메뉴 건너뛰기




Volumn 21, Issue 8, 2007, Pages 1902-1914

Zorro locked nucleic acid induces sequence-specific gene silencing

Author keywords

DNA binding; Gene transcription; Oligonucleotide; Peptide nucleic acid; PNA LNA

Indexed keywords

ANTIGEN; DOUBLE STRANDED DNA; LOCKED NUCLEIC ACID; OLIGONUCLEOTIDE; PEPTIDE NUCLEIC ACID; UNCLASSIFIED DRUG; ZORRO LOCKED NUCLEIC ACID;

EID: 34249820545     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-7225com     Document Type: Article
Times cited : (23)

References (51)
  • 1
    • 10044225983 scopus 로고    scopus 로고
    • Triplex-forming oligonucleotides - sequence-specific DNA ligands as tools for gene inhibition and for modulation of DNA-associated functions
    • Besch, R., Giovannangeli, C., and Degitz, K. (2004) Triplex-forming oligonucleotides - sequence-specific DNA ligands as tools for gene inhibition and for modulation of DNA-associated functions. Curr. Drug. Targets 5, 691-703
    • (2004) Curr. Drug. Targets , vol.5 , pp. 691-703
    • Besch, R.1    Giovannangeli, C.2    Degitz, K.3
  • 3
    • 0035830485 scopus 로고    scopus 로고
    • Transcription inhibition induced by modified triple helix-forming oligonucleotides: A quantitative assay for evaluation in cells
    • Faria, M., Wood, C. D., White, M. R., Helene, C., and Giovannangeli, C. (2001) Transcription inhibition induced by modified triple helix-forming oligonucleotides: a quantitative assay for evaluation in cells. J. Mol. Biol. 306, 15-24
    • (2001) J. Mol. Biol , vol.306 , pp. 15-24
    • Faria, M.1    Wood, C.D.2    White, M.R.3    Helene, C.4    Giovannangeli, C.5
  • 4
    • 21244489606 scopus 로고    scopus 로고
    • Exploring cellular activity of locked nucleic acid-modified triplex-forming oligonucleotides and defining its molecular basis
    • Brunet, E., Alberti, P., Perrouault, L., Babu, R., Wengel, J., and Giovannangeli, C. (2005) Exploring cellular activity of locked nucleic acid-modified triplex-forming oligonucleotides and defining its molecular basis. J. Biol. Chem. 280, 20076-20085
    • (2005) J. Biol. Chem , vol.280 , pp. 20076-20085
    • Brunet, E.1    Alberti, P.2    Perrouault, L.3    Babu, R.4    Wengel, J.5    Giovannangeli, C.6
  • 5
    • 0037197844 scopus 로고    scopus 로고
    • Human XPA and RPA DNA repair proteins participate in specific recognition of triplex-induced helical distortions
    • Vasquez, K. M., Christensen, J., Li, L., Finch, R. A., and Glazer, P. M. (2002) Human XPA and RPA DNA repair proteins participate in specific recognition of triplex-induced helical distortions. Proc. Natl. Acad. Sci. U. S. A. 99, 5848-5853
    • (2002) Proc. Natl. Acad. Sci. U. S. A , vol.99 , pp. 5848-5853
    • Vasquez, K.M.1    Christensen, J.2    Li, L.3    Finch, R.A.4    Glazer, P.M.5
  • 6
    • 0037832279 scopus 로고    scopus 로고
    • Recognition of the DNA minor groove by pyrrole-imidizole polyamides
    • Dervan, P. B., and Edelson, B. S. (2003) Recognition of the DNA minor groove by pyrrole-imidizole polyamides. Curr. Opin. Struct. Biol. 13, 284
    • (2003) Curr. Opin. Struct. Biol , vol.13 , pp. 284
    • Dervan, P.B.1    Edelson, B.S.2
  • 7
    • 0026341239 scopus 로고
    • Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide
    • Nielsen, P. E., Egholm, M., Berg, R. H., and Buchardt, O. (1991) Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Science 254, 1497-1500
    • (1991) Science , vol.254 , pp. 1497-1500
    • Nielsen, P.E.1    Egholm, M.2    Berg, R.H.3    Buchardt, O.4
