Polybrominated diphenyl ethers (PBDEs) in U.S. mothers' milk

Environmental Health Perspectives

Volumn 111, Issue 14, 2003, Pages 1723-1729

  Schecter, Arnold ^a   Pavuk, Marian ^a   Päpke, Olaf ^b   Ryan, John Jake ^c   Birnbaum, Linda ^d   Rosen, Robin ^e  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b ERGO Research   (Germany)

^c HEALTH CANADA   (Canada)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Brominated diphenyl ethers; Brominated flame retardants; Human milk; Nursing mothers

Indexed keywords

1,3 BUTADIENE; ACRYLONITRILE; DIBENZOFURAN DERIVATIVE; DIOXIN; ETHER DERIVATIVE; LIPID; ORGANOCHLORINE DERIVATIVE; POLYBROMINATED BIPHENYL; POLYCHLORINATED BIPHENYL DERIVATIVE; POLYSTYRENE; POLYURETHAN FOAM; RESIN; STYRENE;

ADIPOSE TISSUE; ADULT; ARTICLE; BIOACCUMULATION; BREAST FEEDING; BREAST MILK; COMPUTER; CONTROLLED STUDY; DATA ANALYSIS; ENVIRONMENTAL EXPOSURE; EQUIPMENT; EUROPE; FEMALE; FOOD ANALYSIS; HUMAN; LIPID BLOOD LEVEL; MEASUREMENT; MILK LEVEL; OUTPATIENT DEPARTMENT; PRINTING; PRIORITY JOURNAL; SAMPLING; SWEDEN; TELEVISION; UNITED STATES;

ANIMALIA;

EID: 0242456228     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.6466     Document Type: Article

References (88)

