메뉴 건너뛰기




Volumn 21, Issue 4, 2007, Pages 445-450

The expression of the solute carriers NTCP and OCT-1 is regulated by cholesterol in HepG2 cells

Author keywords

Cholesterol; CYP3A4; HepG2 cells; Uptake transporter

Indexed keywords

CHOLESTEROL; CYTOCHROME P450 3A4; MESSENGER RNA; ORGANIC ANION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 1; PROTEIN; PROTEIN SLC10A1; UNCLASSIFIED DRUG;

EID: 34447540370     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2007.00517.x     Document Type: Conference Paper
Times cited : (12)

References (38)
  • 1
    • 30544450531 scopus 로고    scopus 로고
    • Pharmacogenomics of cholesterol-lowering therapy
    • Schmitz G., Langmann T. Pharmacogenomics of cholesterol-lowering therapy. Vasc. Pharmacol. (2006) 44 75 89.
    • (2006) Vasc. Pharmacol. , vol.44 , pp. 75-89
    • Schmitz, G.1    Langmann, T.2
  • 2
    • 0037119454 scopus 로고    scopus 로고
    • Cholesterol and bile acids regulate xenosensor signalling in drug-mediated induction of cytochromes P450
    • Handschin C., Podvinee M., Amherd R., Looser R., Ourlin J.C., Meyer U.A. Cholesterol and bile acids regulate xenosensor signalling in drug-mediated induction of cytochromes P450. J. Biol. Chem. (2002) 277 29561 29567.
    • (2002) J. Biol. Chem. , vol.277 , pp. 29561-29567
    • Handschin, C.1    Podvinee, M.2    Amherd, R.3    Looser, R.4    Ourlin, J.C.5    Meyer, U.A.6
  • 3
    • 33750027681 scopus 로고    scopus 로고
    • Cytochrome P450s and cholesterol homeostasis
    • Pikuleva I.A. Cytochrome P450s and cholesterol homeostasis. Pharmacol. Ther. (2006) 112 761 773.
    • (2006) Pharmacol. Ther. , vol.112 , pp. 761-773
    • Pikuleva, I.A.1
  • 4
    • 33845306250 scopus 로고    scopus 로고
    • Pharmacogenetics of cytochromes P450 in tropical medicine
    • Ribeiro V., Cavaco I. Pharmacogenetics of cytochromes P450 in tropical medicine. Curr. Drug Targets (2006) 7 1709 1719.
    • (2006) Curr. Drug Targets , vol.7 , pp. 1709-1719
    • Ribeiro, V.1    Cavaco, I.2
  • 5
    • 1242317691 scopus 로고    scopus 로고
    • The sodium bile salt cotransport family SLC10
    • Hagenbuch B., Dawson P. The sodium bile salt cotransport family SLC10. Eur. J. Physiol. (2004) 447 566 570.
    • (2004) Eur. J. Physiol. , vol.447 , pp. 566-570
    • Hagenbuch, B.1    Dawson, P.2
  • 6
    • 27544515516 scopus 로고    scopus 로고
    • Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase
    • Fujino H., Saito T., Ogawa S., Kojima J. Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. J. Pharm. Pharmacol. (2005) 57 1305 1311.
    • (2005) J. Pharm. Pharmacol. , vol.57 , pp. 1305-1311
    • Fujino, H.1    Saito, T.2    Ogawa, S.3    Kojima, J.4
  • 7
    • 33646536542 scopus 로고    scopus 로고
    • Drug and bile acid transporters in rosuvastatin hepatic uptake: Function, expression, and pharmacogenetics
    • Ho R.H., Tirona R.G., Leake B.F. et al. Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology (2006) 130 1793 1806.
    • (2006) Gastroenterology , vol.130 , pp. 1793-1806
    • Ho, R.H.1    Tirona, R.G.2    Leake, B.F.3
  • 8
    • 1242272736 scopus 로고    scopus 로고
    • Organic anion transporting polypeptides of the OATP/SLC21 family: Phylogenetic classificaton as OATP/SLCO superfamily, new nomenclature and molecular/functional properties
    • Hagenbuch B., Meier P.J. Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classificaton as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Eur. J. Physiol. (2004) 447 653 665.
    • (2004) Eur. J. Physiol. , vol.447 , pp. 653-665
    • Hagenbuch, B.1    Meier, P.J.2
  • 9
    • 0029091022 scopus 로고
    • Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver
    • Kullak-Ublick G.A., Hagenbuch B., Stieger B. et al. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology (1995) 109 1274 1282.
