The genetics of colorectal cancer

Annals of Internal Medicine

Volumn 137, Issue 7, 2002, Pages 603-612

  Calvert, Paula M ^a   Frucht, Harold ^a  

^a Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOMATOUS POLYP; ALLELISM; CANCER GENETICS; CANCER RISK; CANCER SCREENING; CANCER SUSCEPTIBILITY; CELL CYCLE; COLONOSCOPY; COLORECTAL CANCER; COLORECTAL CARCINOMA; FAMILIAL CANCER; GENE MUTATION; GENETIC ANALYSIS; GENETIC CODE; GENETIC COUNSELING; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC SCREENING; HIGH RISK POPULATION; HUMAN; LABORATORY TEST; MISMATCH REPAIR; MOLECULAR BIOLOGY; MOLECULAR GENETICS; ONCOGENE; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; TUMOR SUPPRESSOR GENE;

EID: 0036788829     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-137-7-200210010-00012     Document Type: Review

References (58)

1. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 1990;61:759-67. [PMID: 2188735]
2. Weinberg RA. Oncogenes and tumor suppressor genes. CA Cancer J Clin. 1994;44:160-70. [PMID: 7621068]
3. Chung DC, Rustgi AK. DNA mismatch repair and cancer. Gastroenterology. 1995;109:1685-99. [PMID: 7557155]
4. Sherr CJ. Cancer cell cycles. Science. 1996;274:1672-7. [PMID: 8939849]
5. Cancer Genetics and Cancer Predisposition Testing. American Society of Clinical Oncology Curriculum. Alexandria, VA: American Soc of Clinical Oncology; 1998.
6. Knudson AG Jr. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A. 1971;68:820-3. [PMID: 5279523]
7. Knudson AG Jr. Hereditary cancer, oncogenes, and antioncogenes. Cancer Res. 1985;45:1437-43. [PMID: 2983882]
8. Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, et al. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science. 1995;268:1336-8. [PMID: 7761852]
9. Laken SJ, Petersen GM, Gruber SB, Oddoux C, Ostrer H, Giardiello FM, et al. Familial colorectal cancer in Ashkenazim due to a hypetmutable tract in APC Nat Genet. 1997;17:79-83. [PMID: 9288102]
10. Hruban RH, Goggins M, Parsons J, Kern SE. Progression model for pancreatic cancer. Clin Cancer Res. 2000;6:2969-72. [PMID: 10955772]
11. Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, et al. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet. 1998;18:38-43. [PMID: 9425897]
12. Tortola S, Marcuello E, González I, Reyes G, Arribas R, Aiza G, et al. p53 and K-ras gene mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer. J Clin Oncol. 1999;17:1375-81. [PMID: 10334521]
13. Villa E, Dugani A, Rebecchi AM, Vignoli A, Grottola A, Buttafoco P, et al. Identification of subjects at risk for colorectal carcinoma through a test based on K-ras determination in the stool Gastroenterology. 1996;110:1346-53. [PMID: 8613038]
14. Forgacs I. Oncogenes and gastrointestinal cancer. Gut. 1988;29:417-21. [PMID: 3286381]
15. Cartwright C. Intestinal cell growth control: role of Src tyrosine kinases [Editorial]. Gastroenterology. 1998;114:1335-8. [PMID: 9618653]
16. Hamilton SR. The molecular genetics of colorectal neoplasia. Gastroenterology. 1993;105:3-7. [PMID: 8514053]
17. Kapitanovíc S, Radosevíc S, Kapitanovíc M, Andelinovíc S, Ferencíc Z, Tavassoli M, et al. The expression of p185(HER-2/neu) correlates with the stage of disease and survival in colorectal cancer. Gastroenterology. 1997;112:1103-13. [PMID: 9097992]
18. Su LK, Vogelstein B, Kinzler KW. Association of the APC tumor suppressor protein with catenins. Science. 1993;262:1734-7. [PMID: 8259519]
19. Kinzler KW, Vogelstein B. Landscaping the cancer terrain. Science. 1998; 280:1036-7. [PMID: 9616081]