  • 14
    • 0345445891 scopus 로고    scopus 로고
    • Combined triplex/duplex invasion of double-stranded DNA by "tail-clamp" peptide nucleic acid
    • Bentin, T., Larsen, H. J., and Nielsen, P. E. (2003) Combined triplex/duplex invasion of double-stranded DNA by "tail-clamp" peptide nucleic acid. Biochemistry 42, 13987-13995
    • (2003) Biochemistry , vol.42 , pp. 13987-13995
    • Bentin, T.1    Larsen, H.J.2    Nielsen, P.E.3
  • 15
    • 0345014787 scopus 로고    scopus 로고
    • Extending recognition by peptide nucleic acids (PNAs): Binding to duplex DNA and inhibition of transcription by tail-clamp PNA-peptide conjugates
    • Kaihatsu, K., Shah, R. H., Zhao, X., and Corey, D. R. (2003) Extending recognition by peptide nucleic acids (PNAs): binding to duplex DNA and inhibition of transcription by tail-clamp PNA-peptide conjugates. Biochemistry 42, 13996-14003
    • (2003) Biochemistry , vol.42 , pp. 13996-14003
    • Kaihatsu, K.1    Shah, R.H.2    Zhao, X.3    Corey, D.R.4
  • 16
    • 0028075767 scopus 로고
    • Sequence-specific transcription arrest by peptide nucleic acid bound to the DNA template strand
    • Nielsen, P. E., Egholm, M., and Buchardt, O. (1994) Sequence-specific transcription arrest by peptide nucleic acid bound to the DNA template strand. Gene. 149, 139-145
    • (1994) Gene , vol.149 , pp. 139-145
    • Nielsen, P.E.1    Egholm, M.2    Buchardt, O.3
  • 17
    • 0033595778 scopus 로고    scopus 로고
    • In vitro transcriptional and translational block of the bcl-2 gene operated by peptide nucleic acid
    • Mologni, L., Nielsen, P. E., and Gambacorti-Passerini, C. (1999) In vitro transcriptional and translational block of the bcl-2 gene operated by peptide nucleic acid. Biochem. Biophys. Res. Commun. 264, 537-543
    • (1999) Biochem. Biophys. Res. Commun , vol.264 , pp. 537-543
    • Mologni, L.1    Nielsen, P.E.2    Gambacorti-Passerini, C.3
  • 18
    • 0034655249 scopus 로고    scopus 로고
    • Dihydrotestosterone as a selective cellular/nuclear localization vector for anti-gene peptide nucleic acid in prostatic carcinoma cells
    • Boffa, L. C., Scarfi, S., Mariani, M. R., Damonte, G., Allfrey, V. G., Benatti, U., and Morris, P. L. (2000) Dihydrotestosterone as a selective cellular/nuclear localization vector for anti-gene peptide nucleic acid in prostatic carcinoma cells. Cancer Res. 60, 2258-2262
    • (2000) Cancer Res , vol.60 , pp. 2258-2262
    • Boffa, L.C.1    Scarfi, S.2    Mariani, M.R.3    Damonte, G.4    Allfrey, V.G.5    Benatti, U.6    Morris, P.L.7
  • 20
    • 0030006487 scopus 로고    scopus 로고
    • Invasion of the CAG triplet repeats by a complementary peptide nucleic acid inhibits transcription of the androgen receptor and TATA-binding protein genes and correlates with refolding of an active nucleosome containing a unique AR gene sequence
    • Boffa, L. C., Morris, P. L., Carpaneto, E. M., Louissaint, M., and Allfrey, V. G. (1996) Invasion of the CAG triplet repeats by a complementary peptide nucleic acid inhibits transcription of the androgen receptor and TATA-binding protein genes and correlates with refolding of an active nucleosome containing a unique AR gene sequence. J. Biol. Chem. 271, 13228-13233
    • (1996) J. Biol. Chem , vol.271 , pp. 13228-13233
    • Boffa, L.C.1    Morris, P.L.2    Carpaneto, E.M.3    Louissaint, M.4    Allfrey, V.G.5
  • 21
    • 7444245899 scopus 로고    scopus 로고
    • PNA Technology
