메뉴 건너뛰기




Volumn 185, Issue 1-3, 2007, Pages 29-39

Epithelial-mesenchymal transition and colorectal cancer: Gaining insights into tumor progression using LIM 1863 cells

Author keywords

Colorectal cancer; Cytokines; Epithelial mesenchymal transition; Integrins; Tumor progression

Indexed keywords

ALPHAVBETA6 INTEGRIN; INTEGRIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

EID: 34250769394     PISSN: 14226405     EISSN: None     Source Type: Journal    
DOI: 10.1159/000101300     Document Type: Conference Paper
Times cited : (41)

References (85)
  • 2
    • 0035906987 scopus 로고    scopus 로고
    • Epithelial mesenchymal interactions in cancer and development
    • Arias, A.M. (2001) Epithelial mesenchymal interactions in cancer and development. Cell 105: 425-431.
    • (2001) Cell , vol.105 , pp. 425-431
    • Arias, A.M.1
  • 4
    • 9544237126 scopus 로고    scopus 로고
    • The cytokine microenvironment of human colon carcinoma. Lymphocyte expression of tumor necrosis factor-alpha and interleukin-4 predicts improved survival
    • Barth, R.J., Jr., B.J. Camp, T.A. Martuscello, B.J. Dain, V.A. Memoli (1996) The cytokine microenvironment of human colon carcinoma. Lymphocyte expression of tumor necrosis factor-alpha and interleukin-4 predicts improved survival. Cancer 78: 1168-1178.
    • (1996) Cancer , vol.78 , pp. 1168-1178
    • Barth Jr., R.J.1    Camp, B.J.2    Martuscello, T.A.3    Dain, B.J.4    Memoli, V.A.5
  • 5
    • 15244350614 scopus 로고    scopus 로고
    • Gastrointestinal matrix, organization and significance
    • Johnson, L.R, ed, San Diego, Elsevier Science, pp
    • Bates, R.C. (2003) Gastrointestinal matrix, organization and significance; in Johnson, L.R. (ed): Encyclopedia of Gastroenterology. San Diego, Elsevier Science, pp 219-223.
    • (2003) Encyclopedia of Gastroenterology , pp. 219-223
    • Bates, R.C.1
  • 10
    • 0037572319 scopus 로고    scopus 로고
    • Tumor necrosis factor-α stimulates the epithelial to mesenchymal transition of human colonic organoids
    • Bates, R.C., A.M. Mercurio (2003) Tumor necrosis factor-α stimulates the epithelial to mesenchymal transition of human colonic organoids. Mol Biol Cell 14: 1790-1800.
    • (2003) Mol Biol Cell , vol.14 , pp. 1790-1800
    • Bates, R.C.1    Mercurio, A.M.2
  • 11
    • 14944348752 scopus 로고    scopus 로고
    • Transcriptional activation of integrin β6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma
    • Bates, R.C., D.I. Bellovin, C. Brown, E. Maynard, B. Wu, H. Kawakatsu, D. Sheppard, P. Oettgen, A.M. Mercurio (2005) Transcriptional activation of integrin β6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest 115: 339-347.
    • (2005) J Clin Invest , vol.115 , pp. 339-347
    • Bates, R.C.1    Bellovin, D.I.2    Brown, C.3    Maynard, E.4    Wu, B.5    Kawakatsu, H.6    Sheppard, D.7    Oettgen, P.8    Mercurio, A.M.9
  • 12
    • 0035185853 scopus 로고    scopus 로고
    • Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a Rho-A-dependent mechanism
    • Bhowmick, N.A., M. Ghiassi, A. Bakin, M. Aakre, C.A. Lundquist, M.E. Engel, C.L. Arteaga, H.L. Moses (2001) Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a Rho-A-dependent mechanism. Mol Biol Cell 12: 27-36.