1. Asplund L, Hornung M, Peterson RE, Turesson K, Bergman A. 1999. Levels of polybrominated diphenyl ethers (PBDEs) in fish from the Great Lakes and Baltic Sea. Organohalogen Compounds 40:351-354.
2. ATSDR. 1994. Toxicological Profile for Chlorodibenzofurans. Atlanta, GA:Agency for Toxic Substances and Disease Registry.
3. ATSDR. 1998. Toxicological Profile for Chlorinated Dibenzo-p-dioxins. Atlanta, GA:Agency for Toxic Substances and Disease Registry.
4. ASTDR. 2000. Toxicological Profile for Polychlorinated Biphenyls (PCBs). Atlanta, GA:Agency for Toxic Substances and Disease Registry.
5. Aylward LL, Hays SM, LaKind JS, Ryan JJ. 2003. Rapid communication: partitioning of persistent lipophilic compounds, including dioxins, between human milk lipid and blood lipid: an initial assessment. J Toxicol Environ Health A 66:1-5.
6. Betts KS. 2002. Rapidly rising PBDE levels in North America. Environ Sci Technol 36:50-52A.
7. Branchi I, Alleva E, Costa LG. 2002. Effects of perinatal exposure to a polybrominated diphenyl ether (PBDE 99) on mouse nourobehavioural development. Neurotoxicology 23:375-384.
8. BSEF. 2001. Major Brominated Flame Retardants Volume Estimates. Total Market Demand by Region in 2001. Brussels: Bromine Science and Environmental Forum. Available: http://www.bsef-site.com/docs/BFR_vols_2001.doc [accessed 27 August 2003].
9. Darnerud PO, Atuma S, Aune M, Cnattingius S, Wernroth ML, Wicklund GA. 1998. Polybrominated diphenyl ethers (PBDEs) in breast milk from primparous women in Uppsala County, Sweden. Organohalogen Compounds 35:411-414.
10. Darnerud PO, Aune M, Atuma S, Becker W, Bjerselius R, Cnattingius S, et al. 2002. Time trend of polybrominated diphenyl ether (PBDE) levels in breast milk from Uppsala, Sweden, 1996-2001. Organohalogen Compounds 58:233-236.
11. Darnerud PO, Erikson GS, Johannesson T, Larsen PB, Viluksela M. 2001. Polybrominated diphonyl ethers: occurrence, dietary exposure, and toxicology. Environ Health Perspect 109(suppl 1):49-68.
12. Darnerud PO, Thuvander A. 1999. Effects of polybrominated diphenyl ether (PBDE) and polychlorinated biphenyl (PCB) on some immunological parameters after oral exposure in rats and mice. Toxicol Environ Chem 70:229-242.
13. de Wit CA. 2002. An overview of brominated flame retardants in the environment. Chemosphere 46:583-624.
14. Eriksson P, Jakobsson E, Fredriksson A. 1998. Developmental neurotoxicity of brominated flame-retardants, polybrominated diphenyl ethers and tetrabromo-bis-phenol A. Organohalogen Compounds 35:375-377.
15. Eriksson P, Jakobsson E, Fredriksson A. 2001. Brominated flame retardants: a novel class of developmental neurotoxicants in our environment. Environ Health Perspect 109:903-908.
16. Eriksson P, Viberg H, Jakobsson E, Örn U, Fredriksson A. 1999. PBDE, 2,2′,4,4′,5-pentabromodiphenyl ether, causes permanent neurotoxic effects during a defined period of neonatal brain development. Organohalogen Compounds 40:333-336.
17. Eriksson P, Viberg H, Jakobsson E, Örn U, Fredriksson A. 2002. A brominated flame retardant, 2,2′,4,4′,5-penta-bromodiphenl ether: uptake, retention, and induction of neurobehavioral alterations in mice during a critical phase of neonatal brain development. Toxicol Sci 67:98-103.
18. European Parliament. 2002. Directive of the European Parliament and of the Council Amending for the 24th Time Council Directive 76/769/EEC Relating to Restrictions on the Marketing and Use of Certain Dangerous Substances and Preparations (Pentabromodiphenyl Ether, Octabromodiphonyl Ether). PE-CONS 3664/2002 - C5-0500/2002 - 2001/0018(COD). Brussels:European Union. Available: http://www2.europarl.eu.int/omk/ sipade2?PUBREF=-//EP//NONSGML+DOC-C+C5-2002-0500+0+DOC+PDF+V0/ /EN&L=EN&LEVEL=2&NAV=S&LSTDOC=Y [accessed 27 August 2003].
19. Fowles A Fairbrother A, Baecher-Steppan L, Kerkvliet NI. 1994. Immunologic and endocrine effects of the flame-retardant pentabromodiphenyl ether (DE-71) in C57BL/6J mice. Toxicology 86:49-61.
20. Fürst P. 2001. Organochlorine pesticides, dioxins, PCBs and polybrominated biphenylethers in human milk from Germany in the course of time. Organohalogen Compounds 52:185-188.
