메뉴 건너뛰기




Volumn 11, Issue 6, 2007, Pages 644-651

Blockade of metabotropic glutamate receptor 5 activation inhibits mechanical hypersensitivity following abdominal surgery

Author keywords

Hyperalgesia; Metabotropic glutamate receptor 5; MPEP; Post surgical pain

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; DRUG VEHICLE; ISOFLURANE; METABOTROPIC RECEPTOR 5;

EID: 34249285872     PISSN: 10903801     EISSN: 15322149     Source Type: Journal    
DOI: 10.1016/j.ejpain.2006.10.002     Document Type: Article
Times cited : (17)

References (53)
  • 1
    • 0034601150 scopus 로고    scopus 로고
    • Differential distribution of metabotropic glutamate receptors 1a, 1b, and 5 in the rat spinal cord
    • Alvarez F.J., Villalba R.M., Carr P.A., Grandes P., and Somohano P.M. Differential distribution of metabotropic glutamate receptors 1a, 1b, and 5 in the rat spinal cord. J Comp Neurol 422 (2000) 464-487
    • (2000) J Comp Neurol , vol.422 , pp. 464-487
    • Alvarez, F.J.1    Villalba, R.M.2    Carr, P.A.3    Grandes, P.4    Somohano, P.M.5
  • 3
    • 0028046102 scopus 로고
    • Squirrel-monkey lateral thalamus 1. Somatic nociresponsive neurons and their relation to spinothalamic terminals
    • Apkarian A.V., and Shi T. Squirrel-monkey lateral thalamus 1. Somatic nociresponsive neurons and their relation to spinothalamic terminals. J Neurosci 14 (1994) 6779-6795
    • (1994) J Neurosci , vol.14 , pp. 6779-6795
    • Apkarian, A.V.1    Shi, T.2
  • 4
    • 0033545233 scopus 로고    scopus 로고
    • Distribution and developmental changes in metabotropic glutamate receptor messenger RNA expression in the rat lumbar spinal cord
    • Berthele A., Boxall S.J., Urban A., Anneser J.M.H., Zieglgansberger W., Urban L., et al. Distribution and developmental changes in metabotropic glutamate receptor messenger RNA expression in the rat lumbar spinal cord. Devel Brain Res 12 (1999) 39-53
    • (1999) Devel Brain Res , vol.12 , pp. 39-53
    • Berthele, A.1    Boxall, S.J.2    Urban, A.3    Anneser, J.M.H.4    Zieglgansberger, W.5    Urban, L.6
  • 5
    • 0035094199 scopus 로고    scopus 로고
    • Peripheral group I metabotropic glutamate receptors modulate nociception in mice
    • Bhave G., Karim S.M., Carlton R.W., and Gereau R.W. Peripheral group I metabotropic glutamate receptors modulate nociception in mice. Nat Neurosci 4 (2001) 417-423
    • (2001) Nat Neurosci , vol.4 , pp. 417-423
    • Bhave, G.1    Karim, S.M.2    Carlton, R.W.3    Gereau, R.W.4
  • 6
    • 0020606029 scopus 로고
    • Supraspinal connections of neurones in the thoracic spinal cord of the cat: ascending projections and effects of descending impulses
    • Cervero F. Supraspinal connections of neurones in the thoracic spinal cord of the cat: ascending projections and effects of descending impulses. Brain Res 275 (1983) 251-261
    • (1983) Brain Res , vol.275 , pp. 251-261
    • Cervero, F.1
  • 7
    • 0029076498 scopus 로고
    • Visceral pain: mechanisms of peripheral and central sensitization
    • Cervero F. Visceral pain: mechanisms of peripheral and central sensitization. Ann Med 27 (1995) 235-239
    • (1995) Ann Med , vol.27 , pp. 235-239
    • Cervero, F.1
  • 8
    • 0030995878 scopus 로고    scopus 로고
    • Pharmacology and functions of metabotropic glutamate receptors
