Lead (Pb++) promotes apoptosis in newborn rat cerebellar neurons: Pathological implications

Journal of Pharmacology and Experimental Therapeutics

Volumn 279, Issue 1, 1996, Pages 435-442

  Oberto, Alessandra ^a   Marks, Neville ^a   Evans, Hugh L ^b   Guidotti, Alessandro ^a,b,c  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; LEAD;

ANIMAL; APOPTOSIS; ARTICLE; CELL CULTURE; CEREBELLUM; DRUG EFFECT; NECROSIS; NEWBORN; PATHOLOGY; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BRAIN DEVELOPMENT; CELL SIZE; CONTROLLED STUDY; GRANULE CELL; HISTOPATHOLOGY; LEAD POISONING; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SYNAPTOGENESIS;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CALCIUM; CELLS, CULTURED; CEREBELLUM; LEAD; NECROSIS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030302459     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. AMERICAN ACADEMY OF PEDIATRICS: Lead poisoning: From screening to primary prevention. Committee on Environmental Health. Pediatrics 92: 176-183, 1993.
2. AUDESIRK, G.: Electrophysiology of lead intoxication: Effects on voltage-sensitive ion channels. Neurotoxicology 14: 137-148, 1993.
3. BALAZS, R., JORGENSEN, O. S. AND HACK, N.: N-methyl-D-aspartate promotes the survival of cerebellar granule cells in culture. Neuroscience 27: 437-451, 1988.
4. BRADBURY, M. W. B. AND DEANE, R.: Permeability of the blood-brain barrier to lead. Neurotoxicology 14: 131-136, 1993.
5. CARBONI, E. AND WOJCIK, W. J.: Dihydropyridine binding sites regulate calcium influx through specific voltage-sensitive calcium channels in cerebellar granule cells. J. Neurochem. 50: 1279-1286, 1988.
6. +-ATPase activity in synaptosomes and myelin of developing control and intra-uterine growth retarded rats. Neurochem. Int. 12: 39-45, 1988.
7. CHOI, D. W.: Glutamate neurotoxicity and diseases of the nervous system. Neuron 1: 623-634, 1988.
8. CORY-SLECHTA, D. A.: Lead exposure during advanced age: Alteration in kinetics and biochemical effects. Toxicol. and Appl. Pharmacol. 104: 67-78, 1990.
9. ++ dynamics after toxic doses of glutamate in cerebellar granule cells. Proc. Natl. Acad. Sci. U.S.A. 87: 8017-8021, 1990.
10. D'MELLO, S. R., GALLI, C., CIOTTI, T. AND CALISSANO, P.: Induction of apoptosis in cerebellar granule neurons by low potassium: Inhibition of death by insulin-like growth factor I and cAMP. Proc. Natl. Acad. Sci. U.S.A. 90: 10989-10993, 1993.
11. FAVARON, M., MANEV, H., ALHO, H., BERTOLINO, M., FERRET, B., GUIDOTTI, A. AND COSTA, E.: Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex. Proc. Natl. Acad. Sci. U.S.A. 85: 7351-7355, 1988.
12. FRANKLIN, J. L. AND JOHNSON, E. M. JR.: Suppression of programmed cell death by sustained elevation of cytoplasmic calcium. Trends Neurosci. 15: 501-508, 1992.
13. GALLI, C., MEUCCI, O., SCORZIELLO, A., WERGE, M. T., CALISSANO, P. AND SCHETTINI, G.: Apoptosis in cerebellar granule cells is blocked by high KCl, Forscolin and IGF-1 through distinct mechanisms of action: The involvement of intracellular calcium and RNA synthesis. J. Neurosci. 15: 1172-1179, 1995.
14. GALLO, V., CIOTTI, M. T., COLETTI, A., ALOISI, F. AND LEVI, G.: Selective release of glutamate from cerebellar granule cells differentiating in culture. Proc. Natl. Acad. Sci. U.S.A. 79: 7919-7923, 1982.
15. GALLO, V., KINGSBURY, A., BALAZS, R. AND JORGENSEN, O. S.: The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J. Neurosci. 7: 2203-2213, 1987.
