Comparison of the protein-protein interfaces in the p53-DNA crystal structures: Towards elucidation of the biological interface

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 11, 2005, Pages 3988-3993

  Ma, Buyong ^a   Pan, Yongping ^a   Gunasekaran, K ^a   Venkataraghavan, R Babu ^b   Levine, Arnold J ^b   Nussinov, Ruth ^a,c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b INSTITUTE FOR ADVANCED STUDY   (United States)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

Cancer; Gene regulation; Hot spots; p53 dimeric interface; p53 tetramer

Indexed keywords

DEOXYRIBONUCLEOPROTEIN; DIMER; PROTEIN P53; TETRAMER;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DNA BINDING; DNA BINDING MOTIF; DNA SEQUENCE; DNA STRUCTURE; GENE CONTROL; HUMAN; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SEQUENCE ANALYSIS; SIMULATION;

AMINO ACID MOTIFS; COMPUTER SIMULATION; CRYSTALLOGRAPHY; DIMERIZATION; DNA; PROTEIN STRUCTURE, TERTIARY; SOFTWARE; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 15244344824     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0500215102     Document Type: Article

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