Irbesartan normalises the deficiency in glomerular nephrin expression in a model of diabetes and hypertension

Diabetologia

Volumn 44, Issue 7, 2001, Pages 874-877

  Bonnet, F ^a   Cooper, M E ^a   Kawachi, H ^a   Allen, T J ^a   Boner, G ^a   Cao, Z ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Angiotensin II; Angiotensin II receptor antagonist; Diabetes; Diabetic nephropathy; Irbesartan; Nephrin; SHR

Indexed keywords

ALBUMIN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; IRBESARTAN; NEPHRIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC RETINOPATHY; DRUG EFFECT; ESSENTIAL HYPERTENSION; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; RAT; RAT STRAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOZOCIN DIABETES;

ALBUMINURIA; ANALYSIS OF VARIANCE; ANIMALS; BIPHENYL COMPOUNDS; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HYPERTENSION; MALE; MEMBRANE PROTEINS; OLIGONUCLEOTIDE PROBES; PROTEINS; RATS; RATS, INBRED SHR; RECEPTORS, ANGIOTENSIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TETRAZOLES;

EID: 0034933344     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250100546     Document Type: Article

References (10)

1. Nephrin is specifically located at the slit diaphragm of glomular podocytes
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3. Nephrin in experimental glomerular disease
4. Glomerular expression of nephrin is decreased in acquired human nephrotie syndrome
5. Role of angiotensin II and bradykinin in experimental diabetic nephropathy. Functional and structural studies
6. Effects of genetic hypertension on diabetic nephropathy in the rat: Functional and structural characteristics
7. Advanced glycation end products and their receptors co-localise in rat organs susceptible to diabetic microvascular injury
8. Podocyte loss and progressive glomerular injury in type II diabetes
9. Effect of angiotensin-converting enzyme inhibition on glomerular basement membrane permeability and distribution of zonula occludens-1 in MWF rats
10. Blocking angiotensin II synthesis/activity preserves glomerular nephrin in rats with severe nephrosis