16. GAVRIELI, Y., SHERMAN, Y. AND BEN-SASSON, S. A.: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell. Biol. 119: 493-501, 1992.
17. GOLDSTEIN, G. W.: Lead poisoning and brain cell function. Environ. Health Perspect. 89: 91-94, 1990.
18. GOLDSTEIN, G. W.: Neurologic concepts of lead poisoning in children. Pediatric Annals 21: 384-388, 1992.
19. GOLDSTEIN, P., OJCIUS, D. M. AND YOUNG, J. D.-E.: Cell death mechanisms and the immune system. Immunol. Rev. 121: 29-65, 1991.
20. HAGIWARA, S., BYERLY, L.: Calcium channel. Ann. Rev. Neurosci. 4: 69-125, 1981.
21. HAMMOND, P. B. AND DIETRICH, K. N.: Lead exposure in early life: Health consequence. Rev. Environ. Contam. Toxicol. 115: 91-124, 1990.
22. HERRMANN, M., LORENZ, H. M., VOLL, R., GRUNKE, M., WOITH, W. AND KALDEN, J. R.: A rapid and simple method for the isolation of apoptotic DNA fragments. Nucleic Acids Res. 22: 5506-5507, 1994.
23. HOLTZMAN, D., HERMAN, M. M., HSU, J. S. AND MORTELL, P.: The pathogenesis of lead encephalopathy. Effects of lead carbonate feedings on morphology, lead content and mitochondrial respiration in brains of immature and adult rats. Virchows Arch. A. Path. Anat. Histol. 387: 147-164, 1980.
24. HOLTZMAN, D., OLSON, J. E., DE VRIES, C. AND BENSCH, K.: Lead toxicity in primary cultured cerebral astrocytes and cerebellar granular neurons. Toxicol. Appl. Pharmacol. 89: 211-225, 1987.
25. 2+ channel antagonists. J. Med. Chem. 26: 775-785, 1983.
26. KERN, M., AUDESIRK, T. AND AUDESIRK, G.: Effects of inorganic lead on the differentiation and growth of cortical neurons in culture. Neurotoxicology 14: 319-328, 1993.
27. KOH, J-Y., GWAG, B. J., LOBNER, D. AND CHOI, D. W.: Potentiated necrosis of cultured cortical neurons by neurotrophins. Science (Wash. DC) 268: 573-575, 1995.
28. KIEDROWSKI, L. AND COSTA, E.: Glutamate induced destabilization of intracellular calcium concentration homeostasis in cultured cerebellar granule cell: Role of mitochondria in calcium buffering. Mol. Pharmacol. 47: 140-147, 1995.
29. MANEV, H., COSTA, E., WROBLEWSKI, J. T. AND GUIDOTTI, A.: Abusive stimulation of excitatory amino acid receptors: A strategy to limit neurotcxicity. FASEB J. 4: 2789-2797, 1990.
30. 2+ influx elicited by glutamate: Role in neuronal death. Mol. Pharmacol. 36: 106-112, 1989.
31. MANEV, H., FAVARON, M., SIMAN, R., GUIDOTTI, A. AND COSTA, E.: Glutamate neurotoxicity is independent of calpain I inhibition in primary cultures of cerebellar granule cells. J. Neurochem. 57: 1288-1295, 1991.
32. MARINI, A. M. AND PAUL, S. M.: N-methyl-D-aspartate receptor-mediated neuroprotection in cerebellar granule cells requires new RNA and protein synthesis. Proc. Natl. Acad. Sci. U.S.A. 89: 6555-6559, 1992.
33. MARKOVAC, J. AND GOLDSTEIN, G. W.: Lead activates protein kinase C in immature rat brain microvessels. Toxicol. Appl. Pharmacol. 96: 14-23, 1988.
34. MARTIN, D. P., ITO, A., HORIGOME, K., LAMPE, P. A. AND JOHNSON, E. M.: Biochemical characterization of programmed cell death in NGF-deprived sympathetic neurons. J. Neurobiol. 23: 1205-1220, 1992.
35. MARTIN, D. P., SCHMIDT, R. E., DISTEFANO, P. S., LOWRY, O. H., CARTER, J. G. AND JOHNSON, E. M.: Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation. J. Cell Biol. 106: 829-844, 1988.