    • Nielsen, P. E. (2004) PNA Technology. Mol. Biotechnol. 26, 233-248
    • (2004) Mol. Biotechnol , vol.26 , pp. 233-248
    • Nielsen, P.E.1
  • 23
    • 0032560835 scopus 로고    scopus 로고
    • Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C- methyleneribonucleosides
    • Obika, S., Nanbu, D., Hari, Y., Andoh, J.-i., Morio, K.-i., Doi, T., and Imanishi, T. (1998) Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C- methyleneribonucleosides. Tetrahedron Letters 39, 5401
    • (1998) Tetrahedron Letters , vol.39 , pp. 5401
    • Obika, S.1    Nanbu, D.2    Hari, Y.3    Andoh, J.-I.4    Morio, K.-I.5    Doi, T.6    Imanishi, T.7
  • 24
    • 0001459569 scopus 로고    scopus 로고
    • Synthesis of Novel 2′,3′-Linked Bicyclic Thymine Ribonucleosides
    • Koshkin, A. A., and Wengel, J. (1998) Synthesis of Novel 2′,3′-Linked Bicyclic Thymine Ribonucleosides. J. Org. Chem. 63, 2778-2781
    • (1998) J. Org. Chem , vol.63 , pp. 2778-2781
    • Koshkin, A.A.1    Wengel, J.2
  • 25
    • 0035113736 scopus 로고    scopus 로고
    • Locked nucleic acid (LNA): Fine-tuning the recognition of DNA and RNA
    • Braasch, D. A., and Corey, D. R. (2001) Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA. Chem. Biol. 8, 1-7
    • (2001) Chem. Biol , vol.8 , pp. 1-7
    • Braasch, D.A.1    Corey, D.R.2
  • 26
    • 0000484783 scopus 로고    scopus 로고
    • Synthesis of novel bicyclo[2.2.1] ribonucleosides: 2′-amino- and 2′-thio-LNA monomeric nucleosides
    • Singh, S. K., Kumar, R., and Wengel, J. (1998) Synthesis of novel bicyclo[2.2.1] ribonucleosides: 2′-amino- and 2′-thio-LNA monomeric nucleosides. J. Org. Chem. 63, 6078-6079
    • (1998) J. Org. Chem , vol.63 , pp. 6078-6079
    • Singh, S.K.1    Kumar, R.2    Wengel, J.3
  • 27
    • 6344277190 scopus 로고    scopus 로고
    • LNA (locked nucleic acid): High-affinity targeting of complementary RNA and DNA
    • Vester, B., and Wengel, J. (2004) LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA. Biochemistry 43, 13233-13241
    • (2004) Biochemistry , vol.43 , pp. 13233-13241
    • Vester, B.1    Wengel, J.2
  • 28
    • 0036924811 scopus 로고    scopus 로고
    • Antisense inhibition of gene expression in cells by oligonucleotides incorporating locked nucleic acids: Effect of mRNA target sequence and chimera design
    • Braasch, D. A., Liu, Y., and Corey, D. R. (2002) Antisense inhibition of gene expression in cells by oligonucleotides incorporating locked nucleic acids: effect of mRNA target sequence and chimera design. Nucleic Acids Res. 30, 5160-5167
    • (2002) Nucleic Acids Res , vol.30 , pp. 5160-5167
    • Braasch, D.A.1    Liu, Y.2    Corey, D.R.3
  • 29
    • 0038578021 scopus 로고    scopus 로고
    • Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2′-Omethyl RNA, phosphorothioates and small interfering RNA
    • Grunweller, A., Wyszko, E., Bieber, B., Jahnel, R., Erdmann, V. A., and Kurreck, J. (2003) Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2′-Omethyl RNA, phosphorothioates and small interfering RNA. Nucleic Acids Res. 31, 3185-3193
    • (2003) Nucleic Acids Res , vol.31 , pp. 3185-3193
    • Grunweller, A.1    Wyszko, E.2    Bieber, B.3    Jahnel, R.4    Erdmann, V.A.5    Kurreck, J.6
  • 32
    • 3042651091 scopus 로고    scopus 로고
    • Transcription factor decoy oligonucleotides modified with locked nucleic acids: An in vitro study to reconcile biostability with binding affinity