    • (2001) Mol Biol Cell , vol.12 , pp. 27-36
    • Bhowmick, N.A.1    Ghiassi, M.2    Bakin, A.3    Aakre, M.4    Lundquist, C.A.5    Engel, M.E.6    Arteaga, C.L.7    Moses, H.L.8
  • 14
    • 22144497081 scopus 로고    scopus 로고
    • Invasion and metastasis in colorectal cancer: Epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and β-catenin
    • Brabletz, T., F. Hlubek, S. Spaderna, O. Schmalhofer, E. Hiendlmeyer, A. Jung, T. Kirchner (2005a) Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and β-catenin. Cells Tissues Organs 179: 56-65.
    • (2005) Cells Tissues Organs , vol.179 , pp. 56-65
    • Brabletz, T.1    Hlubek, F.2    Spaderna, S.3    Schmalhofer, O.4    Hiendlmeyer, E.5    Jung, A.6    Kirchner, T.7
  • 15
    • 25444495269 scopus 로고    scopus 로고
    • Migrating cancer stem cells - an integrated concept of malignant tumour progression
    • Brabletz, T., A. Jung, S. Spaderna, F. Hlubek, T. Kirchner (2005b) Migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat Rev Cancer 5: 744-749.
    • (2005) Nat Rev Cancer , vol.5 , pp. 744-749
    • Brabletz, T.1    Jung, A.2    Spaderna, S.3    Hlubek, F.4    Kirchner, T.5
  • 16
    • 0027234361 scopus 로고
    • Restricted distribution of integrin beta 6 mRNA in primate epithelial tissues
    • Breuss, J.M., N. Gillett, L. Lu, D. Sheppard, R. Pytela (1993) Restricted distribution of integrin beta 6 mRNA in primate epithelial tissues. J Histochem Cytochem 41: 1521-1527.
    • (1993) J Histochem Cytochem , vol.41 , pp. 1521-1527
    • Breuss, J.M.1    Gillett, N.2    Lu, L.3    Sheppard, D.4    Pytela, R.5
  • 18
    • 0026660349 scopus 로고
    • Characterization of the integrin αvβ6 as a fibronectin-binding protein
    • Busk, M., R. Pytela, D. Sheppard (1992) Characterization of the integrin αvβ6 as a fibronectin-binding protein. J Biol Chem 267: 5790-5796.
    • (1992) J Biol Chem , vol.267 , pp. 5790-5796
    • Busk, M.1    Pytela, R.2    Sheppard, D.3
  • 19
    • 0036788829 scopus 로고    scopus 로고
    • The genetics of colorectal cancer
    • Calvert, P.M., H. Frucht (2002) The genetics of colorectal cancer. Ann Intern Med 137: 603-612.
    • (2002) Ann Intern Med , vol.137 , pp. 603-612
    • Calvert, P.M.1    Frucht, H.2
  • 20
    • 0034744953 scopus 로고    scopus 로고
    • Characterization of cytokine mRNA expression in tumor-infiltrating mononuclear cells and tumor cells freshly isolated from human colorectal carcinomas
    • Csiszar, A., T. Szentes, B. Haraszti, W. Zou, D. Emilie, G.G. Petranyi, E. Pocsik (2001) Characterization of cytokine mRNA expression in tumor-infiltrating mononuclear cells and tumor cells freshly isolated from human colorectal carcinomas. Eur Cytokine Netw 12: 87-96.
    • (2001) Eur Cytokine Netw , vol.12 , pp. 87-96
    • Csiszar, A.1    Szentes, T.2    Haraszti, B.3    Zou, W.4    Emilie, D.5    Petranyi, G.G.6    Pocsik, E.7
  • 22
    • 0034612789 scopus 로고    scopus 로고
    • Role of transforming growth factor-β signaling in cancer
    • de Caestecker, M.P., E. Piek, A.B. Roberts (2000) Role of transforming growth factor-β signaling in cancer. J Natl Cancer Inst 92: 1388-1402.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1388-1402
    • de Caestecker, M.P.1    Piek, E.2    Roberts, A.B.3
  • 23
    • 2942696037 scopus 로고    scopus 로고
    • New chemotherapeutic advances in pancreatic, colorectal, and gastric cancers
    • Diaz-Rubio, E. (2004) New chemotherapeutic advances in pancreatic, colorectal, and gastric cancers. Oncologist 9: 282-294.
    • (2004) Oncologist , vol.9 , pp. 282-294
    • Diaz-Rubio, E.1
  • 24
    • 0033565626 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis
    • Engle, S.J., J.B. Hoying, G.P. Boivin, I. Ormsby, P.S. Gartside, T. Doetschman (1999) Transforming growth factor beta 1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis. Cancer Res 59: 3379-3386.
    • (1999) Cancer Res , vol.59 , pp. 3379-3386
    • Engle, S.J.1    Hoying, J.B.2    Boivin, G.P.3    Ormsby, I.4    Gartside, P.S.5    Doetschman, T.6
  • 25
    • 0033822949 scopus 로고    scopus 로고
    • Angiogenin expression inhuman colorectal cancer: The role of focal macrophage infiltration
    • Etoh, T., K. Shibuta, G.F. Barnard, S. Kitano, M. Mori (2000) Angiogenin expression inhuman colorectal cancer: the role of focal macrophage infiltration. Clin Cancer Res 6: 3545-3551.
    • (2000) Clin Cancer Res , vol.6 , pp. 3545-3551
    • Etoh, T.1    Shibuta, K.2    Barnard, G.F.3    Kitano, S.4    Mori, M.5
  • 26
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon, E.R., B. Vogelstein (1990) A genetic model for colorectal tumorigenesis. Cell 61: 759-767.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 27
    • 0038049137 scopus 로고    scopus 로고
    • Tumour-cell invasion and migration: Diversity and escape mechanisms
    • Friedl, P., K. Wolf (2003) Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 3: 362-374.
    • (2003) Nat Rev Cancer , vol.3 , pp. 362-374
    • Friedl, P.1    Wolf, K.2
  • 28
    • 5444220519 scopus 로고    scopus 로고
    • Collective cell migration in morphogenesis and cancer
    • Friedl, P., Y. Hegerfeldt, M. Tusch (2004) Collective cell migration in morphogenesis and cancer. Int J Dev Biol 48: 441-449.
    • (2004) Int J Dev Biol , vol.48 , pp. 441-449
    • Friedl, P.1    Hegerfeldt, Y.2    Tusch, M.3
  • 29
    • 0034959181 scopus 로고    scopus 로고
    • Transforming growth factor-β1 promotes invasiveness after cellular transformation with activated ras in intestinal epithelial cells
    • Fujimoto, K., H. Sheng, J. Shao, R.D. Beauchamp (2001) Transforming growth factor-β1 promotes invasiveness after cellular transformation with activated ras in intestinal epithelial cells. Exp Cell Res 266: 239-249.
    • (2001) Exp Cell Res , vol.266 , pp. 239-249
    • Fujimoto, K.1    Sheng, H.2    Shao, J.3    Beauchamp, R.D.4
  • 30
    • 0033381357 scopus 로고    scopus 로고
    • The role of transforming growth factor-beta (TGF-beta) in human cancer
    • Gold, L.I. (1999) The role of transforming growth factor-beta (TGF-beta) in human cancer. Crit Rev Oncog 10: 303-360.
    • (1999) Crit Rev Oncog , vol.10 , pp. 303-360
    • Gold, L.I.1
  • 31
    • 31444450593 scopus 로고    scopus 로고
    • Advances in the treatment of metastatic colon cancer
    • Goldberg, R.M. (2005) Advances in the treatment of metastatic colon cancer. Oncologist 10(suppl 3): 40-48.
    • (2005) Oncologist , vol.10 , Issue.SUPPL. 3 , pp. 40-48
    • Goldberg, R.M.1
  • 32
    • 0034098691 scopus 로고    scopus 로고
    • Biology of the adenomatous polyposis coli tumor suppressor
    • Goss, K.H., J. Groden (2000) Biology of the adenomatous polyposis coli tumor suppressor. J Clin Oncol 18: 1967-1979.
    • (2000) J Clin Oncol , vol.18 , pp. 1967-1979
    • Goss, K.H.1    Groden, J.2
  • 33
    • 0347052797 scopus 로고    scopus 로고
    • Molecular aspects of epithelial cell plasticity: Implications for local tumor invasion and metastasis
    • Gotzmann, J., M. Mikula, A. Eger, R. Schulte-Hermann, R. Foisner, H. Beug, W. Mikulits (2004) Molecular aspects of epithelial cell plasticity: implications for local tumor invasion and metastasis. Mutat Res 566: 9-20.
    • (2004) Mutat Res , vol.566 , pp. 9-20
    • Gotzmann, J.1    Mikula, M.2    Eger, A.3    Schulte-Hermann, R.4    Foisner, R.5    Beug, H.6    Mikulits, W.7
  • 35
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D., R.A. Weinberg (2000) The hallmarks of cancer. Cell 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 37
    • 12444342223 scopus 로고
    • Patterns of growth and differentiation in the colon carcinoma cell line LIM 1863
    • Hayward, I.P., R.H. Whitehead (1992) Patterns of growth and differentiation in the colon carcinoma cell line LIM 1863. Int J Cancer 51: 1-8.
    • (1992) Int J Cancer , vol.51 , pp. 1-8
    • Hayward, I.P.1    Whitehead, R.H.2
  • 39
  • 40
    • 0027930489 scopus 로고
    • Colon carcinoma cells switch their response to transforming growth factor beta 1 with tumor progression
    • Hsu, S., F. Huang, M. Hafez, S. Winawer, E. Friedman (1994) Colon carcinoma cells switch their response to transforming growth factor beta 1 with tumor progression. Cell Growth Differ 5: 267-275.
    • (1994) Cell Growth Differ , vol.5 , pp. 267-275
    • Hsu, S.1    Huang, F.2    Hafez, M.3    Winawer, S.4    Friedman, E.5
  • 41
    • 0026770377 scopus 로고
    • Integrins: Versatility, modulation, and signaling in cell adhesion
    • Hynes, R.O. (1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69: 11-25.
    • (1992) Cell , vol.69 , pp. 11-25
    • Hynes, R.O.1
  • 42
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: Bi-directional allosteric signaling machines
    • Hynes, R.O. (2002) Integrins: bi-directional allosteric signaling machines. Cell 110: 673-687.
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 43
    • 0037148532 scopus 로고    scopus 로고
    • Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis: Dissection of ras signaling pathways
    • Janda, E., K. Lehmann, I. Killisch, M. Jechlinger, M. Herzig, J. Downward, H. Beug, S. Grunert (2002) Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis: dissection of ras signaling pathways. J Cell Biol 156: 299-314.
    • (2002) J Cell Biol , vol.156 , pp. 299-314
    • Janda, E.1    Lehmann, K.2    Killisch, I.3    Jechlinger, M.4    Herzig, M.5    Downward, J.6    Beug, H.7    Grunert, S.8
  • 45
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler, K., B. Vogelstein (1996) Lessons from hereditary colorectal cancer. Cell 87: 159-170.
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.1    Vogelstein, B.2
  • 47
    • 0029816609 scopus 로고    scopus 로고
    • Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma
    • Leek, R.D., C.E. Lewis, R. Whitehouse, M. Greenall, J. Clarke, A.L. Harris (1996) Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res 56: 4625-4629.
    • (1996) Cancer Res , vol.56 , pp. 4625-4629
    • Leek, R.D.1    Lewis, C.E.2    Whitehouse, R.3    Greenall, M.4    Clarke, J.5    Harris, A.L.6
  • 48
    • 0034666839 scopus 로고    scopus 로고
    • Raf induces TGFβ production while blocking its apoptotic but not invasive responses: A mechanism leading to increased malignancy in epithelial cells
    • Lehmann, K., E. Janda, C.E. Pierreux, M. Rytomaa, A. Schulze, M. McMahon, C.S. Hill, H. Beug, J. Downward (2000) Raf induces TGFβ production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. Genes Dev 14: 2610-2622.
    • (2000) Genes Dev , vol.14 , pp. 2610-2622
    • Lehmann, K.1    Janda, E.2    Pierreux, C.E.3    Rytomaa, M.4    Schulze, A.5    McMahon, M.6    Hill, C.S.7    Beug, H.8    Downward, J.9
  • 49
    • 0035902141 scopus 로고    scopus 로고
    • The microenvironment of the tumor-host interface
    • Liotta, L., E.C. Kohn (2001) The microenvironment of the tumor-host interface. Nature 411: 375-379.
    • (2001) Nature , vol.411 , pp. 375-379
    • Liotta, L.1    Kohn, E.C.2
  • 51
    • 0030183051 scopus 로고    scopus 로고
    • Tumor suppressor activity of the TGF-beta pathway in human cancers
    • Markowitz, S.D., A.B. Roberts (1996) Tumor suppressor activity of the TGF-beta pathway in human cancers. Cytokine Growth Factor Rev 7: 93-102.
    • (1996) Cytokine Growth Factor Rev , vol.7 , pp. 93-102
    • Markowitz, S.D.1    Roberts, A.B.2
  • 53
    • 30544439661 scopus 로고    scopus 로고
    • The role of bevacizumab as a first-line therapy for colon cancer
    • Marshall, J. (2005) The role of bevacizumab as a first-line therapy for colon cancer. Semin Oncol 32: 43-47.
    • (2005) Semin Oncol , vol.32 , pp. 43-47
    • Marshall, J.1
  • 56
    • 22144461325 scopus 로고    scopus 로고
    • Transforming growth factor-β signaling during epithelial-mesenchymal transformation: Implications for embryogenesis and tumor metastasis
    • Nawshad, A., D. LaGamba, A. Polad, E.D. Hay (2005) Transforming growth factor-β signaling during epithelial-mesenchymal transformation: implications for embryogenesis and tumor metastasis. Cells Tissues Organs 179: 11-23.
    • (2005) Cells Tissues Organs , vol.179 , pp. 11-23
    • Nawshad, A.1    LaGamba, D.2    Polad, A.3    Hay, E.D.4
  • 57
    • 0027163955 scopus 로고
    • Tumor necrosis factor and its receptors in human ovarian cancer. Potential role in disease progression
    • Naylor, M.S., G.W. Stamp, W.D. Foulkes, D. Eccles, F.R. Balkwill (1993) Tumor necrosis factor and its receptors in human ovarian cancer. Potential role in disease progression. J Clin Invest 91: 2194-2206.
    • (1993) J Clin Invest , vol.91 , pp. 2194-2206
    • Naylor, M.S.1    Stamp, G.W.2    Foulkes, W.D.3    Eccles, D.4    Balkwill, F.R.5
  • 58
    • 0029662049 scopus 로고    scopus 로고
    • TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells
    • Oft, M., J. Peli, C. Rudaz, H. Schwarz, H. Beug, E. Reichmann (1996) TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev 10: 2462-2477.
    • (1996) Genes Dev , vol.10 , pp. 2462-2477
    • Oft, M.1    Peli, J.2    Rudaz, C.3    Schwarz, H.4    Beug, H.5    Reichmann, E.6
  • 59
    • 0032547895 scopus 로고    scopus 로고
    • TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis
    • Oft, M., K.H. Heider, H. Berg (1998) TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis. Curr Biol 8: 1243-1252.
    • (1998) Curr Biol , vol.8 , pp. 1243-1252
    • Oft, M.1    Heider, K.H.2    Berg, H.3
  • 60
    • 0033778364 scopus 로고    scopus 로고
    • Tumor necrosis factor: Biology and therapeutic inhibitors
    • Papadakis, K.A., S.R. Targan (2000) Tumor necrosis factor: biology and therapeutic inhibitors. Gastroenterology 119: 1148-1157.
    • (2000) Gastroenterology , vol.119 , pp. 1148-1157
    • Papadakis, K.A.1    Targan, S.R.2
  • 61
    • 0030836678 scopus 로고    scopus 로고
    • Expression of integrin cell adhesion receptors during human airway epithelial repair in vivo
    • Pilewski, J.M., J.D. Latoche, S.M. Arcasoy, S.M. Albelda (1997) Expression of integrin cell adhesion receptors during human airway epithelial repair in vivo. Am J Pathol 273: L256-L263.
    • (1997) Am J Pathol , vol.273
    • Pilewski, J.M.1    Latoche, J.D.2    Arcasoy, S.M.3    Albelda, S.M.4
  • 62
    • 0027364324 scopus 로고
    • Multiple integrins mediate cell attachment to cytoactin/tenascin
    • Prieto, A.L., G.M. Edelman, K.L. Crossin (1993) Multiple integrins mediate cell attachment to cytoactin/tenascin. Proc Natl Acad Sci USA 90: 10154-10158.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10154-10158
    • Prieto, A.L.1    Edelman, G.M.2    Crossin, K.L.3
  • 63
    • 0007782723 scopus 로고
    • Adhesive properties of metastasizing tumor cells
    • Raz, A. (1988) Adhesive properties of metastasizing tumor cells. Ciba Found Symp 141: 323-330.
    • (1988) Ciba Found Symp , vol.141 , pp. 323-330
    • Raz, A.1
  • 64
    • 0027092936 scopus 로고
    • Activation of an inducible c-fos ER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid conversion
    • Reichmann, E., H. Schwarz, E.M. Deiner, I. Leitner, M. Eilers, M. Busslinger, H. Beug (1992) Activation of an inducible c-fos ER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid conversion. Cell 71: 1103-1116.
    • (1992) Cell , vol.71 , pp. 1103-1116
    • Reichmann, E.1    Schwarz, H.2    Deiner, E.M.3    Leitner, I.4    Eilers, M.5    Busslinger, M.6    Beug, H.7
  • 65
    • 0036076481 scopus 로고    scopus 로고
    • Tenascin and β6 integrin are overexpressed in floor of mouth in situ carcinomas and invasive squamous cell carcinomas
    • Regezi, J.A., D.M. Ramos, R. Pytela, N.P. Dekker, R.C.K. Jordan (2002) Tenascin and β6 integrin are overexpressed in floor of mouth in situ carcinomas and invasive squamous cell carcinomas. Oral Oncol 38: 332-336.
    • (2002) Oral Oncol , vol.38 , pp. 332-336
    • Regezi, J.A.1    Ramos, D.M.2    Pytela, R.3    Dekker, N.P.4    Jordan, R.C.K.5
  • 66
    • 0034798707 scopus 로고    scopus 로고
    • Leaving the neighborhood: Molecular mechanisms involved during epithelial-mesenchymal transition
    • Savagner, P. (2001) Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition. Bioessays 23: 912-923.
    • (2001) Bioessays , vol.23 , pp. 912-923
    • Savagner, P.1
  • 67
    • 0033988217 scopus 로고    scopus 로고
    • Effects of transforming growth factor β1 expression in a rat colon carcinoma: Growth inhibition, leukocyte infiltration and production of interleukin-10 and tumor necrosis factor α
    • Schiott, A., A.C.M. Johansson, B. Widegreen, H.O. Sjorgen, M. Lindvall (2000) Effects of transforming growth factor β1 expression in a rat colon carcinoma: growth inhibition, leukocyte infiltration and production of interleukin-10 and tumor necrosis factor α. Cancer Immunol Immunother 48: 579-587.
    • (2000) Cancer Immunol Immunother , vol.48 , pp. 579-587
    • Schiott, A.1    Johansson, A.C.M.2    Widegreen, B.3    Sjorgen, H.O.4    Lindvall, M.5
  • 68
    • 0035871383 scopus 로고    scopus 로고
    • Analysis of the transcriptional program induced by Raf in epithelial cells
    • Schultze, A., K. Lehmann, H.B.J. Jeffries, M. McMahon, J. Downward (2001) Analysis of the transcriptional program induced by Raf in epithelial cells. Genes Dev 15: 981-994.
    • (2001) Genes Dev , vol.15 , pp. 981-994
    • Schultze, A.1    Lehmann, K.2    Jeffries, H.B.J.3    McMahon, M.4    Downward, J.5
  • 70
    • 0034655246 scopus 로고    scopus 로고
    • Suppression of tumor angiogenesis and growth by gene transfer of a soluble form of vascular endothelial growth factor receptor into a remote organ
    • Takayama, K.K., H. Ueno, Y. Nakanishi, T. Sakamoto, K. Inoue, K. Shimizu, H. Oohashi, N. Hara (2000) Suppression of tumor angiogenesis and growth by gene transfer of a soluble form of vascular endothelial growth factor receptor into a remote organ. Cancer Res 60: 2169-2177.
    • (2000) Cancer Res , vol.60 , pp. 2169-2177
    • Takayama, K.K.1    Ueno, H.2    Nakanishi, Y.3    Sakamoto, T.4    Inoue, K.5    Shimizu, K.6    Oohashi, H.7    Hara, N.8
  • 71
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery, J.P. (2002) Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 72
    • 0344845003 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and pathologies
    • Thiery, J.P. (2003) Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 15: 740-746.
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 740-746
    • Thiery, J.P.1
  • 73
    • 0035170731 scopus 로고    scopus 로고
    • Reactive stroma in prostate cancer progression
    • Tuxhorn, J.A., G.E. Ayala, D.R. Rowley (2001) Reactive stroma in prostate cancer progression. J Urol 166: 2472-2483.
    • (2001) J Urol , vol.166 , pp. 2472-2483
    • Tuxhorn, J.A.1    Ayala, G.E.2    Rowley, D.R.3
  • 75
    • 0036467496 scopus 로고    scopus 로고
    • TGF-β signaling: Positive and negative effects on tumorigenesis
    • Wakefield, L.M., A.B. Roberts (2002) TGF-β signaling: positive and negative effects on tumorigenesis. Curr Opin Genet Dev 12: 22-29.
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 22-29
    • Wakefield, L.M.1    Roberts, A.B.2
  • 76
    • 0032217084 scopus 로고    scopus 로고
    • Reciprocal interactions between beta-1 integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology
    • Wang, F., V.M. Weaver, O.W. Petersen, C.A. Larabell, S. Dedhar, P. Briand, R. Lupu, M.J. Bissell (1998) Reciprocal interactions between beta-1 integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proc Natl Acad Sci USA 95: 14821-14826.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 14821-14826
    • Wang, F.1    Weaver, V.M.2    Petersen, O.W.3    Larabell, C.A.4    Dedhar, S.5    Briand, P.6    Lupu, R.7    Bissell, M.J.8
  • 77
    • 0028935608 scopus 로고
    • Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis
    • Warren, R.S., H. Yuan, M.R. Matli, N.A. Gillett, N. Ferrara (1995) Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. J Clin Invest 95: 1789-1797.
