Structure of human factor VIIa/tissue factor in complex with a peptide-mimetic inhibitor: High selectivity against thrombin by introducing two charged groups in P2 and P4

Acta Crystallographica Section F: Structural Biology and Crystallization Communications

Volumn 61, Issue 2, 2005, Pages 169-173

  Kadono, Shojiro ^a   Sakamoto, Akihisa ^a   Kikuchi, Yasufumi ^a   Oh Eda, Masayoshi ^a   Yabuta, Naohiro ^a   Koga, Takaki ^a   Hattori, Kunihiro ^a   Shiraishi, Takuya ^a   Haramura, Masayuki ^a   Kodama, Hirofumi ^a   Ono, Yoshiyuki ^a   Esaki, Toru ^a   Sato, Haruhiko ^a   Watanabe, Yoshiaki ^a   Itoh, Susumu ^a   Ohta, Masateru ^a   Kozono, Toshiro ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBIN; BLOOD CLOTTING FACTOR 7A; PEPTIDE; THROMBOPLASTIN;

ARTICLE; BLOOD CLOTTING; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; HUMAN; MACROMOLECULE; PROTEIN SECONDARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ANTICOAGULANTS; ANTITHROMBINS; BLOOD COAGULATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FACTOR VIIA; HUMANS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; THROMBOPLASTIN;

EID: 33646489195     PISSN: 17443091     EISSN: 17443091     Source Type: Journal    
DOI: 10.1107/S1744309105000047     Document Type: Article

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