Probing the S2 site of factor VIIa to generate potent and selective inhibitors: The structure of BCX-3607 in complex with tissue factor-factor VIIa

Acta Crystallographica Section D: Biological Crystallography

Volumn 63, Issue 6, 2007, Pages 689-697

  Krishnan, Raman ^a   Kotian, Pravin L ^a   Chand, Pooran ^a   Bantia, Shanta ^a   Rowland, Scott ^a   Babu, Y S ^a  

^a BIOCRYST PHARMACEUTICALS INC   (United States)

Author keywords

Factor VII; Small molecule inhibitors; Tissue factor

Indexed keywords

BCX 3607; BCX-3607; BLOOD CLOTTING FACTOR 7A; MULTIPROTEIN COMPLEX; PYRIDINE DERIVATIVE; THROMBOPLASTIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; HUMAN; IN VITRO STUDY; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FACTOR VIIA; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MULTIPROTEIN COMPLEXES; PYRIDINES; THROMBOPLASTIN;

EID: 34249035718     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444907014187     Document Type: Article

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