-
1
-
-
0034527045
-
The fight against rheumatism: From willow bark to COX-1 sparing drugs
-
Vane JR. The fight against rheumatism: From willow bark to COX-1 sparing drugs. J Physiol Pharm 2000;51:573-586.
-
(2000)
J Physiol Pharm
, vol.51
, pp. 573-586
-
-
Vane, J.R.1
-
2
-
-
0142165030
-
The mechanism of action of aspirin
-
Vane JR, Bolting RM. The mechanism of action of aspirin. Thromb Res 2003;110:255-258.
-
(2003)
Thromb Res
, vol.110
, pp. 255-258
-
-
Vane, J.R.1
Bolting, R.M.2
-
3
-
-
0015237292
-
Inhibition of prostaglandin synthesis as a mechanism of action of aspirin-like drugs
-
Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action of aspirin-like drugs. Nat New Biol 1971;231:232-235.
-
(1971)
Nat New Biol
, vol.231
, pp. 232-235
-
-
Vane, J.R.1
-
4
-
-
0017094438
-
Purification of the cyclo-oxygenase that forms prostaglandins: Demonstration of two forms of iron in the holoenzyme
-
Hemler M, Lands WEM, Smith WL. Purification of the cyclo-oxygenase that forms prostaglandins: Demonstration of two forms of iron in the holoenzyme. J Biol Chem 1976;251:5575-5579.
-
(1976)
J Biol Chem
, vol.251
, pp. 5575-5579
-
-
Hemler, M.1
Lands, W.E.M.2
Smith, W.L.3
-
5
-
-
0025754779
-
Expression of a mitogen-responsive gene encoding prostaglandin synthesis is regulated by mRNA splicing
-
Xie W, Chipman JG, Robertson DL, et al. Expression of a mitogen-responsive gene encoding prostaglandin synthesis is regulated by mRNA splicing. Proc Natl Acad Sci USA 1991;88:2692-2696.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 2692-2696
-
-
Xie, W.1
Chipman, J.G.2
Robertson, D.L.3
-
6
-
-
0034685192
-
COX-1, COX-2 and COX-3 and the future treatment of chronic inflammatory disease
-
Willoughby DA, Moore AR, Colville-Nash PR. COX-1, COX-2 and COX-3 and the future treatment of chronic inflammatory disease. Lancet 2000;355:646-648.
-
(2000)
Lancet
, vol.355
, pp. 646-648
-
-
Willoughby, D.A.1
Moore, A.R.2
Colville-Nash, P.R.3
-
7
-
-
0037108979
-
Cox-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure and expression
-
Chandrasekharan NV, Dai H, Roos KL, et al. Cox-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure and expression. Proc Natl Acad Sci USA 2002;99:13926-13931.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 13926-13931
-
-
Chandrasekharan, N.V.1
Dai, H.2
Roos, K.L.3
-
8
-
-
27744529775
-
Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: Evidence for intron 1 retention
-
Qin N, Zhang SP, Reitz TL, et al. Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: Evidence for intron 1 retention. J Pharmacol Exp Ther 2005;315:1298-1305.
-
(2005)
J Pharmacol Exp Ther
, vol.315
, pp. 1298-1305
-
-
Qin, N.1
Zhang, S.P.2
Reitz, T.L.3
-
9
-
-
12844253982
-
-
Davies NM, Good RL, Roupe KA, et al. Cyclooxygenase-3: Axiom, dogma, anomaly, enigma or splice error? - Not as easy as 1, 2, 3. J Pharm Pharmaceut Sci 2004;7:217-226.
-
Davies NM, Good RL, Roupe KA, et al. Cyclooxygenase-3: Axiom, dogma, anomaly, enigma or splice error? - Not as easy as 1, 2, 3. J Pharm Pharmaceut Sci 2004;7:217-226.
-
-
-
-
10
-
-
24144447706
-
Intron 1 retaining cyclooxygenase 1 splice variant is induced by osmotic stress in human intestinal epithelial cells
-
Nurmi JT, Puolakkainen PA, Rautonen NE. Intron 1 retaining cyclooxygenase 1 splice variant is induced by osmotic stress in human intestinal epithelial cells. Prostaglandins Leukot Essent Fatty Acids 2005;73:343-350.
-
(2005)
Prostaglandins Leukot Essent Fatty Acids
, vol.73
, pp. 343-350
-
-
Nurmi, J.T.1
Puolakkainen, P.A.2
Rautonen, N.E.3
-
11
-
-
27544432733
-
Cyclooxygenase variants: The role of alternative splicing
-
Roos KLT, Simmons DL. Cyclooxygenase variants: The role of alternative splicing. Biochem Biophys Res Comm 2005;338:62-69.
-
(2005)
Biochem Biophys Res Comm
, vol.338
, pp. 62-69
-
-
Roos, K.L.T.1
Simmons, D.L.2
-
12
-
-
32244447306
-
Gastrointestinal inflammation: A central component of mucosal defense and repair
-
Martin GR, Wallace JL. Gastrointestinal inflammation: A central component of mucosal defense and repair. Exp Biol Med (Maywood) 2006;231:130-137.