    • Conn P.J., and Pin J.P. Pharmacology and functions of metabotropic glutamate receptors. Ann Rev Pharmacol Toxicol 37 (1997) 205-237
    • (1997) Ann Rev Pharmacol Toxicol , vol.37 , pp. 205-237
    • Conn, P.J.1    Pin, J.P.2
  • 9
    • 0027269633 scopus 로고
    • The effect of pre- versus postinjury infiltration with lidocaine on thermal and mechanical hyperalgesia after heat injury to the skin
    • Dahl J.B., Brennum J., Arendt Nielsen L., Jensen T.S., and Kehlet H. The effect of pre- versus postinjury infiltration with lidocaine on thermal and mechanical hyperalgesia after heat injury to the skin. Pain 53 (1993) 43-51
    • (1993) Pain , vol.53 , pp. 43-51
    • Dahl, J.B.1    Brennum, J.2    Arendt Nielsen, L.3    Jensen, T.S.4    Kehlet, H.5
  • 10
    • 0034073487 scopus 로고    scopus 로고
    • Behavioural evidence supporting a differential role for group I and II metabotropic glutamate receptors in spinal nociceptive transmission
    • Dolan S., and Nolan A.M. Behavioural evidence supporting a differential role for group I and II metabotropic glutamate receptors in spinal nociceptive transmission. Neuropharmacology 39 (2000) 1132-1138
    • (2000) Neuropharmacology , vol.39 , pp. 1132-1138
    • Dolan, S.1    Nolan, A.M.2
  • 11
    • 0036710924 scopus 로고    scopus 로고
    • Behavioural evidence supporting a differential role for spinal group I and II metabotropic glutamate receptors in inflammatory hyperalgesia in sheep
    • Dolan S., and Nolan A.M. Behavioural evidence supporting a differential role for spinal group I and II metabotropic glutamate receptors in inflammatory hyperalgesia in sheep. Neuropharmacol 43 (2002) 319-326
    • (2002) Neuropharmacol , vol.43 , pp. 319-326
    • Dolan, S.1    Nolan, A.M.2
  • 12
    • 0344305540 scopus 로고    scopus 로고
    • Up-regulation of metabotropic glutamate receptor subtypes 3 and 5 in spinal cord in a clinical model of persistent inflammation and hyperalgesia
    • Dolan S., Kelly J.G., Monteiro A.M., and Nolan A.M. Up-regulation of metabotropic glutamate receptor subtypes 3 and 5 in spinal cord in a clinical model of persistent inflammation and hyperalgesia. Pain 106 (2003) 501-512
    • (2003) Pain , vol.106 , pp. 501-512
    • Dolan, S.1    Kelly, J.G.2    Monteiro, A.M.3    Nolan, A.M.4
  • 13
    • 3242678862 scopus 로고    scopus 로고
    • Differential expression of central metabotropic glutamate receptor (mGluR) subtypes in a clinical model of post-surgical pain
    • Dolan S., Kelly J.G., Monteiro A.M., and Nolan A.M. Differential expression of central metabotropic glutamate receptor (mGluR) subtypes in a clinical model of post-surgical pain. Pain 110 (2004) 369-377
    • (2004) Pain , vol.110 , pp. 369-377
    • Dolan, S.1    Kelly, J.G.2    Monteiro, A.M.3    Nolan, A.M.4
  • 14
    • 15744399838 scopus 로고    scopus 로고
    • Psychophysical evidence that central sensitization contributes to secondary mechanical hyperalgesia in human subjects
    • Fuchs P.N., and Peng Y.B. Psychophysical evidence that central sensitization contributes to secondary mechanical hyperalgesia in human subjects. Sem Pain Med 1 (2003) 132-138
    • (2003) Sem Pain Med , vol.1 , pp. 132-138
    • Fuchs, P.N.1    Peng, Y.B.2
  • 15
    • 0032498802 scopus 로고    scopus 로고
    • In vivo antinociceptive activity of anti-rat mGluR(1) and mGluR(5) antibodies in rats
