Smad3 and PKCδ mediate TGF-β1-induced collagen I expression in human mesangial cells

American Journal of Physiology - Renal Physiology

Volumn 285, Issue 3 54-3, 2003, Pages

  Runyan, Constance E ^a   Schnaper, H William ^a   Poncelet, Anne Christine ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Cross talk; Extracellular matrix accumulation; Gene regulation; Glomerulosclerosis; Transforming growth factor signal transduction

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; COLLAGEN TYPE 1; MESSENGER RNA; PROTEIN KINASE C; SERINE; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; DNA BINDING PROTEIN; ENZYME INHIBITOR; PRKCD PROTEIN, HUMAN; PROTEIN KINASE C DELTA; SMAD3 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE TRANSPORT; COL1A2 GENE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DNA BINDING; ENZYME ASSAY; FIBROGENESIS; GENE; GENE ACTIVATION; GENE ACTIVITY; GENE CONSTRUCT; GENE INDUCTION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; MESANGIUM CELL; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TIME; TRANSCRIPTION REGULATION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENETICS; MESANGIUM; METABOLISM;

COLLAGEN TYPE I; DNA-BINDING PROTEINS; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GLOMERULAR MESANGIUM; HUMANS; PROTEIN KINASE C; PROTEIN KINASE C-DELTA; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 0041883785     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00082.2003     Document Type: Article

References (56)

