Caveats of Gene-Targeted and Transgenic Mice

Handbook of Stem Cells

Volumn 1, Issue , 2004, Pages 589-598

  Matthaei, Klaus I ^a  

^a Australian National University   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 34447278957     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012436643-5/50068-7     Document Type: Chapter

References (57)

1. Evans M.J., Kaufman M.H. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981, 292:154-156.
2. Martin G.R. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc. Natl. Acad. Sci. USA 1981, 78:7634-7638.
3. Doetschman T., Gregg R.G., Maeda N., Hooper M.L., Melton D.W., Thompson S., Smithies O. Targeted correction of a mutant HPRT gene in mouse embryonic stem cells. Nature 1987, 330:576-578.
4. Thomas K.R., Capecchi M.R. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 1987, 51:503-512.
5. Gerlai R. Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?. Trends Neurosci. 1996, 19:177-181.
6. Hendry I.A., Kelleher K.L., Bartlett S.E., Leck K.J., Reynolds A.J., Heydon K., Mellick A., Megirian D., Matthaei K.I. Hypertolerance to morphine in G(z α)-deficient mice. Brain Res. 2000, 870:10-19.
7. Ledermann B., Burki K. Establishment of a germ line competent C57BL/6 embryonic stem cell line. Exp. Cell Res. 1991, 197:254-258.
8. Offermanns S., Toombs C.F., Hu Y.H., Simon M.I. Defective platelet activation in G α (q)-deficient mice. Nature 1997, 389:183-186.
9. Kelleher K.L., Matthaei K.I., Hendry I.A. Targeted disruption of the mouse Gzα gene: a role for Gz in platelet function?. Thromb. Haemost. 2001, 85:529-532.
10. Holgate, J., and Hendry, I.A. (Personal communication).
11. Campbell H.D., Sanderson C.J., Wang Y., Hort Y., Martinson M.E., Tucker W.Q., Stellwagen A., Strath M., Young I.G. Isolation, structure, and expression of cDNA and genomic clones for murine eosinophil differentiation factor: Comparison with other eosinophilopoietic lymphokines and identity with interleukin-5. Eur. J. Biochem. 1988, 174:345-352.
12. Coffman R.L., Seymour B.W., Hudak S., Jackson J., Rennick D. Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice. Science 1989, 245:308-310.
13. Sanderson C.J. Interleukin-5, eosinophils, and disease. Blood 1992, 79:3101-3109.
14. De Monchy J.G., Kauffman H.F., Venge P., Koeter G.H., Jansen H.M., Sluiter H.J., De Vries K. Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions. Am. Rev. Respir. Dis. 1985, 131:373-376.
15. Beasley R., Roche W.R., Roberts J.A., Holgate S.T. Cellular events in the bronchi in mild asthma and after bronchial provocation. Am. Rev. Respir. Dis. 1989, 139:806-817.
16. Kopf M., Brombacher F., Hodgkin P.D., Ramsay A.J., Milbourne E.A., Dai W.J., Ovington K.S., Behm C.A., Kohler G., Young I.G., Matthaei K.I. IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T-cell responses. Immunity 1996, 4:15-24.
17. Foster P.S., Hogan S.P., Ramsay A.J., Matthaei K.I., Young I.G. Interleukin-5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J. Exp. Med. 1996, 183:195-201.
18. Corry D.B., Folkesson H.G., Warnock M.L., Erle D.J., Matthay M.A., Wiener-Kronish J.P., Locksley R.M. Interleukin-4, but not interleukin-5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J. Exp. Med. 1996, 183:109-117.
19. Hogan S.P., Matthaei K.I., Young J.M., Koskinen A., Young I.G., Foster P.S. A novel T-cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5. J. Immunol. 1998, 161:1501-1509.
20. McKenzie G.J., Emson C.L., Bell S.E., Anderson S., Fallon P., Zurawski G., Murray R., Grencis R., McKenzie A.N. Impaired development of Th2 cells in IL-13-deficient mice. Immunity 1998, 9:423-432.
21. Webb D.C., McKenzie A.N., Koskinen A.M., Yang M., Mattes J., Foster P.S. Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity. J. Immunol. 2000, 165:108-113.
22. Walter D.M., McIntire J.J., Berry G., McKenzie A.N., Donaldson D.D., DeKruyff R.H., Umetsu D.T. Critical role for IL-13 in the development of allergen-induced airway hyperreactivity. J. Immunol. 2001, 167:4668-4675.
23. Zurawski S.M., Vega F., Huyghe B., Zurawski G. Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction. EMBO. J. 1993, 12:2663-2670.
24. Smerz-Bertling C., Duschl A. Both interleukin-4 and interleukin-13 induce tyrosine phosphorylation of the 140-kDa subunit of the interleukin-4 receptor. J. Biol. Chem. 1995, 270:966-970.
25. Schulte T., Kurrle R., Rollinghoff M., Gessner A. Molecular characterization and functional analysis of murine interleukin-4 receptor allotypes. J. Exp. Med. 1997, 186:1419-1429.
26. Webb D., Matthaei K.I., Cai Y., McKenzie A.N.J., Foster P.S. Polymorphisms in IL-4Ralpha correlate with airways hyperactivity, eosinophila, and ym protein expression in allergic IL-13 -/- mice. J. Immunol. 2004, 172:1092-1098.
27. Leck, K.J., Hendry, I.A., and Matthaei, K.I. (Unpublished).
