Characterization of rat CD8+ uveitogenic T cells specific for interphotoreceptor retinal-binding protein 1177-1191

Journal of Immunology

Volumn 173, Issue 4, 2004, Pages 2849-2854

  Shao, Hui ^a   Sun, Sheher L ^a   Kaplan, Henry J ^a   Sun, Deming ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERPHOTORECEPTOR RETINOID BINDING PROTEIN; INTERPHOTORECEPTOR RETINOID BINDING PROTEIN R16; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; FEMALE; LYMPHOCYTE PROLIFERATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; RAT STRAIN; T LYMPHOCYTE; UVEITIS;

EID: 4043160580     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.4.2849     Document Type: Article

References (37)

1. Donoso, L. A., C. F. Merryman, T. Sery, R. Sanders, T. Vrabec, and S. L. Fong. 1989. Human interstitial retinoid binding protein: a potent uveitopathogenic agent for the induction of experimental autoimmune uveitis. J. Immunol. 143:79.
2. Gery, I., B. Wiggert, T. M. Redmond, T. Kuwabara, M. A. Crawford, B. P. Vistica, and G. J. Chader. 1986. Uveoretinitis and pinealitis induced by immunization with interphotoreceptor retinoid-binding protein. Invest. Ophthalmol. Visual Sci. 27:1296.
3. Broekhuyse, R. M., E. D. Kuhlmann, and H. J. Winkens. 1992. Experimental autoimmune anterior uveitis (EAAU). II. Dose-dependent induction and adoptive transfer using a melanin-bound antigen of the retinal pigment epithelium. Exp. Eye Res. 55:401.
4. Bora, N. S., M. C. Kim, N. H. Kabeer, S. C. Simpson, M. T. Tandhasetti, T. P. Cirrito, A. D. Kaplan, and H. J. Kaplan. 1995. Experimental autoimmune anterior uveitis: induction with melanin-associated antigen from the iris and ciliary body. Invest. Ophthalmol. Visual Sci. 36:1056.
5. Constantinescu, C. S., and E. Lavi. 2000. Anterior uveitis in murine relapsing experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS). Curr. Eye Res. 20:71.
6. Bullington, S. J., and B. H. Waksman. 1958. Uveitis in rabbits with experimental allergic encephalomyelitis. Arch. Ophthalmol. 59:435.
7. Shao, H., S. L. Sun, H. J. Kaplan, and D. Sun. 2002. Induction of autoimmune encephalomyelitis and uveitis in B6 and (B6 × SJL) mice by peptides derived from myelin/oligodendrocyte glycoprotein. J. Neuroimmunol. 132:117.
8. Hu, L. H., T. M. Redmond, H. Sanui, T. Kuwabara, C. G. McAllister, B. Wiggert, G. J. Chader, and I. Gery. 1989. Rat T-cell lines specific to a nonimmunodominant determinant of a retinal protein (IRBP) produce uveoretinitis and pinealitis. Cell. Immunol. 122:251.
9. Agarwal, R. K., Y. Kang, E. Zambidis, D. W. Scott, C. C. Chan, and R. R. Caspi. 2000. Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis. J. Clin. Invest. 106:245.
10. Adamus, G., M. Manczak, B, Sugden, A. Arendt, P. A. Hargrave, and H. Offner. 2000. Epitope recognition and T cell receptors in recurrent autoimmune anterior uveitis in Lewis rats immunized with myelin basic protein. J. Neuroimmunol. 108:122.
11. + T cells are encephalitogenic and produce severe disease in C57BL/6 mice. J. Immunol. 166:7579.
12. Lyons, A. B., and C. R. Parish. 1994. Determination of lymphocyte division by flow cytometry. J. Immunol. Methods 171:131.
13. Lyons, A. B. 2000. Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution. J. Immunol. Methods 243:147.
14. + regulatory T cells. J. Immunol. 171:3348.
15. + T cells are essential to induce experimental autoimmune myasthenia gravis. J. Exp. Med. 184:349.
