Delayed drug hypersensitivity reactions - New concepts

Clinical and Experimental Allergy

Volumn 37, Issue 7, 2007, Pages 989-999

  Posadas, S J ^a   Pichler, W J ^a,b  

^a Clinic for Rheumatology and Clinical Immunology/Allergology   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE; CELECOXIB; CIPROFLOXACIN; CONTRAST MEDIUM; EOTAXIN; FAS LIGAND; GAMMA INTERFERON; GEMIFLOXACIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANZYME B; HAPTEN; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 8; LAMOTRIGINE; LIDOCAINE; MEPIVACAINE; MOXIFLOXACIN; PENICILLIN G; PERFORIN; PHENYLENEDIAMINE; SULFAMETHOXAZOLE; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS; ADAPTIVE IMMUNITY; ALLERGIC ASTHMA; ALLERGIC RHINITIS; ALLERGY TEST; ANTIGEN RECOGNITION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CHRONOLOGY; CONTACT DERMATITIS; COVALENT BOND; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DELAYED HYPERSENSITIVITY; DISEASE CLASSIFICATION; DRUG ERUPTION; DRUG HYPERSENSITIVITY; DRUG METABOLISM; DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYSMPTOM; DRUG RECEPTOR BINDING; EOSINOPHIL; EOSINOPHILIA; ERYTHEMA EXSUDATIVUM MULTIFORME; HUMAN; IMMUNOSTIMULATION; INNATE IMMUNITY; LYMPHOCYTE FUNCTION; MACULOPAPULAR RASH; MAJOR HISTOCOMPATIBILITY COMPLEX; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MONOCYTE; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN STRUCTURE; RESPIRATORY TRACT INFLAMMATION; REVIEW; SEX DIFFERENCE; SKIN ALLERGY; SKIN MANIFESTATION; SKIN TEST; STEVENS JOHNSON SYNDROME; T LYMPHOCYTE ACTIVATION; TH1 CELL; TOXIC EPIDERMAL NECROLYSIS;

ANIMALS; DRUG HYPERSENSITIVITY; HAPTENS; HUMANS; HYPERSENSITIVITY, DELAYED; MODELS, IMMUNOLOGICAL; PHENOTYPE; SKIN; T-LYMPHOCYTES;

EID: 34250784647     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2007.02742.x     Document Type: Review

References (59)

