Iron supplementation protects against lead-induced apoptosis through MAPK pathway in weanling rat cortex

NeuroToxicology

Volumn 28, Issue 4, 2007, Pages 850-859

  Wang, Qiang ^a   Luo, Wenjing ^a   Zhang, Wenbing ^a   Dai, Zhongming ^a   Chen, Yaoming ^a   Chen, Jingyuan ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cortex; ERK; Iron; JNK; Lead

Indexed keywords

ACETIC ACID; CASPASE 3; DNA FRAGMENT; DRINKING WATER; FERROUS SULFATE; IRON; LEAD ACETATE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; TRANSCRIPTION FACTOR ELK 1;

AGAR GEL ELECTROPHORESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN NUCLEUS; BRAIN TOXICITY; CONTROLLED STUDY; DRUG EFFECT; IRON THERAPY; MALE; NICK END LABELING; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; WESTERN BLOTTING;

ADMINISTRATION, ORAL; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; IN SITU NICK-END LABELING; IRON; LEAD; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TRACE ELEMENTS;

ANIMALIA; RATTUS;

EID: 34447307108     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2007.04.004     Document Type: Article

References (57)

1. 2+ promotes lipid oxidation and alterations in membrane physical properties. Toxicology 132 (1999) 19-32
2. Apostoli P, Boffetta P. Why a conference on lead toxicity? Introductory Remarks to the proceedings of the international conference on lead exposure, reproductive toxicity, and carcinogenicity. Gargnano, Italy, 7-9 June 1999. Am J Ind Med 2000; 38:229-30.
3. Bellinger D., Levinton A., Waternaux C., Needleman H., and Rabinowitz P. Longitudinal analysis of environmental exposure to lead and children's intelligence at the age of seven years. N Engl J Med 316 (1987) 1037-1043
4. Beyaert R., Cuenda A., Vanden Berghe W., Plaisance S., Lee J.C., Haegeman G., et al. The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor. EMBO J 15 (1996) 1914-1923
5. Bradford M.M. A rapid and sensitive for the quantitation of microgram quantitites of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
6. Cory-Slechta D.A., Weiss B., and Cox C. Delayed behavioral toxicity of lead with increasing exposure concentration. Toxicol Appl Pharmacol 71 (1983) 342-352
7. Fan L., lyer J., Zhu S., Frick K.K., Wada R.K., Eskenazi A.E., et al. Inhibition of N-myc expression and induction of apoptosis by iron chelation in human neuroblastoma cells. Cancer Res 61 (2001) 1073-1079
8. Fox D.A., Campbell M.L., and Blocker Y.S. Functional alterations and apoptotic cell death in the retina following developmental or adult lead exposure. Neurotoxicology 18 (1997) 645-664
9. Fox D.A., and Chu L.W.F. Rods are selectively altered by lead: II. Ultrastructure and quantitative histology. Exp Eye Res 46 (1988) 613-625
10. Fukuchi K., Tomoyasu S., Tsuruoka N., and Gomi K. Iron deprivation-induced apoptosis in HL-60 cells. FEBS Lett 350 (1994) 139-142
11. Fukuchi K., Tomoyasu S., Watanabe H., Kaetsu S., Tsuruoka N., and Gomi K. Iron deprivation results in an increase in p53 expression. Biol Chem Hoppe Seyler 376 (1995) 627-630
12. Gao Y., Signore A.P., Yin W., Cao G., Yin X.M., Sun F., et al. Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway. J Cereb Blood Flow Metab 25 (2005) 694-712
13. Geilen C.C., Wieprecht M., and Orfanos C.E. The mitogenactivated protein kinases system (MAP kinase cascade): its role in skin signal transduction. J Dermatol Sci 12 (1996) 255-262
14. Godwin H.A. The biological chemistry of lead. Curr Opin Chem Biol 5 (2001) 223-227
