Transient middle cerebral artery occlusion by intraluminal suture: II. Neurological deficits, and pixel-based correlation of histopathology with local blood flow and glucose utilization

Journal of Cerebral Blood Flow and Metabolism

Volumn 17, Issue 12, 1997, Pages 1281-1290

  Zhao, Weizhao ^a   Belayev, Ludmila ^a   Ginsberg, Myron D ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Auto radiography; Cerebral infarction; Focal cerebral ischemia; Image processing; Penumbra; Stroke

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN INFARCTION; CELL SURVIVAL; CONTROLLED STUDY; GLUCOSE UTILIZATION; HEMISPHERE; HISTOPATHOLOGY; IMAGE ANALYSIS; IMAGE PROCESSING; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; RAT; SUTURE;

EID: 0030670117     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199712000-00003     Document Type: Article

References (35)

1. Alexis NE, Back T, Zhao W, Dietrich WD, Watson BD, Ginsberg MD (1996) Neurobehavioral consequences of induced spreading depression following photothrombotic middle cerebral artery occlusion. Brain Res 706:273-282
2. Back T, Ginsberg MD, Dietrich WD, Watson BD (1996) Induction of spreading depression in the ischemic hemisphere following experimental middle cerebral artery occlusion: effect on infarct morphology. J Cereb Blood Flow Metab 16:202-213
3. Back T, Nedergaard M, Ginsberg MD: The ischemic penumbra: pathophysiology, and relevance of spreading depression-like phenomena. In: Cerebrovascular Disease: Pathophysiology, Diagnosis and Treatment (Ginsberg MD, Bougousslavsky J, eds), Cambridge Blackwell Scientific, (in press)
4. Barth TM, Jones TA, Schallen T (1990) Functional subdivisions of the rat somatic sensorimotor cortex. Behav Brain Res 39:73-95
5. Bartus RT, Dean RL, Cavanaugh K, Eveleth D, Carriero DL, Lyeth G (1995) Time-related neuronal changes following middle cerebral artery occlusion: implications for therapeutic intervention and the role of calpain. J Cereb Blood Flow Metab 15:969-979
6. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H (1986) Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17: 472-476
7. Belayev L, Alonso OF, Busto R, Zhao W, Ginsberg MD (1996) Middle cerebral artery occlusion in the rat intraluminal by suture: neurological and pathological evaluation of an improved model. Stroke 27:1616-1623
8. Belayev L, Busto R, Zhao W, Ginsberg MD (1995) HU-211, a novel noncompetitive N-methyl-D-aspartate antagonist, improves neurological deficit and reduces infarct volume after reversible focal cerebral ischemia in the rat. Stroke 26:2313-2320
9. Belayev L, Zhao W, Busto R, Ginsberg MD (1997) Transient middle cerebral artery occlusion by intraluminal suture: I. Three-dimensional autoradiographic image-analysis of local cerebral glucose metabolism - blood flow interrelationships during ischemia and early recirculation. J Cereb Blood Flow Metab 17:1266-1280
10. Buchan AM, Xue D, Slivka A (1992) A new model of temporary focal neocortical ischemia in the rat. Stroke 23:273-279
11. Charriaut-Marlangue C, Margaill I, Plotkine M, Ben-Ari Y (1995) Early endonuclease activation following reversible focal ischemia in the rat brain. J Cereb Blood Flow Metab 15:385-388
12. De Ryck M, Van Reempts J, Borgers M, Wauquier A, Janssen PAJ (1989) Photochemical stroke model: flunarizine prevents sensorimotor deficits after neocortical infarcts in rats. Stroke 20:1383-1390
13. De Ryck M, Van Reempts J, Duytschaever H, Van Deuren B, Clincke G (1992) Neocortical localization of tactile/proprioceptive limb placing reactions in the rat. Brain Res 573:44-60