36. NICHOLSON, D. W., ALI, A., THORNBERRY, N. A., VAILLANCOURT, J. P., DING, C. K., GALLANT, M., GAREAU, Y., GRIFFIN, P. R., LABELLE, M., LAZEBNIK, Y. A., MUNDAY, N. A., RAJU, S. M., SMULSON, M. E., YAMIN, T-T., UU, V. L., AND MILLER, D. K.: Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature (Lond.) 376: 37-43, 1995.
37. NICOLETTI, F., WROBLEWSKI, J. T., NOVELLI, A., ALHO, H., GUIDOTTI, A. AND COSTA, E.: The activation of inositol phospholipid metabolism as a signal-transduction system for excitatory amino acids in primary cultures of cerebellar granule cells. J. Neurosci. 16: 1905-19011, 1986.
38. OBERHAMMER, F., FRITSCH, G., SCHMIED, M., PAVELKA, M., PRINZ, D., PURCHIO, T., LASSMANN, H. AND SCHULTE-HERMANN, R.: Condensation of the chromatin at the membrane of an apoptotic nucleus is not associated with activation of an endonuclease. J. Cell. Sci. 104: 317-326, 1993.
39. OPPENHEIM, R. W.: Cell death during development of the nervous system. Annu. Rev. Neurosci. 14: 453-501, 1991.
40. RAFF, M. C., BARRES, B. A., BURNE, J. F., COLES, H. S., ISHIZAKI, Y. AND JACOBSON, M. D.: Programmed cell death and the control of cell survival: Lessons from the nervous system. Science (Wash. DC) 262: 695-698, 1993.
41. RODIER, P. M.: Developing brain as a target of toxicity. Envir. Health Persp. 6: 73-76, 1995.
42. SCHLEGEL, J., PETERS, I. AND ORRENIUS, S.: Isolation and partial characterization of a protease involved in Fas-induced apoptosis. FEBS Letters 364: 142-145, 1995.
43. SCHRAMM, M., EIMERL, S. AND COSTA, E.: Serum and depolarizing agents cause acute neurotoxicity in cultured cerebellar granule cells: Role of the glutamate receptor responsive to N-methyl-D-aspartate. Proc. Natl. Acad. Sci. U.S.A. 87: 1193-1197, 1990.
44. TALLARIDA, R. L. AND MURRAY, R. B.: Manual of Pharmacological Calculations with Computer Programs (Springer-Verlag, New York, 1987).
45. TIFFANY-CASTIGLIONI, E., SIERRA, E. M., WU, J-N. AND ROWLES, T. K.: Lead toxicity in neuroglia. Neurotoxicology 10: 417-444, 1989.
46. UJIHARA, H. AND ALBUQUERQUE, E. X.: Developmental changes of the inhibition by lead of NMDA-activated currents in cultured hippocampal neurons. J. Pharmacol. Exp. Ther. 263: 868-875, 1992.
47. U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES: Toxicological profile for lead. Draft for public comment. Clement International Corporation, 1992.
48. VACCARINO, F., GUIDOTTI, A. AND COSTA, E.: Ganglioside inhibition of glutamate-mediated protein kinase C translocation in primary cultures of cerebellar neurons. Proc. Natl. Acad. Sci. U.S.A. 84: 8707-8711, 1987.
49. VAUX, D. L.: Toward an understanding of the molecular mechanism of physiological cell death. Proc. Natl. Acad. Sci. U.S.A. 90: 786-789, 1993.
50. WOOD, K. A., DIPASQUALE, B. AND YOULE, J.: In situ labeling of granule cells for apoptosis-associated DNA fragmentation reveals different mechanisms of cell loss in developing cerebellum. Neuron 11: 621-632, 1993.
51. YAN, G., NI, B., WELLER, M., WOOD, K. A. AND PAUL, S. M.: Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons. Brain Res. 43: 43-51, 1994.
52. YAN, G., IRWIN, R. P., LIN, S., WELLER, M., WOOD, K. A. AND PAUL, S. M.: Diphenylhydantoin induces apoptotic cell death of cultured rat cerebellar granule neurons. J. Pharmacol. Exp. Ter. 274: 983-990, 1995.