Chronic fluoxetine administration inhibits extracellular signal-regulated kinase 1/2 phosphorylation in rat brain

Journal of Neurochemistry

Volumn 93, Issue 6, 2005, Pages 1551-1560

  Fumagalli, F ^a   Molteni, R ^a   Calabrese, F ^a,b   Frasca, A ^a   Racagni, G ^a,b   Riva, M A ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b IRCCS ISTITUTO CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI   (Italy)

Author keywords

Antidepressants; Frontal cortex; Hippocampus; Mitogen activated protein kinase; Mood disorders

Indexed keywords

ANTIDEPRESSANT AGENT; DITHIOTHREITOL; EGTAZIC ACID; FLUOXETINE; IMIPRAMINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN SYNAPTOSOME; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; DEPRESSION; DRUG MECHANISM; ENZYME PHOSPHORYLATION; FRONTAL CORTEX; HIPPOCAMPUS; MALE; MOOD DISORDER; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BRAIN; CELL NUCLEUS; CYTOPLASM; FLUOXETINE; FRONTAL LOBE; HIPPOCAMPUS; IMIPRAMINE; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN UPTAKE INHIBITORS;

EID: 20744432159     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03149.x     Document Type: Article

References (33)

1. Brunet A., Roux D., Lenormand P., Dowd S., Keyse S. and Pouyssegur J. (1999) Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. EMBO J. 18, 664-674.
2. Cavanaugh J. E., Ham J., Hetman M., Poser S., Yan C. and Xia Z. (2001) Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons. J. Neurosci. 21, 434-443.
3. Charney D. S. and Manji H. K. (2004) Life stress, genes, and depression: multiple pathways lead to increased risk and new opportunities for intervention. Sci. STKE 2004 (225): 225. Review.
4. Colucci-D'Amato L., Perrone-Capano C. and di Porzio U. (2003) Chronic activation of ERK and neurodegenerative diseases. Bioessays 5, 1085-1095.
5. Crispino M., Kaplan B. B., Martin R., Alvarez J., Chun J. T., Benech J. C. and Giuditta A. (1997) Active polysomes are present in the large synaptic endings of the synaptosomal fraction from squid brain. J. Neurosci. 17, 7694-7702.
6. Dias B. G., Banerjee S. B., Duman R. S. and Vaidya V. A. (2003) Differential regulation of brain derived neurotrophic factor transcripts by antidepressant treatments in the adult rat brain. Neuropharmacology 45, 553-563.
7. Duman R. S. (2002) Pathophysiology of depression: the concept of synaptic plasticity. Eur. Psychiat. 17, 306-310.
8. Einat H., Yuan P., Gould T. D., Li J., Du J., Zhang L., Manji H. K. and Chen G. (2003) The role of the extracellular signal-regulated kinase signaling pathway in mood modulation. J. Neurosci. 23, 7311-7316.
9. English J. D. and Sweatt J. D. (1996) Activation of p42 mitogen-activated protein kinase in hippocampal long term potentiation. J. Biol. Chem. 271, 24 329-24 332.
10. de Foubert G., Carney S. L., Robinson C. S. et al. (2004) Fluoxetine-induced change in rat brain expression of Brain Derived Neurotrophic Factor varies depending on length of treatment. Neuroscience 128, 597-604.
11. Galetic I., Maira S. M., Andjelkovic M. and Hemmings B. A. (2003) Negative regulation of ERK and Elk by protein kinase B modulates C-Fos transcription. J. Biol. Chem. 278, 4416-4423.
12. Gould T. D., Quiroz J. A., Singh J., Zarate C. A. and Manji H. K. (2004) Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers. Mol. Psychiat. 9, 734-755.
13. Hendrick J. P., Galdi S., Kukol J., Gold S. J. and Snyder G. L. (2004) Electroconvulsive seizures (ECS) modulate phosphoprotein substrates differentially in mouse striatum and cortex. Soc. Neurosci. 30, 356.6.
