Induction of renal cytochrome P450 arachidonic acid epoxygenase activity by dietary γ-linolenic acid

Journal of Pharmacology and Experimental Therapeutics

Volumn 317, Issue 2, 2006, Pages 732-738

  Yu, Zhigang ^a   Ng, Valerie Y ^a   Su, Ping ^a   Engler, Marguerite M ^a   Engler, Mary B ^a   Huang, Yong ^a   Lin, Emil ^a   Kroetz, Deanna L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

14,15 EPOXY 5,8,11 ICOSATRIENOIC ACID; 20 HYDROXYICOSATETRAENOIC ACID; 8,9 EPOXYICOSATRIENOIC ACID; ARACHIDONIC ACID; BORAGE OIL; CYTOCHROME P450; CYTOCHROME P450 2C11; CYTOCHROME P450 2C23; CYTOCHROME P450 2J; CYTOCHROME P450 ARACHIDONIC ACID EPOXYGENASE; EPOXYICOSATRIENOIC ACID; GAMMA LINOLENIC ACID; KIDNEY ENZYME; MESSENGER RNA; RNA; SESAME SEED OIL; UNCLASSIFIED DRUG; VASOCONSTRICTOR AGENT; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ANTIHYPERTENSIVE THERAPY; ARACHIDONIC ACID METABOLISM; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DIETARY INTAKE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INDUCTION; ENZYME MECHANISM; FAT INTAKE; FATTY ACID SYNTHESIS; FEEDING; HYPERTENSION; ICOSANOID METABOLISM; KIDNEY; KIDNEY CORTEX; KIDNEY MICROSOME; LOW FAT DIET; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; QUANTITATIVE ANALYSIS; RAT; RNA ANALYSIS; RNA ISOLATION; SPONTANEOUSLY HYPERTENSIVE RAT; TISSUE LEVEL; VASOCONSTRICTION; VASODILATATION;

ANIMALS; ARACHIDONIC ACIDS; BLOTTING, WESTERN; CYTOCHROME P-450 ENZYME SYSTEM; DIETARY FATS; ENZYME INDUCTION; GAMMA-LINOLENIC ACID; HYPERTENSION; KIDNEY; MALE; OXYGENASES; RATS; RATS, INBRED SHR;

EID: 33645876790     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.098558     Document Type: Article

References (41)

