Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277

Nucleic Acids Research

Volumn 30, Issue 11, 2002, Pages 2340-2348

  Buzek, Jiri ^a,c   Latonen, Leena ^a   Kurki, Sari ^a   Peltonen, Karita ^a   Laiho, Marikki ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c INSTITUTE OF MATHEMATICS   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; CYTOSINE; DNA; PROTEIN P21; PROTEIN P53; RIBONUCLEOTIDE REDUCTASE;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; CONTROLLED STUDY; DIPLOIDY; DNA BINDING; DNA DAMAGE; DNA REPAIR; DNA RESPONSIVE ELEMENT; FIBROBLAST; GENE CONTROL; GENE INDUCTION; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN CELL; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INDUCTION; SITE DIRECTED MUTAGENESIS; TUMOR SUPPRESSOR GENE;

EID: 0036606407     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/30.11.2340     Document Type: Article

References (46)

1. Surfing the p53 network
2. p53 protein exhibits 3′-to-5′ exonuclease activity
3. WAF1, a potential mediator of p53 tumor suppression
4. 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression
5. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
6. A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
7. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
8. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
9. p53AIP1, a potential mediator of p53-dependent apoptosis and its regulation by Ser-46-phosphorylated p53
10. A model for p53-induced apoptosis
11. Definition of a consensus binding site for p53
12. p53 stimulates TFIID-TFIIA-promoter complex assembly and p53-T antigen complex inhibits TATA binding protein-TATA interaction
13. Tumor suppressor p53 can participate in transcriptional induction of the GADD45 promoter in the absence of direct DNA binding
14. Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21 (WAF1/Cip1) gene by the p53 tumor suppressor protein
15. Crystal structure of a p53 tumor suppressor DNA complex-understanding tumorigenic mutations
16. The p53 protein is an unusually shaped tetramer that binds directly to DNA
17. Architectural accommodation in the complex of four p53 DNA binding domain peptides with the p21/waf1/cip1 DNA response element
18. Latent and active p53 are identical in conformation
19. Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment
20. Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo
21. DNA-conformation is an important determinant of sequence-specific DNA binding by tumor suppressor p53
22. Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA
23. Redox modulation of p53 conformation and sequence-specific DNA binding in vitro
24. Role of cysteine residues in regulation of p53 function
25. Mutation of conserved domain II alters the sequence specificity of DNA binding by the p53 protein
26. p53 transactivation and protein accumulation are independently regulated by UV light in different phases of the cell cycle
27. Differential activation of p53 targets in cells treated with ultraviolet radiation that undergo both apoptosis and growth arrest
28. UV-radiation induced dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts
29. Increased salt concentration reversibly destabilizes p53 quarternary structure
30. One mechanism for cell type-specific regulation of the bax promoter by the tumor suppressor p53 is dictated by the p53 response element
31. The tumor suppressor protein p53 requires a cofactor to activate transcriptionally the human BAX promoter
32. Redox signalling and transition metals in the control of the p53 pathway
33. Mutations at position 277 modify the DNA-binding specificity of human p53 in vitro
34. IARC database of p53 gene mutations in human tumors and cell lines: Updated compilation, revised formats and new visualisation tools
35. In vivo evidence for binding of p53 to consensus binding sites in the p21 and GADD45 genes in response to ionizing radiation
36. Kinetics of p53 binding to promoter sites in vivo
37. Discrimination of DNA binding sites by mutant p53 proteins
38. Increased apoptosis induction by 121F mutant p53
39. Drosophila p53 binds a damage response element at the reaper locus
40. Redox state regulates binding of p53 to sequence-specific DNA, but not to non-specific or mismatched DNA
41. Effect of p53 protein redox states on binding to supercoiled and linear DNA
42. Thioredoxin-dependent redox regulation of p53-mediated p21 activation
43. A mutation in a thioredoxin reductase homolog suppresses p53-induced growth inhibition in the fission yeast Schizosaccharomyces pombe
44. Regulation of p53 by metal ions and by antioxidants: Dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper
45. Pyrrolidine dithiocarbamate prevents p53 activation and promotes p53 cysteine residue oxidation
46. p53 protein oxidation in cultured cells in response to pyrrolidine dithiocarbamate: A novel method for relating the amount of p53 oxidation in vivo to the regulation of p53-responsive genes