-
(2006)
Exp Biol Med (Maywood)
, vol.231
, pp. 130-137
-
-
Martin, G.R.1
Wallace, J.L.2
-
13
-
-
23644433791
-
COX-1 and COX-2 conversely promote and suppress ischemia-reperfusion gastric injury in mice
-
Hiratsuka T, Futagami S, Tatsuguchi A, et al. COX-1 and COX-2 conversely promote and suppress ischemia-reperfusion gastric injury in mice. Scand J Gastroenterol 2005;40:903-913.
-
(2005)
Scand J Gastroenterol
, vol.40
, pp. 903-913
-
-
Hiratsuka, T.1
Futagami, S.2
Tatsuguchi, A.3
-
14
-
-
14844307023
-
Mucosal expression of cyclooxygenase isoforms 1 and 2 is increased with worsening damage to the gastric mucosa
-
Bhandari P, Bateman AC, Mehta RL, et al. Mucosal expression of cyclooxygenase isoforms 1 and 2 is increased with worsening damage to the gastric mucosa. Histopathology 2005;46:280-286.
-
(2005)
Histopathology
, vol.46
, pp. 280-286
-
-
Bhandari, P.1
Bateman, A.C.2
Mehta, R.L.3
-
15
-
-
33645353617
-
Expression of cyclooxygenase-1 and cyclooxygenase-2 in human renal allograft rejection - A prospective study
-
Hoffmann U, Banas B, Kruger B, et al. Expression of cyclooxygenase-1 and cyclooxygenase-2 in human renal allograft rejection - A prospective study. Transpl Int 2006;19:203-212.
-
(2006)
Transpl Int
, vol.19
, pp. 203-212
-
-
Hoffmann, U.1
Banas, B.2
Kruger, B.3
-
16
-
-
3042571674
-
Effects of flunixin meglumine or etodolac treatment on mucosal recovery of equine jejunum after ischemia
-
Tomlinson JE, Wilder BO, Young KM, et al. Effects of flunixin meglumine or etodolac treatment on mucosal recovery of equine jejunum after ischemia. Am J Vet Res 2004;65:761-769.
-
(2004)
Am J Vet Res
, vol.65
, pp. 761-769
-
-
Tomlinson, J.E.1
Wilder, B.O.2
Young, K.M.3
-
17
-
-
27544489924
-
An intronic enhancer regulated COX-1 gene expression
-
DeLong CJ, Smith WL. An intronic enhancer regulated COX-1 gene expression. Biochem Biophys Res Commun 2005;338:53-61.
-
(2005)
Biochem Biophys Res Commun
, vol.338
, pp. 53-61
-
-
DeLong, C.J.1
Smith, W.L.2
-
18
-
-
23844502011
-
Is COX-2 a 'collateral' target in cancer prevention?
-
Kashfi K, Rigas B. Is COX-2 a 'collateral' target in cancer prevention? Biochem Soc Trans 2005;33:724-727.
-
(2005)
Biochem Soc Trans
, vol.33
, pp. 724-727
-
-
Kashfi, K.1
Rigas, B.2
-
19
-
-
11144286024
-
Constitutive and functional expression of cyclooxygenase 2 in the murine proximal colon
-
Porcher C, Horowitz B, Ward SM, et al. Constitutive and functional expression of cyclooxygenase 2 in the murine proximal colon. Neurogastroenterol Motil 2004;16:785-799.
-
(2004)
Neurogastroenterol Motil
, vol.16
, pp. 785-799
-
-
Porcher, C.1
Horowitz, B.2
Ward, S.M.3
-
20
-
-
15044358766
-
Differential expression of COX-1 and COX-2 in the gastrointestinal tract of the rat
-
Haworth R, Oakley K, McCormack N, et al. Differential expression of COX-1 and COX-2 in the gastrointestinal tract of the rat. Toxicol Pathol 2005;33:239-245.
-
(2005)
Toxicol Pathol
, vol.33
, pp. 239-245
-
-
Haworth, R.1
Oakley, K.2
McCormack, N.3
-
21
-
-
0029907525
-
Exacerbation of inflammation- associated colonic injury in rat through inhibition of cyclooxygenase-2
-
Reuter BK, Asfaha S, Buret A, et al. Exacerbation of inflammation- associated colonic injury in rat through inhibition of cyclooxygenase-2. J Clin Invest 1996;98:2076-2085.
-
(1996)
J Clin Invest
, vol.98
, pp. 2076-2085
-
-
Reuter, B.K.1
Asfaha, S.2
Buret, A.3
-
22
-
-
0031884213
-
Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats
-
Schmassmann A, Peskar BM, Stettler C, et al. Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats. Br J Pharmacol 1998;123:795-804.
-
(1998)
Br J Pharmacol
, vol.123
, pp. 795-804
-
-
Schmassmann, A.1
Peskar, B.M.2
Stettler, C.3
-
23
-
-
0033613852
-
Functional coupling between various phospholipase A2s and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathways
-
Murakami M, Kambe T, Shimbara S, et al. Functional coupling between various phospholipase A2s and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathways. J Biol Chem 1999;274:3103-3115.
