Design and synthesis of novel quinolinone-3-aminoamides and their α-lipoic acid adducts as antioxidant and anti-inflammatory agents

Journal of Medicinal Chemistry

Volumn 50, Issue 10, 2007, Pages 2450-2458

  Detsi, Anastasia ^a   Bouloumbasi, Dionysia ^a   Prousis, Kyriakos C ^a   Koufaki, Maria ^b   Athanasellis, Giorgos ^a   Melagraki, Georgia ^a   Afantitis, Antreas ^a   Igglessi Markopoulou, Olga ^a   Kontogiorgis, Christos ^c   Hadjipavlou Litina, Dimitra J ^c  

^a NATIONAL TECHNICAL UNIVERSITY OF ATHENS   (Greece)

^b INSTITUTE OF BIOLOGY   (Greece)

^c ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; N (1,2 DIHYDRO 4 HYDROXY 1 METHYL 2 OXO 3 QUINOLINECARBONYL) N' (1,2 DITHIOLANE 3 PENTANOYL)ETHYLENEDIAMINE; N (1,2 DIHYDRO 4 HYDROXY 1 METHYL 2 OXO 3 QUINOLINECARBONYL) N' (1,2 DITHIOLANE 3 PENTANOYL)HEXAMETHYLENEDIAMINE; N (1,2 DIHYDRO 4 HYDROXY 2 OXO 1 PHENYL 3 QUINOLINECARBONYL) N' (1,2 DITHIOLANE 3 PENTANOYL) 1,2 PHENYLENEDIAMINE; N (1,2 DIHYDRO 4 HYDROXY 2 OXO 1 PHENYL 3 QUINOLINECARBONYL) N' (1,2 DITHIOLANE 3 PENTANOYL)ETHYLENEDIAMINE; N (1,2 DIHYDRO 4 HYDROXY 2 OXO 1 PHENYL 3 QUINOLINECARBONYL) N' (1,2 DITHIOLANE 3 PENTANOYL)HEXAMETHYLENEDIAMINE; N 2 PHENYLAMINO 1,2 DIHYDRO 4 HYDROXY 1 METHYL 2 OXO 3 QUINOLINECARBOXAMIDE; N 4 PHENYLAMINO 1,2 DIHYDRO 4 HYDROXY 1 METHYL 2 OXO 3 QUINOLINECARBOXAMIDE; N 4 PHENYLAMINO 1,2 DIHYDRO 4 HYDROXY 1 PHENYL 2 OXO 3 QUINOLINECARBOXAMIDE; N ETHYLAMINO 1,2 DIHYDRO 4 HYDROXY 2 OXO 1 PHENYL 3 QUINOLINECARBOXAMIDE; N HEXYLAMINO 1,2 DIHYDRO 4 HYDROXY 1 METHYL 2 OXO 3 QUINOLINECARBOXAMIDE; NORDIHYDROGUAIARETIC ACID; QUINOLINE DERIVATIVE; TROLOX C; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; BIPHENYL COMPOUNDS; CARRAGEENAN; DIMETHYL SULFOXIDE; EDEMA; FEMALE; HYDRAZINES; HYDROXYL RADICAL; LIPOXYGENASE INHIBITORS; MALE; OXIDATION-REDUCTION; QUINOLONES; RATS; RATS, INBRED F344; STRUCTURE-ACTIVITY RELATIONSHIP; THIOCTIC ACID;

EID: 34249031803     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm061173n     Document Type: Article

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