Increased calpain expression following experimental cerebral venous thrombosis in rats

Thrombosis Research

Volumn 112, Issue 4, 2003, Pages 239-243

  Liebetrau, Martin ^a   Gabriejcic Geiger, Dusica ^b   Meyer, Phillip ^c   Roether, Joachim ^c   Hamann, Gerhard F ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Calpain; Cerebral ischemia; Cerebral venous thrombosis; Immunohistochemistry; Microtubule associated protein 2

Indexed keywords

CALPAIN; PHOSPHATIDYLETHANOLAMINE; POLYCLONAL ANTIBODY; PROTEIN KINASE (CALCIUM,CALMODULIN);

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY LIGATION; ARTICLE; BRAIN ISCHEMIA; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; ENZYME SUBSTRATE; IMMUNOHISTOCHEMISTRY; MALE; NEUROIMAGING; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STAINING; SUPERIOR COLLICULUS; SUPERIOR SAGITTAL SINUS; VIDEORECORDING;

EID: 1342345209     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2003.12.013     Document Type: Article

References (18)

1. Breteau G., Mounier-Vehier F., Godefroy O., Gauvrit J.Y., Mackowiak-Cordoliani M.A., Girot M.et al. Cerebral venous thrombosis 3-year clinical outcome in 55 consecutive patients. J. Neurol. 250:2003;29-35.
2. Nakase H., Kempski O.S., Heimann A., Takeshima T., Tintera J. Microcirculation after cerebral venous occlusions as assessed by laser Doppler scanning. J. Neurosurg. 87:1997;307-314.
3. Kurokawa Y., Hashi K., Okuyama T., Uede T. Regional ischemia in cerebral venous hypertension due to embolic occlusion of the superior sagittal sinus in the rat. Surg. Neurol. 34:1990;390-395.
4. Frerichs K.U., Deckert M., Kempski O., Schurer L., Einhaupl K., Baethmann A. Cerebral sinus and venous thrombosis in rats induces long-term deficits in brain function and morphology-evidence for a cytotoxic genesis. J. Cereb. Blood Flow Metab. 14:1994;289-300.
5. Sakaki T., Kakizaki T., Takeshima T., Miyamoto K., Tsujimoto S. Importance of prevention of intravenous thrombosis and preservation of the venous collateral flow in bridging vein injury during surgery: an experimental study. Surg. Neurol. 44:1995;158-162.
6. Rother J., Waggie K., van Bruggen N., de Crespigny A.J., Moseley M.E. Experimental cerebral venous thrombosis: evaluation using magnetic resonance imaging. J. Cereb. Blood Flow Metab. 16:1996;1353-1361.
7. Sorimachi H., Ishiura S., Suzuki K. Structure and physiological function of calpains. Biochem. J. 328:1997;721-732.
8. Neumar R.W., Meng F.H., Mills A.M., Xu Y.A., Zhang C., Welsh F.A.et al. Calpain activity in the rat brain after transient forebrain ischemia. Exp. Neurol. 170:2001;27-35.
9. Liebetrau M., Staufer B., Auerswald E.A., Gabrijelcic-Geiger D., Fritz H., Zimmermann C.et al. Increased intracellular calpain detection in experimental focal cerebral ischemia. NeuroReport. 10:1999;529-534.
10. Huh G.Y., Glantz S.B., Je S., Morrow J.S., Kim J.H. Calpain proteolysis of alpha II-spectrin in the normal adult human brain. Neurosci. Lett. 316:2001;41-44.
11. Takagaki Y., Itoh Y., Aoki Y., Ukai Y., Yoshikuni Y., Kimura K. Inhibition of ischemia-induced fodrin breakdown by a novel phenylpyrimidine derivative NS-7: an implication for its neuroprotective action in rats with middle cerebral artery occlusion. J. Neurochem. 68:1997;2507-2513.
12. Saatman K.E., Bozyczko C.D., Marcy V., Siman R., McIntosh T.K. Prolonged calpain-mediated spectrin breakdown occurs regionally following experimental brain injury in the rat. J. Neuropathol. Exp. Neurol. 55:1996;850-860.
13. Yamashima T. Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates. Prog. Neurobiol. 62:2000;273-295.
14. Hamann G.F., Liebetrau M., Martens H., Burggraf D., Kloss C.U., Bultemeier G.et al. Microvascular basal lamina injury after experimental focal cerebral ischemia and reperfusion in the rat. J. Cereb. Blood Flow Metab. 22:2002;526-533.
15. Hong S.C., Goto Y., Lanzino G., Soleau S., Kassell N.F., Lee K.S. Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia. Stroke. 25:1994;663-669.
16. Markgraf C.G., Velayo N.L., Johnson M.P., McCarty D.R., Medhi S., Koehl J.R.et al. Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats. Stroke. 29:1998 (Jan.);152-158.
17. Bartus R.T., Baker K.L., Heiser A.D., Sawyer S.D., Dean R.L., Elliott P.J.et al. Postischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage. J. Cereb. Blood Flow Metab. 14:1994;537-544.
18. Yamashima T., Tonchev A.B., Tsukada T., Saido T.C., Imajoh-Ohmi S., Momoi T.et al. Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates. Hippocampus. 13:2003;791-800.