15. Hoffbrand A.V., Ganeshaguru K., Hooton J.W.L., and Tattersall M.N.H. Effect of iron deficiency and deferroxamine on DNA synthesis in human cells. Br J Haematol 33 (1976) 517-526
16. Holtzman D., DeVries C., Nguyen H., Olson J., and Bensch K. Maturation of resistance to lead encephalopathy: cellular and subcellular mechanisms. Neurotoxicology 5 (1984) 97-124
17. Ip Y.T., and Davis R.J. Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development. Curr Opin Cell Biol 10 (1998) 205-219
18. Jordan A., and Reichard P. Ribonucleotide reductases. Ann Rev Biochem 67 (1998) 71-98
19. Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 270 (1995) 16483-16486
20. Kern M., Audesirk T., and Audesirk G. Effects of inorganic lead on the differentiation and growth of cortical neurons in culture. Neurotoxicology 14 (1993) 319-327
21. Kortenjann M., and Shaw P.E. The growing family of MAP kinases: regulation and specificity. Crit Rev Oncog 6 (1995) 99-115
22. Kyriakis J.M., and Avruch J. Protein kinase cascades activated by stress and inflammatory cytokines. Bioessays 18 (1996) 567-577
23. Leal R.B., Cordova F.M., Lynn H., Bobrovskaya L., and Dunkley P.R. Lead-stimulate P38mapk-dependent Hsp27 phosphorylation. Toxicol Appl Pharmacol 178 (2002) 44-51
24. Lindahl L.S., Bird L., Legare M.E., Mikeska G., Bratton G.R., and Tiffany-Castiglioni E. Differential ability of astroglia and neuronal cells to accumulate lead: dependence on cell type and on degree of differentiation. Toxicol Sci 50 (1999) 236-243
25. Lockshin R.A. Programmed cell death: history and future of a concept. J Soc Biol 199 (2005) 169-173
26. Maciejewski J.P., Selleri C., Sato T., Cho H.J., Keefer L.K., Nathan C.F., et al. Nitric oxide suppression of human hematopoiesis in vitro. Contribution to inhibitory action of interferon-gamma and tumor necrosis factor-alpha. J Clin Invest 96 (1995) 1085-1092
27. Marais R., and Marshall C.J. Control of the ERK MAP kinase cascade by Ras and Raf. Cancer Surv 27 (1996) 101-125
28. Matsuzawa A., and Ichijo H. Molecular mechanisms of the decision between life and death: regulation of apoptosis by apoptosis signal-regulating kinase 1. J Biochem 130 (2001) 1-8
29. Moriguchi T., Gotoh Y., and Nishida E. Roles of the MAP kinase cascade in vertebrates. Adv Pharmacol 36 (1996) 121-137
30. Murata K., Araki S., Yokoyama K., Uchida E., and Fujimura Y. Assessment of central, peripheral, and autonomic nervous system functions in lead workers: neuroelectrophysiological studies. Environ Res 61 (1993) 323-336
31. Nebreda A.R., and Gavin A.C. Perspectives: signal transduction. Cell survival demands some risk. Science 286 (1999) 1309-1310
32. 2+) promotes apoptosis in newborn rat cerebellar neurons: pathological implications. J Pharmacol Exp Ther 279 (1996) 435-442
33. Okuno S., Saito A., Hayashi T., and Chan P.H. The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia. J Neurosci 24 (2004) 7879-7887
34. Pahl P.M., Horwitz M.A., Horwitz K.B., and Horwitz L.D. Desferriexochelin induces death by apoptosis in human breast cancer cells but does not kill normal breast cells. Breast Cancer Res Treat 69 (2001) 69-79
35. Paul A., Wilson S., Belham C.M., Robinson C.J.M., Scott P.H., Gould G.W., et al. Stress-activated protein kinases: activation, regulation and function. Cell Signal 9 (1997) 403-410
36. Press M.F. Lead encephalopathy in neonatal Long-Evans rats: morphologic studies. J Neuropathol Exp Neurol 36 (1977) 169-193
