Chronic lead exposure alters transthyretin concentration in rat cerebrospinal fluid: The role of the choroid plexus

Toxicology and Applied Pharmacology

Volumn 139, Issue 2, 1996, Pages 445-450

  Zheng, Wei ^a,b   Shen, Huan ^a   Blaner, William S ^a   Zhao, Qiuqu ^a   Ren, Xiaojun ^a   Graziano, Joseph H ^a,b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEAD; METAL ION; PREALBUMIN;

ANIMAL MODEL; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BODY WEIGHT; CEREBROSPINAL FLUID; CHOROID PLEXUS; CONTROLLED STUDY; DOSE RESPONSE; HISTOPATHOLOGY; LEAD POISONING; MALE; NONHUMAN; RABBIT; RADIOIMMUNOASSAY; RAT;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0030220601     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0186     Document Type: Article

References (44)

1. Aldred, A. R., Brack, C. M., and Schreiber, G. (1995). The cerebral expression of plasma protein genes in different species. Comp. Biochem. Physiol 111B, 1-15.
2. Blaner, W. S. (1990). Radioimmunoassays for retinol-binding protein, cellular retinol-binding protein, and cellular retinoic acid-binding protein. Methods Enzymol. 189, 270-281.
3. Blay, P., Nilsson, C., Owman, C., Aldred, A., and Schreiber, G. (1993). Transthyretin expression in rat brain: Effect of thyroid functional state and role in thyroxine transport. Brain Res. 632, 114-120.
4. Bressler, J., Forman, S., and Goldstein, G. W. (1994). Phospholipid metabolism in neural microvascular endothelial cells after exposure to lead in vitro. Toxicol. Appl. Pharmacol. 126, 352-360.
5. Cavallaro, T., Martone, R. L., Stylianopoulou, F., and Herber, J. (1993). Differential expression of the insulin-like growth factor-II and transthyretin genes in the developing rat choroid plexus. J. Neuropathol. Exp. Neurol. 52, 153-162.
6. Chanoine, J. P., Alex, S., Fang, S. L., Stone, S., Leonard, J. L., Korhle, J., and Braverman, L. E. (1992). Role of transthyretin in the transport of thyroxine from the blood to the choroid plexus, the cerebrospinal fluid, and the brain. Endocrinology 130, 933-938.
7. Cohn, J., and Cory-Slechta, D. A. (1993). Subsensitivity of lead-exposed rats to the accuracy-impairing and rate-altering effects of MK-801 on a multiple schedule of repeated learning and performance. Brain Res. 600, 208-218.
8. Cory-Slechta, D. A., Weiss, B., and Cox, C. (1983). Delayed behavioral toxicity of lead with increasing exposure concentration. Toxicol. Appl. Pharmacol. 71, 342-352.
9. Davson, H., and Segal, M. B. (1996). Physiology of the CSF and Blood-Brain Barrier, pp. 15-18. CRC Press, New York.
10. Dickson, P. W., Aldred, A. R., Marley, P. D., Tu, G. F., Hewlett, G. J., and Schreiber, G. (1985). High prealbumin and transferrin mRNA levels in the choroid plexus of rat brain. Biochem. Biophys. Res. Commun. 127, 890-895.
11. Dickson, P. W., Aldred, A. R., Marley, P. D., Bannister, D., and Schreiber, G. (1986). Rat choroid plexus specializes in the synthesis and the secretion of transthyretin (prealbumin). Regulation of transthyretin synthesis in choroid plexus is independent from that of liver. J. Biol. Chem. 261, 3475-3478.
12. Dingwall-Fordyce, I., and Lane, R. E. (1963). A following up study of lead workers. Br. J. Indust. Med. 20, 313.
13. Dratman, M. B., Crutchfield, F. L., and Schoenhoff, M. B. (1991). Transport of iodothyronines from bloodstream to brain: Contributions by blood:brain and choroid plexusxerebrospinal fluid barrier. Brain Res. 554, 229-236.
14. Dussault, J. H., and Ruel, J. (1987). Thyroid hormones and brain development. Ann. Rev. Physiol. 49, 321-334.
15. Fernandez, F., and Hilligoss, D. (1982). An improved graphite furnace method for the determination of lead in blood using matrix modification and the L'vov platform. Atomic Spectr. 3, 130-131.
16. Friedheim, E., Corvi, C., Graziano, J., Donnelli, T., and Breslin, D. (1983). Choroid plexus as protective sink for heavy metals? Lancet i(8331), 981-982.
17. Glorieux, J., Dussault, J. H., Letarte, J., Guyde, H., and Morissette, J. (1983). Preliminary results on the mental development of hypothyroid children detected by the Quebec Screening Program. J. Pediatr. 102, 19-22.
18. Goldstein, G. W. (1984). Brain capillaries: A target for inorganic lead poisoning. Neurotoxicology 5, 167-176.