20. Kirsch DG, Kastan MB. Tumor-suppressor p53: implications for tumor development and prognosis. J Clin Oncol. 1998;16:3158-68. [PMID: 9738588]
21. Kressner U, Inganäs M, Byding S, Blikstad I, Påhlman L, Glimelius B, et al. Prognostic value of p53 genetic changes in colorectal cancer. J Clin Oncol. 1999;17:593-9. [PMID: 10080604]
22. Fearon ER, Cho KR, Nigro JM, Kern SE, Simons JW, Ruppert JM, et al. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science. 1990;247:49-56. [PMID: 2294591]
23. Sun XF, Rütten S, Zhang H, Nordenskjöld B. Expression of the deleted in colorectal cancer gene is related to prognosis in DNA diploid and low proliferative colorectal adenocarcinoma, J Clin Oncol. 1999;17:1745-50. [PMID: 10561211]
24. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, et al. Genetic alterations during colorectal-tumor development. N Engl J Med. 1988;319:525-32. [PMID: 2841597]
25. Papadopoulos N, Nicolaides NC, Liu B, Parsons R, Lengauer C, Palombo F, et al. Mutations of GTBP in genetically unstable cells. Science. 1995;268: 1915-7. [PMID: 7604266]
26. Baker SM, Bronner CE, Zhang L, Plug AW, Robatzek M, Warren G, et al. Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell. 1995;82:309-19. [PMID: 7628019]
27. Papadopoulos N, Nicolaides NC, Wei YF, Ruben SM, Carter KC, Rosen CA, et al. Mutation of a mutL homolog in hereditary colon cancer. Science. 1994;263:1625-9. [PMID: 81282511]
28. Boland CR, Thibodeau SN, Hamilton SR, Sidransky D, Eshleman JR, Burt RW, et al. A National Cancer Institute Workshop on Microsarellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res. 1998;58:5248-57. [PMID: 9823339]
29. Parc YR, Halling KC, Wang L, Christensen ER, Cunningham JM, French AJ, et al. HMSH6 alterations in patients with microsatellite instability-low colorectal cancer. Cancer Res. 2000;60:2225-31. [PMID: 10786688]
30. Syngal S, Weeks JC, Schrag D, Garber JE, Kuntz KM. Benefits of colonoscopic surveillance and prophylactic colectomy in patients with hereditary nonpolyposis colorectal cancer mutations. Ann Intern Med. 1998;129:787-96. [PMID: 9841584]
31. Giardiello FM, Hamilton SR, Krush AJ, Piantadosi S, Hylind LM, Celano P, et al. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N Engl J Med. 1993;328:1313-6. [PMID: 8385741]
32. He TC, Chan TA, Vogelstein B, Kinzler KW. PPARΔ is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell. 1999;99:335-45. [PMID: 10555149]
33. Yang WL, Frucht H. Activation of the PPARγ pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells. Carcinogenesis. 2001;22:1379-83. [PMID: 11532858]
34. Frucht H, Gazdar AF, Park JA, Oie H, Jensen RT. Characterization of functional receptors for gastrointestinal hormones on human colon cancer cells. Cancer Res. 1992;52:1114-22. [PMID: 1310640]
35. Frucht H, Jensen RT, Dexter D, Yang WL, Xiao Y. Human colon cancer cell proliferation mediated by the M3 muscarinic cholinergic receptor. Clin Cancer Res. 1999;5:2532-9. [PMID: 10499630]
36. Yang WL, Frucht H. Cholinergic receptor up-regulates COX-2 expression and prostaglandin E(2) production in colon cancer cells. Carcinogenesis. 2000; 21:1789-93. [PMID: 11023534]
37. 3 muscarinic receptors on a colon cancer cell line. Biochem Biophys Acta. 2002; [In press]
38. Reddy BS, Wynder EL. Metabolic epidemiology of colon cancer. Fecal bile acids and neutral sterols in colon cancer patients and patients with adenomarous polyps. Cancer. 1977;39:2533-9. [PMID: 872053]
