Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel β2-subunits

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 26, 2002, Pages 17072-17077

  Chen, Chunling ^a   Bharucha, Vandana ^a,f   Chen, Yuan ^c   Westenbroek, Ruth E ^c   Brown, Angus ^d,g   Malhotra, Jyoti Dhar ^a   Jones, Dorothy ^a   Avery, Christy ^a   Gillespie III, Patrick J ^b   Kazen Gillespie, Kristin A ^a   Kazarinova Noyes, Katie ^e   Shrager, Peter ^e   Saunders, Thomas L ^b   Macdonald, Robert L ^a,h   Ransom, Bruce R ^d   Scheuer, Todd ^c   Catterall, William A ^c   Isom, Lori L ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

^e UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^f KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

^g UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^h VANDERBILT UNIVERSITY   (United States)

Author keywords

Action potential conduction; Auxiliary subunits; Epilepsy; Gene targeting

Indexed keywords

PILOCARPINE; SAXITOXIN; SODIUM CHANNEL; SODIUM ION;

ACTION POTENTIAL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CHANNEL GATING; CONTROLLED STUDY; DENSITY; EXCITABILITY; HIPPOCAMPUS; IN VIVO STUDY; MEASUREMENT; MOUSE; NERVE CELL; NEUROLOGIC EXAMINATION; NONHUMAN; OPTIC NERVE; PRIORITY JOURNAL; SEIZURE; SODIUM CURRENT;

ACTION POTENTIALS; ANIMALS; DISEASE SUSCEPTIBILITY; MICE; MICE, KNOCKOUT; NERVE FIBERS; NEURAL CONDUCTION; PILOCARPINE; PROTEIN SUBUNITS; SEIZURES; SODIUM; SODIUM CHANNELS;

ANIMALIA;

EID: 0037168659     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.212638099     Document Type: Article

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