    • Fundytus M.E., Fisher K., Dray A., Henry J.L., and Coderre T.J. In vivo antinociceptive activity of anti-rat mGluR(1) and mGluR(5) antibodies in rats. NeuroReport 9 (1998) 31-735
    • (1998) NeuroReport , vol.9 , pp. 31-735
    • Fundytus, M.E.1    Fisher, K.2    Dray, A.3    Henry, J.L.4    Coderre, T.J.5
  • 16
    • 0032853255 scopus 로고    scopus 로고
    • 2-methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist
    • Gasparini F., Lingenhohl K., Stoehr N., Flor P.J., Heinrich M., Vranesic I., et al. 2-methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology 38 (1999) 1493-1503
    • (1999) Neuropharmacology , vol.38 , pp. 1493-1503
    • Gasparini, F.1    Lingenhohl, K.2    Stoehr, N.3    Flor, P.J.4    Heinrich, M.5    Vranesic, I.6
  • 17
    • 0028147491 scopus 로고
    • Effects of extracorporeal shock-wave lithotripsy on referred hyperalgesia from renal/ureteral calculosis
    • Giamberardino M.A., de Bigontina P., Martegiani C., and Vecchiet L. Effects of extracorporeal shock-wave lithotripsy on referred hyperalgesia from renal/ureteral calculosis. Pain 56 (1994) 77-83
    • (1994) Pain , vol.56 , pp. 77-83
    • Giamberardino, M.A.1    de Bigontina, P.2    Martegiani, C.3    Vecchiet, L.4
  • 18
    • 0034306944 scopus 로고    scopus 로고
    • Ovariohysterectomy in the rat: a model of surgical pain for evaluation of pre-emptive analgesia?
    • Gonzalez M.I., Field M.J., Bramwell S., McCleary S., and Singh L. Ovariohysterectomy in the rat: a model of surgical pain for evaluation of pre-emptive analgesia?. Pain 88 (2000) 79-88
    • (2000) Pain , vol.88 , pp. 79-88
    • Gonzalez, M.I.1    Field, M.J.2    Bramwell, S.3    McCleary, S.4    Singh, L.5
  • 19
    • 0037334233 scopus 로고    scopus 로고
    • Acute activation of the spinal cord metabotropic glutamate subtype-5 receptor leads to cold hypersensitivity in the rat
    • Hama A.T. Acute activation of the spinal cord metabotropic glutamate subtype-5 receptor leads to cold hypersensitivity in the rat. Neuropharmacology 44 (2003) 423-430
    • (2003) Neuropharmacology , vol.44 , pp. 423-430
    • Hama, A.T.1
  • 20
    • 0033538893 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors in superficial laminae of the rat dorsal horn
    • Jia H., Rustioni A., and Valtschanoff J.G. Metabotropic glutamate receptors in superficial laminae of the rat dorsal horn. J Comp Neurol 410 (1999) 627-642
    • (1999) J Comp Neurol , vol.410 , pp. 627-642
    • Jia, H.1    Rustioni, A.2    Valtschanoff, J.G.3
  • 21
    • 0034936359 scopus 로고    scopus 로고
    • Effect of postoperative analgesia on surgical outcome
    • Kehlet H., and Holte K. Effect of postoperative analgesia on surgical outcome. Br J Anaesth 87 (2001) 62-72
    • (2001) Br J Anaesth , vol.87 , pp. 62-72
    • Kehlet, H.1    Holte, K.2
  • 22
    • 6444244298 scopus 로고    scopus 로고
    • In vitro and in vivo characterization of MPEP, an allosteric modulator of the metabotropic glutamate receptor subtype 5: Review article
    • Kuhn R., Pagano A., Stoehr N., Vranesic I., Flor P.J., Lingenhohl K., et al. In vitro and in vivo characterization of MPEP, an allosteric modulator of the metabotropic glutamate receptor subtype 5: Review article. Amino Acids 23 (2002) 207-211
    • (2002) Amino Acids , vol.23 , pp. 207-211
    • Kuhn, R.1    Pagano, A.2    Stoehr, N.3    Vranesic, I.4    Flor, P.J.5    Lingenhohl, K.6
