The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 21, 2005, Pages 4752-4756

  Kohrt, Jeffrey T ^a   Filipski, Kevin J ^a   Cody, Wayne L ^a   Cai, Cuiman ^a   Dudley, Danette A ^a   Van Huis, Chad A ^a   Willardsen, J Adam ^a   Rapundalo, Stephen T ^a   Saiya Cork, Kamlai ^a   Leadley, Robert J ^a   Narasimhan, Lakshmi ^a   Zhang, Erli ^a   Whitlow, Marc ^b   Adler, Marc ^b   McLean, Kirk ^b   Chou, Yuo Ling ^b   McKnight, Cecile ^b   Arnaiz, Damian O ^b   Shaw, Kenneth J ^b   Light, David R ^b   Edmunds, Jeremy J ^a   more..

^a PFIZER INC   (United States)

^b BAYER AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 7A INHIBITOR; HYDROXYBENZOIC ACID; PYRIDINE DERIVATIVE; TISSUE FACTOR PATHWAY INHIBITOR;

ARTICLE; CHEMICAL INTERACTION; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; FACTOR VIIA; FACTOR XA; FIBRINOLYTIC AGENTS; HUMANS; INHIBITORY CONCENTRATION 50; PROTEIN BINDING; PROTHROMBIN TIME; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOPLASTIN;

EID: 25444523466     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.07.059     Document Type: Article

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