Polymorphisms in IL-4Rα Correlate with Airways Hyperreactivity, Eosinophilia, and Ym Protein Expression in Allergic IL-13-/- Mice

Journal of Immunology

Volumn 172, Issue 2, 2004, Pages 1092-1098

  Webb, Dianne C ^a   Matthaei, Klaus I ^a   Cai, Yeping ^a   McKenzie, Andrew N J ^b   Foster, Paul S ^a  

^a Biology and Environment   (Australia)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; COMPLEMENTARY DNA; GENOMIC DNA; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4 RECEPTOR; ISOLEUCINE; OVALBUMIN; RNA; THREONINE; UNCLASSIFIED DRUG; YM PROTEIN;

ALLERGIC REACTION; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISSOCIATION; DNA SEQUENCE; ELECTROPHORETIC MOBILITY; EOSINOPHILIA; FEMALE; GLYCOSYLATION; LUNG LAVAGE; LUNG PARENCHYMA; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN POLYMORPHISM; PROTEIN PROCESSING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TH2 CELL; WESTERN BLOTTING;

EID: 1642454710     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.2.1092     Document Type: Article

References (52)

1. Walker, C., E. Bode, L. Boer, T. T. Hansel, K. Blaser, and J. C. Virchow, Jr. 1992. Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am. Rev. Respir. Dis. 146:109.
2. Robinson, D. S., Q. Hamid, S. Ying, A. Tsicopoulos, J. Barkans, A. M. Bentley, C. Corrigan, S. R. Durham, and A. B. Kay. 1992. Predominant TH2-like bronchoalveolar lavage T-lymphocyle population in atopic asthma. N. Engl. J. Med. 326:298.
3. Brusselle, G., J. Kips, G. Joos, H. Bluethmann, and R. Pauwels. 1995. Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice. Am. J. Respir. Cell Mol. Biol. 12:254.
4. Corry, D. B., H. G. Folkesson, M. L. Warnock, D. J. Erle, M. A. Matthay, J. P. Wiener-Kronish, and R. M. Locksley. 1996. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J. Exp. Med. 183:109.
5. Cohn, L., J. S. Tepper, and K. Bottomly. 1998. Cutting edge: IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells. J. Immunol. 161:3813.
6. Hogan, S. P., A. Mould, H. Kikutani, A. J. Ramsay, and P. S. Foster. 1997. Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins. J. Clin. Invest. 99:1329.
7. Hogan, S. P., K. I. Matthaei, J. M. Young, A. Koskinen, I. G. Young, and P. S. Foster. 1998. A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5. J. Immunol. 161:1501.
8. Webb, D. C., A. N. J. McKenzie, A. M. L. Koskinen, M. Yang, J. Mattes, and P. S. Foster. 2000. Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity. J. Immunol. 165:108.
9. Grünig, G., M. Warnock, A. E. Wakil, R. Venkayya, F. Brombacher, D. M. Rennick, D. Sheppard, M. Mohrs, D. D. Donaldson, R. M. Locklsley, and D. B. Corry. 1998. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282:2261.
10. Wills-Karp, M., J. Luyimbazi, X. Xu, B. Schofield, T. Y. Neben, C. L. Karp, and D. D. Donaldson. 1998. Interleukin-13: central mediator of allergie asthma. Science 282:2258.
11. Mohrs, M., D. A. Lacy, and R. M. Locksley. 2003. Stat signals release activated naive Th cells from an anergic checkpoint. J. Immunol. 170:1870.
12. Nelms, K., A. D. Keegan, J. Zamorano, J. J. Ryan, and W. E. Paul. 1999. The IL-4 receptor: signaling mechanisms and biologic functions. Annu. Rev. Immunol. 17:701.
13. Finkelman, F. D., I. M. Katona, J. F. Urban, Jr., J. Holmes, J. Ohara, A. S. Tung, J. V. Sample, and W. E. Paul. 1988. IL-4 is required to generate and sustain in vivo IgE responses. J. Immunol. 141:2335.
14. De Vries, J. 1998. The role of IL-13 and its receptor in allergy and inflammatory responses. J. Allergy Clin. Immunol. 102:165.
15. Graber, P., D. Gretener, S. Herren, J.-P. Aubry, G. Elson, J. Poudrier, S. Lecoanet-Henchoz, S. Alouani, C. Losberger, J.-Y. Bonnefoy, et al. 1998. The distribution of IL-13 receptor α1 expression on B cells, T cells and monocytes and its regulation by IL-13 and IL-4. Eur. J. Immunol. 28:4286.
