Strategies to search and design stabilizers of protein-protein interactions: A feasibility study

Proteins: Structure, Function and Genetics

Volumn 68, Issue 1, 2007, Pages 170-186

  Block, Peter ^a   Weskamp, Nils ^a   Wolf, Alexander ^b   Klebe, Gerhard ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

Docking; H+ ATPase 14 3 3; Interface stabilizers; Protein protein interfaces; Rim exposed binding pockets; Virtual screening

Indexed keywords

ACETYLCHOLINESTERASE; ADENYLATE CYCLASE; BREFELDIN A; CARBONATE DEHYDRATASE II; CD86 ANTIGEN; CYCLOOXYGENASE 2; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DIHYDROFOLATE REDUCTASE; FORSKOLIN; FUSICOCCIN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; LIGAND; MAMMALIAN TARGET OF RAPAMYCIN; MOCIMYCIN; PACLITAXEL; PLANT TOXIN; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MDM2; PROTEIN P53; PROTEINASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; SOLVENT; TACROLIMUS;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; ENZYME ACTIVE SITE; FEASIBILITY STUDY; HYDROGEN BOND; HYDROPHILICITY; LIGAND BINDING; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN DATA BANK; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SOLVATION; SURFACE PLASMON RESONANCE;

14-3-3 PROTEINS; BINDING SITES; COMPUTATIONAL BIOLOGY; DATABASES, PROTEIN; GLYCOSIDES; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOTOXINS; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEINS; PROTON-TRANSLOCATING ATPASES; SMALL MOLECULE LIBRARIES;

EID: 34249874926     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21296     Document Type: Article

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