LNAzymes: Incorporation of LNA-type monomers into DNAzymes markedly increases RNA cleavage

Journal of the American Chemical Society

Volumn 124, Issue 46, 2002, Pages 13682-13683

  Vester, Birte ^a   Lundberg, Lars Bo ^a   Sørensen, Mads D ^b   Babu, B Ravindra ^a   Douthwaite, Stephen ^c   Wengel, Jesper ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENZYME; NUCLEIC ACID;

ARTICLE; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME SUBSTRATE COMPLEX; RNA CLEAVAGE; RNA SEQUENCE; THERMOSTABILITY;

DNA, CATALYTIC; NUCLEIC ACID CONFORMATION; RNA; STEREOISOMERISM; THYMINE NUCLEOTIDES;

EID: 0037145999     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0276220     Document Type: Article

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7. (a) We define LNA as an oligonucleotide containing one or more 2′-O,4′-C-methylene-β-D-ribofuranosyl nucleotide monomer (s) (ref 4a). Similarly, we define α-L-LNA as an oligonucleotide containing one or more 2′-O,4′-C-methylene-α-L-ribofuranosyl nucleotide monomer(s) (ref 5a)
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