-
(1999)
J Biol Chem
, vol.274
, pp. 3103-3115
-
-
Murakami, M.1
Kambe, T.2
Shimbara, S.3
-
24
-
-
23944439888
-
Sequential induction of prostaglandin E and D synthases in inflammation
-
Schuligoi R, Grill M, Heinemann A, et al. Sequential induction of prostaglandin E and D synthases in inflammation. Biochem Biophys Res Commun 2005;335:684-689.
-
(2005)
Biochem Biophys Res Commun
, vol.335
, pp. 684-689
-
-
Schuligoi, R.1
Grill, M.2
Heinemann, A.3
-
25
-
-
33644664887
-
Contrasting effects of peroxisome-proliferator-activated receptor (PPAR) gamma agonists on membrane-associated prostaglandin E2 synthase-1 in IL-1beta-stimulated rat chondrocytes: Evidence for PPARgamma-independent inhibition by 15-deoxy-Delta12,14 prostaglandin J2
-
Bianchi A, Moulin D, Sebillaud S, et al. Contrasting effects of peroxisome-proliferator-activated receptor (PPAR) gamma agonists on membrane-associated prostaglandin E2 synthase-1 in IL-1beta-stimulated rat chondrocytes: Evidence for PPARgamma-independent inhibition by 15-deoxy-Delta12,14 prostaglandin J2. Arthritis Res Ther 2005;7:R1325-1337.
-
(2005)
Arthritis Res Ther
, vol.7
-
-
Bianchi, A.1
Moulin, D.2
Sebillaud, S.3
-
26
-
-
0035053973
-
Cyclopentenone prostaglandins: New insights on biological activities and cellular targets
-
Straus DS, Glass CK. Cyclopentenone prostaglandins: New insights on biological activities and cellular targets. Med Res Rev 2001;21:185-210.
-
(2001)
Med Res Rev
, vol.21
, pp. 185-210
-
-
Straus, D.S.1
Glass, C.K.2
-
27
-
-
0034986726
-
COX in a crystal ball: Current status and future promise of prostaglandin research
-
Fitzgerald GA, Loll P. COX in a crystal ball: Current status and future promise of prostaglandin research. J Clin. Invest 2001;107:1335-1337.
-
(2001)
J Clin. Invest
, vol.107
, pp. 1335-1337
-
-
Fitzgerald, G.A.1
Loll, P.2
-
28
-
-
0035662474
-
Dual acting antiinflammatory drugs: A reappraisal
-
Bertolini A, Ottani A, Sandrini M. Dual acting antiinflammatory drugs: A reappraisal. Pharmacol Res 2000;44:437-450.
-
(2000)
Pharmacol Res
, vol.44
, pp. 437-450
-
-
Bertolini, A.1
Ottani, A.2
Sandrini, M.3
-
29
-
-
0030461132
-
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
-
Kurumbail RG, Stevens AM, Gierse JK, et al. Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature 1996;384:644-648.
-
(1996)
Nature
, vol.384
, pp. 644-648
-
-
Kurumbail, R.G.1
Stevens, A.M.2
Gierse, J.K.3
-
30
-
-
1242271208
-
3-Phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells
-
Kulp SK, Yang YT, Hung CC, et al. 3-Phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells. Cancer Res 2004;64:1444-1451.
-
(2004)
Cancer Res
, vol.64
, pp. 1444-1451
-
-
Kulp, S.K.1
Yang, Y.T.2
Hung, C.C.3
-
31
-
-
17744418769
-
The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis
-
Steinbach G, Lynch PM, Phillips RK, et al. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med 2000;342:1946-1952.
-
(2000)
N Engl J Med
, vol.342
, pp. 1946-1952
-
-
Steinbach, G.1
Lynch, P.M.2
Phillips, R.K.3
-
32
-
-
0033575760
-
Malignant transformation and antineoplastic actions of nonsteroidal antiin-flammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts
-
Zhang X, Morham SG, Langenbach R, et al. Malignant transformation and antineoplastic actions of nonsteroidal antiin-flammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts. J Exp Med 1999;190:451-159.
-
(1999)
J Exp Med
, vol.190
, pp. 451-159
-
-
Zhang, X.1
Morham, S.G.2
Langenbach, R.3
-
33
-
-
0034816925
-
Cyclooxygenase-independent actions of cyclooxygenase inhibitors
-
Tegeder I, Pfeilschifter J, Geisslinger G. Cyclooxygenase-independent actions of cyclooxygenase inhibitors. FASEB J 2001;15:2057-2072.
-
(2001)
FASEB J
, vol.15
, pp. 2057-2072
-
-
Tegeder, I.1
Pfeilschifter, J.2
Geisslinger, G.3
-
34
-
-
0028300256
-
Antinociceptive actions of R(-)-flurbiprofen-a non-cyclooxygenase inhibiting 2-arylpropionic acid-in rats
-
Geisslinger G, Ferreira SH, Menzel S, et al. Antinociceptive actions of R(-)-flurbiprofen-a non-cyclooxygenase inhibiting 2-arylpropionic acid-in rats. Life Sci 1994;54:PL173-PL177.
