Differential effects of commercial polybrominated diphenyl ether and polychlorinated biphenyl mixtures on intracellular signaling in rat brain in vitro

Toxicological Sciences

Volumn 85, Issue 2, 2005, Pages 952-962

  Kodavanti, Prasada Rao S ^a   Ward, Thomas R ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Calcium signaling; Cytotoxicity; Intracellular signaling; Neurotoxicity; Polybrominated diphenyl ethers (PBDEs); Polychlorinated biphenyls (PCBs); Protein kinase C

Indexed keywords

AROCLOR 1254; CALCIUM ION; CALCIUM PHOSPHATE DIBASIC; ORGANOHALOGEN DERIVATIVE; PHORBOL ESTER; POLYBROMINATED DIPHENYL ETHER; POLYCHLORINATED BIPHENYL DERIVATIVE; PROTEIN KINASE C; TRITIUM;

ANIMAL TISSUE; ARTICLE; BINDING ASSAY; BRAIN REGION; BRAIN TOXICITY; BRAIN WEIGHT; CALCIUM TRANSPORT; CELL COMMUNICATION; CEREBELLUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; FRONTAL CORTEX; GRANULE CELL; HIPPOCAMPUS; IN VITRO STUDY; INTRACELLULAR TRANSPORT; ISOLATION PROCEDURE; MALE; MICROSOME; MITOCHONDRION; NEUROCHEMISTRY; NEUROTOXICITY; NONHUMAN; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION; TOXICOKINETICS;

ANIMALS; BRAIN; CALCIUM; CALCIUM RADIOISOTOPES; CALCIUM SIGNALING; CELLS, CULTURED; CEREBELLUM; ENVIRONMENTAL POLLUTANTS; MALE; MICROSOMES; MITOCHONDRIA; PHORBOL ESTERS; POLYBROMINATED BIPHENYLS; POLYCHLORINATED BIPHENYLS; PROTEIN KINASE C; PROTEIN TRANSPORT; RATS; RATS, LONG-EVANS; SIGNAL TRANSDUCTION;

EID: 20544442213     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfi147     Document Type: Article

References (59)