    • (1995) Gastroenterology , vol.109 , pp. 1274-1282
    • Kullak-Ublick, G.A.1    Hagenbuch, B.2    Stieger, B.3
  • 10
    • 0034709561 scopus 로고    scopus 로고
    • Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family
    • Tamai I., Nezu J., Uchino H. et al. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem. Biophys. Res. Commun. (2000) 273 251 260.
    • (2000) Biochem. Biophys. Res. Commun. , vol.273 , pp. 251-260
    • Tamai, I.1    Nezu, J.2    Uchino, H.3
  • 11
    • 0032957616 scopus 로고    scopus 로고
    • Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells
    • Eckhardt U., Schroeder A., Stieger B. et al. Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells. Am. J. Physiol. (1999) 276 G1037 1042.
    • (1999) Am. J. Physiol. , vol.276
    • Eckhardt, U.1    Schroeder, A.2    Stieger, B.3
  • 12
    • 0032793959 scopus 로고    scopus 로고
    • OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine
    • Cvetkovic M., Leake B., Fromm M.F., Wilkinson G.R., Kim R.B. OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab. Dispos. (1999) 27 866 871.
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 866-871
    • Cvetkovic, M.1    Leake, B.2    Fromm, M.F.3    Wilkinson, G.R.4    Kim, R.B.5
  • 13
  • 14
    • 0037131885 scopus 로고    scopus 로고
    • Pharmacogenomics of organic anion-transporting polypeptides (OATP)
    • Tirona R.G., Kim R.B. Pharmacogenomics of organic anion-transporting polypeptides (OATP). Adv. Drug Deliv. Rev. (2002) 54 1343 1352.
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 1343-1352
    • Tirona, R.G.1    Kim, R.B.2
  • 15
    • 85009583484 scopus 로고    scopus 로고
    • Intestinal absorption of drugs mediated by drug transporters: Mechanisms and regulation
    • Katsura T., Inui K. Intestinal absorption of drugs mediated by drug transporters: mechanisms and regulation. Drug Metab. Pharmacokin. (2003) 18 1 15.
    • (2003) Drug Metab. Pharmacokin. , vol.18 , pp. 1-15
    • Katsura, T.1    Inui, K.2
  • 16
    • 0042468096 scopus 로고    scopus 로고
    • Impact of drug transporter studies on drug discovery and development
    • Mizuno N., Niwa T., Yotsumoto Y., Sugiyama Y. Impact of drug transporter studies on drug discovery and development. Pharmacol. Rev. (2003) 55 425 461.
    • (2003) Pharmacol. Rev. , vol.55 , pp. 425-461
    • Mizuno, N.1    Niwa, T.2    Yotsumoto, Y.3    Sugiyama, Y.4
  • 17
    • 3042569768 scopus 로고    scopus 로고
    • Polyspecific organic cation transporters: Their functions and interactions with drugs
    • Koepsell H. Polyspecific organic cation transporters: their functions and interactions with drugs. Trends Pharmacol. Sci. (2004) 25 375 381.
    • (2004) Trends Pharmacol. Sci. , vol.25 , pp. 375-381
    • Koepsell, H.1
  • 18
    • 0035169839 scopus 로고    scopus 로고
    • Release of non-neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters
    • Wessler I., Roth E., Deutsch C. et al. Release of non-neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters. Br. J. Pharmacol. (2001) 134 951 956.
    • (2001) Br. J. Pharmacol. , vol.134 , pp. 951-956
    • Wessler, I.1    Roth, E.2    Deutsch, C.3
  • 19
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. (1987) 162 156 159.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 20
    • 0030812885 scopus 로고    scopus 로고
    • In vitro metabolism of simvastatin in humans: Identification of metabolizing enzymes and effect of the drug on hepatic P450s
    • Prueksaritanont T., Gorham L.M., Ma B. et al. In vitro metabolism of simvastatin in humans: identification of metabolizing enzymes and effect of the drug on hepatic P450s. Drug Metab. Dispos. (1997) 25 1191 1199.
    • (1997) Drug Metab. Dispos. , vol.25 , pp. 1191-1199
