Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns

Journal of Immunology

Volumn 165, Issue 6, 2000, Pages 2982-2986

  Kelly, B L ^a   Locksley, R M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 13; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CHROMOSOME 11; GENE CLUSTER; GENE EXPRESSION; GENETIC POLYMORPHISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; TH2 CELL;

EID: 0034665338     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.6.2982     Document Type: Article

References (30)

1. Functional diversity of helper T lymphocytes
2. Cytokines induce the development of functionally heterogeneous T helper cell subsets
3. + T cells
4. Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region
5. Helper T cell differentiation is controlled by the cell cycle
6. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
7. + T lymphocytes
8. Reversibility of T helper 1 and 2 populations is lost after long-term stimulation
9. Regulation of IL-4 expression by activation of individual alleles
10. Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region
11. Mvfw, a dominant modifier of murine von Willebrand factor, results from altered lineage-specific expression of a glycosyltransferase
12. Monoallelic expression of the interleukin-2 locus
13. Mice with a fluorescent marker for interleukin 2 gene activation
14. Coexpression of granulocyte-macrophage colony-stimulating factor, γ interferon, and interleukins 3 and 4 is random in murine alloreactive T-lymphocyte clones
15. Heterogeneity of single cell cytokine gene expression in clonal T cell populations
16. Flow cytometric determination of cytokines in activated murine T helper lymphocytes: Expression of interleukin-10 in interferon-γ and in interleukin-4-expressing cells
17. Dissociated expression of granulocyte-macrophage CSF and IL-3 in short term T cell clones from normal mice
18. + T cell phenotype development
19. + T cells activated in a T helper type 2-like response in vivo
20. + T cell can give rise to progeny expressing type 1 or type 2 cytokine genes and can retain its multipotentiality through many cell divisions
21. + T cell populations
22. Identification of a coordinate regulator of interleukins 4, 13 and 5 by cross-species sequence comparisons
23. Cytokine receptors and signal transduction
24. Transcriptional regulation of mouse granulocyte-macrophage colony stimulating factor/IL-3 locus
25. A T cell-specific enhancer in the interleukin-3 locus is activated cooperatively by Oct and NFAT elements within a DNase I-hypersensitivity site
26. Linkage mapping of the human CSF2 and IL3 genes
27. The human granulocyte-macrophage colony-stimulating factor gene is autonomously regulated in vivo by an inducible tissue-specific enhancer
28. Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation
29. A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation
30. Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators