Non-covalent presentation of sulfamethoxazole to human CD4+ T cells is independent of distinct human leucocyte antigen-bound peptides

Clinical and Experimental Allergy

Volumn 32, Issue 11, 2002, Pages 1635-1643

  Burkhart, C ^a   Britschgi, M ^a   Strasser, I ^a   Depta, J P H ^a   Von Greyerz, S ^a   Barnaba, V ^b   Pichler, W J ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b POLICLINICO UMBERTO I   (Italy)

Author keywords

Drug hypersensitivity; MHC bound peptide; Non peptide T cell antigens; Sulfamethoxazole; T lymphocytes

Indexed keywords

ACID; ANTIGEN; CD4 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE; SULFAMETHOXAZOLE; ALLERGEN; HLA ANTIGEN CLASS 2;

ANTIGEN PRESENTING CELL; ARTICLE; CELL CLONE; CELL PROLIFERATION; CELL SPECIFICITY; CELL SURFACE; CONTROLLED STUDY; COVALENT BOND; ELUTION; HUMAN; HUMAN CELL; INCUBATION TIME; LEUKOCYTE; MONITORING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL DIVISION; COCULTURE; DRUG HYPERSENSITIVITY; IMMUNOLOGY;

ALLERGENS; ANTIGEN-PRESENTING CELLS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIVISION; COCULTURE TECHNIQUES; DRUG HYPERSENSITIVITY; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; SULFAMETHOXAZOLE;

EID: 0036434911     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2002.01513.x     Document Type: Article

References (39)

1. Landsteiner K, Jacoby J. Studies on the sensitization of animals with simple chemical compounds. J Exp Med 1935; 61:643-56.
2. Schnyder B, Mauri-Hellweg D, Zanni M, Bettens F, Pichler WJ. Direct, MHC-dependent presentation of the drug sulfamethoxazole to human αβ T cell clones. J Clin Invest 1997; 100:136-41.
3. Zanni MP, von Greyerz S, Schnyder B et al. HLA-restricted, processing- and metabolism-independent pathway of drug recognition by human αβ T lymphocytes. J Clin Invest 1998; 102:1591-8.
4. Zanni MP, von Greyerz S, Hari Y, Schnyder B, Pichler WJ. Recognition of local anesthetics by αβ+ T cells. J Invest Dermatol 1999; 112:197-204.
5. von Greyerz S, Zanni MP, Frutig K, Schnyder B, Burkhart C, Pichler WJ. Interaction of sulfonamide derivatives with the TCR of sulfamethoxazole-specific human αβ+ T cell clones. J Immunol 1999; 162:595-602.
6. Ortmann B, Martin S, von Bonin A, Schlitz E, Hoschutzky H, Weltzien HU. Synthetic peptides anchor T cell-specific TNP epitopes to MHC antigens. J Immunol 1992; 148:1445-50.
7. Martin S, von Bonin A, Fessler C, Pflugfelder U, Weltzien HU. Structural complexity of antigenic determinants for class I MHC-restricted, hapten-specific T cells. J Immunol 1993; 151:678-87.
8. Cavani A, Hackett CJ, Wilson KJ, Rothbard JB, Katz SI. Characterization of epitopes recognized by hapten-specific CD4+ T cells. J Immunol 1995; 154:1232-8.
9. Kohler J, Hartmann U, Grimm R, Pflugfelder U, Weltzien HU. Carrier-independent hapten recognition and promiscuous MHC restriction by CD4 T cells induced by trinitrophenylated peptides. J Immunol 1997; 158:591-7.
10. Padovan E, Bauer T, Tongio MM, Kalbacher H, Weltzien HU. Penicilloyl peptides are recognized as T cell antigenic determinants in penicillin allergy. Eur J Immunol 1997; 27:1303-7.
11. Gelber C, Gemmell L, McAteer D et al. Down-regulation of poison ivy/oak-induced contact sensitivity by treatment with a class II MHC binding peptide: Hapten conjugate. J Immunol 1997; 158:2425-34.
12. Nalefski EA, Rao A. Nature of the ligand recognized by a hapten- and carrier-specific, MHC-restricted T cell receptor. J Immunol 1993; 150:3806-16.
13. d restricted cytotoxic T lymphocyte clones specific for a photoreactive peptide derivative. Labeling of the α-chain correlates with Jα segment usage. J Exp Med 1993; 177:1247-56.
14. Schnyder B, Burkhart C, Schnyder-Frutig K et al. Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4+ T cells from allergic individuals. J Immunol 2000; 164:6647-54.
15. Nisini R, Paroli M, Accapezzato D et al. Human CD4+ T cell response to hepatitis delta virus: Identification of multiple epitopes and characterization of T helper cytokine profiles. J Virol 1997; 71:2241-51.
16. Wyss-Coray T, Gallati H, Pracht I et al. Antigen-presenting human T cells and antigen-presenting B cells induce similar cytokine profile in specific T cell clones. Eur J Immunol 1993; 23:3350-7.
17. Sugawara S, Abo T, Kumagai K. A simple method to eliminate the antigenicity of surface class I MHC molecules from the membrane of viable cells by acid treatment at pH 3. J Immunol Meth 1987; 100:83-90.
18. Busch R, Strang G, Howland K, Rothbard JB. Degenerate binding of immunogenic peptides to HLA-DR on B cell surfaces. Int Immunol 1990; 2:443-51.
19. Adorini L, Appella E, Doria G, Cardinaux F, Nagy ZA. Competition for antigen presentation in living cells involves exchange of peptides bound by class II MHC molecules. Nature 1989; 342:800-3.
20. O'Sullivan D, Sidney J, Appella E et al. Characterization of the specificity of peptide binding to four DR haplotypes. J Immunol 1990; 145:1799-808.
21. Busch R, Rothbard JB. Detection of peptide-MHC complexes on the surface of intact cells. J Immunol Meth 1990; 134:1-22.
22. Panina-Bordignon P, Tan A, Termijtelen A, Demotz S, Corradin G, Lanzavecchia A. Universally immunogenic T cell epitopes: Promiscuous binding to human MHC class II and promiscuous recognition by T cells. Eur J Immunol 1989; 19:2237-42.
23. Storkus WJ, Zeh HJ III, Salter RD, Lotze MT. Identification of T cell epitopes: Rapid isolation of class I-presented peptides from viable cells by mild acid elution. J Immunother 1993; 14:94-103.
24. Harding CV, Unanue ER. Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T cell stimulation. Nature 1990; 346:574-6.
25. Demotz S, Grey HM, Sette A. The minimal number of class II MHC-antigen complexes needed for T cell activation. Science 1990; 249:1028-30.
26. Valitutti S, Lanzavecchia A. Serial triggering of TCRs: A basis for the sensitivity and specificity of antigen recognition. Immunol Today 1997; 18:299.
27. Pinet V, Vergelli M, Martin R, Bakke O, Long EO. Antigen presentation mediated by recycling of surface HLA-DR molecules. Nature 1995; 375:603-4.
28. Pettit LD, Gregor JE, Kozlowski H. Complex Formation Between Metal Ions and Peptides. Perspectives on Bioorganic Chemistry. Stamford, CT: JAI Press, 1991.
29. Romagnoli P, Labhardt AM, Sinigaglia F. Selective interaction of Ni with a MHC-bound peptide. EMBO J 1991; 10:1303.
30. Richeldi L, Sorrentino R, Saltini C. HLA-DPB1 glutamate 69: A genetic marker of berrylium disease. Science 1993; 262:242-4.
31. Zanni MP, Mauri-Hellweg D, Brander C et al. Characterization of lidocaine-specific T cells. J Immunol 1997; 158:1139-48.
32. von Greyerz S, Burkhart C, Pichler WJ. Molecular basis of drug recognition by specific T-cell receptors. Int Arch Allergy Immunol 1999; 119:173-80.
33. Zanni MP, von Greyerz S, Schnyder B, Wendland T, Pichler WJ. Allele-unrestricted presentation of lidocaine by HLA-DR molecules to specific αβ+ T cell clones. Int Immunol 1998; 10:507-15.
34. Corr M, Slanetz AE, Boyd LF et al. T cell receptor-MHC class I peptide interactions: Affinity, kinetics, and specificity. Science 1994; 265:946-9.
35. Khandekar SS, Brauer PP, Naylor JW et al. Affinity and kinetics of the interactions between an αβ T-cell receptor and its superantigen and class II-MHC/peptide ligands. Mol Immunol 1997; 34:493-503.
36. Stern LJ, Wiley DC. The human class II MHC protein HLA-DR 1 assembles as empty alpha beta heterodimers in the absence of antigenic peptide. Cell 1992; 68:465-77.
37. Moulon C, Vollmer J, Weltzien HU. Characterization of processing requirements and metal cross-reactivities in T cell clones from patients with allergic contact dermatitis to nickel. Eur J Immunol 1995; 25:3308-15.
38. Artik S, von Vultrée C, Gleichmann E, Schwarz T, Griem P. Nickel allergy in mice: Enhanced sensitization capacity of nickel at higher oxidation states. J Immunol 1999; 163:1143-52.
39. Bevan MJ, High determinant density may explain the phenomenon of alloreactivity. Immunol Today 1984; 5:128-30.