesions in nephrotic adults. Am J Kidney Dis 27: 647-651, 1996
47. Valeri A, Barisoni L, Appel GB, Siegle R, D'Agati V: Idiopathic collapsing focal segmental glomerulosclerosis: A clinicopathologic study. Kidney Int 50: 1734-1746, 1996
48. Habib R, Girardin E, Gagnadoux M-F, Hinglais N, Levy M, Broyer M: Immunopathological findings in idiopathic nephrosis: Clinical significance of glomerular "immune deposits." Pediatr Nephrol 2: 402-408, 1988
49. Apperloo AJ, de Zeeuw D, de Long PE: Short-term antiproteinuric response to antihypertensive treatment predicts long-term GFR decline in patients with non-diabetic renal disease. Kidney Int 45[Suppl 45]: 174-178, 1994
50. Coleman JE, Watson AR: Hyperlipidemia, diet and simvastatin therapy in steroid-resistant nephrotic syndrome of childhood. Pediatr Nephrol 10: 171-174, 1996