    • Prueksaritanont, T.1    Gorham, L.M.2    Ma, B.3
  • 21
    • 0025168996 scopus 로고
    • Identification of the rabbit and human cytochromes P-450IIIA as the major enzymes involved in the N-demethylation of diltiazem
    • Pichard L., Gillet G., Fabre I. et al. Identification of the rabbit and human cytochromes P-450IIIA as the major enzymes involved in the N-demethylation of diltiazem. Drug Metab. Dispos. (1990) 18 711 719.
    • (1990) Drug Metab. Dispos. , vol.18 , pp. 711-719
    • Pichard, L.1    Gillet, G.2    Fabre, I.3
  • 22
    • 0037274419 scopus 로고    scopus 로고
    • Evaluation of the toxicological relevance of CYP3A4 induction
    • Plant N.J., Gibson G.G. Evaluation of the toxicological relevance of CYP3A4 induction. Curr. Opin. Drug Discov. Dev. (2003) 6 50 56.
    • (2003) Curr. Opin. Drug Discov. Dev. , vol.6 , pp. 50-56
    • Plant, N.J.1    Gibson, G.G.2
  • 23
    • 0017306762 scopus 로고
    • Identification of bile acids in the serum and urine in cholestasis. Evidence for 6alpha-hydroxylation of bile acids in man
    • Summerfield J.A., Billing B.H., Shackleton C.H. Identification of bile acids in the serum and urine in cholestasis. Evidence for 6alpha-hydroxylation of bile acids in man. Biochem. J. (1976) 154 507 516.
    • (1976) Biochem. J. , vol.154 , pp. 507-516
    • Summerfield, J.A.1    Billing, B.H.2    Shackleton, C.H.3
  • 24
    • 0028801475 scopus 로고
    • Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease
    • George J., Murray M., Byth K., Farrell G.C. Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease. Hepatology (1995) 21 120 128.
    • (1995) Hepatology , vol.21 , pp. 120-128
    • George, J.1    Murray, M.2    Byth, K.3    Farrell, G.C.4
  • 25
    • 1642483471 scopus 로고    scopus 로고
    • Feed-forward regulation of bile acid detoxification by CYP3A4 - Studies in humanized transgenic mice
    • Stedman C., Robertson G., Coulter S., Liddle C. Feed-forward regulation of bile acid detoxification by CYP3A4 - studies in humanized transgenic mice. J. Biol. Chem. (2004) 279 11336 11343.
    • (2004) J. Biol. Chem. , vol.279 , pp. 11336-11343
    • Stedman, C.1    Robertson, G.2    Coulter, S.3    Liddle, C.4
  • 26
    • 0035914467 scopus 로고    scopus 로고
    • Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450
    • Schuetz E.G., Strom S., Yasuda K. et al. Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. J. Biol. Chem. (2001) 276 39411 39418.
    • (2001) J. Biol. Chem. , vol.276 , pp. 39411-39418
    • Schuetz, E.G.1    Strom, S.2    Yasuda, K.3
  • 27
    • 33751186142 scopus 로고    scopus 로고
    • Molecular determinants in the transport of a bile acid-derived diagnostic agent in tumoral and nontumoral cell lines of human liver
    • Libra A., Fernetti C., Lorusso V. et al. Molecular determinants in the transport of a bile acid-derived diagnostic agent in tumoral and nontumoral cell lines of human liver. J. Pharmacol. Exp. Ther. (2006) 319 809 817.
    • (2006) J. Pharmacol. Exp. Ther. , vol.319 , pp. 809-817
    • Libra, A.1    Fernetti, C.2    Lorusso, V.3
  • 29
    • 0037427956 scopus 로고    scopus 로고
    • Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat
    • Geier A., Dietrich C.G., Gerloff T. et al. Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat. Biochim. Biophys. Acta (2003) 1609 87 94.
    • (2003) Biochim. Biophys. Acta , vol.1609 , pp. 87-94
    • Geier, A.1    Dietrich, C.G.2    Gerloff, T.3
  • 30
    • 0034950514 scopus 로고    scopus 로고
    • The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp
    • Denson L.A., Sturm E., Echevarria W. et al. The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp. Gastroenterology (2001) 121 140 147.
    • (2001) Gastroenterology , vol.121 , pp. 140-147