21. Fürst P, Fürst C, Wilmers K. 1994. Human milk as a bioindicator for body burden of PCDDs, PCDFs, organochlorine pesticides, and PCBs. Environ Health Perspect 102(suppl 1):187-193.
22. Fürst P, Püpke O. 2002. PCDDs, PCDFs, and dioxin-like PCBs in human milk and blood from Germany. Organohalogen Compounds 55:251-254.
23. Gillner M, Jakobsson E. 1996. Structure-affinity relationships for thyroid and dioxin receptor binding of halogenated naphthalenes and diphenylethers. Organohalogen Compounds 29:220-221.
24. Hale RC, La Guardia MJ, Harvey E, Mainor TM. 2002. Potential role of fire retardant treated polyurethane foam as a source of brominated diphenyl ethers to the US environment. Chemosphere 46:729-735.
25. Hallgren S, Darnerud PO. 1998. Effects of polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and chlorinated paraffins (CPs) on thyroid horpnone levels and enzyme activities in rats. Organohalogen Compounds 35:391-394.
26. Hallgren S, Darnerud PO. 2002. Polybrominated diphenyl ethers (PBDEs), polychlorinated bilphenyls (PCBs) and chlorinated paraffins (CPs) in rats-testing interactions and mechanisms for thyroid hormone effects. Toxicology 177:227-243.
27. Hallgren S, Sinjari T, Hakansson H, Darnerud PO. 2001. Effects of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) on thyroid hormone and vitamin A levels in rats and mice. Arch Toxicol 75:200-208.
28. Hardy ML. 2002a. A comparison of the properties of the major commercial PBDPO/PBDE product to those of major PBB and PCB products. Chemosphere 46:717-728.
29. Hardy ML. 2002b. The toxicology of the three commercial polybrominated diphenyl oxide (ether) flame retardants. Chemosphere 46:757-777.
30. Howie L, Dickerson R, Davis D, Safe S. 1990. Immunosuppressive and monooxygenase induction activities of polychlorinated diphenyl ether congeners in C57BL/6N mice: quantitative structure-activity relationships. Toxicol Appl Pharmacol 105:254-263.
31. Huwe JK, Lorentzsen M, Thuresson K, Bergman A. 2000. Polybrominated diphenyl ethers in chickens. Organohalogen Compounds 47:429-432.
32. IARC. 1997. Polychlorinated Dibenzo-para-dioxins and Polychlorinated Dibenzofurans. Monogr Eval Carcinog Risk Hum 69.
33. Institute of Medicine. 1996. Veterans and Agent Orange: Update 1996. Washington, DC:National Academy Press.
34. Institute of Medicine. 1998. Veterans and Agent Orange: Update 1998. Washington, DC:National Academy Press.
35. Institute of Medicine. 2002. Veterans and Agent Orange: Update 2000. Washington, DC:National Academy Press.
36. Internationa Comparisons on Dioxins. 2001. Final Report 2001:4. Folkehelsa, Norway:National Institute of Public Health.
37. International Program on Chemical Safety (IPCS). 1994. Brominated Diphenyl Ethers. Environ Health Criteria 162. Geneva:World Health Organization.
38. Jacobs M, Covaci A, Schopens P. 2001. Investigation of polybrominated diphenyl ethers in Scottish and European farmed Atlantic salmon (Salmo salar), salmon aquaculture food and fish oils. Organohalogen Compounds 51:239-242.
39. Jakobsson K, Thuresson K, Rylander L, Sjodin A, Hagmar L, Bergman A. 2002. Exposure to polybrominated diphenyl ethers and tetrabromobisphenol A among computer technicians, Chemosphere 46:709-716.
40. Johnson A, Olson N. 2001. Analysis and occurrence of polybrominated diphenyl ethers in Washington State freshwater fish. Arch Environ Contam Toxicol 41:339-344.
41. Knoth W, Mann W, Meyer R, Nebhuth J. 2002. Polybrominated diphenylether in house dust. Organohalogen Compounds 58:213-216.
42. Leonards PEG, Santillo D, Brigden K, van der Veen I, Hesselingen JV, de Boer J, et al. 2001. Brominated flame retardants in office dust samples. In: Proceedings of the Second International Workshop on Brominated Flame Retardants, 14-16 May 2001, Stockholm, Sweden. Stockholm:Swedish Chemical Society, 299-302.
43. Lichtensteiger W, Ceccatelli R, Faass O, Fleischmann I, Schlumpf M. 2003. Effects of polybrominated diphenylethers (PBDE) on reproductive organ and brain development and gone expression in rats [Abstract]. Toxicologist 72:133-134.
