Active-site mutants of class B β-lactamases: Substrate binding and mechanistic study

Cellular and Molecular Life Sciences

Volumn 59, Issue 12, 2002, Pages 2136-2143

  Prosperi Meys, C ^a   De Seny, D ^a   Llabres, G ^a   Galleni, M ^a   Lamotte Brasseur, J ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Catalytic mechanism; Metallo lactamase; Molecular mechanics; Molecular modeling; Penicillin binding; Zinc enzyme

Indexed keywords

BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; LIGAND; PENICILLIN G; ZINC;

ANTIBIOTIC RESISTANCE; ARTICLE; BACILLUS CEREUS; CATALYSIS; DRUG BINDING; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME STRUCTURE; ENZYME SUBSTRATE; MOLECULAR MECHANICS; MOLECULAR MODEL; MUTATION; NONHUMAN; PLASTICITY; PROTEIN MODIFICATION; X RAY ANALYSIS;

BACILLUS CEREUS; BACTERIAL PROTEINS; BETA-LACTAMASES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; HISTIDINE; MOLECULAR STRUCTURE; MUTATION; PENICILLIN G; PENICILLINS; PROTEIN BINDING;

BACILLUS CEREUS;

EID: 0036971224     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000180200013     Document Type: Article

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