Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-Binding domain during oxidative stress

Biochemistry

Volumn 46, Issue 26, 2007, Pages 7765-7780

  Velu, Chinavenmeni S ^a   Niture, Suryakant K ^a   Doneanu, Catalin E ^b   Pattabiraman, Nagarajan ^c   Srivenugopal, Kalkunte S ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c GEORGETOWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING SITES; DNA; OXIDATIVE STRESS; TUMORS;

CYSTEINES; GLUTATHIONYLATION; HUMAN P53; NITROSATIVE STRESSES;

ENZYME INHIBITION;

CAMPTOTHECIN; CISPLATIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYSTEINE; DIMER; DNA; GLUTATHIONE; PROTEIN P53; RECOMBINANT PROTEIN; THIOL; TRANSCRIPTION FACTOR;

ARTICLE; BINDING SITE; BIOTINYLATION; CARCINOGENESIS; CHEMICAL REACTION; CONJUGATION; DIMERIZATION; DNA BINDING MOTIF; DNA DAMAGE; DNA SEQUENCE; ENZYME ASSAY; GENE INACTIVATION; GLUTATHIONYLATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INHIBITION KINETICS; MASS SPECTROMETER; MOLECULAR MODEL; NITROSATIVE STRESS; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; TUMOR CELL; TUMOR SUPPRESSOR GENE;

ACETYLCYSTEINE; AMINO ACID SEQUENCE; BINDING SITES; BUTHIONINE SULFOXIMINE; CAMPTOTHECIN; CELL LINE, TUMOR; CROSS-LINKING REAGENTS; CYSTEINE; DIAMIDE; DNA DAMAGE; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; GLUTARAL; GLUTATHIONE; GLUTATHIONE DISULFIDE; HUMANS; HYDROGEN PEROXIDE; MODELS, MOLECULAR; OXIDATIVE STRESS; PHOSPHORYLATION; RECOMBINANT PROTEINS; TANDEM MASS SPECTROMETRY; TERT-BUTYLHYDROPEROXIDE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34347329257     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700425y     Document Type: Article

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