-
(1994)
Life Sci
, vol.54
-
-
Geisslinger, G.1
Ferreira, S.H.2
Menzel, S.3
-
35
-
-
13844273087
-
PI3K-Akt pathway: Its functions and alterations in human cancer
-
Osaki M, Oshimura M, Ito H. PI3K-Akt pathway: Its functions and alterations in human cancer. Apoptosis 2004;9:667-676.
-
(2004)
Apoptosis
, vol.9
, pp. 667-676
-
-
Osaki, M.1
Oshimura, M.2
Ito, H.3
-
36
-
-
3042562279
-
From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors
-
Zhu J, Huang JW, Tseng PH, et al. From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer Res 2004;64:4309-4318.
-
(2004)
Cancer Res
, vol.64
, pp. 4309-4318
-
-
Zhu, J.1
Huang, J.W.2
Tseng, P.H.3
-
37
-
-
0034681264
-
The multiple roles of PTEN in tumor suppression
-
Di Cristofano A, Pandolfi PP. The multiple roles of PTEN in tumor suppression. Cell 2000;100:387-390.
-
(2000)
Cell
, vol.100
, pp. 387-390
-
-
Di Cristofano, A.1
Pandolfi, P.P.2
-
38
-
-
16344389993
-
Celecoxib inhibits prostate cancer growth: Evidence of a cyclooxygenase-2-independent mechanism
-
Patel MI, Subbaramaiah K, Du B, et al. Celecoxib inhibits prostate cancer growth: Evidence of a cyclooxygenase-2-independent mechanism. Clin Cancer Res 2005;11:1999-2007.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 1999-2007
-
-
Patel, M.I.1
Subbaramaiah, K.2
Du, B.3
-
39
-
-
22044448663
-
Celecoxib induces hemeoxygenase expression in glomerular mesangial cells
-
Hou CC, Hung SL, Kao SH, et al. Celecoxib induces hemeoxygenase expression in glomerular mesangial cells. Ann NY Acad Sci 2005;1042:235-245.
-
(2005)
Ann NY Acad Sci
, vol.1042
, pp. 235-245
-
-
Hou, C.C.1
Hung, S.L.2
Kao, S.H.3
-
40
-
-
1842839916
-
Heme oxygenase-1 induction by hemin protects against gut ischemia/ reperfusion injury
-
Attuwaybi BO, Kozar RA, Moore-Olufemi SD, et al. Heme oxygenase-1 induction by hemin protects against gut ischemia/ reperfusion injury. J Surg Res 2004;118:53-57.
-
(2004)
J Surg Res
, vol.118
, pp. 53-57
-
-
Attuwaybi, B.O.1
Kozar, R.A.2
Moore-Olufemi, S.D.3
-
41
-
-
23644436020
-
-
Deshane J, Wright M, Agarwal A. Heme oxygenase-1 expression in disease states. Acta Biochim Pol2005, 52:273-284.
-
Deshane J, Wright M, Agarwal A. Heme oxygenase-1 expression in disease states. Acta Biochim Pol2005, 52:273-284.
-
-
-
-
42
-
-
0347991871
-
Akt2, phosphatidylinositol 3-kinase, and PTEN are in lipid rafts of intestinal cells: Role in absorption and differentiation
-
Li X, Leu S, Cheong A, et al. Akt2, phosphatidylinositol 3-kinase, and PTEN are in lipid rafts of intestinal cells: Role in absorption and differentiation. Gastroenterology 2004;126:122-135.
-
(2004)
Gastroenterology
, vol.126
, pp. 122-135
-
-
Li, X.1
Leu, S.2
Cheong, A.3
-
45
-
-
0037227666
-
Phosphatidylinositol-3-kinase (PI3'K) signaling is required for prostaglandin-induced mucosal recovery in ischemia-injured porcine ileum
-
Little D, Dean RA, Young KM, et al. Phosphatidylinositol-3-kinase (PI3'K) signaling is required for prostaglandin-induced mucosal recovery in ischemia-injured porcine ileum. Am J Physiol Gastrointest Liver Physiol 2003;284:G46-56.
-
(2003)
Am J Physiol Gastrointest Liver Physiol
, vol.284
-
-
Little, D.1
Dean, R.A.2
Young, K.M.3
-
47
-
-
0035092246
-
Aspirin, but not the more selective cyclooxygenase (COX)-2 inhibitors meloxicam and SC58125, aggravates postischaemic cardiac dysfunction, independent of COX function
-
Heindl B, Becker BF. Aspirin, but not the more selective cyclooxygenase (COX)-2 inhibitors meloxicam and SC58125, aggravates postischaemic cardiac dysfunction, independent of COX function. Naunyn Schmiedebergs Arch Pharmacol 2001;363:233-40.
