Functional dissection of the cytoplasmic subregions of the IL-2 receptor βc chain in primary lymphocyte populations

EMBO Journal

Volumn 17, Issue 22, 1998, Pages 6551-6557

  Fujii, Hodaka ^a   Ogasawara, Kouetsu ^a   Otsuka, Hidefumi ^a   Suzuki, Misao ^b   Yamamura, Ken Ichi ^b   Yokochi, Taeko ^a   Miyazaki, Tadaaki ^a   Suzuki, Haruhiko ^c,d   Mak, Tak W ^c   Taki, Shinsuke ^a   Taniguchi, Tadatsugu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TORONTO   (Canada)

^d NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

T cells; Interleukin 2 receptor c chain; Lymphocyte development; Natural killer cells; T cell growth

Indexed keywords

INTERLEUKIN 2 RECEPTOR; RECEPTOR SUBUNIT; STAT3 PROTEIN; STAT5 PROTEIN;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; CYTOPLASM; LYMPHOCYTE CULTURE; LYMPHOCYTE SUBPOPULATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSGENE;

ANIMALS; BASE SEQUENCE; CELL DIVISION; CELL LINE; CYTOPLASM; DNA PRIMERS; DNA, COMPLEMENTARY; INTERLEUKIN-2; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MICE; MUTAGENESIS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTES;

ANIMALIA;