1. Abeliovich, A., Paylor, R., Chen, C., Kim, J. J., Wehner, J. M., and Tonegawa, S. (1993). PKC-gamma mutant mice exhibit mild deficit in spatial and contextual learning. Cell 75, 1263-1271.
2. Betts, K. S. (2002). Rapidly rising PBDE levels in North America. Environ. Sci. Technol. 36, 50-52A.
3. Bimbaum, L. S., and Staskal, D. F. (2004). Brominated flame retardants: Cause for concern? Environ. Health Perspect. 112, 9-17.
4. Bradford, M. M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
5. Branchi, I., Alleva, E., and Costa, L. G. (2002). Effects of perinatal exposure to a polybrominated diphenyl ether (PBDE 99) on mouse neurobehavioural development. Neurotoxicology 23, 375-384.
6. Carlson, G. P. (1980). Induction of xenobiotic metabolism in rats by short-term administration of brominated diphenyl ethers. Toxicol. Lett. 5, 19-25.
7. Chen, S. J., Sweatt, J. D., and Klann, E. (1997). Enhanced phosphorylation of the postsynaptic protein kinase C substrate RC3/neurogranin during long-term potentiation. Brain Res. 749, 181-187.
8. Dodd, P. R., Hardy, J. A., Oakley, A. E., Edwardson, J. A., Perry, E. K., Delaunoy, J. P. (1981). A rapid method for preparing synaptosomes: Comparison with alterative procedures. Brain Res. 226, 107-118.
9. Eriksson, P. (1997). Developmental neurotoxicity of environmental agents in the neonate. Neurotoxicology 18, 719-726.
10. Eriksson, P., and Fredriksson, A. (1996). Developmental neurotoxicity of four ortho-substituted polychlorinated biphenyls in the neonatal mouse. Environ. Toxicol. Pharmacol. 1, 155-165.
11. Eriksson, P., Jakobsson, E., and Fredriksson, A. (2001). Brominated flame retardants: A novel class of developmental neurotoxicants in our environment? Environ. Health Perspect. 109, 903-908.
12. Eriksson, P., Viberg, H., Jakobsson, E., Orn, U., and Fredriksson A. (2002). A brominated flame retardant, 2,2′,4,4′,5-pentabromodiphenyl ether: Up-take, retention, and induction of neurobehavioral alterations in mice during a critical phase of neonatal brain development. Toxicol. Sci. 67, 98-103.
13. Felipo, V., Minana, M.-D., and Grisolia, S. (1993). Inhibitors of protein kinase C prevent the toxicity of glutamate in primary neuronal cultures. Brain Res. 604, 192-196.
14. Gallo, V., Kingsbury, A., Balazs, R., and Jergensen, O. S. (1987). The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J. Neurosci. 7, 2203-2213.
15. Gill, U., Chu I., Ryan, J. J., and Feeley, M. (2004). Polybrominated diphenyl ethers: Human tissue levels and toxicology. Rev. Environ. Contam. Toxicol. 182, 55-96.
16. Girard, P. R., and Kuo, J. F. (1990). Protein kinase C and its 80-kilodalton substrate protein in neuroblastoma cell neurite outgrowth. J. Neurochem. 54, 300-306.
17. Gray, E. G., and Whittaker, V. P. (1962). The isolation of nerve endings from brain: An electron microscope study of cell fragments derived by homogenization and centrifugation. J. Anat. (Lond.) 96, 79-88.
18. Hale, R. C., Alaee, M., Manchester-Neesvig, J. B., Stapleton, H. M., and Ikonomou, M. G. (2003). Polybrominated diphenyl ether flame retardants in the North American environment. Environ. Intl. 29, 771-779.
19. Hooper, K., and McDonald, T. A. (2000). The PBDEs: An emerging environmental challenge and another reason for breast-milk monitoring programs. Environ. Health Perspect. 108, 387-392.
20. Kang, J.-H., Park, I.-S., Oh, W.-Y., Lim, H.-K., Wang, S.-Y., Lee S. Y., Choi, K. H., Kim, J.-I., Jung, S.-Y., Suh, C. K., et al. (2004). Inhibition of Aroclor 1254-induced depletion of stored calcium prevents the cell death in catecholaminergic cells. Toxicology 200, 93-101.
21. Kater, S. B., and Mills, L. R. (1991). Regulation of growth cone behavior by calcium. J. Neurosci. 11, 891-899.