14. Du C, Hu R, Csernansky CA, Hsu CY, Choi DW (1996) Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis? J Cereb Blood Flow Metab 16:196-201
15. Garcia JH, Wagner S, Liu K-F, Hu X-j (1995) Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats: statistical validation. Stroke 26:627-635
16. Hakim AM, Hogan MJ, Carpenter S (1992) Time course of cerebral blood flow and histological outcome after focal cerebral ischemia in rats. Stroke 23:1138-1143
17. Kaplan B, Brint S, Tanabe J, Jacewicz M, Wang X-J, Pulsinelli W (1991) Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia. Stroke 22:1032-1039
18. Lassen NA (1982) Incomplete cerebral infarction - focal incomplete ischemic tissue necrosis not leading to emollision. Stroke 13:522-523
19. Li Y, Chopp M, Jiang N, Yao F, Zaloga C (1995) Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 15:389-397
20. Linnik MD, Miller JA, Sprinkle-Cavallo J, Mason PJ, Thompson FY, Montgomery LR, Schroeder KK (1995) Apoptotic DNA fragmentation in the rat cerebral cortex induced by permanent middle cerebral artery occlusion. Mol Brain Res 32:116-124
21. Markgraf CG, Green EJ, Hurwitz BE, Morikawa E, Dietrich WD, McCabe PM, Ginsberg MD, Schneiderman N (1992) Sensorimotor and cognitive consequences of middle cerebral artery occlusion in rats. Brain Res 575:238-246
22. Markgraf CG, Kraydieh S, Prado R, Watson BD, Dietrich WD, Ginsberg MD (1993) Comparative histopathologic consequences of photothrombotic occlusion of the distal middle cerebral artery in Sprague-Dawley and Wistar rats. Stroke 24:286-292
23. Memezawa H, Minamisawa H, Smith M-L, Siesjö BK (1992a) Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat. Exp Brain Res 89:67-78
24. Memezawa H, Smith M-L, Siesjö BK (1992b) Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats. Stroke 23:552-559
25. Mies G, Auer LM, Ebhardt G, Traupe H, Heiss W-D (1983) Flow and neuronal density in tissue surrounding chronic infarction. Stroke 14:22-27
26. Nagasawa H, Kogure K (1989) Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion. Stroke 20:1037-1043
27. 2 antagonist, markedly reduces infarct size following middle cerebral artery occlusion in the rat. Neurology 38:1667-1673
28. Nedergaard M (1987) Neuronal injury in the infarct border: a neuropathological study in the rat. Acta Neuropathol (Berl) 73:267-274
29. Strong AJ, Tomlinson BE, Venables GS, Gibson G, Hardy JA (1983) The cortical ischaemic penumbra associated with occlusion of the middle cerebral artery in the cat: 2. Studies of histopathology, water content, and in vitro neurotransmitter uptake. J Cereb Blood Flow Metab 3:97-108
30. Takagi K, Ginsberg MD, Globus MY-T, Dietrich WD, Martinez E, Kraydieh S, Busto R (1993) Changes in amino acid neurotransmitters and cerebral blood flow in the ischemic penumbral region following middle cerebral artery occlusion in the rat: correlation with histopathology. J Cereb Blood Flow Metab 13:575-585
31. Wahl F, Allix M, Plotkine M, Boulu RG (1992) Neurological and behavioral outcomes of focal cerebral ischemia in rats. Stroke 23: 267-272
32. Zea Longa E, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84-91
33. Zhao W, Ginsberg MD, Prado R, Belayev L (1996) Depiction of infarct frequency distribution by computer-assisted image-mapping in rat brains with middle cerebral artery occlusion: comparison of photothrombotic and intraluminal suture models. Stroke 27:1112-1117
34. Zhao W, Ginsberg MD, Smith DW (1995) Three-dimensional quantitative autoradiography by disparity analysis: theory and application to image-averaging of local cerebral glucose utilization. J Cereb Blood Flow Metab 15:552-565
35. Zilles K (1985) The Cortex of the Rat. Springer-Verlag, New York