EID: 0032538799     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Adachi, M., Ishino, M., Torigoe, T., Minami, Y., Matozaki, T., Miyazaki, T., Taniguchi, T., Hinoda, Y. and Imai, K. (1997) Interleukin-2 induces tyrosine phosphorylation of SHP-2 through IL-2 receptor β chain. Oncogene, 14, 1629-1633.
2. Ascherman, D.P., Migone, T.-S., Friedmann, M.C. and Leonard, W.J. (1997) Interleukin-2 (IL-2)-mediated induction of the IL-2 receptor α chain gene. J. Biol. Chem., 272, 8704-8709.
3. Brennan, P., Babbage, J.W., Burgering, B.M.T., Groner, B., Reif, K. and Cantrell, D.A. (1997) Phosphatidylinositol 3-kinase couples the interleukin 2 receptor to the cell cycle regulator E2F. Immunity, 7, 1-20.
4. Cantrell, D.A., Izquierdo, M., Reif, K. and Woodrow, M. (1993) Regulation of PtdIns-3-kinase and the guanine nucleotide binding proteins p21ras during signal transduction by the T cell antigen receptor and the interleukin-2 receptor. Semin. Immunol., 5, 319-326.
5. DiSanto, J.P. (1997) Cytokines: shared receptors, distinct functions. Curr. Biol., 7, R424-R426.
6. Endo, T.A. et al. (1997) A new protein containing an SH2 domain that inhibits JAK kinases. Nature, 387, 921-924.
7. Friedmann, M.C., Migone, T.-S., Russell, S.M. and Leonard, W.J. (1996) Different interleukin 2 receptor β-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation. Proc. Natl Acad. Sci. USA, 93, 2077-2082.
8. Fujii, H. et al. (1995) Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor β chain but is not essential for the proliferative signal transmission. Proc. Natl Acad. Sci. USA, 92, 5482-5486.
9. Georgopoulos, K., Bigby, M., Wang, J.-H., Molnar, A., Wu, P., Winandy, S. and Sharpe, A. (1994) The Ikaros gene is required for the development of all lymphoid lineages. Cell, 79, 143-156.
10. Giri, J.G. et al. (1994) Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J., 13, 2822-2830.
11. Goldsmith, M.A. et al. (1995) Growth signal transduction by the human interleukin-2 receptor cytoplasmic tyrosines of the beta chain and non-tyrosine residues of the γc chain. J. Biol. Chem., 270, 21729-21737.
12. Hatakeyama, M., Mori, H., Doi, T. and Taniguchi, T. (1989a) A restricted cytoplasmic region of IL-2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization. Cell, 59, 837-845.
13. Hatakeyama, M., Tsudo, M., Minamoto, S., Kono, T., Doi, T., Miyata, T., Miyasaka, M. and Taniguchi, T. (1989b) Interleukin-2 receptor β chain gene: generation of three receptor forms by cloned human α and β chain cDNAs. Science, 244, 551-556.
14. lck: identification of novel intermolecular association. Science, 252, 1523-1528.
15. lck. Proc. Natl Acad. Sci. USA, 88, 1996-2000.
16. Ihle, J.N. (1995) Cytokine receptor signalling. Nature, 377, 591-594.
17. Kimura, S., Abe, K., Suzuki, M., Ogawa, M., Yoshioka, K. Yamamura, K.-I. and Miike, T. (1997) 2.1 kb 5′-flanking region of the brain type dystrophin gene directs the expression of lacZ in the cerebral cortex, but not in the hippocampus. J. Neurosci., 147, 13-20.
18. Kishimoto, T., Taga, T. and Akira, S. (1994) Cytokine signal transduction. Cell, 76, 253-262.
19. Klingmuller, U., Wu, H., Hsiao, J.G., Toker, A., Duckworth, B.C., Cantley, L.C. and Lodish, H.F. (1997) Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc. Natl Acad. Sci. USA, 94, 3016-3021.
20. Kneiz, B., Herman, T., Yonehara, S. and Schimpl, A. (1995) Normal clonal expansion but impaired Fas-mediated cell death and anergy in IL-2 deficient mice. Eur. J. Immunol., 25, 2572-2377.
21. Kono, T., Doi, T., Yamada, G., Hatakeyama, M., Minamoto, S., Tsudo, M., Miyasaka, M., Miyata, T. and Taniguchi, T. (1990) Murine interleukin 2 receptor β chain: dysregulated gene expression in lymphoma line EL-4 caused by a promoter insertion. Proc. Natl Acad. Sci. USA, 87, 1806-1810.
22. Leonard, W.J., Noguchi, M., Russell, S.M. and McBride, O.W. (1994) The molecular basis of X-linked severe combined immunodeficiency: the role of the interleukin-2 receptor γ chain as a common γ chain, γc. Immunol. Rev., 138, 61-86.
23. Lin, J.-X. et al. (1995) The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13 and IL-15. Immunity, 2, 331-339.
24. Miyazaki, T. et al. (1994) Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science, 266, 1045-1047.
25. + hematopoietic progenitor cells. Blood, 87, 2632-2640.
26. Naka, T. et al. (1947) Structure and function of a new STAT-induced STAT inhibitor. Nature, 387, 924-929.
27. Nikajima, H., Liu, X.-W., Wynshaw-Boris, A., Rosenthal, L.A., Imada, K., Finbloom, D.S., Hennighausen, L. and Leonard, W.J. (1997) An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor a chain induction. Immunity, 7, 691-701.
28. Nakamura, Y., Russell, S.M., Mess, S.A., Friedmann, M., Erdos, M., Francois, C., Jacques, Y. Adelstein, S. and Leonard, W.J. (1994) Heterodimerization of the IL-2 receptor β-and γ-chain cytoplasmic domain is required for signalling. Nature, 369, 330-333.
29. Nelson, B.H., Lord, J.D. and Greenberg, P.D. (1994) Cytoplasmic domains of the interleukin-2 receptor β and γ chains mediate the signal for T-cell proliferation. Nature, 369, 333-336.
30. O'Shea, J.J. (1997) Jaks, STATs, cytokine signal transduction and immunoregulation: are we there yet? Immunity, 7, 1-11.
31. Ogasawara, K., Hida, S., Azimi, N., Tagaya, Y., Sato, T., Yokochi-Fukuda, T., Waldmann, T.A., Taniguchi, T. and Taki, S. (1998) Requirement for IRF-1 in the microenvironment supporting natural-killer-cell development. Nature, 391, 700-703.
32. Paul, W.E. and Seder, R.A. (1994) Lymphocyte responses and cytokines. Cell, 76, 241-251.
33. Rafaeli, Y., Van Parjis, L., London, C.A., Tschopp, J. and Abbas, A.K. (1998) Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity, 8, 615-623.
34. Ravichandran, K.S., Igras, V., Shoelson, S.E., Fesik, S.W. and Burakoff, S.J. (1996) Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling. Proc. Natl Acad. Sci. USA, 93, 5275-5280.
35. Rodig, S.J. et al. (1998) Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic response. Cell, 93, 373-383.
36. Russell, S.M. et al. (1994) Interaction of IL-2Rβ and γc chains with Jak1 and Jak3: implications for XSCID and XCID. Science, 266, 1042-1045.
37. Sadlack, B., Merz, H., Schorle, H. Schimpl, A., Feller, A.C. and Horak, I. (1993) Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell, 75, 253-261.
38. Sato, T., Minami, Y., Kono, T., Yamada, K., Kawahara, A., Taniguchi, T. and Kaziro, Y. (1997) Interleukin 2-induced activation of ras requires two domains of interleukin 2 receptor β subunit, the essential region for growth stimulation and lck-binding domain. J. Biol. Chem., 267, 25423-25427.
39. Starr, R. et al. (1997) A family of cytokine-inducible inhibitors of sugnalling. Nature, 387, 917-921.
40. Sugamura, K., Asao, H., Kondo, M., Tanaka, N., Ishii, N., Ohbo, K., Nakamura, M. and Takeshita, T. (1996) The interleukin-2 receptor γ chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Annu. Rev. Immunol. 14, 179-205.
41. Suzuki, H. et al. (1995) Deregulated T cell activate and autoimmunity in mice lacking interleukin-2 receptor β. Science, 268, 1472-1476.
42. Suzuki, M., Abe, K., Yoshinaga, K., Obinata, M., Furusawa, M. and Abe, K. (1996) Specific arrest of spermatogenesis caused by apoptotic cell death in transgenic mice. Genes Cells, 1, 1077-1086.
43. Suzuki, H., Duncan, G.S., Takimoto, H. and Mak, T.W. (1997a) Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor β chain. J. Exp. Med., 185, 499-505.
44. Suzuki, H., Hayakawa, A., Bouchard, D., Nakashima, I. and Mak, T.W. (1997b) Normal thymic selection, superantigen-induced deletion and Fas-mediated apoptosis of T cells in IL-2 receptor β chain-deficient mice. Int. Immunol., 9, 1367-1374.
45. Taniguchi, T. (1995) Cytokine signaling through nonreceptor protein tyrosine kinases. Science, 268, 251-255.
46. Van Parjis, L., Biuckians, A., Ibraghimov, A., Alt, F.W., Willerford, D. and Abbas, A.K. (1997) Functional responses and apoptosis in CD25 (IL-2Rα)-deficient lymphocytes expressing a transgenic antigen receptor. J. Immunol., 158, 3738-3745.
47. Waldmann, T.A. (1989) The multi-subunit interleukin-2 receptor. Annu. Rev. Biochem., 58, 875-911.
48. Willerford, D.M., Chen, J., Ferry, J.A., Davidson, L., Ma, A. and Alt, F.W. (1995) Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment. Immunity, 3, 521-530.
49. Wu, H., Klingmuller, U., Acurio, A., Hsiao, J.G. and Lodish, H.F. (1997) Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation. Proc. Natl Acad. Sci. USA, 94, 1806-1810.
50. Zhumabekov, T., Corbella, P., Tolaini, M. and Kioussis, D. (1995) Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice. J. Immunol. Methods, 185, 133-140.