-
(2001)
Naunyn Schmiedebergs Arch Pharmacol
, vol.363
, pp. 233-240
-
-
Heindl, B.1
Becker, B.F.2
-
48
-
-
33645876790
-
Induction of renal cytochrome P450 arachidonic acid epoxygenase activity by dietary γ-Linolenic acid
-
Yu Z, Ng VY, Su P, et al. Induction of renal cytochrome P450 arachidonic acid epoxygenase activity by dietary γ-Linolenic acid. J Pharmacol Exp Ther 2006;317:732-738.
-
(2006)
J Pharmacol Exp Ther
, vol.317
, pp. 732-738
-
-
Yu, Z.1
Ng, V.Y.2
Su, P.3
-
49
-
-
27744561554
-
Cardiovascular complications of non-steroidal anti-inflammatory drugs
-
Fosslien E. Cardiovascular complications of non-steroidal anti-inflammatory drugs. Ann Clin Lab Sci 2005;35:347-385.
-
(2005)
Ann Clin Lab Sci
, vol.35
, pp. 347-385
-
-
Fosslien, E.1
-
50
-
-
0037652327
-
Nonsteroidal antiinflammatory drugs and a selective cyclooxygenase 2 inhibitor uncouple mitochondria in intact cells
-
Krause MM, Brand MD, Krauss S, et al. Nonsteroidal antiinflammatory drugs and a selective cyclooxygenase 2 inhibitor uncouple mitochondria in intact cells. Arthritis Rheum 2003;48:1438-1444.
-
(2003)
Arthritis Rheum
, vol.48
, pp. 1438-1444
-
-
Krause, M.M.1
Brand, M.D.2
Krauss, S.3
-
51
-
-
0031036081
-
Uncoupling effects of diclofenac and aspirin in the perfused liver and isolated hepatic mitochondria of rat
-
Petrescu I, Tarba C. Uncoupling effects of diclofenac and aspirin in the perfused liver and isolated hepatic mitochondria of rat. Biochim Biophys Acta 1997;1318:385-394.
-
(1997)
Biochim Biophys Acta
, vol.1318
, pp. 385-394
-
-
Petrescu, I.1
Tarba, C.2
-
52
-
-
0033811024
-
Comparison of the intestinal toxicity of celecoxib, a selective COX-2 inhibitor, and indomethacin in the experimental rat
-
Tibble JA, Sigthorsson G, Foster R, et al. Comparison of the intestinal toxicity of celecoxib, a selective COX-2 inhibitor, and indomethacin in the experimental rat. Scand J Gastroenterol 2000;35:802-807.
-
(2000)
Scand J Gastroenterol
, vol.35
, pp. 802-807
-
-
Tibble, J.A.1
Sigthorsson, G.2
Foster, R.3
-
53
-
-
0344097396
-
Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal antiinflammatory drugs
-
Moreno-Sanchez R, Bravo C, Vasquez C, et al. Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal antiinflammatory drugs. Biochem Pharmacol 1999;57:743-752.
-
(1999)
Biochem Pharmacol
, vol.57
, pp. 743-752
-
-
Moreno-Sanchez, R.1
Bravo, C.2
Vasquez, C.3
-
54
-
-
8644243944
-
Sulfone COX-2 inhibitors increase susceptibility of human LDL and plasma to oxidative modification: Comparison to sulfonamide COX-2 inhibitors and NSAIDs
-
Walter MF, Jacob RF, Day CA, et al. Sulfone COX-2 inhibitors increase susceptibility of human LDL and plasma to oxidative modification: Comparison to sulfonamide COX-2 inhibitors and NSAIDs. Atherosclerosis 2004;177:235-243.
-
(2004)
Atherosclerosis
, vol.177
, pp. 235-243
-
-
Walter, M.F.1
Jacob, R.F.2
Day, C.A.3
-
55
-
-
0025132245
-
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
-
Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 1990;347:645-650.
-
(1990)
Nature
, vol.347
, pp. 645-650
-
-
Issemann, I.1
Green, S.2
-
56
-
-
0033793133
-
Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation
-
Chinetti G, Fruchart JC, Staels B. Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflamm Res 2000;49:497-505.
-
(2000)
Inflamm Res
, vol.49
, pp. 497-505
-
-
Chinetti, G.1
Fruchart, J.C.2
Staels, B.3
-
57
-
-
0028321529
-
Differential expression and activation of a family of murine peroxisome proliferator-activated receptors
-
Kliewer SA, Forman BM, Blumberg B, et al. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc Nat Acad Sci USA 1994;91:7355-7359.
-
(1994)
Proc Nat Acad Sci USA
, vol.91
, pp. 7355-7359
-
-
Kliewer, S.A.1
Forman, B.M.2
Blumberg, B.3
-
58
-
-
0034965596
-
Peroxisome proliferator-activated receptors in inflammation control
-
Delerive P, Fruchart J-C, Staels B. Peroxisome proliferator-activated receptors in inflammation control. J Endocrin 2001;169:453-459.
-
(2001)
J Endocrin
, vol.169
, pp. 453-459
-
-
Delerive, P.1
Fruchart, J.-C.2
Staels, B.3
-
59
-
-
0034713444
-
Roles of PPARs in health and disease
-
Kersten S, Desvergne B, Wahli W. Roles of PPARs in health and disease. Nature 2000;405:421-424.