1. 1 expression by antisense oligonucleotides suppressed extracellular matrix accumulation in experimental glomerulonephritis. Kidney Int 50: 148-155, 1996.
2. Attisano L and Wrana JL. Smads as transcriptional co-modulators. Curr Opin Cell Biol 12: 235-243, 2000.
3. 1-induced activation of the Raf-MEK-MAPK signaling pathway in rat lung fibroblasts via a PKC-dependent mechanism. Biochem Biophys Res Commun 249: 456-460, 1998.
4. 2(I) indentifies structurally conserved features of the protein and the gene. Biochemistry 22: 1139-1145, 1983.
5. Border WA and Noble NA. TGF-β in kidney fibrosis: a target for gene therapy. Kidney Int 51: 1388-1396, 1997.
6. Border WA, Noble NA, Yamamoto T, Harper JR, Yamaguchi Y, Pierschbacher MD, and Ruoslahti E. Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease. Nature 360: 361-364, 1992.
7. 1. Nature 346: 371-374, 1990.
8. 1(I) collagen chain. Nucleic Acids Res 10: 5925-5934, 1982.
9. Corbit KC, Foster DA, and Rosner MR. Protein kinase Cδ mediates neurogenic but not mitogenic activation of mitogen-activated protein kinase in neuronal cells. Mol Cell Biol 19: 4209-4218, 1999.
10. De Caestecker MP, Yahata T, Wang D, Parks WT, Huang S, Hill CS, Shioda T, Roberts AB, and Lechleider RJ. The Smad4 activation domain (SAD) is a proline-rich p300-dependent transcriptional activation domain. J Biol Chem 275: 2115-2122, 2000.
11. Ettinger SL, Lauener RW, and Duronio V. Protein kinase Cδ specifically associates with phosphatidylinositol 3-kinase following cytokine stimulation. J Biol Chem 271: 14514-14518, 1996.
12. Gschwendt M, Müller HJ, Kielbassa K, Zang R, Kittstein W, Rincke G, and Marks F. Rotterin, a novel protein kinase inhibitor. Biochem Biophys Res Commun 199: 93-98, 1994.
13. Halstead J, Kemp K, and Ignotz RA. Evidence for involvement of phosphatidylcholine-phospholipase C and protein kinase C in transforming growth factor-β signaling. J Biol Chem 270: 13600-13603, 1995.
14. Han DC, Isono M, Hoffman BB, and Ziyadeh FN. High glucose stimulates proliferation and collagen type I synthesis in renal cortical fibroblasts: mediation by autocrine activation of TGF-β. J Am Soc Nephrol 10: 1891-1899, 1999.
15. Haneda M, Araki S, Togawa M, Sugimoto T, Isono M, and Kikkawa R. Mitogen-activated protein kinase cascade is activated in glomeruli of diabetic rats and glomerular mesangial cells cultured under high glucose conditions. Diabetes 46: 847-853, 1997.
16. Hansch GM, Wagner C, Burger A, Dong W, Staehler G, and Stoek M. Matrix protein synthesis by glomerular mesangial cells in culture: effects of transforming growth factor β (TGFβ) and platelet-derived growth factor (PDGF) on fibronectin and collagen type IV mRNA. J Cell Physiol 163: 451-457, 1995.
17. Hattori Y, Kakishita H, Akimoto K, Matsumura M, and Kasai K. Glycated serum albumin-induced vascular smooth muscle cell proliferation through activation of mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by protein kinase C. Biochem Biophys Res Commun 281: 891-896, 2001.
18. Hayashi H, Abdollah S, Qiu Y, Cai J, Xu YY, Grinnell BW, Richardson MA, Topper JN, Gimbrone MA Jr, Wrana JL, and Falb D. The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling. Cell 89: 1165-1173, 1997.
19. 1 activates MAP kinase in human mesangial cells: a possible role in collagen expression. Kidney Int 56: 1710-1720, 1999.
20. Hayashida T and Schnaper H. A Smad/ERK amplification loop for TGF-β-stimulated collagen expression in human mesangial cells (Abstract). J Am Soc Nephrol 13: 86A, 2002.
21. Imamura T, Takase M, Nishihara A, Oeda E, Hanai JI, Kawabata M, and Miyazono K. Smad6 inhibits signalling by the TGF-β superfamily. Nature 389: 622-626, 1997.
22. Jaken S. Protein kinase C isozymes and substrates. Curr Opin Cell Biol 8: 168-173, 1996.
23. Jimenez SA, Gaidarova S, Saitta B, Sandorfi N, Herrich DJ, Rosenbloom JC, Kucich U, Abrams WR, and Rosenbloom J. Role of protein kinase C-δ in regulation of collagen gene expression in scleroderma fibroblasts. J Clin Invest 108: 1395-1403, 2001.
24. Kagami S, Border WA, Miller DE, and Noble NA. Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-β expression in rat glomerular mesangial cells. J Clin Invest 93: 2431-2437, 1994.
25. Kaname S, Uchida S, Ogata E, and Kurokawa K. Autocrine secretion of transforming growth factor-β in cultured rat mesangial cells. Kidney Int 42: 1319-1327, 1992.
26. 1 develop progressive renal disease. Lab Invest 74: 991-1003, 1996.
27. Koya D, Haneda M, Nakagawa H, Isshiki K, Sato H, Maeda S, Sugimoto T, Yasuda H, Kashiwagi A, Ways DK, Kin GL, and Kikkawa R. Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J 14: 439-447, 2000.
28. Koya D, Jirousek MR, Lin YW, Ishii H, Kuboki K, and King GL. Characterization of protein kinase C β isoform activation on the gene expression of transforming growth factor-β, extracellular matrix components, and prostanoids in glomeruli of diabetic rats. J Clin Invest 100: 115-126, 1997.