16. Liblau, R. S., F. S. Wong, L. T. Mars, and P. Santamaria. 2002. Autoreactive CD8 T cells in organ-specific autoimmunity: emerging targets for therapeutic intervention. Immunity 17:1.
17. + T cells in a model for multiple sclerosis. J. Exp. Med. 194:669.
18. Wong, F. S., I. Visintin, L. Wen, R. A. Flavell, and C. A. Janeway. 1996. CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. J. Exp. Med. 183:67.
19. + T cells are required for iodine accelerated thyroiditis in NOD mice. Cell. Immunol. 192:113.
20. Sanui, H., T. M. Redmond, S. Kotake, B. Wiggert, L. H. Hu, H. Margalit, J. A. Berzofsky, G. J. Chader, and I. Gery. 1989. Identification of an immunodominant and highly immunopathogenic determinant in the retinal interphotoreceptor retinoid-binding protein (IRBP). J. Exp. Med. 169:1947.
21. Shao, H., Y.-X. Fu, L. Song, S. Sun, H. J. Kaplan, and D. Sun. 2003. LTβR-Ig treatment blocks actively induced, but not adoptively transferred, uveitis in Lewis rats. Eur. J. Immunol. 33:1743.
22. Shao, H., S. Lei, S. Sun, J. Xiang, H. J. Kaplan, and D. Sun. 2003. CpG-containing oligodeoxynucleotide 1826 converts the weak uveitogenic rat interphotoreceptor retinoid-binding protein peptide 1181-1191 into a strong uveitogen. J. Immunol. 171:4780.
23. Shao, H., L. Song, S. L. Sun, H. J. Kaplan, and D. Sun. 2003. Conversion of monophasic to recurrent autoimmune disease by autoreactive T cell subsets. J. Immunol. 171:5624.
24. + T cells in experimental autoimmune encephalomyelitis. J. Immunol. 143:2867.
25. Sun, D., X. Hu, J. Le, and R. H. Swanborg. 1994. Characterization of brain-isolated rat encephalitogenic T cell lines. Eur. J. Immunol. 24:1359.
26. 68-88 peptide. Eur. J. Immunol. 25:1687.
27. Sun, D., Y. Qin, J. Chluba, J. T. Epplen, and H. Wekerle. 1988. Suppression of experimentally-induced autoimmune encephalomyelitis by cytolytic T-T cell interactions. Nature 332:843.
28. Sun, D. 1992. Synthetic peptides representing sequence 39 to 59 of rat Vβ8 TCR fail to elicit regulatory T cells reactive with Vβ8 TCR on rat encephalitogenic T cells. Cell. Immunol. 141:200.
29. + MOG-specific T cells on oligomeric MHC class I molecules. Int. Immunol. 15:261.
30. Tuohy, V. K., Z. Lu, R. A. Sobel, R. A. Laursen, and M. B. Lees. 1988. A synthetic peptide from myelin proteolipid protein induces experimental allergic encephalomyelitis. J. Immumol. 141:1126.
31. s) tetramers. J. Immunol. 170:870.
32. + T cell line and clone that induce experimental autoimmune uveoretinitis in B 10.A mice. J. Immunol. 156:1654.
33. Rozenszajn, L. A., C. Muellenberg-Coulombre, I. Gery, M. El-Saied, T. Kuwabara, M. Mochizuki, Z. Lando, and R. B. Nussenblatt. 1986. Induction of experimental autoimmune uveoretinitis by T-cell lines. Immunology 57:559.
34. Gregerson, D. S., W. F. Obritsch, S. P. Fling, and J. D. Cameron. 1986. S-antigen-specific rat T cell lines recognize peptide fragments of S-antigen and mediate experimental autoimmune uveoretinitis and pinealitis. J. Immunol. 136:2875.
35. McPherson, S. W., J. Yang, C. C. Chan, C. Dou, and D. S. Gregerson. 2003. Resting CD8 T cells recognize β-galactosidase expressed in the immune-privileged retina and mediate autoimmune disease when activated. Immunology 110:386.
36. Sedgwick, J., S. W. Brostoff, and D. Mason. 1987. Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. J. Exp. Med. 165:1058.
37. 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis. Lab. Invest. 63:162.