    • Crinelli, R., Bianchi, M., Gentilini, L., Palma, L., Sorensen, M. D., Bryld, T., Babu, R. B., Arar, K., Wengel, J., and Magnani, M. (2004) Transcription factor decoy oligonucleotides modified with locked nucleic acids: an in vitro study to reconcile biostability with binding affinity. Nucleic Acids Res. 32, 1874-1885
    • (2004) Nucleic Acids Res , vol.32 , pp. 1874-1885
    • Crinelli, R.1    Bianchi, M.2    Gentilini, L.3    Palma, L.4    Sorensen, M.D.5    Bryld, T.6    Babu, R.B.7    Arar, K.8    Wengel, J.9    Magnani, M.10
  • 34
    • 0037145999 scopus 로고    scopus 로고
    • Vester, B., Lundberg, L. B., Sorensen, M. D., Babu, B. R., Douthwaite, S., and Wengel, J. (2002) LNAzymes: incorporation of LNA-type monomers into DNAzymes markedly increases RNA cleavage. J. Am. Chem. Soc. 124, 13682-13683
    • Vester, B., Lundberg, L. B., Sorensen, M. D., Babu, B. R., Douthwaite, S., and Wengel, J. (2002) LNAzymes: incorporation of LNA-type monomers into DNAzymes markedly increases RNA cleavage. J. Am. Chem. Soc. 124, 13682-13683
  • 35
    • 0344874534 scopus 로고    scopus 로고
    • Use of locked nucleic acid oligonucleotides to add functionality to plasmid DNA
    • Hertoghs, K. M., Ellis, J. H., and Catchpole, I. R. (2003) Use of locked nucleic acid oligonucleotides to add functionality to plasmid DNA. Nucleic Acids Res. 31, 5817-5830
    • (2003) Nucleic Acids Res , vol.31 , pp. 5817-5830
    • Hertoghs, K.M.1    Ellis, J.H.2    Catchpole, I.R.3
  • 36
    • 0036773706 scopus 로고    scopus 로고
    • Targeted nucleotide exchange in Saccharomyces cerevisiae directed by short oligonucleotides containing locked nucleic acids
    • Parekh-Olmedo, H., Drury, M., and Kmiec, E. B. (2002) Targeted nucleotide exchange in Saccharomyces cerevisiae directed by short oligonucleotides containing locked nucleic acids. Chem. Biol. 9, 1073-1084
    • (2002) Chem. Biol , vol.9 , pp. 1073-1084
    • Parekh-Olmedo, H.1    Drury, M.2    Kmiec, E.B.3
  • 37
    • 22844432244 scopus 로고    scopus 로고
    • Intercalator conjugates of pyrimidine locked nucleic acid-modified triplex-forming oligonucleotides: Improving DNA binding properties and reaching cellular activities
    • Brunet, E., Corgnali, M., Perrouault, L., Roig, V., Asseline, U., Sorensen, M. D., Babu, B. R., Wengel, J., and Giovannangeli, C. (2005) Intercalator conjugates of pyrimidine locked nucleic acid-modified triplex-forming oligonucleotides: improving DNA binding properties and reaching cellular activities. Nucleic Acids Res. 33, 4223-4234
    • (2005) Nucleic Acids Res , vol.33 , pp. 4223-4234
    • Brunet, E.1    Corgnali, M.2    Perrouault, L.3    Roig, V.4    Asseline, U.5    Sorensen, M.D.6    Babu, B.R.7    Wengel, J.8    Giovannangeli, C.9
  • 41
    • 0034595364 scopus 로고    scopus 로고
    • Inhibition of gene expression and cell proliferation by triple helix-forming oligonucleotides directed to the c-myc gene
    • Catapano, C. V., McGuffie, E. M., Pacheco, D., and Carbone, G. M. (2000) Inhibition of gene expression and cell proliferation by triple helix-forming oligonucleotides directed to the c-myc gene. Biochemistry 39, 5126-5138
    • (2000) Biochemistry , vol.39 , pp. 5126-5138
    • Catapano, C.V.1    McGuffie, E.M.2    Pacheco, D.3    Carbone, G.M.4
  • 42
    • 13444283433 scopus 로고    scopus 로고
    • Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network
    • Petersson, B., Nielsen, B. B., Rasmussen, H., Larsen, I. K., Gajhede, M., Nielsen, P. E., and Kastrup, J. S. (2005) Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network. J. Am. Chem. Soc. 127, 1424-1430