44. Liem AKD, Albers JMC, Baumann RA, van Beuzekom AC, den Hartog RS, Hoogerbrugge R, et al. 1995. PCBs, PCDD/PCDFs and organochlorine pesticides in human milk in the Netherlands. Levels and trends. Organohalogen Compounds 26:69-74.
45. Lind Y, Aune M, Atuma S, Becker W, Bjerselius R, Glynn A, et al. 2002. Food intake of the brominated flame retardants PBDEs and HBCD in Sweden. Organohalogen Compounds 58:181-184.
46. Mazdai A, Dodder NG, Abernathy MP, Hites RA, Bigsby RM. 2003. Polybrominated diphenyl ethers in maternal and fetal blood samples. Environ Health Perspect 111:1249-1252; doi:10.1289/ehp.6146 [Online 10 March 2003].
47. McDonald TA. 2002. A perspective on the potential health risks of PBDEs. Chemosphere 46:745-755.
48. Meerts IA, Assink Y, Cenijn PH, Van Den Berg JH, Weijers BM, Bergman A, et al. 2002. Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat. Toxicol Sci 68:361-371.
49. Meerts IA, Letcher RJ, Hoving S, Marsh G, Bergman A, Lemmen JG, et al. 2001. In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PDBEs, and polybrominated bisphenol A compounds. Environ Health Perspect 109:399-407.
50. Meerts IATM, Luijks EAC, Marsh G, Jakobsson E, Bergman Å, Brouwer A. 1998. Polybrominated diphenylethers (PBDEs) as Ah-receptor agonists and antagonists. Organohalogen Compounds 37:147-150.
51. Meironyté Guvenius D, Aronsson A, Ekman-Ordeberg G, Bergman Å, Norén K. 2003. Human prenatal and postnatal exposure to polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorobiphenylols and pentachlorophenol. Environ Health Perspect 111:1235-1241; doi:10.1289/ehp.5946 [Online 21 January 2003].
52. Meironyté Guvenius D, Norén K, Bergman Ä. 1999. Analysis of polybrominated diphenyl ethers in Swedish human milk. A time-related trend study, 1972-1997. J Toxicol Environ Health A 58:329-341.
53. Morse DC, Groen D, Veerman M, van Amerongen CJ, Koeter HBWM, Smits van Proije, et al. 1993. Interference of polybrominated biphenyls in hepatic and brain thyroid hormone metabolism in fetal and neonatal rats. Toxicol Appl Pharmacol 122:27-33.
54. Noren K, Meironyte D. 1998. Contaminants in Swedish human milk. Decreasing levels of organochlorine and increasing levels of organobromine compounds. Organohalogen Compounds 38:1-4.
55. Noren K, Meironyte D. 2000. Certain organochlorine and organobromine contaminants in Swedish human milk in perspective of past 20-30 years. Chemosphere 40:1111-1123.
56. 1 Mice (Feed Studies). Technical Report 309. Research Triangle Park, NC:National Toxicology Program.
57. Ohta S, Ishizuka D, Nishimura H, Nakao T, Aozasa O, Shimidzu Y, et al. 2002. Comparison of polybrominated diphenyl ethers in fish, vegetables and meats and levels in human milk of nursing mothers in Japan. Chemosphere 46:680-696.
58. Olsman H, Bavel B, Kalbin G, Pettersonn A, Seetnlund S, Strid A. 2002. Formation of dioxin-like compounds as photoproducts of decabrominated diphenyl ether (DEBDE) during UV-irradiation. Organohalogen Compounds 58: 41-44.
59. Päpke O. 1998. PCDD/PCDF: human background data for Germany, a 10-year experience. Environ Health Perspect 106(suppl 2):723-731.
60. Päpke O, Bathe L, Bergman A, Fürst P, Meironyte-Guvenius D, Herrmann T, et al. 2001. Determination of PBDEs in human milk from the United States - comparison of results from three laboratories. Organohalogen Compounds 52:197-200.
61. Pardini A, Jones C, Noble L, Kreiser B, Malcom H, Bruce B, et al. 2001. Persistent pollutants in land-applied sludges. Nature 412:140-141.
62. Petreas M, She J, Brown FR, Winkler J, Windham G, Rogers E, et al. 2003. High body burdens of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) in California women. Environ Health Perspect 111:1175-1179.
63. Pijnenburg AMCM, Everts JW, de Boer J, Boon JP. 1995. Polybrominated biphenyl and diphenylether flame retardants: analysis, toxicity, and environmental occurrence. In: Reviews of Environmental Contamination and Toxicology, Vol 141 (Ware GW, ed). New York:Springer-Verlag, 1-20.
64. Ryan JJ, Patry B. 2000. Determination of brominated diphenyl ethers (BDEs) and levels in Canadian human milk. Organohalogen Compounds 47:57-60.