1. Rawlins M, Thompson W. Mechanisms of adverse drug reactions. In : Davies D, ed. Textbook of adverse drug reactions. New York : Oxford University Press, 1991 18 45.
2. Borda I, Slone D, Jick H. Assessment of adverse reactions within a drug surveillance program. JAMA 1968 205 : 645 7.
3. Coombs PR, Gell PG. Classification of allergic reactions responsible for clinical hypersensitivity and disease. In : Gell RR, ed. Clinical aspects of immunology. Oxford : Oxford University Press, 1968 575 96.
4. Romagnani S. The Th1/Th2 paradigm. Immunol Today 1997 18 : 263 6.
5. Pichler WJ. Pharmacological interaction of drugs with antigen-specific immune receptors: the p-i concept. Curr Opin Allergy Clin Immunol 2002 2 : 301 5.
6. Gerber BO, Pichler WJ. Noncovalent interactions of drugs with immune receptors may mediate drug-induced hypersensitivity reactions. AAPS J 2006 8 : E160 5.
7. Pichler WJ. Immune mechanism of drug hypersensitivity. Immunol Allergy Clin North Am 2004 24 : 373 97.
8. Pichler WJ, Yawalkar N, Britschgi M et al. Cellular and molecular pathophysiology of cutaneous drug reactions. Am J Clin Dermatol 2002 3 : 229 38.
9. Pichler WJ. Delayed drug hypersensitivity reactions. Ann Intern Med 2003 139 : 683 93.
10. Hari Y, Urwyler A, Hurni M et al. Distinct serum cytokine levels in drug- and measles-induced exanthema. Int Arch Allergy Immunol 1999 120 : 225 9.
11. Nassif A, Bensussan A, Dorothee G et al. Drug specific cytotoxic T-cells in the skin lesions of a patient with toxic epidermal necrolysis. J Invest Dermatol 2002 118 : 728 33.
12. Yawalkar N, Hari Y, Frutig K et al. T cells isolated from positive epicutaneous test reactions to amoxicillin and ceftriaxone are drug specific and cytotoxic. J Invest Dermatol 2000 115 : 647 52.
13. Schnyder B, Frutig K, Mauri-Hellweg D, Limat A, Yawalkar N, Pichler WJ. T-cell-mediated cytotoxicity against keratinocytes in sulfamethoxazol-induced skin reaction. Clin Exp Allergy 1998 28 : 1412 7.
14. Maria VA, Victorino RM. Diagnostic value of specific T cell reactivity to drugs in 95 cases of drug induced liver injure. Gut 1997 41 : 534 40.
15. Spanou Z, Keller M, Britschgi M et al. Involvement of drug-specific t cells in acute drug-induced interstitial nephritis. J Am Soc Nephrol 2006 17 : 2919 27.
16. Britschgi M, Steiner UC, Schmid S et al. T-cell involvement in drug-induced acute generalized exanthematous pustulosis. J Clin Invest 2001 107 : 1433 41.
17. Keller M, Spanou Z, Schaerli P et al. T cell-regulated neutrophilic inflammation in autoinflammatory diseases. J Immunol 2005 175 : 7678 86.
18. Padovan E, Bauer T, Tongio MM, Kalbacher H, Weltzien HU. Penicilloyl peptides are recognized as T cell antigenic determinants in penicillin allergy. Eur J Immunol 1997 27 : 1303 7.
19. Aiba S, Manome H, Nakagawa S et al. p38 mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiCl2 and 2,4-dinitrochlorobenzene. J Invest Dermatol 2003 120 : 390 9.
20. Arrighi JF, Rebsamen M, Rousset F, Kindler V, Hauser C. A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-alpha, and contact sensitizers. J Immunol 2001 166 : 3837 45.
21. Griem P, Wulferink M, Sachs B, Gonzalez JB, Gleichmann E. Allergic and autoimmune reactions to xenobiotics: how do they arise? Immunol Today 1998 19 : 133 41.
22. Park BK, Pirmohamed M, Kitteringham NR. Role of drug disposition in drug hypersensitivity: a chemical, molecular, and clinical perspective. Chem Res Toxicol 1998 11 : 969 87.
23. Naisbitt DJ, Gordon SF, Pirmohamed M, Park BK. Immunological principles of adverse drug reactions: the initiation and propagation of immune responses elicited by drug treatment. Drug Safety 2000 23 : 483 507.
24. Knowles SR, Uetrecht J, Shear NH. Idiosyncratic drug reactions: the reactive metabolite syndromes. Lancet 2000 356 : 1587 91.
25. Crispe IN. Hepatic T cells and liver tolerance. Nat Rev Immunol 2003 3 : 51 62.
26. Bowen DG, Zen M, Holz L, Davis T, McCaughan GW, Bertolino P. The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity. J Clin Invest 2004 114 : 701 12.
27. Schnyder B, Mauri-Hellweg D, Zanni M, Bettens F, Pichler WJ. Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alpha-beta T cell clones. J Clin Invest 1997 100 : 136 41.
28. Zanni MP, von Greyerz S, Schnyder B et al. HLA-restricted, processing- and metabolism-independent pathway of drug recognition by human ab T lymphocytes. J Clin Invest 1998 102 : 1591 8.
29. Zanni MP, Mauri-Hellweg D, Brander C et al. Characterization of lidocaine-specific T cells. J Immunol 1997 158 : 1139 48.
30. Naisbitt DJ, Farrell J, Wong G et al. Characterization of drug-specific T cells in lamotrigine hypersensitivity. J Allergy Clin Immunol 2003 111 : 1393 403.
31. Naisbitt DJ, Britschgi M, Wong G et al. Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones. Mol Pharmacol 2003 63 : 732 41.