    • Denson, L.A.1    Sturm, E.2    Echevarria, W.3
  • 31
    • 0037200089 scopus 로고    scopus 로고
    • Interleukin-1 beta-mediated suppression of RXR:RAR transactivation of the Ntcp promoter is JNK-dependent
    • Li D., Zimmerman T.L., Thevananther S., Lee H.Y., Kurie J.M., Karpen S.J. Interleukin-1 beta-mediated suppression of RXR:RAR transactivation of the Ntcp promoter is JNK-dependent. J. Biol. Chem. (2002) 277 31416 31422.
    • (2002) J. Biol. Chem. , vol.277 , pp. 31416-31422
    • Li, D.1    Zimmerman, T.L.2    Thevananther, S.3    Lee, H.Y.4    Kurie, J.M.5    Karpen, S.J.6
  • 32
    • 0032524012 scopus 로고    scopus 로고
    • Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors
    • Trauner M., Arrese M., Lee H., Boyer J.L., Karpen S.J. Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. J. Clin. Invest. (1998) 101 2092 2100.
    • (1998) J. Clin. Invest. , vol.101 , pp. 2092-2100
    • Trauner, M.1    Arrese, M.2    Lee, H.3    Boyer, J.L.4    Karpen, S.J.5
  • 33
    • 0030994363 scopus 로고    scopus 로고
    • Regulation of the rat liver sodium-dependent bile acid cotransporter gene by prolactin. Mediation of transcriptional activation by Stat5
    • Ganguly T.C., O'Brien M.L., Karpen S.J., Hyde J.F., Suchy F.J., Vore M. Regulation of the rat liver sodium-dependent bile acid cotransporter gene by prolactin. Mediation of transcriptional activation by Stat5. J. Clin. Invest. (1997) 99 2906 2914.
    • (1997) J. Clin. Invest. , vol.99 , pp. 2906-2914
    • Ganguly, T.C.1    O'Brien, M.L.2    Karpen, S.J.3    Hyde, J.F.4    Suchy, F.J.5    Vore, M.6
  • 34
    • 0035853165 scopus 로고    scopus 로고
    • The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
    • Staudinger J.L., Goodwin B., Jones S.A. et al. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc. Natl Acad. Sci. USA (2001) 98 3369 3374.
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 3369-3374
    • Staudinger, J.L.1    Goodwin, B.2    Jones, S.A.3
  • 35
    • 0035813209 scopus 로고    scopus 로고
    • Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1 alpha
    • Jung D., Hagenbuch B., Gresh L., Pontoglio M., Meier P.J., Kullak-Ublick G.A. Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1 alpha. J. Biol. Chem. (2001) 276 37206 37214.
    • (2001) J. Biol. Chem. , vol.276 , pp. 37206-37214
    • Jung, D.1    Hagenbuch, B.2    Gresh, L.3    Pontoglio, M.4    Meier, P.J.5    Kullak-Ublick, G.A.6
  • 36
    • 2342452711 scopus 로고    scopus 로고
    • Down-regulation of the organic cation transporter 1 of rat liver in obstructive cholestasis
    • Denk G.U., Soroka C.J., Mennone A., Koepsell H., Beuers U., Boyer J.L. Down-regulation of the organic cation transporter 1 of rat liver in obstructive cholestasis. Hepatology (2004) 39 1382 1389.
    • (2004) Hepatology , vol.39 , pp. 1382-1389
    • Denk, G.U.1    Soroka, C.J.2    Mennone, A.3    Koepsell, H.4    Beuers, U.5    Boyer, J.L.6
  • 37
    • 7644239482 scopus 로고    scopus 로고
    • Regulation of the human organic cation transporter hOCT1
    • Ciarimboli G., Struwe K., Arndt P. et al. Regulation of the human organic cation transporter hOCT1. J. Cell. Physiol. (2004) 201 420 428.
    • (2004) J. Cell. Physiol. , vol.201 , pp. 420-428
    • Ciarimboli, G.1    Struwe, K.2    Arndt, P.3
  • 38
    • 1842848068 scopus 로고    scopus 로고
    • X-ray structure of the hRORalpha LBD at 1.63 A: Structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha
    • Kallen J.A., Schlaeppi J.M., Bitsch F. et al. X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha. Structure (2002) 10 1697 1707.
    • (2002) Structure , vol.10 , pp. 1697-1707
    • Kallen, J.A.1    Schlaeppi, J.M.2    Bitsch, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.