Myf-5m1/Myf-6m1 compound heterozygous mouse mutants down-regulate Myf-5 expression and exert rib defects: Evidence for long-range cis effects on Myf-5 transcription

Developmental Biology

Volumn 174, Issue 1, 1996, Pages 140-147

  Floß, Thomas ^a   Arnold, Hans Henning ^a   Braun, Thomas ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HETEROZYGOSITY; MOUSE; MUTANT; NEWBORN; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; SKELETON; STAINING; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; GENETICS; HETEROZYGOTE; MOUSE MUTANT; PHYSIOLOGY; PRENATAL DEVELOPMENT; RIB;

ANIMALIA;

DNA BINDING PROTEIN; MESSENGER RNA; MUSCLE PROTEIN; MYF5 PROTEIN, MOUSE; MYOGENIC FACTOR; MYOGENIC FACTOR 5; MYOGENIC FACTOR 6; TRANSACTIVATOR PROTEIN;

ANIMALS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HETEROZYGOTE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MUSCLE PROTEINS; MYOGENIC REGULATORY FACTOR 5; MYOGENIC REGULATORY FACTORS; RIBS; RNA, MESSENGER; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 0029664986     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.1996.0058     Document Type: Article

References (14)

1. Arnold, H.-H., and Braun, T. (1993). Myogenic control genes in vertebrates. In "Advances in Developmental Biology" (P. M. Wassarman, Ed.), pp. 111-158 JAI Press, Greenwich.
2. Atchley, W. R., Fitch, W. M., and Bronner-Fraser, M. (1994). Molecular evolution of the MyoD family of transcription factors. Proc. Natl. Acad. Sci. USA 91, 11522-11526.
3. Bober, E., Lyons, G. E., Braun, T., Cossu, G., Buckingham, M., and Arnold, H. H. (1991). The muscle regulatory gene, Myf-6, has a biphasic pattern of expression during early mouse development. J. Cell Biol. 113, 1255-1265.
4. Brau̇n, T., Bober, E., Buschhausen, D. G., Kohtz, S., Grzeschik, K. H., and Arnold, H. H. (1989). Differential expression of myogenic determination genes in muscle cells: Possible autoactivation by the Myf gene products. EMBO J. 8, 3617-3625.
5. Braun, T., Bober, E., Winter, B., Rosenthal, N., and Arnold, H.-H. (1990). Myf-6, a new member of the human gene family of myogenic determination factors: Evidence for a gene cluster on chromosome 12. EMBO J. 9, 821-831.
6. Braun, T., Rudnicki, M. A., Arnold, H.-H., and Jaenisch, R. (1992). Targeted inactivation of the muscle regulatory gene myf-5 results in abnormal rib development and perinatal death. Cell 71, 369-382.
7. Braun, T., and Arnold, H.-H. (1994). ES-cells carrying two inactivated Myf-5 alleles form skeletal muscle cells: Activation of an alternative Myf-5-independent differentiation pathway. Dev. Biol. 164, 24-36.
8. Braun, T., Bober, E., Rudnicki, M. A., Jaenisch, R., and Arnold, H. H. (1994). MyoD expression marks the onset of skeletal myogenesis in Myf-5 mutant mice. Development 120, 3083-3092.
9. Braun, T., and Arnold, H.-H. (1995). Inactivation of Myf-6 and Myf-5 genes in mice leads to alterations in skeletal muscle development. EMBO J. 14, 1176-1186.
10. Breindl, M., Harbers, K., and Jaenisch, R. (1984). Retrovirus-induced lethal mutation in collagen I gene of mice is associated with an altered chromatin structure. Cell 38, 9-16.
11. Cheng, T. C., Wallace, M. C., Merlie, J. P., and Olson, E. N. (1993). Separable regulatory elements governing myogenin transcription in mouse embryogenesis. Science 261, 215-218.
12. Fiering, S., Kim, C. G., Epner, E. M., and Groudine, M. (1993). An "in-out" strategy using gene targeting and FLP recombinase for the functional dissection of complex DNA regulatory elements: Analysis of the β-globin locus control region. Proc. Natl. Acad. Sci. USA 90, 8469-8473.
13. Goldhammer, D. J., Brunk, B. P., Faerman, A., King, A., Shani, M., and Emerson, C. P., Jr. (1995). Embryonic activation of the myoD gene is regulated by a highly conserved distal control element. Development 121, 637-649.
14. Hanscombe, O., Whyatt, D., Fraser, P., Yannoutsos, N., Greaves, D., Dillon, N., and Grosveld, F. (1991). Importance of globin gene order for correct developmental expression. Genes Dev. 5, 1387-1394.