19. Hagen, G. A., and Elliott, W. J. (1973). Transport of thyroid hormones in serum and cerebral spinal fluid. J. Clin. Endocrinol. Metab. 37, 415-422.
20. Hammond, P. B., Minnema, D. J., and Succop, P. A. (1993). Reversibility of lead-induced depression of growth. Toxicol. Appl. Toxicol. 123, 9-15.
21. Herbert, J., Wilcox, J. N., Pham, K. C., Fremeau, R. T., Zeviani, M., Dwork, A., Soprano, D. R., Makover, A., Goodman, D. S., Zimmerman, E. A., Roberts, J. L., and Schon, E. A. (1986). Transthyretin: A choroid plexus-specific transport protein in human brain. Neurology 36, 900-911.
22. Ingenbleek, Y., and Young, V. (1994). Transthyretin (prealbumin) in health and disease: Nutritional implications. Annu. Rev. Nutr. 14, 495-533.
23. Johanson, C. E. (1995). Ventricles and cerebrospinal fluid. In Neuroscience in Medicine (P. M. Conn, Ed.), pp. 171-196. Lippincott, Philadelphia.
24. Jorgensen, O. S. (1988). Neural cell adhesion molecule (NCAM) and prealbumin in cerebrospinal fluid from depressed patients. Acta Psychiatr. Scand. 345(Suppl.), 29-37.
25. Kim, C. S., and O'Tuama, L. A. (1978). Selective changes in tyrosine transport by isolated choroid plexus exposed to inorganic lead. Toxicol. Appl. Pharmacol. 45, 213-217.
26. Larsen, P. D., and DeLallo, L. (1989). Cerebrospinal fluid transthyretin in the neonate and blood - cerebrospinal fluid barrier permeability. Ann. Neurol. 25, 628-630.
27. Legrand, J. (1984). Effect of thyroid hormones on central nervous system development. In Neurobehavioral Teratology (J. Yanai, Ed.), pp. 331-363. Elsevier, New York.
28. Levine, S. (1987). Choroid plexus: Target for systemic disease and pathway to the brain. Lab. Invest. 56, 231-233.
29. Manton, W. I., Kirkpatrick, J. B., and Cook, J. D. (1984). Does the choroid plexus really protect the brain from lead? Lancet ii(8398), 351.
30. Navab, M., Smith, J. E., and Goodman, D. S. (1977). Rat plasma prealbumin. Metabolic studies on effects of vitamin A status and on tissue distribution. J. Biol. Chem. 252, 5107-5114.
31. Nilsson, C., Lindvall-Axelsson, M., and Owman, C. (1992). Neuroendocrine regulatory mechanisms in the choroid plexus - cerebrospinal fluid system. Brain Res. Rev. 17, 109-138.
32. Ormerod, W. E., and Venkatesan, S. (1970). The choroid plexus in African sleeping-sickness. Lancet 2(676), 777.
33. Perkin-Elmer (1984). Analytical Methods for Atomic Absorption Spectrophotometry. Publication B332, Perkin-Elmer, Norwalk.
34. Philip, K. A., Dascombe, M. J., Fraser, P. A., and Pentreath, V. W. (1994). Blood-brain barrier damage in experimental African trypanosomiasis. Ann. Trop. Med. Parasitol. 88, 607-616.
35. Rudin, D. O. (1981). The choroid plexus and system disease in mental illness. II. Systemic lupus erythematosus: A combined transport dysfunction model for schizophrenia. Biol. Psychiatr. 16, 373-97.
36. Scheffe, H. (1967). The Analysis of Variance. Wiley, New York.
37. Schreiber, G., Aldred, A. R., Jaworowski, A., Nilsson, C., Achen, M. G., and Segal, M. B. (1990). Thyroxine transport from blood to brain via transthyretin synthesis in choroid plexus. Am. J. Physiol. 258, R338-R345.
38. Smith, D. W., Blizzard, R. M., and Wilkins, L. (1957). The mental prognosis in hypothyroidism of infancy in childhood. Pediatrics 19, 1011-1022.
39. Smith, Q. R. (1991). The blood-brain barrier and the regulation of amino acid uptake and availability to brain. Adv. Exp. Med. Biol. 291, 55-71.
40. Southwell, B. R., Duan, W., Alcorn, D., Brack, C., Richardson, S. J., Kohrle, J., and Schreiber, G. (1993). Thyroxine transport to the brain: Role of protein synthesis by the choroid plexus. Endocrinology 133, 2116-2126.
41. Thomas, T., Schreiber, G., and Jaworowski, A. (1989). Developmental patterns of gene expression of secreted proteins in brain and choroid plexus. Devl. Biol. 134, 38-47.
42. Wade, S., Bleiberg-Daniel, E., and LeMoullac, B. (1988). Rat transthyretin: the effects of acute short-term food deprivation and refeeding on the serum and cerebrospinal fluid concentration and on the hepatic mRNA level. J. Nutr. 118, 199-205.
43. Zheng, W., Perry, D. F., Nelson, D. L., and Aposhian, H. V. (1991). Protection of cerebrospinal fluid against toxic metals by the choroid plexus. FASEB J. 5, 2188-2193.
44. Zheng, W. (1996). The choroid plexus and metal toxicities. In Toxicology of Metals (L. W. Chang, Ed.), pp. 605-622. CRC Press, New York.