  • 23
    • 0025868408 scopus 로고
    • Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms
    • LaMotte R.H., Shain C.N., Simone D.A., and Tsai E.-F.P. Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. J Neurophysiol 66 (1991) 190-211
    • (1991) J Neurophysiol , vol.66 , pp. 190-211
    • LaMotte, R.H.1    Shain, C.N.2    Simone, D.A.3    Tsai, E.-F.P.4
  • 24
    • 0031466072 scopus 로고    scopus 로고
    • Post-operative central hypersensitivity and pain: the pre-emptive value of pethidine for ovariohysterectomy
    • Lascelles B.D.X., Cripps P.J., Jones A., and Waterman A.E. Post-operative central hypersensitivity and pain: the pre-emptive value of pethidine for ovariohysterectomy. Pain 73 (1997) 461-471
    • (1997) Pain , vol.73 , pp. 461-471
    • Lascelles, B.D.X.1    Cripps, P.J.2    Jones, A.3    Waterman, A.E.4
  • 25
    • 0027193908 scopus 로고
    • Acute mechanical hyperalgesia is produced by coactivation of AMPA and metabotropic receptors
    • Meller S.T., Dykstra C.L., and Gebhart G.F. Acute mechanical hyperalgesia is produced by coactivation of AMPA and metabotropic receptors. NeuroReport 4 (1993) 879-882
    • (1993) NeuroReport , vol.4 , pp. 879-882
    • Meller, S.T.1    Dykstra, C.L.2    Gebhart, G.F.3
  • 26
    • 0030050543 scopus 로고    scopus 로고
    • Acute thermal hyperalgesia in the rat is produced by activation of N-methyl d-aspartate receptors and protein kinase C and production of nitric oxide
    • Meller S.T., Dykstra C., and Gebhart G.F. Acute thermal hyperalgesia in the rat is produced by activation of N-methyl d-aspartate receptors and protein kinase C and production of nitric oxide. Neuroscience 71 (1996) 327-335
    • (1996) Neuroscience , vol.71 , pp. 327-335
    • Meller, S.T.1    Dykstra, C.2    Gebhart, G.F.3
  • 27
    • 0025370632 scopus 로고
    • Visceral pain: a review of experimental studies
    • Ness T.J., and Gebhart G.F. Visceral pain: a review of experimental studies. Pain 41 (1990) 167-234
    • (1990) Pain , vol.41 , pp. 167-234
    • Ness, T.J.1    Gebhart, G.F.2
  • 28
    • 0035478759 scopus 로고    scopus 로고
    • Peripheral metabotropic glutamate receptors: fight the pain where it hurts
    • Neugebauer V. Peripheral metabotropic glutamate receptors: fight the pain where it hurts. Trends Neurosci 24 (2001) 550-552
    • (2001) Trends Neurosci , vol.24 , pp. 550-552
    • Neugebauer, V.1
  • 29
    • 0032797964 scopus 로고    scopus 로고
    • Role of metabotropic glutamate receptor subtype mGluR1 in brief nociception and central sensitization of primate STT cells
    • Neugebauer V., Chen P.S., and Willis W.D. Role of metabotropic glutamate receptor subtype mGluR1 in brief nociception and central sensitization of primate STT cells. J Neurophysiol 82 (1999) 272-282
    • (1999) J Neurophysiol , vol.82 , pp. 272-282
    • Neugebauer, V.1    Chen, P.S.2    Willis, W.D.3
  • 30
    • 0033638723 scopus 로고    scopus 로고
    • Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism
    • O'Leary D.M., Movsesyan V., Vicini S., and Faden A.I. Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism. Br J Pharmacol 131 (2000) 1429-1437
    • (2000) Br J Pharmacol , vol.131 , pp. 1429-1437
    • O'Leary, D.M.1    Movsesyan, V.2    Vicini, S.3    Faden, A.I.4
  • 31
    • 0032102818 scopus 로고
    • Secondary hyperalgesia to heat stimuli after burn injury in man