-
(2000)
Nature
, vol.405
, pp. 421-424
-
-
Kersten, S.1
Desvergne, B.2
Wahli, W.3
-
60
-
-
0035894284
-
Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H2 synthases by ibuprofen, naproxen, and indomethacin
-
Jaradat MS, Wongsud B, Phornchirasilp S, et al. Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H2 synthases by ibuprofen, naproxen, and indomethacin. Biochem Pharmacol 2001;62:1587-1595.
-
(2001)
Biochem Pharmacol
, vol.62
, pp. 1587-1595
-
-
Jaradat, M.S.1
Wongsud, B.2
Phornchirasilp, S.3
-
61
-
-
4143070446
-
15-deoxy-Δ12,14- prostaglandin J2 inhibits IL-1β-induced IKK enzymatic activity and IκBα degradation in rat chondrocytes through a PPARγ- independent pathway
-
Boyault S, Bianchi A, Moulin D, et al. 15-deoxy-Δ12,14- prostaglandin J2 inhibits IL-1β-induced IKK enzymatic activity and IκBα degradation in rat chondrocytes through a PPARγ- independent pathway. FEBS Letters 2004;572:33-40.
-
(2004)
FEBS Letters
, vol.572
, pp. 33-40
-
-
Boyault, S.1
Bianchi, A.2
Moulin, D.3
-
62
-
-
0035127894
-
Endogenous PPARγ mediates anti-inflammatory activity in murine ischemia-reperfusion injury
-
Nakajima A, Wada K, Miki H, et al. Endogenous PPARγ mediates anti-inflammatory activity in murine ischemia-reperfusion injury. Gastroenterology 2001;120:460-469.
-
(2001)
Gastroenterology
, vol.120
, pp. 460-469
-
-
Nakajima, A.1
Wada, K.2
Miki, H.3
-
63
-
-
0242526756
-
Phosphorylation of PPARγ via active ERK1/2 leads to its physical association with p65 and inhibition of NF-κB
-
Chen F, Wang M, O'Connor JP, et al. Phosphorylation of PPARγ via active ERK1/2 leads to its physical association with p65 and inhibition of NF-κB. J Cell Biochem 2003;90:732-744.
-
(2003)
J Cell Biochem
, vol.90
, pp. 732-744
-
-
Chen, F.1
Wang, M.2
O'Connor, J.P.3
-
64
-
-
0031057517
-
Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site
-
Adams M, Reginato MJ, Shao D, et al. Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site. J Biol Chem 1997;272:5128-5132.
-
(1997)
J Biol Chem
, vol.272
, pp. 5128-5132
-
-
Adams, M.1
Reginato, M.J.2
Shao, D.3
-
65
-
-
20444497357
-
Receptor-independent actions of PPAR thiazolidinedione agonists: Is mitochondrial function the key?
-
Feinstein DL, Spagnolo A, Akar C, et al. Receptor-independent actions of PPAR thiazolidinedione agonists: Is mitochondrial function the key? Biochem Pharm 2005;70:177-188.
-
(2005)
Biochem Pharm
, vol.70
, pp. 177-188
-
-
Feinstein, D.L.1
Spagnolo, A.2
Akar, C.3
-
66
-
-
19944430692
-
A PPAR-gamma ligand, 15-deoxy-Delta 12,14-prostaglandin J(2), inhibited gastric mucosal injury induced by ischemia-reperfusion in rats
-
Takagi T, Naito Y, Ichikawa H, et al. A PPAR-gamma ligand, 15-deoxy-Delta 12,14-prostaglandin J(2), inhibited gastric mucosal injury induced by ischemia-reperfusion in rats. Redox Rep 2004;9:376-381.
-
(2004)
Redox Rep
, vol.9
, pp. 376-381
-
-
Takagi, T.1
Naito, Y.2
Ichikawa, H.3
-
67
-
-
19944370429
-
The selective cyclooxygenase-2 inhibitor celecoxib modulates the formation of vasoconstrictor eicosanoids and activates PPARγ. Influence of albumin
-
López-Parra M, Clària J, Titos E, et al. The selective cyclooxygenase-2 inhibitor celecoxib modulates the formation of vasoconstrictor eicosanoids and activates PPARγ. Influence of albumin. J Hepatol 2005;42:75-81.
-
(2005)
J Hepatol
, vol.42
, pp. 75-81
-
-
López-Parra, M.1
Clària, J.2
Titos, E.3
-
68
-
-
0031013395
-
Peroxisome proliferator- activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs
-
Lehmann JM, Lenhard JM, Oliver BB, et al. Peroxisome proliferator- activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 1997;272:3406-3410.
-
(1997)
J Biol Chem
, vol.272
, pp. 3406-3410
-
-
Lehmann, J.M.1
Lenhard, J.M.2
Oliver, B.B.3
-
69
-
-
0033583029
-
Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelial cells
-
Meade EA, McIntyre TM, Zimmerman GA, et al. Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelial cells. J Biol Chem 1999;274:8328-8334.