39. Hill MJ, Drasar BS, Williams RE, Meade TW, Cox AG, Simpson JE, et al. Faecal bile-acids and clostridia in patients with cancer of the large bowel. Lancet. 1975;1:535-9. [PMID: 47015]
40. Hill MJ. Bile acids and colorectal cancer: hypothesis. Eur J Cancer Prev. 1991;1 Suppl 2:69-74. [PMID: 1842736]
41. Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, Koskenvuo M, et al. Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med. 2000; 343:78-85. [PMID: 10891514]
42. Ekbom A, Yuen J, Adami HO, McLaughlin JK, Chow WH, Persson I, et al. Cholecystectomy and colorectal cancer. Gastroenterology. 1993;105:142-7. [PMID: 8514031]
43. Giovannucci E, Colditz GA, Stampfer MJ. A meta-analysis of cholecystectomy and risk of colorectal cancer. Gastroenterology. 1993;105:130-41. [PMID: 8514030]
44. Zuccato E, Venturi M, Di Leo G, Colombo L, Bertolo C, Doldi SB, et al. Role of bile acids and metabolic activity of colonic bacteria in increased risk of colon cancer after cholecystectomy. Dig Dis Sci. 1993;38:514-9. [PMID: 8444084]
45. Giardiello FM, Brensinger JD, Petersen GM, Luce MC, Hylind LM, Bacon JA, et al. The use and interpretation of commercial APC gene testing for familial adenomatous polyposis. N Engl J Med. 1997;336:823-7. [PMID: 9062090]
46. Vasen HF, Mecklin JP, Khan PM, Lynch HT. The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC). Dis Colon Rectum. 1991;34:424-5. [PMID: 2022152]
47. Vasen HF, Watson P, Mecklin JP, Lynch HT. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology. 1999; 116:1453-6. [PMID: 10348829]
48. Syngal S, Fox EA, Li C, Dovidio M, Eng C, Kolodner RD, et al. Interpretation of genetic test results for hereditary nonpolyposis colorectal cancer: implications for clinical predisposition resting. JAMA. 1999;282:247-53. [PMID: 10422993]
49. Terdiman JP, Gum JR Jr, Conrad PG, Miller GA, Weinberg V, Crawley SC, et al. Efficient detection of hereditary nonpolyposis colorectal cancer gene carriers by screening for tumor microsatellite instability before germline genetic testing. Gastroenterology. 2001;120:21-30. [PMID: 11208710]
50. Petersen GM. Genetic testing and counseling in familial adenomatous polyposis. Oncology (Huntingt). 1996;10:89-94; discussion 97-8. [PMID: 8924369]
51. Matloff ET, Shappell H, Brierley K, Bernhardt BA, McKinnon W, Peshkin BN. What would you do? Specialists' perspectives on cancer genetic testing, prophylactic surgery, and insurance discrimination. J Clin Oncol. 2000;18:248492. [PMID: 10856109]
52. Lynch HT, Paulson J, Severin M, Lynch J, Lynch P. Failure to diagnose hereditary colorectal cancer and its medicolegal implications: a hereditary nonpolyposis colorectal cancer case. Dis Colon Rectum. 1999;42:31-5. [PMID: 10211517]
53. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell. 1996;87:159-70. [PMID: 8861899]
54. Frazier ML, Su LK, Amos CI, Lynch PM. Current applications of genetic technology in predisposition testing and microsatellite instability assays. J Clin Oncol. 2000;18:70S-4S. [PMID: 11060331]
55. Ponder B. Genetic testing for cancer risk. Science. 1997;278:1050-4. [PMID: 9353178]
56. Winawer SJ, Fletcher RH, Miller L, Godlee F, Stolar MH, Mulrow CD, et al. Colorectal cancer screening: clinical guidelines and rationale. Gastroenterology. 1997;112:594-642. [PMID: 9024315]
57. Desch CE, Benson AB 3rd, Smith TJ, Flynn PJ, Krause C, Loprinzi CL, et al. Recommended colorectal cancer surveillance guidelines by the American Society of Clinical Oncology. J Clin Oncol. 1999;17:1312. [PMID: 10561194]
58. Burt RW. Colon cancer screening. Gastroenterology. 2000;119:837-53. [PMID: 10982778]