Delayed-type hypersensitivity reaction to paraphenylenediamine is mediated by 2 different pathways of antigen recognition by specific αβ+ human t-cell clones

Journal of Allergy and Clinical Immunology

Volumn 109, Issue 6, 2002, Pages 1005-1011

  Sieben, Sonja ^a   Kawakubo, Yo ^b   Masaoudi, Tames Al ^a   Merk, Hans F ^a   Blömeke, Brunhilde ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Antigen processing; Bandrowski s base; Cytokine; Delayed type hypersensitivity; Paraphenylenediamine; Pbmc; T lymphocytes; T cell clone; T cell receptor

Indexed keywords

BANDROWSKI BASE; BASE; CD4 ANTIGEN; CELL SURFACE MARKER; CONTACT ALLERGEN; CYTOCHROME P450; CYTOKINE; GAMMA INTERFERON; HLA DP ANTIGEN; INTERLEUKIN 4; INTERLEUKIN 5; PHENYLENEDIAMINE; T LYMPHOCYTE RECEPTOR; THYMIDINE; TRITIUM; UNCLASSIFIED DRUG;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; AUTOOXIDATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DELAYED HYPERSENSITIVITY; DNA SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LYMPHOCYTE CLONE; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MALE; METABOLISM; MONONUCLEAR CELL; POLYCLONAL ACTIVATION; PRIORITY JOURNAL; SKIN ALLERGY; T LYMPHOCYTE;

EID: 0036279452     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2002.123872     Document Type: Article

References (41)

1. The diagnostic evaluation, treatment, and prevention of allergic contact dermatitis in the new millennium
2. Investigation of the prohapten concept. Cross reactions between 1.4-substituted benzene derivatives in the guinea pig
3. Paraphenylenediamine, a contact allergen, induces oxidative stress and ICAM-1 expression in human keratinocytes
4. The participation of proliferative keratinocytes in the preimmune response to sensitizing agents
5. N-acetylation of paraphenylenediamine in human skin and keratinocytes
6. Cross sensitization in guinea pigs between p-phenylene diamine and oxidation products thereof
7. T cell reactivity to penicillin: Phenotypic analysis of in vitro activated cell subsets
8. T cell recognition of haptens, a molecular view
9. T cell immune responses to haptens. Structural models for allergic and autoimmune reactions
10. Drug metabolism, danger signals, and drug-induced hypersensitivity
11. Drug disposition and drug hypersensitivity
12. Multiple cytochrome P450-isoenzymes mRNA are expressed in dendritic cells
13. Direct, MHC-dependent presentation of the drug sulfamethoxazole to human αβ T cell clones
14. Allele-unrestricted presentation of lidocaine by HLA-DR molecules to specific αβ+ T cell clones
15. The repertoire of T cell antigen receptor beta-chain variable regions associated with psoriasis vulgaris
16. Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones
17. Dissociation of allergenic and immunogenic functions in contact sensitivity to para-phenylenediamine
18. Further investigation of the prohapten concept: Reactions to benzene derivatives in man
19. Isolation and characterization of Ni-specific T cell clones from patients with Ni-contact dermatitis
20. T cells in allergic responses to haptens and proteins
21. Roles of CD4+ and CD8+ T cells in murine contact sensitivity revealed by in vivo monoclonal antibody depletion
22. Processing of urushiol (poison ivy) hapten by both endogenous and exogenous pathways for presentation to T cells in vitro
23. Dominance of BV17 element in nickel-specific human T cell receptors relates to severity of contact sensitivity
24. Dichotomy of blood- and skin derived IL-4-producing allergen-specific T cells and restricted Vβ repertoire in nickel-mediated contact dermatitis
25. Characterization of lidocaine-specific T cells
26. Th1 lymphokine production profiles of nickel-specific CD4+ T-lymphocyte clones from nickel contact allergic and non-allergic individuals
27. Preferential usage of TCR-Vbeta17 by peripheral and cutaneous T cells in nickel-induced contact dermatitis
28. Th2-type infiltrating T cells in nickel-induced contact dermatitis
29. Immediate-type hypersensitivity response followed by a late reaction is induced by epicutaneous application of contact sensitizing agents in mice
30. Repeated elicitation of contact hypersensitivity induces shift in cutaneous cytokine milieu from a T helper cell type 1 to a T helper cell type 2 profile
31. Antigen-dependent and -indpendente IFN-γ modulation by penicillins
32. Characterization of T cell responses to fragrances
33. Identification and characterization of autoreactive T cell responses to bullous pemphigoid antigen 2 in patients and healthy controls
34. Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine
35. Class II determinants recognized by TNP-spcific clones and human T cell lines
36. HLA class II restriction specificty for nickel-reactive T lymphocytes
37. MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation
38. The role of cytochrome P450 enzymes in hepatic, extrahepatic human drug toxicity
39. Immunologic mechanisms of cutaneous drug reactions
40. HLA-restricted, processing- and metabolism-independent pathway of drug recognition by human αβ T lymphocytes
41. Recognition of sulfamethoxazole and its reactive metabolites by drug- specific CD4+ T cells from allergic individuals