-
(1999)
J Biol Chem
, vol.274
, pp. 8328-8334
-
-
Meade, E.A.1
McIntyre, T.M.2
Zimmerman, G.A.3
-
70
-
-
27644481210
-
Peroxisome proliferator-activated receptor gamma mediates protection against cyclooxygenase-2-induced gut dysfunction in a rodent model of mesenteric ischemia/reperfusion
-
Sato N, Kozar RA, Zou L, et al. Peroxisome proliferator-activated receptor gamma mediates protection against cyclooxygenase-2-induced gut dysfunction in a rodent model of mesenteric ischemia/reperfusion. Shock 2005;24:462-469.
-
(2005)
Shock
, vol.24
, pp. 462-469
-
-
Sato, N.1
Kozar, R.A.2
Zou, L.3
-
71
-
-
33645802403
-
Differential induction of PPARγ by luminal glutamine and iNOS by luminal arginine in the rodent post ischemic small bowel
-
Sato N, Moore FA, Kone BC, et al. Differential induction of PPARγ by luminal glutamine and iNOS by luminal arginine in the rodent post ischemic small bowel. Am J Physiol Gastrointest Liver Physiol 2006;290:616-623.
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
, pp. 616-623
-
-
Sato, N.1
Moore, F.A.2
Kone, B.C.3
-
72
-
-
0038587747
-
The two faces of IKK and NF-κB inhibition: Prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion
-
Chen LW, Egan L, Li ZW, et al. The two faces of IKK and NF-κB inhibition: Prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med 2003;9:575-581.
-
(2003)
Nat Med
, vol.9
, pp. 575-581
-
-
Chen, L.W.1
Egan, L.2
Li, Z.W.3
-
73
-
-
29744443925
-
Transcription factor NF-κB: A sensor for smoke and stress signals
-
Ahn KS, Aggarwal BB. Transcription factor NF-κB: A sensor for smoke and stress signals. Ann NY Acad Sci 2005;1056:218-233.
-
(2005)
Ann NY Acad Sci
, vol.1056
, pp. 218-233
-
-
Ahn, K.S.1
Aggarwal, B.B.2
-
74
-
-
0038481659
-
Inhibitory effects of indomethacin and meloxicam on NF-kappa B in mouse peritoneal macrophages
-
Hu YF, Guo Y, Cheng GF. Inhibitory effects of indomethacin and meloxicam on NF-kappa B in mouse peritoneal macrophages. Yao Xue Xue Bao 2001;36:161-164.
-
(2001)
Yao Xue Xue Bao
, vol.36
, pp. 161-164
-
-
Hu, Y.F.1
Guo, Y.2
Cheng, G.F.3
-
75
-
-
0042884177
-
Inhibitory effect of meloxicam on human polymorphonuclear leukocyte adhesion to human synovial cell
-
Li LC, Hou Q, Guo Y, et al. Inhibitory effect of meloxicam on human polymorphonuclear leukocyte adhesion to human synovial cell. Yao Xue Xue Bao 2002;37:103-107.
-
(2002)
Yao Xue Xue Bao
, vol.37
, pp. 103-107
-
-
Li, L.C.1
Hou, Q.2
Guo, Y.3
-
76
-
-
0037334544
-
Selective inhibitors of cyclooxygenase-2 delay the activation of nuclear factor KB and attenuate the expression of inflammatory genes in murine macrophages treated with lipopolysaccharide
-
Callejas NA, Fernandez-Martinez A, Castrillo A, et al. Selective inhibitors of cyclooxygenase-2 delay the activation of nuclear factor KB and attenuate the expression of inflammatory genes in murine macrophages treated with lipopolysaccharide. Mol Pharmacol 2003;63:671-677.
-
(2003)
Mol Pharmacol
, vol.63
, pp. 671-677
-
-
Callejas, N.A.1
Fernandez-Martinez, A.2
Castrillo, A.3
-
77
-
-
4644289081
-
Anti-inflammatory drugs and tumor necrosis factor-α production from monocytes: Role of transcription factor NFκB and implication for rheumatoid arthritis therapy
-
Lavagno L, Gunella G, Bardelli C, et al. Anti-inflammatory drugs and tumor necrosis factor-α production from monocytes: Role of transcription factor NFκB and implication for rheumatoid arthritis therapy. Eur J Pharm 2004;501:199-208.
-
(2004)
Eur J Pharm
, vol.501
, pp. 199-208
-
-
Lavagno, L.1
Gunella, G.2
Bardelli, C.3
-
78
-
-
11244334168
-
Nonsteroidal antiinflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation
-
Takada Y, Bhardwaj A, Potdar P, et al. Nonsteroidal antiinflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 2004;23:9247-9258.
-
(2004)
Oncogene
, vol.23
, pp. 9247-9258
-
-
Takada, Y.1
Bhardwaj, A.2
Potdar, P.3
-
79
-
-
0035914407
-
Positive and negative regulation of NF-κB by COX-2. Roles of different prostaglandins
-
Poligone B, Baldwin AS. Positive and negative regulation of NF-κB by COX-2. Roles of different prostaglandins. J Biol Chem 2001;276:38658-38664.