28. Goldman L.A., Cutrone E.C., Kotenko S.V., Krause C.D., Langer J.A. Modifications of vectors pEF-BOS, pcDNA1, and pcDNA3 result in improved convenience and expression. Biotechniques 1996, 21:1013-1015.
29. Jang S.K., Pestova T.V., Hellen C.U., Witherell G.W., Wimmer E. Cap-independent translation of picornavirus RNAs: structure and function of the internal ribosomal entry site. Enzyme 1990, 44:292-309.
30. Noben-Trauth N., Kohler G., Burki K., Ledermann B. Efficient targeting of the IL-4 gene in a BALB/c embryonic stem cell line. Transgenic Res. 1996, 5:487-491.
31. Hagg T. Neuronal cell death: retraction. Science 1999, 285:340.
32. Crusio W.E. Gene-targeting studies: new methods, old problems. Trends Neurosci. 1996, 19:186-187. discussion 188-189.
33. Jacks T., Remington L., Williams B.O., Schmitt E.M., Halachmi S., Bronson R.T., Weinberg R.A. Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 1994, 4:1-7.
34. Blackburn, A.C. (Personal communication).
35. Simpson E.M., Linder C.C., Sargent E.E., Davisson M.T., Mobraaten L.E., Sharp J.J. Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice. Natl. Genet. 1997, 16:19-27.
36. Reiner S.L., Locksley R.M. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 1995, 13:151-177.
37. Kopf M., Brombacher F., Kohler G., Kienzle G., Widmann K.H., Lefrang K., Humborg C., Ledermann B., Solbach W. IL-4-deficient Balb/c mice resist infection with Leishmania major. J. Exp. Med. 1996, 184:1127-1136.
38. Kelly B.L., Locksley R.M. Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns. J. Immunol. 2000, 165:2982-2986.
39. Olson E.N., Arnold H.H., Rigby P.W., Wold B.J. Know your neighbors: three phenotypes in null mutants of the myogenic bHLH gene MRF4. Cell 1996, 85:1-4.
40. Floss T., Arnold H.H., Braun T. Myf-5(m1)/Myf-6(m1) compound heterozygous mouse mutants down-regulate Myf-5 expression and exert rib defects: evidence for long-range cis effects on Myf-5 transcription. Dev. Biol. 1996, 174:140-147.
41. Mohn A.R., Gainetdinov R.R., Caron M.G., Koller B.H. Mice with reduced NMDA-receptor expression display behaviors related to schizophrenia. Cell 1999, 98:427-436.
42. Loots G.G., Locksley R.M., Blankespoor C.M., Wang Z.E., Miller W., Rubin E.M., Frazer K.A. Identification of a coordinate regulator of interleukin-4, -13, and -5 by cross-species sequence comparisons. Science 2000, 288:136-140.
43. Mohrs M., Blankespoor C.M., Wang Z.E., Loots G.G., Afzal V., Hadeiba H., Shinkai K., Rubin E.M., Locksley R.M. Deletion of a coordinate regulator of type 2 cytokine expression in mice. Natl. Immunol. 2001, 2:842-847.
44. Mattick J.S. Noncoding RNAs: The architects of eukaryotic complexity. EMBO Rep. 2001, 2:986-991.
45. Campbell H.D., Fountain S., McLennan I.S., Berven L.A., Crouch M.F., Davy D.A., Hooper J.A., Waterford K., Chen K.S., Lupski J.R., Ledermann B., Young I.G., Matthaei K.I. Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development. Mol. Cell Biol. 2002, 22:3518-3526.
46. Campbell H.D., Fountain S., Young I.G., Weitz S., Lichter P., Hoheisel J.D. Fliih, the murine homologue of the Drosophila melanogaster flightless I gene: Nucleotide sequence, chromosomal mapping, and overlap with Llglh. DNA Seq. 2000, 11:29-40.
47. Campbell H.D., Young I.G., Matthaei K.I. Mammalian homologues of the Drosophila melanogaster flightless I gene involved in early development. Curr. Genomics 2000, 1:59-70.
48. Whitelaw E., Martin D.I. Retrotransposons as epigenetic mediators of phenotypic variation in mammals. Natl. Genet. 2001, 27:361-365.
49. Mutant mice and neuroscience: recommendations concerning genetic background. (Banbury Conference on Genetic background in mice). Neuron 1997, 19:755-759.
50. Mattes J., Yang M., Mahalingam S., Kuehr J., Webb D.C., Simson L., Hogan S.P., Koskinen A., McKenzie A.N., Dent L.A., Rothenberg M.E., Matthaei K.I., Young I.G., Foster P.S. Intrinsic defect in T-cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma. J. Exp. Med. 2002, 195:1433-1444.
51. Gu H., Zou Y.R., Rajewsky K. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 1993, 73:1155-1164.
52. Mills A.A. Changing colors in mice: an inducible system that delivers. Genes Dev. 2001, 15:1461-1467.
53. Cronin C.A., Gluba W., Scrable H. The lac operator-repressor system is functional in the mouse. Genes Dev. 2001, 15:1506-1517.
54. Lomeli H., Ramos-Mejia V., Gertsenstein M., Lobe C.G., Nagy A. Targeted insertion of Cre recombinase into the TNAP gene: excision in primordial germ cells. Genesis 2000, 26:116-117.
55. Feng G., Mellor R.H., Bernstein M., Keller-Peck C., Nguyen Q.T., Wallace M., Nerbonne J.M., Lichtman J.W., Sanes J.R. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 2000, 28:41-51.
56. Srinivas S., Watanabe T., Lin C.S., William C.M., Tanabe Y., Jessell T.M., Costantini F. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 2001, 1:4.
57. Friedrich G., Soriano P. Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 1991, 5:1513-1523.