37. Raingeaud J., Gupta S., Rogers J.S., Dickens M., Han J., Ulevitch R.J., et al. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem 270 (1995) 7420-7426
38. Ramesh G.T., Manna S.K., Aggarwal B.B., and Jadhav A.L. Lead activates nuclear transption factor-nB, activator protein-1 and amino-terminal c-Jun kinase in pheochromocytoma cells. Toxicol Appl Pharmacol 155 (1999) 280-286
39. Rosen J.F. Adverse effects of lead at low exposure levels: trends in the treatment of childhood lead poisoning. Toxicology 97 (1995) 11-17
40. Scortegagna M., and Hanbauer I. The effect of lead exposure and serum deprivation on mesencephalic primary cultures. Neurotoxicology 18 (1997) 331-339
41. Sinha S.P., Sharma S., Meenakshi V., Srivastava S., and Srivastava M.M. Neurotoxic effects of lead exposure among printing press workers. Bull Environ Contam Toxicol 51 (1993) 490-493
42. Stark M., Wolff J.E., and Korbmacher A. Modulation of glial cell differentiation by exposure to lead and cadmium. Neurotoxicol Teratol 14 (1992) 247-252
43. Su B., and Karin M. Mitogen-activated protein kinase cascades and regulation of gene expression. Curr Opin Immunol 8 (1996) 402-411
44. Tiffany-Castiglioni E., Garcia D.M., Wu J.N., Zmudzki J., and Bratton G.R. Effects of lead on viability and intracellular metal content of C6 rat glioma cells. J Toxicol Environ Health 23 (1988) 267-279
45. Tomoyasu S., Fukuchi K., Yajima K., Watanabe K., Suzuki H., Kawakami K., et al. Suppression of HL-60 cell proliferation by deferoxamine: changes in c-myc expression. Anticancer Res 13 (1993) 407-410
46. Toyokuni S. Iron-induced carcinogenesis: the role of redox regulation. Free Radic Biol Med 20 (1996) 553-566
47. Treisman R. Regulation of transcription by MAP kinase cascades. Curr Opin Cell Biol 8 (1996) 205-215
48. Villeda-Hernandez J., Barroso-Moguel R., Mendez-Armenta M., Nava-Ruiz C., Huerta-Romero R., and Rios C. Enhanced brain regional lipid peroxidation in developing rats exposed to low level lead acetate. Brain Res Bull 55 (2001) 247-251
49. Waskiewicz A.J., and Cooper J.A. Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. Curr Opin Cell Biol 7 (1995) 798-805
50. Weinberg E.D. Iron, asbestos, and carcinogenicity. Lancet 1 (1989) 1399-1400
51. Whitmarsh A.J., and Davis R.J. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med 74 (1996) 589-607
52. Williams T.M., Ndifor A.M., Near J.T., and Reams-Brown R.R. Lead enhances NGF-induced neurite outgrowth in PC12 cells by potentiating ERK/MAPK activation. Neurotoxicology 21 (2000) 1081-1089
53. Xia Z., Dickens M., Raingeaud J., Davis R.J., and Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270 (1995) 1326-1331
54. Yoshino T., Kishi H., Nagata T., Tsukada K., Saito S., and Muraguchi A. Differential involvement of p38 MAP kinase pathway and Bax translocation in the mitochondria-mediated cell death in TCR- and dexamethasone-stimulated thymocytes. Eur J Immunol 31 (2001) 2702-2708
55. Zawia N.H., and Harry G.J. Developmental exposure to lead interferes with glial and neuronal differential gene expression in the rat cerebellum. Toxicol Appl Pharmacol 138 (1996) 43-47
56. Zhao Q., Slavkovich V., and Zheng W. Lead exposure promotes translocation of protein kinase C activity in rat choroid plexus in vitro, but not in vivo. Toxicol Appl Pharmacol 149 (1998) 99-106
57. Zheng W., Shen H., Blaner W.S., Zhao Q., Ren X., and Graziano J.H. Chronic lead exposure alters transthyretin concentration in rat cerebrospinal fluid: the role of the choroid plexus. Toxicol Appl Pharmacol 139 (1996) 445-450