14. Hochholdinger F., Baier G., Nogalo A., Bauer B., Grunicke H. H. and Uberall F. (1999) Novel membrane-targeted ERK1 and ERK2 chimeras which act as dominant negative, isotype-specific mitogen-activated protein kinase inhibitors of Ras-Raf-mediated transcriptional activation of C-fos in NIH 3T3 cells. Mol. Cell Biol. 19, 8052-8065.
15. Huang E. J. and Reichardt L. F. (2003) Trk receptors: roles in neuronal signal transduction. Annu. Rev. Biochem. 72, 609-642.
16. Kaplan D. R. and Miller F. D. (2000) Neurotrophin signal transduction in the nervous system. Curr. Opin. Neurobiol. 10, 381-391.
17. Keyse S. M. (1995) An emerging family of dual specificity MAP kinase phosphatases. Biochim. Biophys. Acta 1265, 152-160.
18. Kodama M., Russell D. S. and Duman R. S. (2005) Electroconvulsive seizures increase the expression of MAP kinase phosphatases in limbic regions of rat brain. Neuropsychopharmacology 30, 360-371.
19. Manier D. H., Shelton R. C. and Sulser F. (2002) Noradrenergic antidepressants: does chronic treatment increase or decrease nuclear CREB-P? J. Neural Transm. 109, 91-99.
20. Maragnoli M. E., Fumagalli F., Gennarelli M., Racagni G. and Riva M. A. (2004) Fluoxetine and olanzapine have synergistic effects in the modulation of fibroblast growth factor 2 expression within the rat brain. Biol. Psychiat. 55, 1095-1102.
21. Nibuya M., Morinobu S. and Duman R. S. (1995) Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J. Neurosci. 15, 7539-7547.
22. Nibuya M., Nestler E. J. and Duman R. S. (1996) Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J. Neurosci. 16, 2365-2372.
23. Pearson G., Robinson F., Beers Gibson T., Xu B. E., Karandikar M., Berman K. and Cobb M. H. (2001) Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 22, 153-183.
24. Runden E., Seglen P. O., Haug F. M., Ottersen O. P., Wieloch T., Shamloo M. and Laake J. H. (1998) Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism. J. Neurosci. 18, 7296-7305.
25. Saarelainen T., Hendolin P., Lucas G. et al. (2003) Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects. J. Neurosci. 23, 349-357.
26. Saba-El-Leil M. K., Vella F. D., Vernay B., Voisin L., Chen L., Labrecque N., Ang S. L. and Meloche S. (2003) An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. EMBO Rep. 4, 964-968.
27. Schaeffer H. J. and Weber M. J. (1999) Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol. Cell Biol. 19, 2435-2444.
28. Sweatt J. D. (2001) The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory. J. Neurochem. 76, 1-10.
29. Thiriet N., Humblot N., Burgun C., Aunis D. and Zwiller J. (1998) Cocaine and fluoxetine induce the expression of the hVH-5 gene encoding a MAP kinase phosphatase. Mol. Brain Res. 62, 150-157.
30. Thome J., Sakai N., Shin K., Steffen C., Zhang Y. J., Impey S., Storm D. and Duman R. S. (2000) cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment. J. Neurosci. 20, 4030-4036.
31. Trentani A., Kuipers S. D., Ter Horst G. J. and Den Boer J. A. (2002) Selective chronic stress-induced in vivo ERK 1/2 hyperphosphorylation in medial prefrontocortical dendrites: implications for stress-related cortical pathology? Eur. J. Neurosci. 15, 1681-1691.
32. Xing J., Ginty D. D. and Greenberg M. E. (1996) Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science 273, 959-963.
33. Ying S. W., Futter M., Rosenblum K., Webber M. J., Hunt S. P., Bliss T. V. and Bramham C. R. (2002) Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. J. Neurosci. 22, 1532-1540.