65. Ryan JJ, Patry B. 2001. Body burdens and food exposure in Canada for polybrominated diphenyl ethers (BDEs). Organohalogen Compounds 51:226-229.
66. Ryan JJ, Patry B, Mills P, Beaudoin G. 2002. Recent trends in levels of brominated diphenyl ethers in human milks from Canada. Organohalogen Compounds 58:173-176.
67. Schecter AJ, ed. 1994. Dioxins and Health. New York:Plenum Press.
68. Schecter AJ, Gasiewicz TA. 2003. Dioxins and Health. 2nd ed. New York:John Wiley and Sons.
69. Schecter AJ, Kassis I, Päpke O. 1998. Partitioning of dioxins, dibenzofurans, and coplanar PCBs in blood, milk, adipose tissue, placenta and cord blood from five American women. Chemosphere 37:1817-1823.
70. Schecter AJ, Mes J, Davies D. 1989. Polychlorinated biphenyl (PCB), DDT, DDE and hexachlorobenzene (HCB) and PCDD/F isomer levels in various organs in autopsy tissue from North American patients. Chemosphere 18:811-818.
71. Schecter AJ, Päpke O, Ball M, Ryan JJ. 1991. Partitioning of dioxins and dibenzofurans: whole blood, blood plasma and adipose tissue. Chemosphere 23:1913-1919.
72. Schecter AJ, Päpke O, Piskac AL. 2000. Dioxin levels in milk and blood from Germany and the USA. Are dioxin blood levels decreasing in both countries? Organohalogen Compounds 48:68-71.
73. Schroeter-Kermani C, Hel D, Hermann T, Päpke O. 2000. The German environmental specimen bank - application in trend monitoring of PBDEs in human blood. Organohalogen Compounds 47:49-52.
74. She J, Petreas M, Winkler J, Visita P, McKinney M, Jones R, Kopec D. 2000. Harbor seals as indicators of halogenated contaminants in San Francisco Bay. Organohalogen Compounds 49:422425.
75. She J, Petreas M, Winkler J, Visita P, McKinney M, Kopec D. 2002. Polybrominated diphenyl ethers (PBDEs) in the San Francisco Bay Area: measurements in harbor seal blubber and human breast adipose tissue. Chemosphere 46:697-707.
76. Sjödin A, Hagmar L, Klasson-Wehler E, Kronholm-Diab K, Jakobsson E, Bergman A. 1999. Flame retardant exposure: polybrominated diphenyl ethers in blood from Swedish workers. Environ Health Perspect 107:643-648.
77. Sjödin A, Patterson DG, Bergman Å. 2001. Brominated flame retardants in serum from US blood donors. Environ Sci Technol 35:3830-3833.
78. Sjödin A, Patterson DG, Bergman Å. 2003. A review on human exposure to brominated flame retardant-particularly polybrominated diphenyl ethers. Environ Int 29: 829-839.
79. Smith D. 1999. Worldwide trends in DDT levels in human breast milk. Int J Epidemiol 28:179-188.
80. Startin JR. 1994. Dioxins in food. In: Dioxins and Health (Schecter AJ, ed). NewYork:Plenum Press, 115-138.
81. Stoker TE, Ferrell J, Hedge JM, Crofton KM, Cooper RL, Laws SC. 2003. Assessment of DE-71, a commercial polybrominated dibyenyl ether (PBDE) mixture, in the EDSP male pubertal protocol [Abstract]. Toxicologist 72:135-136.
82. Strandman T, Koistinen J, Vartiainen T. 2000. Polybrominated diphenyl ethers (PBDEs) in placenta and human milk. Organohalogen Compounds 47:61-64.
83. Thomsen C, Lundanes E, Becher G. 2002. Brominated flame retardants in archived serum samples from Norway: a study on temporal trends and the role of age. Environ Sci Technol 36:1414-1418.
84. U.S. EPA. 1984. Health and Environmental Effects Profile for Brominated Diphenyl Ethers. EPA/600/X-84/133. Washington, DC:U.S. Environmental Protection Agency.
85. van Bavel B, Hardell L, Kitti A, Lijedahl M, Karlsson M, Pettersson A, et al. 2002. High levels of PBDEs in 5% of 220 blood samples from the Swedish population. Organohalogen Compounds 58:161-164.
86. Viberg H, Fredriksson A, Erilksson P. 2002. Neonatal exposure to the brominated flame retardant 2,2′,4,4′,5-pentabromodiphenyl ether causes altered susceptibility in the cholinergic transmitter system in the adult mouse. Toxicol Sci 67:104-107.
87. WHO. 1991. Levels of PCBs, PCDDs and PCDFs in Human Milk and Blood: Second Round of Quality Control Studies. Environment and Health in Europe 37. Copenhagen:FADL 1-76.
88. Zegers BN, Lewis WE, Tjoen-A-Choy MR, Smeenk C, Siebert U, Boon J. 2001. Levels of some polybrominated diphenyl ether (PBDE) flame-retardants in animals of different trophic levels of the North Sea food web. Organohalogen Compounds 52:18-21.