NMR characterization of interleukin-2 in complexes with the IL-2Rα receptor component, and with low molecular weight compounds that inhibit the IL-2/IL-Rα interaction

Protein Science

Volumn 12, Issue 4, 2003, Pages 811-822

  Emerson, S Donald ^a,b   Palermo, Robert ^a,c   Liu, Chao Min ^a   Tilley, Jefferson W ^a   Chen, Li ^a   Danho, Waleed ^a   Madison, Vincent S ^a,c   Greeley, David N ^a   Ju, Grace ^a   Fry, David C ^a  

^a HOFFMANN LA ROCHE INC   (United States)

^b PFIZER INC   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

HSQC perturbation mapping; Interleukin 2; Interleukin 2 receptor; Nuclear magnetic resonance; Protein binding inhibitors; Protein protein interactions

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; LIGAND; PEPTIDE DERIVATIVE; PHENYLALANINE; RECEPTOR SUBUNIT;

ARTICLE; BINDING SITE; COMPLEX FORMATION; ION EXCHANGE; LIGAND BINDING; MOLECULAR WEIGHT; MUTAGENESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; PICHIA; RECEPTORS, INTERLEUKIN;

MURINAE;

EID: 0037379162     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.0232803     Document Type: Article

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