-
(2001)
J Biol Chem
, vol.276
, pp. 38658-38664
-
-
Poligone, B.1
Baldwin, A.S.2
-
80
-
-
0035403764
-
Celecoxib loses its anti-inflammatory efficacy at high doses through activation of NFκB
-
Niederberger E, Tegeder I, Vetter G, et al. Celecoxib loses its anti-inflammatory efficacy at high doses through activation of NFκB. FASEB J 2001;15:1622-1824.
-
(2001)
FASEB J
, vol.15
, pp. 1622-1824
-
-
Niederberger, E.1
Tegeder, I.2
Vetter, G.3
-
81
-
-
0036156738
-
Absence of nuclear factor KB inhibition by NSAIDs in hepatocytes
-
Callejas NA, Casado M, Bosca L, et al. Absence of nuclear factor KB inhibition by NSAIDs in hepatocytes. Hepatology 2002;35:341-348.
-
(2002)
Hepatology
, vol.35
, pp. 341-348
-
-
Callejas, N.A.1
Casado, M.2
Bosca, L.3
-
82
-
-
29644435432
-
Lipopolysaccharide induces cyclooxygenase-2 in intestinal epithelium via a noncanonical p38 MAPK pathway
-
Grishin AV, Wang J, Potoka DA, et al. Lipopolysaccharide induces cyclooxygenase-2 in intestinal epithelium via a noncanonical p38 MAPK pathway. J Immunol 2006;176:580-588.
-
(2006)
J Immunol
, vol.176
, pp. 580-588
-
-
Grishin, A.V.1
Wang, J.2
Potoka, D.A.3
-
83
-
-
0036959446
-
The role of mitogen-activated protein kinases and their relationship with NF-κB and PPARγ in indomethacin-induced apoptosis of colon cancer cells
-
Kim TI, Jin SH, Kang EH, et al. The role of mitogen-activated protein kinases and their relationship with NF-κB and PPARγ in indomethacin-induced apoptosis of colon cancer cells. Ann NY Acad Sci 2002;973:241-245.
-
(2002)
Ann NY Acad Sci
, vol.973
, pp. 241-245
-
-
Kim, T.I.1
Jin, S.H.2
Kang, E.H.3
-
84
-
-
2642546700
-
Mitogen-activated protein kinases regulate COX-2 and mucosal recovery in ischemic-injured porcine ileum
-
Shifflett DE, Jones SL, Moeser AJ, et al. Mitogen-activated protein kinases regulate COX-2 and mucosal recovery in ischemic-injured porcine ileum. Am J Physiol Gastrointest Liver Physiol 2004;286:G906-G913.
-
(2004)
Am J Physiol Gastrointest Liver Physiol
, vol.286
-
-
Shifflett, D.E.1
Jones, S.L.2
Moeser, A.J.3
-
85
-
-
25644435619
-
-
Naito Y, Mizushima K, Yoshikawa T. Global analysis of gene expression in gastric ischemia-reperfusion: A future therapeutic direction for mucosal protective drugs. Dig Dis Sci 2005;50Suppl 1:S45-55.
-
Naito Y, Mizushima K, Yoshikawa T. Global analysis of gene expression in gastric ischemia-reperfusion: A future therapeutic direction for mucosal protective drugs. Dig Dis Sci 2005;50Suppl 1:S45-55.
-
-
-
-
86
-
-
0036086261
-
Indomethacin lowers the threshold thermal exposure for hyperthermic radio-sensitization and heat-shock inhibition of ionizing radiation-induced activation of NF-kappaB
-
Locke JE, Bradbury CM, Wei SJ, et al. Indomethacin lowers the threshold thermal exposure for hyperthermic radio-sensitization and heat-shock inhibition of ionizing radiation-induced activation of NF-kappaB. Int J Radiat Biol 2002;78:493-502.
-
(2002)
Int J Radiat Biol
, vol.78
, pp. 493-502
-
-
Locke, J.E.1
Bradbury, C.M.2
Wei, S.J.3
-
87
-
-
0346728756
-
Indomethacin and ibuprofen induce Hsc70 nuclear localization and activation of the heat shock response in HeLa cells
-
Lagunas L, Bradbury CM, Laszlo A, et al. Indomethacin and ibuprofen induce Hsc70 nuclear localization and activation of the heat shock response in HeLa cells. Biochem Biophys Res Commun 2004;313:863-870.
-
(2004)
Biochem Biophys Res Commun
, vol.313
, pp. 863-870
-
-
Lagunas, L.1
Bradbury, C.M.2
Laszlo, A.3
-
88
-
-
0032949624
-
Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines that induce HSP70 in human monocytes
-
Nousby JN, Cahil CM, Chu B, et al. Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines that induce HSP70 in human monocytes. Cytokine 1999;11:347-358.
-
(1999)
Cytokine
, vol.11
, pp. 347-358
-
-
Nousby, J.N.1
Cahil, C.M.2
Chu, B.3
|