22. Kodavanti, P. R. S. (2004). Intracellular signaling and developmental neurotoxicity. In Molecular Neurotoxicology: Environmental Agents and Transcription-Transduction Coupling (N. H. Zawia, Ed.), pp. 151-182. CRC Press, Boca Raton, FL.
23. 3H]arachidonic acid release in rat cerebellar granule neurons. Toxicol. Sci. 68, 451-457.
24. 2+ buffering and protein kinase C activity in the absence of changes in tyrosine hydroxylase. Toxicol. Appl. Pharmacol. 153, 186-198.
25. Kodavanti, P. R. S., Kannan, N., Yamashita, N., Derr-Yellin, E. C., Ward, T. R., Burgin, D. E., Tilson, H. A., and Birnbaum, L. S. (2001). Differential effects of two lots of Aroclor 1254: Congener-specific analysis and neurochemical end points. Environ. Health Perspect. 109, 1153-1161.
26. Kodavanti, P. R. S., Mundy, W. R., Derr-Yellin, E. C., and Tilson, H. A. (2000). Developmental exposure to Aroclor 1254 alters calcium buffering and protein kinase C activity in the brain. Toxicol. Sci. 54 (suppl.), 76-77.
27. Kodavanti, P. R. S., Mundy, W. R., Tilson, H. A., and Harry, G. J. (1993a). Effects of selected neuroactive chemicals on calcium transporting systems in rat cerebellum and on survival of cerebellar granule cells. Fundam. Appl. Toxicol. 21, 308-316.
28. 2+-homeostasis in rat cerebellar granule cells. Toxicol. Appl. Pharmacol. 123, 97-106.
29. Kodavanti, P. R. S., and Tilson, H. A. (2000). Neurochemical effects of environmental chemicals: In vitro and in vivo correlations on second messenger pathways. Ann. N. Y. Acad. Sci. 919, 97-105.
30. 3H]phorbol ester binding in rat cerebellar granule cells by polychlorinated biphenyl mixtures and congeners: Structure-activity relationships. Toxicol. Appl. Pharmacol. 130, 140-148.
31. 2+ sequestration in rat cerebellum by polychlorinated biphenyl mixtures and congeners: Structure-activity relationships. Arch. Toxicol. 70, 150-157.
32. Longnecker, M. P., Wolff, M. S., Gladen, B. C., Brock, J. W., Grandjean, P., Jacobson, J. L., Korrick, S. A., Rogan, W.J., Weisglas-Kuperus, N., Hertz-Picciotto, I., et al. (2003). Comparison of polychlorinated biphenyl levels across studies of human neurodevelopment. Environ. Health Perspect. 111, 65-70.
33. Loo, D. T., and Rillema, J. R. (1998). Measurement of cell death. Methods Cell Biol. 57, 251-264.
34. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951). Protein measurement with folin-phenol reagent. J. Biol. Chem. 193, 265-275.
35. Madia, F., Giordano, G., Fattori, V., Vitalone, A., Branchi, I., Capone, F., and Costa, L. G. (2004). Differential in vitro neurotoxicity of the flame retardant PBDE-99 and of the PCB Aroclor 1254 in human astrocytoma cells. Toxicol. Lett. 154, 11-21.
36. Mattson, M. P. (1991). Evidence for the involvement of protein kinase C in neurodegenerative changes in cultured human cortical neurons. Exp. Neurol. 112, 95-103.
37. Mazdai, A., Dodder, N. G., Abernathy, M. P., Hites, R. A., and Bigsby, R. M. (2003). Polybrominated diphenyl ethers in maternal and fetal blood samples. Environ. Health Perspect. 111, 1249-1252.
38. Moore, L., Chen, T, Knapp, H. R, Jr., and Landon, E. L. (1975). Energy dependent calcium sequestration activity in rat liver microsomes. J. Biol. Chem. 250, 4562-4568.
39. Murphy, S., McCabe, N., Morrow, C., and Pearce, B. (1987). Phorbol ester stimulates proliferation of astrocytes in primary cultures. Brain Res. 428, 133-135.
40. Nicotera, P., Bellomo, G., and Orrenius, S. (1992). Calcium-mediated mechanisms in chemically induced cell death. Ann. Rev. Pharmacol. Toxicol. 32, 449-70.
41. Noren, K., and Meironyte, D., (2000). Certain organochlorine and organo-bromine contaminants in Swedish human milk in perspective of past 20-30 years. Chemosphere 40, 1111-23.
42. Olivero, J., and Ganey, P. E. (2000). Role of protein phosphorylation in activation of phospholipase A2 by the polychlorinated biphenyl mixture, Aroclor 1242. Toxicol. Appl. Pharmacol. 163, 9-16.