32. Schmid DA, Depta JP, Luthi M, Pichler WJ. Transfection of drug-specific T-cell receptors into hybridoma cells: tools to monitor drug interaction with T-cell receptors and evaluate cross-reactivity to related compounds. Mol Pharmacol 2006 70 : 356 65.
33. Christiansen C. Late-onset allergy-like reactions to X-ray contrast media. Curr Opin Allergy Clin Immunol 2002 2 : 333 9.
34. Zanni MP, von Greyerz S, Hari Y, Schnyder B, Pichler WJ. Recognition of local anesthetics by alphabeta+ T cells. J Invest Dermatol 1999 112 : 197 204.
35. Sieben S, Kawakubo Y, Al Masaoudi T, Merk HF, Blomeke B. Delayed-type hypersensitivity reaction to paraphenylenediamine is mediated by 2 different pathways of antigen recognition by specific alphabeta human T-cell clones. J Allergy Clin Immunol 2002 109 : 1005 11.
36. Schmid DA, Depta J, Pichler WJ. T cell-mediated hypersensitivity to quinolones - mechanisms and crossreactivity. Clin Exp Allergy 2006 36 : 59 69.
37. Christiansen C, Pichler WJ, Skotland T. Delayed allergy-like reactions to X-ray contrast media: mechanistic considerations. Eur Radiol 2000 10 : 1965 75.
38. Wu Y, Sanderson JP, Farrell J et al. Activation of T cells by carbamazepine and carbamazepine metabolites. J Allergy Clin Immunol 2006 118 : 233 41.
39. Burkhart C, von Greyerz S, Depta JP et al. Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells. Br J Pharmacol 2001 132 : 623 30.
40. Zanni MP, von Greyerz S, Schnyder B, Wendland T, Pichler WJ. Allele-unrestricted presentation of lidocaine by HLA-DR molecules to specific αβ+ T cell clones. Int Immunol 1998 10 : 507 15.
41. von Greyerz S, Bultemann G, Schnyder K et al. Degeneracy and additional alloreactivity of drug-specific human alpha beta(+) T cell clones. Int Immunol 2001 13 : 877 85.
42. Burkhart C, Britschgi M, Strasser I et al. Non-covalent presentation of sulfamethoxazole to human CD4+ T cells is independent of distinct human leucocyte antigen-bound peptides. Clin Exp Allergy 2002 32 : 1635 43.
43. Park BK, Kitteringham NR, Powell H, Pirmohamed M. Advances in molecular toxicology: towards understanding idiosyncratic drug toxicity. Toxicology 2000 153 : 39 60.
44. Swanson HI. Cytochrome P450 expression in human keratinocytes: an aryl hydrocarbon receptor perspective. Chem Biol Interact 2004 149 : 69 79.
45. Janmohamed A, Dolphin CT, Phillips IR, Shephard EA. Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450. Biochem Pharmacol 2001 62 : 777 86.
46. Lee JL, Mukhtar H, Bickers DR, Kopelovich L, Athar M. Cyclooxygenases in the skin: pharmacological and toxicological implications. Toxicol Appl Pharmacol 2003 192 : 294 306.
47. Reilly TP, Lash LH, Doll MA, Hein DW, Woster PM, Svensson CK. A role for bioactivation andcovalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions. J Invest Dermatol 2000 114 : 1164 73.
48. Roychowdhury S, Svensson CK. Mechanisms of drug-induced delayed-type hypersensitivity reactions in the skin. AAPS J 2005 7 : E834 46.
49. Kimber I, Cumberbatch M. Dendritic cells and cutaneous immune responses to chemical allergens. Toxicol Appl Pharmacol 1992 117 : 137 46.
50. Shortman K, Liu YJ. Mouse and human dendritic cell subtypes. Nat Rev Immunol 2002 2 : 151 6.
51. Becker D, Mohamadzadeh M, Reske K, Knop J. Increased level of intracellular MHC class II molecules in murine Langerhans cells following in vivo and in vitro administration of contact allergens. J Invest Dermatol 1992 99 : 545 9.
52. Girolomoni G, Simon JC, Bergstresser PR, Cruz PD Jr. Freshly isolated spleen dendritic cells and epidermal Langerhans cells undergo similar phenotypic and functional changes during short-term culture. J Immunol 1990 145 : 2820 6.
53. Neisius U, Brand P, Plochmann S, Saloga J, Knop J, Becker D. Detection of increased tyrosine phosphorylation in murine Langerhans cells after stimulation with contact sensitizers. Arch Dermatol Res 1999 291 : 22 7.
54. Aiba S, Katz SI. Phenotypic and functional characteristics of in vivo-activated Langerhans cells. J Immunol 1990 145 : 2791 6.
55. Verrier AC, Schmitt D, Staquet MJ. Fragrance and contact allergens in vitro modulate the HLA-DR and E-cadherin expression on human epidermal Langerhans cells. Int Arch Allergy Immunol 1999 120 : 56 62.
56. Enk AH, Katz SI. Early molecular events in the induction phase of contact sensitivity. Proc Natl Acad Sci USA 1992 8 : 1398 402.
57. Schaerli P, Ebert L, Willimann K et al. A skin-selective homing mechanism for human immune surveillance T cells. J Exp Med 2004 199 : 1265 75.
58. Devillier P. Comparing the new antihistamines: the role of pharmacological parameters. Clin Exp Allergy 2006 36 : 5 7.
59. Schmid DA, Campi P, Pichler WJ. Hypersensitivity reactions to quinolones. Curr Pharm Des 2006 12 : 3313 26.