    • Pedersen J.L., and Kehlet H. Secondary hyperalgesia to heat stimuli after burn injury in man. Pain 76 (1988) 377-384
    • (1988) Pain , vol.76 , pp. 377-384
    • Pedersen, J.L.1    Kehlet, H.2
  • 32
    • 0141738771 scopus 로고    scopus 로고
    • Spinal glutamate receptor antagonists differentiate primary and secondary mechanical hyperalgesia caused by incision
    • Pogatzki E.M., Niemeier J.S., Sorkin L.S., and Brennan T.J. Spinal glutamate receptor antagonists differentiate primary and secondary mechanical hyperalgesia caused by incision. Pain 105 (2003) 97-107
    • (2003) Pain , vol.105 , pp. 97-107
    • Pogatzki, E.M.1    Niemeier, J.S.2    Sorkin, L.S.3    Brennan, T.J.4
  • 33
    • 0027288157 scopus 로고
    • Preoperative morphine pre-empts postoperative pain
    • Richmond C.E., Bromley L.M., and Woolf C.J. Preoperative morphine pre-empts postoperative pain. Lancet 342 (1993) 73-75
    • (1993) Lancet , vol.342 , pp. 73-75
    • Richmond, C.E.1    Bromley, L.M.2    Woolf, C.J.3
  • 35
    • 0035252363 scopus 로고    scopus 로고
    • Behavioural effects of laparotomy and analgesic effects of ketoprofen and carprofen in rats
    • Roughan J.V., and Flecknell P.A. Behavioural effects of laparotomy and analgesic effects of ketoprofen and carprofen in rats. Pain 90 (2001) 65-74
    • (2001) Pain , vol.90 , pp. 65-74
    • Roughan, J.V.1    Flecknell, P.A.2
  • 36
    • 0031901499 scopus 로고    scopus 로고
    • Reduction of sensory and metabotropic glutamate receptor responses in the thalamus by the novel metabotropic glutamate receptor-1-selective antagonist S-2-methyl-4-carboxy-phenylglycine
    • Salt T.E., and Turner J.P. Reduction of sensory and metabotropic glutamate receptor responses in the thalamus by the novel metabotropic glutamate receptor-1-selective antagonist S-2-methyl-4-carboxy-phenylglycine. Neuroscience 85 (1998) 655-658
    • (1998) Neuroscience , vol.85 , pp. 655-658
    • Salt, T.E.1    Turner, J.P.2
  • 37
    • 0025827277 scopus 로고
    • Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons
    • Simone D.A., Sorkin L.S., Oh U., Chung J.M., Owens C., LaMotte R.H., et al. Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons. J Neurophysiol 66 (1991) 228-246
    • (1991) J Neurophysiol , vol.66 , pp. 228-246
    • Simone, D.A.1    Sorkin, L.S.2    Oh, U.3    Chung, J.M.4    Owens, C.5    LaMotte, R.H.6
  • 38
    • 0037448117 scopus 로고    scopus 로고
    • The mGluR5 selective antagonist 6-methyl-2-(phenylethynyl)-pyridine reduces the spinal neuron pain-related activity in mononeuropathic rats
    • Sotgiu M.L., Bellomi P., and Biella G.E.M. The mGluR5 selective antagonist 6-methyl-2-(phenylethynyl)-pyridine reduces the spinal neuron pain-related activity in mononeuropathic rats. Neurosci Lett 342 (2003) 85-88
    • (2003) Neurosci Lett , vol.342 , pp. 85-88
    • Sotgiu, M.L.1    Bellomi, P.2    Biella, G.E.M.3
  • 39
    • 0030661767 scopus 로고    scopus 로고
    • Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery
    • Stubhaug A., Breivik H., Eide P.K., Kreunen M., and Foss A. Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery. Acta Anaesthesth Scand 41 (1997) 1124-1132
    • (1997) Acta Anaesthesth Scand , vol.41 , pp. 1124-1132
    • Stubhaug, A.1    Breivik, H.2    Eide, P.K.3    Kreunen, M.4    Foss, A.5
  • 40