43. Petreas, M., She, J., Brown, F. R., Winkler, J., Windham, G., Rogers, E., Zhao, G., Bhatia, R., and Charles, M. J. (2003). High body burdens of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) in California women. Environ. Health Perspect. 111, 1175-1179.
44. Rayne, S., Ikonomou, M. G., and Antcliffe, B. (2003). Rapidly increasing polybrominated diphenyl ether concentrations in the Columbia river system from 1992 to 2000. Environ. Sci. Technol. 37, 2847-2854.
45. Reistad, T., Mariussen, E., and Fonnum, F. (2005). The effect of a brominated flame retardant, tetrabromobisphenol-A, on free radical formation in human neutrophil granulocytes: The involvement of the MAP kinase pathway and protein kinase C. Toxicol. Sci. 83, 89-100.
46. Sasaki, T., Kawai, K., Saijo-Kurita, K., and Ohno, T. (1992). Detergent cytotoxicity: Simplified assay of cytolysis by measuring LDH activity. Toxicol. In Vitro 6, 451-457.
47. Schantz, S. L., Seo, B. W., Wong, P. W., and Pessah, I. N. (1997). Long-term effects of developmental exposure to 2,2′,3,5′,6-pentachlorobiphenyl (PCB 95) on locomotor activity, spatial learning and memory and brain ryanodine binding. Neurotoxicology 18, 457-467.
48. Schecter, A., Pavuk, M., Papke, O., Ryan, J. J., Bimbaum, L., and Rosen, R. (2003). Polybrominated diphenyl ethers in U.S. mothers' milk. Environ. Health Perspect. 111, 1723-1729.
49. Shain, W., Bush, B., and Seegal, R. (1991). Neurotoxicity of polychlorinated biphenyls: Structure-activity relationships of individual congeners. Toxicol. Appl. Pharmacol. 111, 33-42.
50. Sharma, R., Derr-Yellin, E. C., House, D. E., and Kodavanti, P. R. S. (2000). Age-dependent effects of Aroclor 1254 on calcium uptake by subcellular organelles in selected brain regions of rat. Toxicology 156, 13-25.
51. Shin, H.-J., Gye, M.-C., Chung, K.-H., and Yoo, B.-S. (2002). Activity of protein kinase C modulates the apoptosis induced by polychlorinated biphenyls in human leukemic HL-60 cells. Toxicol. Lett. 135, 25-31.
52. Vaccarino, F. M., Liljequist, S., and Tallman, J. F. (1991). Modulation of protein kinase C translocation by excitatory and inhibitory amino acids in primary cultures of neurons. J. Neurochem. 57, 391-396.
53. Van Esch, G. J. (1994). Environmental Health Criteria 162: Brominated Diphenyl Ethers. WHO, Geneva.
54. Verity, M. A., Saraflan, T. S., Guerra, W., Ettinger, A., and Sharp, J. (1990). Ionic modulation of triethyllead neurotoxicity in cerebellar granule cell culture. NeuroToxicology 11, 415-426.
55. Viberg, H., Fredriksson, A., and Eriksson, P. (2002). Neonatal exposure to the brominated flame Retardant, 2,2′,4,4′,5-pentabromodiphenyl ether causes altered susceptibility in the cholinergic transmitter system in the adult mouse. Toxicol. Sci. 67, 104-107.
56. Viberg, H., Fredriksson, A., and Eriksson, P. (2004). Investigations of strain and/or gender differences in developmental neurotoxic effects of polybrominated diphenyl ethers in mice. Toxicol. Sci. 81, 344-353.
57. Viberg, H., Fredriksson, A., Jakobsson, E., and Eriksson, P. (2003a). Neurobehavioral derangements in adult mice receiving decabrominated diphenyl ether (PBDE 209) during a defined period of neonatal brain development. Toxicol. Sci. 76, 112-120.
58. Viberg, H., Fredriksson, A., Jakobsson, E., and Eriksson, P. (2003b). Neonatal exposure to polybrominated diphenyl ether (PBDE-153) disrupts spontaneous behaviour, impairs learning and memory, and decreases hippocampal cholinergic receptors in adult mice. Toxicol. Appl. Pharmacol. 192, 95-106.
59. Walkowiak J., Wiener, J. A., Fastabend, A., Heinzow, B., Kramer U., Schmidt, E., Steingruber, H. J., Wundram S., and Winneke, G. (2001). Environmental exposure to polychlorinated biphenyls and quality of the home environment: Effects on psychodevelopment in early childhood. Lancet 358, 1602-1607.