    • (1995) J Clin Invest , vol.95 , pp. 1789-1797
    • Warren, R.S.1    Yuan, H.2    Matli, M.R.3    Gillett, N.A.4    Ferrara, N.5
  • 79
    • 0030936450 scopus 로고    scopus 로고
    • Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies
    • Weaver, V.M., O.W. Petersen, F. Wang, C.A. Larabell, P. Briand, C. Damsky, M.J. Bissell (1997) Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol 137: 231-245.
    • (1997) J Cell Biol , vol.137 , pp. 231-245
    • Weaver, V.M.1    Petersen, O.W.2    Wang, F.3    Larabell, C.A.4    Briand, P.5    Damsky, C.6    Bissell, M.J.7
  • 80
    • 0023265494 scopus 로고
    • A new colon carcinoma cell line (LIM 1863) that grows as organoids with spontaneous differentiation into crypt-like structures in vitro
    • Whitehead, R.H., J.K. Jones, A. Gabriel, R.E. Lukies (1987) A new colon carcinoma cell line (LIM 1863) that grows as organoids with spontaneous differentiation into crypt-like structures in vitro. Cancer Res 47: 2683-2689.
    • (1987) Cancer Res , vol.47 , pp. 2683-2689
    • Whitehead, R.H.1    Jones, J.K.2    Gabriel, A.3    Lukies, R.E.4
  • 81
    • 0027274028 scopus 로고
    • Tumor necrosis factor alpha as an autocrine and paracrine growth factor for ovarian cancer: Monokine induction of tumor cell proliferation and tumor necrosis factor alpha expression
    • Wu, S., C.M. Boyer, R.S. Whitaker, A. Berchuck, J.R. Weiner, J.B. Weinberg, R.C. Bast Jr. (1993) Tumor necrosis factor alpha as an autocrine and paracrine growth factor for ovarian cancer: monokine induction of tumor cell proliferation and tumor necrosis factor alpha expression. Cancer Res 53: 1939-1944.
    • (1993) Cancer Res , vol.53 , pp. 1939-1944
    • Wu, S.1    Boyer, C.M.2    Whitaker, R.S.3    Berchuck, A.4    Weiner, J.R.5    Weinberg, J.B.6    Bast Jr., R.C.7
  • 82
  • 83
    • 0035156083 scopus 로고    scopus 로고
    • Transforming growth factor-β signal transduction in epithelial cells
    • Yue, J., K.M. Mulder (2001) Transforming growth factor-β signal transduction in epithelial cells. Pharmacol Ther 91: 1-34.
    • (2001) Pharmacol Ther , vol.91 , pp. 1-34
    • Yue, J.1    Mulder, K.M.2
  • 84
    • 0028987192 scopus 로고
    • Transforming growth factor-beta 1 modulates beta 1 and beta 5 integrin receptors and induces the de novo expression of the alpha v beta 6 heterodimer in normal human keratinocytes: Implications for wound healing
    • Zambruno, G., P.C. Marchisio, A. Marconi, C. Vaschieri, A. Melchiori, A. Giannetti, M. DeLuca (1995) Transforming growth factor-beta 1 modulates beta 1 and beta 5 integrin receptors and induces the de novo expression of the alpha v beta 6 heterodimer in normal human keratinocytes: implications for wound healing. J Cell Biol 129: 853-865.
    • (1995) J Cell Biol , vol.129 , pp. 853-865
    • Zambruno, G.1    Marchisio, P.C.2    Marconi, A.3    Vaschieri, C.4    Melchiori, A.5    Giannetti, A.6    DeLuca, M.7
  • 85
    • 9644252907 scopus 로고    scopus 로고
    • The immunology of colorectal cancer
    • Zbar, A.P. (2004) The immunology of colorectal cancer. Surg Oncol 13: 45-53.
    • (2004) Surg Oncol , vol.13 , pp. 45-53
    • Zbar, A.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.