    • 26944448583 scopus 로고    scopus 로고
    • Effect of metabotropic glutamate receptor subtype 5 antagonist, 2-methyl-6-(phenylethynyl)-pyridine on mechanosensory afferents innervating rat hind paw following inflammation
    • Su X., and Urban M.O. Effect of metabotropic glutamate receptor subtype 5 antagonist, 2-methyl-6-(phenylethynyl)-pyridine on mechanosensory afferents innervating rat hind paw following inflammation. Neurosci Lett 390 (2005) 123-128
    • (2005) Neurosci Lett , vol.390 , pp. 123-128
    • Su, X.1    Urban, M.O.2
  • 41
    • 0026534771 scopus 로고
    • Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans
    • Torebjörk H.E., Lundberg L.E.R., and LaMotte R.H. Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans. J Physiol (Lon) 448 (1992) 765-780
    • (1992) J Physiol (Lon) , vol.448 , pp. 765-780
    • Torebjörk, H.E.1    Lundberg, L.E.R.2    LaMotte, R.H.3
  • 42
    • 0030822505 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor mRNA expression in rat spinal cord
    • Valerio A., Paterlini M., Biofava M., Memo M., and Spano P. Metabotropic glutamate receptor mRNA expression in rat spinal cord. NeuroReport 8 (1997) 2695-2699
    • (1997) NeuroReport , vol.8 , pp. 2695-2699
    • Valerio, A.1    Paterlini, M.2    Biofava, M.3    Memo, M.4    Spano, P.5
  • 43
    • 0001028505 scopus 로고
    • Referred pain from viscera: when the symptom persists despite the extinction of the visceral focus
    • Vecchiet L., Giamberardino M.A., and de Bigontina P. Referred pain from viscera: when the symptom persists despite the extinction of the visceral focus. Adv Pain Res Therapeut 20 (1992) 101-110
    • (1992) Adv Pain Res Therapeut , vol.20 , pp. 101-110
    • Vecchiet, L.1    Giamberardino, M.A.2    de Bigontina, P.3
  • 44
    • 0033758569 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function I. Selective blockade of mGlu5 receptors in models of acute persistent and chronic pain
    • Walker K., Bowes M., Panesar M., Davis A., Gentry C., Kesingland A., et al. Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function I. Selective blockade of mGlu5 receptors in models of acute persistent and chronic pain. Neuropharmacology 40 (2001) 1-9
    • (2001) Neuropharmacology , vol.40 , pp. 1-9
    • Walker, K.1    Bowes, M.2    Panesar, M.3    Davis, A.4    Gentry, C.5    Kesingland, A.6
  • 45
    • 0033763535 scopus 로고    scopus 로고
    • mGlu5 receptors and nociceptive function II mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia
    • Walker K., Reeve A., Bowes M., Winter J., Wotherspoon G., Davis A., et al. mGlu5 receptors and nociceptive function II mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia. Neuropharmacol 40 (2001) 10-19
    • (2001) Neuropharmacol , vol.40 , pp. 10-19
    • Walker, K.1    Reeve, A.2    Bowes, M.3    Winter, J.4    Wotherspoon, G.5    Davis, A.6
  • 46
    • 0002370053 scopus 로고
    • Neurophysiological mechanisms of referred pain and hyperalgesia
    • Vecchiet L., Albe-Fessard D., Lindblom U., and Giamberardino M.A. (Eds), Elsevier, Amsterdam
    • Wall P.D. Neurophysiological mechanisms of referred pain and hyperalgesia. In: Vecchiet L., Albe-Fessard D., Lindblom U., and Giamberardino M.A. (Eds). New Trends in Referred Pain and Hyperalgesia (1993), Elsevier, Amsterdam 3-12
    • (1993) New Trends in Referred Pain and Hyperalgesia , pp. 3-12