16. Obiri, N. I., P. Leland, T. Murata, W. Debinski, and R. K. Puri. 1997. The IL-13 receptor structure differs on various cell types and may share more than one component with IL-4 receptor. J. Immunol. 158:756.
17. + TH0, Th1 and Th2 T cell clones and EBV-transformed B cells. Int. Immunol. 7:1405.
18. To, Y., M. Dohi, R. Tanaka, A. Sato, K. Nakagome, and K. Yamamoto. 2001. Early interleukin 4-dependent response can induce airway hyperreactivity before development of airway inflammation in a mouse model of asthma. Lab. Invest. 81:1385.
19. Taube, C., C. Duez, Z.-H. Cui, K. Takeda, Y.-H. Rha, J.-W. Park, A. Balhorn, D. D. Donaldson, A. Dakhama, and E. W. Gelfand. 2002. The role of IL-13 in established allergic airway disease. J. Immunol. 169:6482.
20. Zhu, Z., R. J. Homer, Z. Wang, Q. Chen, G. P. Geba, J. Wang, Y. Zhang, and J. A. Elias. 1999. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J. Clin. Invest. 103:779.
21. Lee, C. G., R. J. Homer, Z. Zhu, S. Lanone, X. Wang, V. Koteliansky, J. M. Shipley, P. Gotwals, P. Noble, Q. Chen, et al. 2001. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor β1. J. Exp. Med. 194:809.
22. Webb, D. C., A. N. J. McKenzie, and P. S. Foster. 2001. Expression of the Ym2 lectin binding protein is dependent on IL-4 and IL-13 signal transduction: identification of a novel allergy-associated protein. J. Biol. Chem. 276:41969.
23. Walter, D. M., J. J. McIntire, G. Berry, A. N. J. McKenzie, D. D. Donaldson, R. H. DeKruyff, and D. T. Umetsu. 2001. Critical role for IL-13 in the development of allergen-induced airway hyperreactivity. J. Immunol. 167:4668.
24. McKenzie, G. J., C. L. Emson, S. E. Bell, S. Anderson, P. Fallon, G. Zurawski, R. Murray, R. Grencis, and A. N. J. McKenzie. 1998. Impaired development of Th2 cells in IL-13-deficient mice. Immunity 9:423.
25. Foster, P. S., S. P. Hogan, A. J. Ramsay, K. I. Matthaei, and I. G. Young. 1996. Interleukin-5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J. Exp. Med. 183:195.
26. Hamelmann, E., J. Schwarze, K. Takeda, A. Oshiba, G. L. Larsen, C. G. Irvin, and E. W. Gelfand. 1997. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am. J. Respir. Crit. Care Med. 156:766.
27. Yang, M., S. P. Hogan, P. J. Henry, K. I. Matthaei, A. N. J. McKenzie, I. G. Young, M. E. Rothenberg, and P. S. Foster. 2001. Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-α chain and STAT-6 independently of IL-5 and eotaxin. Am. J. Respir. Cell Mol. Biol. 25:522.
28. Schulte, T., R. Kurrle, M. Röllinghoff, and A. Gessner. 1997. Molecular characterization and functional analysis of murine interleukin 4 receptor allotypes. J. Exp. Med. 9:1419.
29. Shackelton, L. M., D. M. Mann, and A. J. T. Millis. 1995. Identification of a 38-kDa heparin-binding glycoprotein (gp38k) in differentiating vascular smooth muscle cells as a member of a group of proteins associated with tissue remodeling. J. Biol. Chem. 270:13076.
30. Rejman, J. J., and W. L. Hurley. 1988. Isolation and characterization of a novel 39 kilodalton whey protein from bovine mammary secretions collected during the nonlactating period. Biochem. Biophys. Res. Commun. 150:329.
31. Openakker, G., P. M. Rudd, C. P. Ponting, and R. A. Dwek. 1993. Concepts and principles of glycobiology. FASEB J. 7:1330.
32. Kumar, R. K., C. Herbert, M. Yang, A. M. L. Koskinen, A. N. J. McKenzie, and P. S. Foster. 2002. Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma. Clin. Exp. Allergy 32:1104.
33. Schleimer, R. P., S. A. Sterbinsky, J. Kaiser, C. A. Bickel, D. A. Klunk, K. Tomioka, W. Newman, F. W. Luscinskas, M. A. Gimbrone Jr., B. W. McIntyre, and B. S. Bochner. 1992. IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. J. Immunol. 148:1086.
34. Rankin, J. A., D. E. Picarella, G. P. Geba, U.-A. Temann, B. Prasad, B. DiCosmo, A. Tarallo, B. Stripp, J. Whitsett, and R. A. Flavell. 1996. Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity. Proc. Natl. Acad. Sci. USA 93:7821.