29. Kucich U, Rosenbloom JC, Abrams WR, and Rosenbloom J. Transforming growth factor-β stabilizes elastin mRNA by a pathway requiring active Smads, protein kinase C-δ, and p38. Am J Respir Cell Mol Biol 26: 183-188, 2002.
30. 1 stimulation of fibronectin transcription in cultured human lung fibroblasts requires active geranylgeranyl transferase I, phosphatidylcholine-specific phospholipase C, protein kinase C-δ, and p38, but not erk1/erk2. Arch Biochem Biophys 374: 313-324, 2000.
31. Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, and Parker PJ. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 281: 2042-2045, 1998.
32. Liu X, Sun Y, Constantinescu SN, Karam E, Weinberg RA, and Lodish HF. Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc Natl Acad Sci USA 94: 10669-10674, 1997.
33. Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, Marmé D, and Schächtele C. Selective inhibition of protein kinase C isoenzymes by indolocarbazole Gö 6976. J Biol Chem 268: 9194-9197, 1993.
34. Massagué J and Wotton D. Transcriptional control by the TGF-β/Smad signaling system. EMBO J 19: 1745-1754, 2000.
35. Mochly-Rosen D and Gordon AS. Anchoring proteins for protein kinase C; a means for isozyme selectivity. FASEB J 12: 35-42, 1998.
36. Nakao A, Afrakthe M, Morén A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, and ten Dijke P. Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling. Nature 389: 631-635, 1997.
37. + channels via phospholipase C and protein kinase C-δ in reactive astrocytes from adult rat brain. J Biol Chem 277: 1974-1980, 2002.
38. Piek E, Heldin CH, and ten Dijke P. Specificity, diversity, and regulation by TGF-β superfamily signaling. FASEB J 13: 2105-2124, 1999.
39. Poncelet AC, de Caestecker MP, and Schnaper HW. The transforming growth factor-β/SMAD signaling pathway is present and functional in human mesangial cells. Kidney Int 56: 1354-1365, 1999.
40. 1. Am J Physiol Renal Physiol 275: F458-F466, 1998.
41. 2(I) collagen expression in human glomerular mesangial cells. J Biol Chem 276: 6983-6992, 2001.
42. Riser BL, Cortes P, Yee J, Sharba AK, Asano K, Rodrigues-Barbero A, and Narins RG. Mechanical strain- and high glucose-induced alterations in mesangial cell collagen metabolism: role of TGF-β. J Am Soc Nephrol 9: 827-836, 1998.
43. Ruiz-Ortega M, Largo R, Bustos C, Gomez-Garre D, and Egido J. Platelet-activating factor stimulates gene expression and synthesis of matrix proteins in cultured rat and human mesangial cells: role of TGF-β. J Am Soc Nephrol 8: 1266-1275, 1997.
44. Schnaper HW, Kopp JB, Hubchak SC, Poncelet AC, Stetler-Stevenson WG, Bruggeman LA, Klotman PE, and Kleinman HK. Increased expression of extracellular matrix proteins and decreased expression of matrix proteases after serial passage of glomerular mesangial cells. J Cell Sci 109: 2521-2528, 1996.
45. Sharma K and Ziyadeh FN. Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-β as key mediator. Diabetes 44: 1139-1146, 1995.
46. Studer RK, Craven PA, and DeRubertis FR. Antioxidant inhibition of protein kinase C-signaled increases in transforming growth factor-β in mesangial cells. Metabolism 46: 918-925, 1997.
47. Tamaoki T and Nakano H. Potent and specific inhibitors of protein kinase C of microbial origin. Biotechnology 8: 732-735, 1990.
48. Uchiyama-Tanaka Y, Matsubara H, Mori Y, Kosaki A, Kishimoto N, Amano K, Higashiyama S, and Iwasaka T. Involvement of HB-EGF and EGF receptor transactivation in TGF-β-mediated fibronectin expression in mesangial cells. Kidney Int 62: 799-808, 2002.
49. Ueda Y, Hirai S, Osada S, Suzuki A, Mizuno K, and Ohno S. Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J Biol Chem 271: 23512-23519, 1996.
50. Villalba M, Kasibhatla S, Genestier L, Mahboubi A, Green DR, and Altman A. Protein kinase Cθ cooperates with calcineurin to induce Fas ligand expression during activation-induced T cell death. J Immunol 163: 5813-5819, 1999.
51. 1 promoter in mesangial cells. J Am Soc Nephrol 11: 2007-2016, 2000.
52. Wrenn RW, Raeuber CL, Herman LE, Walton WJ, and Rosenquist TH. Transforming growth factor-β: signal transduction via protein kinase C in cultured embryonic vascular smooth muscle cells. In Vitro Cell Dev Biol 29A: 73-78, 1993.
53. Yakymovych I, ten Dijke P, Heldin CH, and Souchelnytskyi S. Regulation of Smad signaling by protein kinase C. FASEB J 15: 553-555, 2001.
54. Zawel L, Le Dai J, Buckhaults P, Zhou S, Kinzler KW, Vogelstein B, and Kern SE. Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell 1: 611-617, 1998.
55. Zhuang S, Hirai SI, and Ohno S. Hyperosmolality induces activation of cPKC and nPKC, a requirement for ERK1/2 activation in NIH/3T3 cells. Am J Physiol Cell Physiol 278: C102-C109, 2000.
56. Ziyadeh FN, Sharma K, Ericksen M, and Wolf G. Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by activation of transforming growth factor-β. J Clin Invest 93: 536-542, 1994.