    • (2005) J. Am. Chem. Soc , vol.127 , pp. 1424-1430
    • Petersson, B.1    Nielsen, B.B.2    Rasmussen, H.3    Larsen, I.K.4    Gajhede, M.5    Nielsen, P.E.6    Kastrup, J.S.7
  • 43
    • 0032567339 scopus 로고    scopus 로고
    • Generation of destabilized green fluorescent protein as a transcription reporter
    • Li, X., Zhao, X., Fang, Y., Jiang, X., Duong, T., Fan, C., Huang, C. C., and Kain, S. R. (1998) Generation of destabilized green fluorescent protein as a transcription reporter. J. Biol. Chem. 273, 34970-34975
    • (1998) J. Biol. Chem , vol.273 , pp. 34970-34975
    • Li, X.1    Zhao, X.2    Fang, Y.3    Jiang, X.4    Duong, T.5    Fan, C.6    Huang, C.C.7    Kain, S.R.8
  • 44
    • 27944467877 scopus 로고    scopus 로고
    • Increased stability and specificity through combined hybridization of peptide nucleic acid (PNA) and locked nucleic acid (LNA) to supercoiled plasmids for PNA-anchored "Bioplex"" formation
    • Lundin, K. E., Hasan, M., Moreno, P. M., Tornquist, E., Oprea, I., Svahn, M. G., Simonson, E. O., and Smith, C. I. E. (2005) Increased stability and specificity through combined hybridization of peptide nucleic acid (PNA) and locked nucleic acid (LNA) to supercoiled plasmids for PNA-anchored "Bioplex"" formation. Biomolecular Engineering 22, 185
    • (2005) Biomolecular Engineering , vol.22 , pp. 185
    • Lundin, K.E.1    Hasan, M.2    Moreno, P.M.3    Tornquist, E.4    Oprea, I.5    Svahn, M.G.6    Simonson, E.O.7    Smith, C.I.E.8
  • 45
    • 12844282889 scopus 로고    scopus 로고
    • Alternative nucleic acid analogues for programmable assembly: Hybridization of LNA to PNA
    • Ng, P. S., and Bergstrom, D. E. (2005) Alternative nucleic acid analogues for programmable assembly: hybridization of LNA to PNA. Nano. Lett. 5, 107-111
    • (2005) Nano. Lett , vol.5 , pp. 107-111
    • Ng, P.S.1    Bergstrom, D.E.2
  • 46
    • 2042542807 scopus 로고    scopus 로고
    • Cooperative strand invasion of supercoiled plasmid DNA by mixed linear PNA and PNA-peptide chimeras
    • Lundin, K. E., Ge, R., Svahn, M. G., Tornquist, E., Leijon, M., Branden, L. J., and Smith, C. I. (2004) Cooperative strand invasion of supercoiled plasmid DNA by mixed linear PNA and PNA-peptide chimeras. Biomol. Eng. 21, 51-59
    • (2004) Biomol. Eng , vol.21 , pp. 51-59
    • Lundin, K.E.1    Ge, R.2    Svahn, M.G.3    Tornquist, E.4    Leijon, M.5    Branden, L.J.6    Smith, C.I.7
  • 48
    • 33745928141 scopus 로고    scopus 로고
    • Biological activity and biotechnological aspects of peptide nucleic acid
    • Lundin, K. E., Good, L., Stromberg, R., Graslund, A., and Smith, C. I. (2006) Biological activity and biotechnological aspects of peptide nucleic acid. Adv. Genet. 56, 1-51
    • (2006) Adv. Genet , vol.56 , pp. 1-51
    • Lundin, K.E.1    Good, L.2    Stromberg, R.3    Graslund, A.4    Smith, C.I.5
  • 49
    • 0028175775 scopus 로고
    • Peptide nucleic acid. DNA strand displacement loops as artificial transcription promoters
    • Mollegaard, N. E., Buchardt, O., Egholm, M., and Nielsen, P. E. (1994) Peptide nucleic acid. DNA strand displacement loops as artificial transcription promoters. Proc. Natl. Acad. Sci. U. S. A. 91, 3892-3895
    • (1994) Proc. Natl. Acad. Sci. U. S. A , vol.91 , pp. 3892-3895
    • Mollegaard, N.E.1    Buchardt, O.2    Egholm, M.3    Nielsen, P.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.