35. Henderson, W. R. J., E. Y. Chi, and C. R. Maliszewski. 2000. Soluble IL-4 receptor inhibits airway inflammation following allergen challenge in a mouse model of asthma. J. Immunol. 164:1086.
36. Emson, C. L., S. E. Bell, A. Jones, W. Wisden, and A. N. J. McKenzie. 1998. Interleukin (IL)-4-independent induction of immunoglobulin (Ig)E, and perturbation of T cell development in transgenic mice expressing IL-13. J. Exp. Med. 188:399.
37. Grunewald, S. M., M. Teufel, K. Erb, A. Nelde, M. Mohrs, F. Brombacher, E. B. Bröcker, W. Sebald, and A. Duschl. 2001. Upon prolonged allergen exposure IL-4 and IL-4Rα knockout mice produce specific IgE leading to anaphylaxis. Int. Arch. Allergy Immunol. 125:322.
38. Coyle, A. J., G. Le Gros, C. Bertrand, S. Tsuyuki, C. H. Heusser, M. Kopf, and G. P. Anderson. 1995. Interleukin-4 is required for the induction of lung Th2 mucosal immunity. Am. J. Respir. Cell Mol. Biol. 13:54.
39. Wierenga, E. A., and G. Messer. 2000. Regulation of intereleukin 4 gene transcription: alterations in atopic disease? Am. J. Respir. Crit. Care Med. 162:S81.
40. Takemoto, N., Y. Kamogawa, H. J. Lee, H. Kurata, K. Arai, A. O'Garra, N. Arai, and S. Miyatake. 2000. Cutting edge: chromatin remodeling at the IL-4/IL-13 intergenic regulatory region for Th2-specific cytokine gene cluster. J. Immunol. 165:6687.
41. Zhang, D.-H., L. Yang, and A. Ray. 1998. Cutting edge: differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3. J. Immunol. 161:3817.
42. Ferber, I. A., H.-J. Lee, F. Zonin, V. Heath, A. Mui, N. Arai, and A. O'Garra. 1999. GATA-3 significantly down-regulates IFN-γ production from developing Th1 cells in addition to inducing IL-4 and IL-5. Clin. Imnunol. 91:134.
43. Khurana Hershey, G. K. 2003. IL-13 receptors and signaling pathways: an evolving web. J. Allergy Clin. Immunol. 111:677.
44. Whitehead, G. S., J. K. L. Walker, K. G. Berman, W. M. Foster, and D. A. Schwartz. 2003. Allergen-induced airway disease is mouse strain dependent. Am. J. Physiol. Lung Cell. Mol. Physiol. 285:L32.
45. Takeda, K., A. Haczku, J. J. Lee, C. G. Irvin, and E. W. Gelfand. 2001. Strain dependence of airway hyperresponsiveness reflects differences in eosinophil localization in the lung. Am. J. Physiol. Lung Cell. Mol. Physiol. 281:L394.
46. Hershey, G. K. K., M. F. Friedrich, L. A. Esswein, M. L. Thomas, and T. A. Chatila. 1997. The association of atopy with a gain-of-function mutation in the α subunit of the interleukin-4 receptor. N. Engl. J. Med. 337:1720.
47. Mitsuyasu, H., K. Izuhara, X. Q. Mao, P. S. Gao, Y. Arinobu, T. Enomoto, M. Kawai, S. Sasaki, Y. Dake, N. Hamasaki, et al. 1998. Ile50Val variant of IL4Rα up-regulates IgE synthesis and associates with atopic asthma. Nat. Genet. 19:119.
48. Ober, C., S. A. Leavitt, A. Tsalenko, T. D. Howard, D. M. Hoki, R. Daniel, D. L. Newman, X. Wu, R. Parry, L. A. Lester, et al. 2000. Variation in the interleukin-4 receptor α gene confers susceptibility to 0asthma and atopy in ethnically diverse populations. Am. J. Hum. Genet. 66:517.
49. Wjst, M., S. Kruse, T. Illlg, and K. Deichmann. 2002. Asthma and IL-4 receptor α gene variants. Eur. J. Immunogen. 29:263.
50. Mitsuyasu, H., Y. Yanagihara, X.-Q. Mao, P.-S. Gao, Y. Arinobu, K. Ihara, A. Takabayashi, T. Hara, T. Enomoto, S. Sasaki, et al. 1999. Cutting edge: dominant effect of Ile50Val variant of the human IL-4 receptor α chain in IgE synthesis. J. Immunol. 162:1227.
51. Hage, T., W. Sebald, and P. Reinemer. 1999. Crystal structure of the interleukin-4 receptor α chain complex reveals a mosaic binding interface. Cell 97:271.
52. McIntyre, J. J., S. E. Umetsu, O. Akbari, M. Potter, V. K. Kuchroo, G. S. Barsh, G. J. Freeman, D. T. Umetsu, and R. H. deKruyff. 2001. Identification of Tapr (an airway hyperreactivity regulatory locus) and linked Tim gene family. Nat. Immun. 2:1109.