1. Campbell WB, Gebremedhin D, Pratt PF, and Harder DR (1996) Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ Res 78:415-423.
2. Capdevila J, Chacos N, Werringloer J, Prough RA, and Estabrook RW (1981) Liver microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid. Proc Natl Acad Sci USA 78:5362-5366.
3. Church JPRV and Schoene NW (1977) Effect of essential fatty acid deficiency on blood pressure in the spontaneously hypertensive rat. Fed Proc 36:1159.
4. Delachambre MC, Narce M, Asdrubal P, and Poisson JP (1998) Changes in tissue polyunsaturated fatty acids with age, in spontaneously hypertensive rats. Lipids 33:795-801.
5. Engler MM and Engler MB (1998) Dietary borage oil alters plasma, hepatic and vascular tissue fatty acid composition in spontaneously hypertensive rats. Prostaglandins Leukotrienes Essent Fatty Acids 59:11-15.
6. Engler MM, Engler MB, Erickson SK, and Paul SM (1992) Dietary γ-linolenic acid lowers blood pressure and alters aortic reactivity and cholesterol metabolism in hypertension. J Hypertens 10:1197-1204.
7. Engler MM, Schambelan M, Engler MB, Ball DL, and Goodfriend TL (1998) Effects of dietary γ-linolenic acid on blood pressure and adrenal angiotensin receptors in hypertensive rats. Proc Soc Exp Biol Med 218:234-237.
8. Fan YY, Ramos KS, and Chapkin RS (2001) Dietary γ-linolenic acid suppresses aortic smooth muscle cell proliferation and modifies atherosclerotic lesions in apolipoprotein E knockout mice. J Nutr 131:1675-1681.
9. Fields LE, Burt VL, Cutler JA, Hughes J, Roccella EJ, and Sorlie P (2004) The burden of adult hypertension in the United States 1999 to 2000: a rising tide. Hypertension 44:398-404.
10. Hecker M, Bara AT, Bauersachs J, and Busse R (1994) Characterization of endothelium-derived hyperpolarizing factor as a cytochrome P450-derived arachidonic acid metabolite in mammals. J Physiol (Lond) 481:407-414.
11. Holla VR, Makita K, Zaphiropoulos PG, and Capdevila JH (1999) The kidney cytochrome P-450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading. J Clin Investig 104:751-760.
12. Hornych A, Oravec S, Girault F, Forette B, and Horrobin DF (2002) The effect of γ-linolenic acid on plasma and membrane lipids and renal prostaglandin synthesis in older subjects. Bratisl Lek Listy 103:101-107.
13. Huang YS, Cantrill RC, DeMarco A, Campbell L, Lin X, Horrobin DF, and Mills DE (1994) Differences in the metabolism of 18:2n-6 and 18:3n-6 by the liver and kidney may explain the anti-hypertensive effect of 18:3n-6. Biochem Med Metab Biol 51:27-34.
14. Ingram AJ, Parbtani A, Clark WF, Spanner E, Huff MW, Philbrick DJ, Holub BJ, and Scholey JW (1996) Dietary alteration of dihomo-γ-linolenic acid/arachidonic acid ratio in a rat 5/6-renal-ablation model. J Am Soc Nephrol 7:1024-1031.
15. Karara A, Dishman E, Jacobson H, Falck JR, and Capdevila JH (1990) Arachidonic acid epoxygenase: stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex. FEBS Lett 268:227-230.
16. Karara A, Makita K, Jacobson HR, Falck JR, Guengerich FP, DuBois RN, and Capdevila JH (1993) Molecular cloning, expression and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase. J Biol Chem 268:13565-13570.
17. Kroetz DL, Huse LM, Thuresson A, and Grillo MP (1997) Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney. Mol Pharmacol 52:362-372.
18. Kroetz DL and Zeldin DC (2002) Cytochrome P450 pathways of arachidonic acid metabolism. Curr Opin Lipidol 13:273-283.
19. Makita K, Takahashi K, Karara A, Jacobson HR, Falck JR, and Capdevila JH (1994) Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet. J Clin Investig 94:2414-2420.
20. Mathews C, Van Holde K, and Ahern K (2000) Lipid metabolism I: fatty acids, triacylglycerols and lipoproteins, in Biochemistry, p 660, Benjamin/Cummings, San Francisco.
21. Mills DE, Ward RP, Mah M, and DeVette L (1989) Dietary N-6 and N-3 fatty acids and salt-induced hypertension in the borderline hypertensive rat. Lipids 24:17-24.
22. Muller DN, Theuer J, Shagdarsuren E, Kaergel E, Honeck H, Park JK, Markovic M, Barbosa-Sicard E, Dechend R, Wellner M, et al. (2004) A peroxisome proliferator-activated receptor-α activator induces renal CYP2C23 activity and protects from angiotensin II-induced renal injury. Am J Pathol 164:521-532.
23. Narce M and Poisson JP (1995) Age-related depletion of linoleic acid desaturation in liver microsomes from young spontaneously hypertensive rats. Prostaglandins Leukotrienes Essent Fatty Acids 53:59-63.
24. Newman JW, Watanabe T, and Hammock BD (2002) The simultaneous quantification of cytochrome P450-dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS. J Lipid Res 43:1563-1578.
25. Node K, Huo Y, Ruan X, Yang B, Spiecker M, Ley K, Zeldin DC, and Liao JK (1999) Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science (Wash DC) 285:1276-1279.
26. αs mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids. J Biol Chem 276:15983-15989.
27. Sarkis A and Roman RJ (2004) Role of cytochrome P450 metabolites of arachidonic acid in hypertension. Curr Drug Metab 5:245-256.
28. Singer P, Moritz V, Wirth M, Berger I, and Forster D (1990) Blood pressure and serum lipids from SHR after diets supplemented with evening primrose, sunflowerseed or fish oil. Prostaglandins Leukotrienes Essent Fatty Acids 40:17-20.
29. Singer P, Voigt S, and Moritz V (1983) Changes of polyunsaturated fatty acids in serum lipids of spontaneously hypertensive rats during the onset of high blood pressure. Prostaglandins Leukotrienes Med 12:399-408.
30. Song BJ, Veech RL, Park SS, Gelboin HV, and Gonzalez FJ (1989) Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization. J Biol Chem 264:3568-3572.
31. Su P, Kaushal KM, and Kroetz DL (1998) Inhibition of renal arachidonic acid ω-hydroxylase activity with ABT reduces blood pressure in the SHR. Am J Physiol 275:R426-R438.
32. Sun J, Sui X, Bradbury JA, Zeldin DC, Conte MS, and Liao JK (2002) Inhibition of vascular smooth muscle cell migration by cytochrome P450 epoxygenase-derived eicosanoids. Circ Res 90:1020-1027.
33. Wang MH, Smith A, Zhou Y, Chang HH, Lin S, Zhao X, Imig JD, and Dorrance AM (2003) Downregulation of renal CYP-derived eicosanoid synthesis in rats with diet-induced hypertension. Hypertension 42:594-599.
34. Wu S, Chen W, Murphy E, Gabel S, Tomer KB, Foley J, Steenbergen C, Falck JR, Moomaw CR, and Zeldin DC (1997) Molecular cloning, expression and functional significance of a cytochrome P450 highly expressed in rat heart myocytes. J Biol Chem 272:12551-12559.
35. Wu S, Moomaw CR, Tomer KB, Falck JR, and Zeldin DC (1996) Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart. J Biol Chem 271:3460-3468.
36. Xu F, Falck JR, Ortiz de Montellano PR, and Kroetz DL (2004) Catalytic activity and isoform-specific inhibition of rat cytochrome P450 4F enzymes. J Pharmacol Exp Ther 308:887-895.
37. Xu F, Straub WO, Pak W, Su P, Maier KG, Yu M, Roman RJ, Ortiz De Montellano PR, and Kroetz DL (2002) Antihypertensive effect of mechanism-based inhibition of renal arachidonic acid ω-hydroxylase activity. Am J Physiol 283:R710-R720.
38. Yu Z, Huse LM, Adler P, Graham L, Ma J, Zeldin DC, and Kroetz DL (2000a) Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney. Mol Pharmacol 57:1011-1020.
39. Yu Z, Xu F, Huse LM, Morisseau C, Draper AJ, Newman JW, Parker C, Graham L, Engler MM, Hammock BD, et al. (2000b) Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circ Res 87:992-998.
40. Zeldin DC, Kobayashi J, Falck JR, Winder BS, Hammock BD, Snapper JR, and Capdevila JH (1993) Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase. J Biol Chem 268:6402-6407.
41. Zeldin DC, Moomaw CR, Jesse N, Tomer KB, Beetham J, Hammock BD, and Wu S (1996) Biochemical characterization of the human liver cytochrome P450 arachidonic acid epoxygenase pathway. Arch Biochem Biophys 330:87-96.