Reduction of sensory and metabotropic glutamate receptor responses in the thalamus by the novel metabotropic glutamate receptor-1-selective antagonist S-2-methyl-4-carboxy-phenylglycine

Neuroscience

Volumn 85, Issue 3, 1998, Pages 655-658

  Salt, T E ^a   Turner, J P ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Iontophoresis; LY367385; Metabotropic glutamate receptor antagonist; mGluR1; Nociception; Somatosensory; Thalamus

Indexed keywords

GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; METABOTROPIC RECEPTOR;

ANALGESIC ACTIVITY; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; RECEPTOR BLOCKING; SENSORY NERVE CELL; SOMATOSENSORY STIMULATION; THALAMUS;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BENZOATES; CYCLOLEUCINE; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GLYCINE; MALE; N-METHYLASPARTATE; NAPHTHOLS; NEURONS, AFFERENT; NEUROPROTECTIVE AGENTS; PROPYLENE GLYCOLS; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; THALAMUS;

EID: 0031901499     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(98)00048-7     Document Type: Article

References (26)

1. Abe T., Sugihara H., Nawa H., Shigemoto R., Mizuno N., Nakanishi S. Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. J. biol. Chem. 267:1992;13361-13368.
2. Aniksztejn L., Otani S., Ben-Ari Y. Quisqualate metabotropic receptors modulate NMDA currents and facilitate induction of long-term potentiation through protein kinase C. Eur. J. Neurosci. 4:1992;500-505.
3. Charpak S., Gähwiler B. H. Glutamate mediates a slow synaptic response in hippocampal slice cultures. Proc. R. Soc. Lond. B. 243:1991;221-226.
4. Clark B. P., Baker S. R., Goldsworthy J., Harris J. R., Kingston A. E. (+)-2-Methyl-4-carboxyphenylglycine (LY367385) selectively antagonises metabotropic glutamate mGluR1 receptors. Bioorg. Med. Chem. Lett. 7:1997;2777-2780.
5. Eaton S. A., Birse E. F., Wharton B., Sunter D. C., Udvarhelyi P. M., Watkins J. C., Salt T. E. Mediation of thalamic sensory responses in vivo by ACPD-activated excitatory amino acid receptors. Eur. J. Neurosci. 5:1993;186-189.
6. Eaton S. A., Salt T. E. Role of N-methyl-D-aspartate and metabotropic glutamate receptors in cortico-thalamic excitatory postsynaptic potentials in vivo. Neuroscience. 73:1996;1-5.
7. Eaton S. A., Salt T. E. Thalamic NMDA receptors and nociceptive sensory synaptic transmission. Neurosci. Lett. 110:1990;297-302.
8. Fitzjohn S. M., Irving A. J., Palmer M. J., Harvey J., Lodge D., Collingridge G. L. Activation of group I mGluRs potentiates NMDA responses in rat hippocampal slices. Neurosci. Lett. 203:1996;211-213.
9. Godwin D. W., Van Horn S. C., Erisir A., Sesma M., Romano C., Sherman S. M. Ultrastructural localization suggests that retinal and cortical inputs access different metabotropic glutamate receptors in the lateral geniculate nucleus. J. Neurosci. 16:1996;8181-8192.
10. Kingston A. E., Burnett J. P., Mayne N. G., Lodge D. Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects on mGluR1α and mGluR5α subtypes. Neuropharmacology. 34:1995;887-894.
11. Martin L. J., Blackstone C. D., Huganir R. L., Price D. L. Cellular localization of a metabotropic glutamate receptor in rat brain. Neuron. 9:1992;259-270.
12. Masu M., Tanabe Y., Tsuchida K., Shigemoto R., Nakanishi S. Sequence and expression of a metabotropic glutamate receptor. Nature. 349:1991;760-765.
13. 2+ of NMDA responses in spinal cord neurones. Nature. 309:1984;261-263.
14. McCormick D. A., Von Krosigk M. Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors. Proc. natn. Acad. Sci. U.S.A. 89:1992;2774-2778.
15. Nakanishi S. Molecular diversity of glutamate receptors and implications for brain function. Science. 258:1992;597-603.
16. Nowak L., Bregestovski P., Ascher P., Herbet A., Prochiantz A. Magnesium gates glutamate-activated channels in mouse central neurones. Nature. 307:1984;462-465.
17. Peschanski M., Guilbaud G., Gautron M., Besson J. M. Encoding of noxious heat messages in neurons of the ventrobasal thalamic complex of the rat. Brain Res. 197:1980;401-413.
18. Pin J.-P., Duvoisin R. The metabotropic glutamate receptors: structure and functions. Neuropharmacology. 34:1995;1-26.
19. Pisani A., Calabresi P., Centonze D., Bernardi G. Enhancement of NMDA responses by group I metabotropic glutamate receptor activation in striatal neurones. Br. J. Pharmacol. 120:1997;1007-1114.
20. Romano C., Van den Pol A. N., O'Malley K. L. Enhanced early developmental expression of the metabotropic glutamate receptor mGluR5 in rat brain: protein, mRNA splice variants, and regional distribution. J. comp. Neurol. 367:1996;403-412.
21. Salt T. E. Excitatory amino acid receptors and synaptic transmission in the rat ventrobasal thalamus. J. Physiol. 391:1987;499-510.
22. Salt T. E., Eaton S. A. The function of metabotropic excitatory amino acid receptors in synaptic transmission in the thalamus: studies with novel phenylglycine antagonists. Neurochem. Int. 24:1994;451-458.
23. Salt T. E., Eaton S. A. Modulation of sensory neurone excitatory and inhibitory responses in the ventrobasal thalamus by activation of metabotropic excitatory amino acid receptors. Neuropharmacology. 34:1995;1043-1051.
24. Shigemoto R., Nakanishi S., Mizuno N. Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: an in situ hybridization study in adult and developing rat. J. comp. Neurol. 322:1992;121-135.
25. Turner J. P., Salt T. E. Effect of metabotropic glutamate receptor activation on rat thalamocortical neurones in vitro. Soc. Neurosci. Abstr. 22:1996;631.
26. Vidnyanszky Z., Goercs T. J., Negyessy L., Kuhn R., Knoepfel T., Hamori J. Immunohistochemical visualization of the mGluR1a metabotropic glutamate receptor at synapses of corticothalamic terminals originating from area 17 of the rat. Eur. J. Neurosci. 8:1996;1061-1071.