    • Wall, P.D.1
  • 47
    • 0031003790 scopus 로고    scopus 로고
    • Concentration-effect relations for intravenous lidocaine infusions in human volunteers
    • Wallace M.S., Laitin S., Licht D., and Yaksh T.L. Concentration-effect relations for intravenous lidocaine infusions in human volunteers. Anesthesiology 86 (1997) 1262-1272
    • (1997) Anesthesiology , vol.86 , pp. 1262-1272
    • Wallace, M.S.1    Laitin, S.2    Licht, D.3    Yaksh, T.L.4
  • 48
    • 0021286757 scopus 로고
    • Muscle but not cutaneous C-afferent input produces prolonged increases in the excitability of the flexion reflex in the rat
    • Wall P.D., and Woolf C.J. Muscle but not cutaneous C-afferent input produces prolonged increases in the excitability of the flexion reflex in the rat. J Physiol 356 (1984) 443-458
    • (1984) J Physiol , vol.356 , pp. 443-458
    • Wall, P.D.1    Woolf, C.J.2
  • 49
    • 0001824422 scopus 로고
    • Hyperalgesia and Allodynia: summary and overview
    • Willis W. (Ed), Raven Press, New York
    • Willis W.D. Hyperalgesia and Allodynia: summary and overview. In: Willis W. (Ed). Hyperalgesia and Allodynia (1992), Raven Press, New York 1-11
    • (1992) Hyperalgesia and Allodynia , pp. 1-11
    • Willis, W.D.1
  • 50
    • 0027166359 scopus 로고
    • Preemptive analgesia treating postoperative pain by preventing the establishment of central sensitization
    • Woolf C.J., and Chong M.S. Preemptive analgesia treating postoperative pain by preventing the establishment of central sensitization. Anesthes Analges 77 (1993) 362-379
    • (1993) Anesthes Analges , vol.77 , pp. 362-379
    • Woolf, C.J.1    Chong, M.S.2
  • 51
    • 0031589694 scopus 로고    scopus 로고
    • Behavioural and electrophysiological evidence supporting a role for group I metabotropic glutamate receptors in the mediation of nociceptive inputs to the rat spinal cord
    • Young M.R., Fleetwood-Walker S.M., Dickinson T., Blackburn-Munro G., Sparrow H., Birch P.J., et al. Behavioural and electrophysiological evidence supporting a role for group I metabotropic glutamate receptors in the mediation of nociceptive inputs to the rat spinal cord. Brain Res 777 (1997) 161-169
    • (1997) Brain Res , vol.777 , pp. 161-169
    • Young, M.R.1    Fleetwood-Walker, S.M.2    Dickinson, T.3    Blackburn-Munro, G.4    Sparrow, H.5    Birch, P.J.6
  • 52
    • 9944223305 scopus 로고    scopus 로고
    • Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities
    • Zhu C.Z., Wilson S.G., Mikusa J.P., Wismer C.T., Gauvin D.M., Lynch J.J., et al. Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities. Eur J Pharmacol 506 (2004) 107-118
    • (2004) Eur J Pharmacol , vol.506 , pp. 107-118
    • Zhu, C.Z.1    Wilson, S.G.2    Mikusa, J.P.3    Wismer, C.T.4    Gauvin, D.M.5    Lynch, J.J.6
  • 53
    • 20044392668 scopus 로고    scopus 로고
    • Role of central and peripheral mGluR5 receptors in post-operative pain in rats
    • Zhu C.Z., Hsieh G., El-Kouhen O., Wilson S.G., Mikusa J.P., Hollingsworth P.R., et al. Role of central and peripheral mGluR5 receptors in post-operative pain in rats. Pain 114 (2005) 195-202
    • (2005) Pain , vol.114 , pp. 195-202
    • Zhu, C.Z.1    Hsieh, G.2    El-Kouhen, O.3    Wilson, S.G.4    Mikusa, J.P.5    Hollingsworth, P.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.